메뉴 건너뛰기




Volumn 198, Issue 10, 2017, Pages 3999-4011

Antibody distance from the cell membrane regulates antibody effector mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CD137 ANTIGEN; CD20 ANTIGEN; CD52 ANTIGEN; EPITOPE; HYBRID PROTEIN; MONOCLONAL ANTIBODY; RITUXIMAB; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; TUMOR ANTIGEN;

EID: 85019688652     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601473     Document Type: Article
Times cited : (90)

References (64)
  • 1
    • 39749182212 scopus 로고    scopus 로고
    • A decade of rituximab: Improving survival outcomes in non- Hodgkin's lymphoma
    • Molina, A. 2008. A decade of rituximab: Improving survival outcomes in non- Hodgkin's lymphoma. Annu. Rev. Med. 59: 237-250.
    • (2008) Annu. Rev. Med. , vol.59 , pp. 237-250
    • Molina, A.1
  • 2
    • 84858416256 scopus 로고    scopus 로고
    • Antibody-based immunotherapy of cancer
    • Weiner, L. M., J. C. Murray, and C. W. Shuptrine. 2012. Antibody-based immunotherapy of cancer. Cell 148: 1081-1084.
    • (2012) Cell , vol.148 , pp. 1081-1084
    • Weiner, L.M.1    Murray, J.C.2    Shuptrine, C.W.3
  • 3
    • 68849108368 scopus 로고    scopus 로고
    • Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
    • Ivanov, A., S. A. Beers, C. A. Walshe, J. Honeychurch, W. Alduaij, K. L. Cox, K. N. Potter, S. Murray, C. H. Chan, T. Klymenko, et al. 2009. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J. Clin. Invest. 119: 2143-2159.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2143-2159
    • Ivanov, A.1    Beers, S.A.2    Walshe, C.A.3    Honeychurch, J.4    Alduaij, W.5    Cox, K.L.6    Potter, K.N.7    Murray, S.8    Chan, C.H.9    Klymenko, T.10
  • 4
    • 79955979273 scopus 로고    scopus 로고
    • Novel type II anti- CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actindependent, lysosome-mediated cell death in B-cell malignancies
    • Alduaij, W., A. Ivanov, J. Honeychurch, E. J. Cheadle, S. Potluri, S. H. Lim, K. Shimada, C. H. Chan, A. Tutt, S. A. Beers, et al. 2011. Novel type II anti- CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actindependent, lysosome-mediated cell death in B-cell malignancies. Blood 117: 4519-4529.
    • (2011) Blood , vol.117 , pp. 4519-4529
    • Alduaij, W.1    Ivanov, A.2    Honeychurch, J.3    Cheadle, E.J.4    Potluri, S.5    Lim, S.H.6    Shimada, K.7    Chan, C.H.8    Tutt, A.9    Beers, S.A.10
  • 6
    • 0001321260 scopus 로고
    • Complement fixation on cell surfaces by 19S and 7S antibodies
    • Borsos, T., and H. J. Rapp. 1965. Complement fixation on cell surfaces by 19S and 7S antibodies. Science 150: 505-506.
    • (1965) Science , vol.150 , pp. 505-506
    • Borsos, T.1    Rapp, H.J.2
  • 9
    • 0022567063 scopus 로고
    • The membrane attack complex of complement
    • Müller-Eberhard, H. J. 1986. The membrane attack complex of complement. Annu. Rev. Immunol. 4: 503-528.
    • (1986) Annu. Rev. Immunol. , vol.4 , pp. 503-528
    • Müller-Eberhard H , J.1
  • 10
    • 84862495640 scopus 로고    scopus 로고
    • Properties of mouse and human IgG receptors and their contribution to disease models
    • Bruhns, P. 2012. Properties of mouse and human IgG receptors and their contribution to disease models. Blood 119: 5640-5649.
    • (2012) Blood , vol.119 , pp. 5640-5649
    • Bruhns, P.1
  • 11
    • 38049103314 scopus 로고    scopus 로고
    • Mechanisms of granule-dependent killing
    • Cullen, S. P., and S. J. Martin. 2008. Mechanisms of granule-dependent killing. Cell Death Differ. 15: 251-262.
    • (2008) Cell Death Differ. , vol.15 , pp. 251-262
    • Cullen, S.P.1    Martin, S.J.2
  • 14
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes, R. A., T. L. Towers, L. G. Presta, and J. V. Ravetch. 2000. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat. Med. 6: 443-446.
    • (2000) Nat. Med. , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 15
    • 69049115069 scopus 로고    scopus 로고
    • Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    • López-Albaitero, A., S. C. Lee, S. Morgan, J. R. Grandis, W. E. Gooding, S. Ferrone, and R. L. Ferris. 2009. Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. Cancer Immunol. Immunother. 58: 1853-1864.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1853-1864
    • López-Albaitero, A.1    Lee, S.C.2    Morgan, S.3    Grandis, J.R.4    Gooding, W.E.5    Ferrone, S.6    Ferris, R.L.7
  • 18
    • 80055061034 scopus 로고    scopus 로고
    • One target, different effects: A comparison of distinct therapeutic antibodies against the same targets
    • Shim, H. 2011. One target, different effects: A comparison of distinct therapeutic antibodies against the same targets. Exp. Mol. Med. 43: 539-549.
    • (2011) Exp. Mol. Med. , vol.43 , pp. 539-549
    • Shim, H.1
  • 20
    • 1642306050 scopus 로고    scopus 로고
    • Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents
    • Cragg, M. S., and M. J. Glennie. 2004. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood 103: 2738-2743.
    • (2004) Blood , vol.103 , pp. 2738-2743
    • Cragg, M.S.1    Glennie, M.J.2
  • 22
    • 58149162030 scopus 로고    scopus 로고
    • Type II (tositumomab) anti-CD20 monoclonal antibody out performs type i (rituximablike) reagents in B-cell depletion regardless of complement activation
    • Beers, S. A., C. H. Chan, S. James, R. R. French, K. E. Attfield, C. M. Brennan, A. Ahuja, M. J. Shlomchik, M. S. Cragg, and M. J. Glennie. 2008. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximablike) reagents in B-cell depletion regardless of complement activation. Blood 112: 4170-4177.
    • (2008) Blood , vol.112 , pp. 4170-4177
    • Beers, S.A.1    Chan, C.H.2    James, S.3    French, R.R.4    Attfield, K.E.5    Brennan, C.M.6    Ahuja, A.7    Shlomchik, M.J.8    Cragg, M.S.9    Glennie, M.J.10
  • 24
    • 0035760902 scopus 로고    scopus 로고
    • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59
    • Golay, J., M. Lazzari, V. Facchinetti, S. Bernasconi, G. Borleri, T. Barbui, A. Rambaldi, and M. Introna. 2001. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59. Blood 98: 3383-3389.
    • (2001) Blood , vol.98 , pp. 3383-3389
    • Golay, J.1    Lazzari, M.2    Facchinetti, V.3    Bernasconi, S.4    Borleri, G.5    Barbui, T.6    Rambaldi, A.7    Introna, M.8
  • 26
    • 0023691376 scopus 로고
    • Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies
    • Bindon, C. I., G. Hale, and H. Waldmann. 1988. Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies. Eur. J. Immunol. 18: 1507-1514.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1507-1514
    • Bindon, C.I.1    Hale, G.2    Waldmann, H.3
  • 28
    • 0037434791 scopus 로고    scopus 로고
    • Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
    • Cho, H. S., K. Mason, K. X. Ramyar, A. M. Stanley, S. B. Gabelli, D. W. Denney, Jr., and D. J. Leahy. 2003. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421: 756-760.
    • (2003) Nature , vol.421 , pp. 756-760
    • Cho, H.S.1    Mason, K.2    Ramyar, K.X.3    Stanley, A.M.4    Gabelli, S.B.5    Denney, D.W.6    Leahy, D.J.7
  • 30
    • 73349128756 scopus 로고    scopus 로고
    • Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees
    • Varghese, B., A. Widman, J. Do, B. Taidi, D. K. Czerwinski, J. Timmerman, S. Levy, and R. Levy. 2009. Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees. Blood 114: 4477-4485.
    • (2009) Blood , vol.114 , pp. 4477-4485
    • Varghese, B.1    Widman, A.2    Do, J.3    Taidi, B.4    Czerwinski, D.K.5    Timmerman, J.6    Levy, S.7    Levy, R.8
  • 31
    • 0018726056 scopus 로고
    • A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines
    • Kearney, J. F., A. Radbruch, B. Liesegang, and K. Rajewsky. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123: 1548-1550.
    • (1979) J. Immunol. , vol.123 , pp. 1548-1550
    • Kearney, J.F.1    Radbruch, A.2    Liesegang, B.3    Rajewsky, K.4
  • 32
    • 0024556150 scopus 로고
    • Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
    • Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and L. R. Pease. 1989. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension. Gene 77: 61-68.
    • (1989) Gene , vol.77 , pp. 61-68
    • Horton, R.M.1    Hunt, H.D.2    Ho, S.N.3    Pullen, J.K.4    Pease, L.R.5
  • 34
    • 31544450721 scopus 로고    scopus 로고
    • Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinaselike phosphodiesterase 3b precursor
    • Perosa, F., E. Favoino, M. A. Caragnano, and F. Dammacco. 2006. Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinaselike phosphodiesterase 3b precursor. Blood 107: 1070-1077.
    • (2006) Blood , vol.107 , pp. 1070-1077
    • Perosa, F.1    Favoino, E.2    Caragnano, M.A.3    Dammacco, F.4
  • 35
  • 36
    • 53149151480 scopus 로고    scopus 로고
    • Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximabopsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving
    • Beum, P. V., M. A. Lindorfer, and R. P. Taylor. 2008. Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximabopsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving. J. Immunol. 181: 2916-2924.
    • (2008) J. Immunol. , vol.181 , pp. 2916-2924
    • Beum, P.V.1    Lindorfer, M.A.2    Taylor, R.P.3
  • 37
    • 0025878925 scopus 로고
    • Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone
    • Xia, M. Q., M. Tone, L. Packman, G. Hale, and H. Waldmann. 1991. Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur. J. Immunol. 21: 1677-1684.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1677-1684
    • Xia, M.Q.1    Tone, M.2    Packman, L.3    Hale, G.4    Waldmann, H.5
  • 38
    • 0027194472 scopus 로고
    • Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositolanchored glycoprotein which is an exceptionally good target for complement lysis
    • Xia, M. Q., G. Hale, M. R. Lifely, M. A. Ferguson, D. Campbell, L. Packman, and H.Waldmann. 1993. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositolanchored glycoprotein which is an exceptionally good target for complement lysis. Biochem. J. 293: 633-640.
    • (1993) Biochem. J. , vol.293 , pp. 633-640
    • Xia, M.Q.1    Hale, G.2    Lifely, M.R.3    Ferguson, M.A.4    Campbell, D.5    Packman, L.6    Waldmann, H.7
  • 39
    • 51649110602 scopus 로고    scopus 로고
    • Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk earlyintermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab
    • Zent, C. S., C. R. Secreto, B. R. LaPlant, N. D. Bone, T. G. Call, T. D. Shanafelt, D. F. Jelinek, R. C. Tschumper, and N. E. Kay. 2008. Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk earlyintermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab. Leuk. Res. 32: 1849-1856.
    • (2008) Leuk. Res. , vol.32 , pp. 1849-1856
    • Zent, C.S.1    Secreto, C.R.2    LaPlant, B.R.3    Bone, N.D.4    Call, T.G.5    Shanafelt, T.D.6    Jelinek, D.F.7    Tschumper, R.C.8    Kay, N.E.9
  • 40
    • 0024566393 scopus 로고
    • Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • Dyer, M. J., G. Hale, F. G. Hayhoe, and H. Waldmann. 1989. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype. Blood 73: 1431-1439.
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1    Hale, G.2    Hayhoe, F.G.3    Waldmann, H.4
  • 41
  • 42
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • Uchida, J., Y. Hamaguchi, J. A. Oliver, J. V. Ravetch, J. C. Poe, K. M. Haas, and T. F. Tedder. 2004. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J. Exp. Med. 199: 1659-1669.
    • (2004) J. Exp. Med. , vol.199 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 43
    • 0033522647 scopus 로고    scopus 로고
    • 1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen. [Published erratum appears in 1999 J. Mol. Biol. 292: 1161.]
    • James, L. C., G. Hale, H. Waldmann, and A. C. Bloomer. 1999. 1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen. [Published erratum appears in 1999 J. Mol. Biol. 292: 1161.] J. Mol. Biol. 289: 293-301.
    • (1999) J. Mol. Biol. , vol.289 , pp. 293-301
    • James, L.C.1    Hale H Waldmann, G.2    Bloomer, A.C.3
  • 44
    • 0035181218 scopus 로고    scopus 로고
    • Comparative efficiencies of C-terminal signals of native glycophosphatidylinositol (GPI)- anchored proproteins in conferring GPI-anchoring
    • Chen, R., J. J. Knez, W. C. Merrick, and M. E. Medof. 2001. Comparative efficiencies of C-terminal signals of native glycophosphatidylinositol (GPI)- anchored proproteins in conferring GPI-anchoring. J. Cell. Biochem. 84: 68-83.
    • (2001) J. Cell. Biochem. , vol.84 , pp. 68-83
    • Chen, R.1    Knez, J.J.2    Merrick, W.C.3    Medof, M.E.4
  • 45
    • 67649213025 scopus 로고    scopus 로고
    • Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity
    • Bournazos, S., S. P. Hart, L. H. Chamberlain, M. J. Glennie, and I. Dransfield. 2009. Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity. J. Immunol. 182: 8026-8036.
    • (2009) J. Immunol. , vol.182 , pp. 8026-8036
    • Bournazos, S.1    Hart, S.P.2    Chamberlain, L.H.3    Glennie, M.J.4    Dransfield, I.5
  • 46
    • 65549114676 scopus 로고    scopus 로고
    • Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    • Bruhns, P., B. Iannascoli, P. England, D. A. Mancardi, N. Fernandez, S. Jorieux, and M. Daëron. 2009. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113: 3716-3725.
    • (2009) Blood , vol.113 , pp. 3716-3725
    • Bruhns, P.1    Iannascoli, B.2    England, P.3    Mancardi, D.A.4    Fernandez, N.5    Jorieux, S.6    Daëron, M.7
  • 49
    • 0027211704 scopus 로고
    • Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
    • Banner, D. W., A. D'Arcy, W. Janes, R. Gentz, H. J. Schoenfeld, C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation. Cell 73: 431-445.
    • (1993) Cell , vol.73 , pp. 431-445
    • Banner, D.W.1    D'Arcy, A.2    Janes, W.3    Gentz, R.4    Schoenfeld, H.J.5    Broger, C.6    Loetscher, H.7    Lesslauer, W.8
  • 51
    • 68149156979 scopus 로고    scopus 로고
    • Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
    • Wyzgol, A., N. Müller, A. Fick, S. Munkel, G. U. Grigoleit, K. Pfizenmaier, and H. Wajant. 2009. Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J. Immunol. 183: 1851-1861.
    • (2009) J. Immunol. , vol.183 , pp. 1851-1861
    • Wyzgol, A.1    Müller, N.2    Fick, A.3    Munkel, S.4    Grigoleit, G.U.5    Pfizenmaier, K.6    Wajant, H.7
  • 52
    • 13544252809 scopus 로고    scopus 로고
    • Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes
    • Nam, K. O., H. Kang, S. M. Shin, K. H. Cho, B. Kwon, B. S. Kwon, S. J. Kim, and H. W. Lee. 2005. Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes. J. Immunol. 174: 1898-1905.
    • (2005) J. Immunol. , vol.174 , pp. 1898-1905
    • Nam, K.O.1    Kang, H.2    Shin, S.M.3    Cho, K.H.4    Kwon, B.5    Kwon, B.S.6    Kim, S.J.7    Lee, H.W.8
  • 53
    • 70350041296 scopus 로고    scopus 로고
    • Paths reunited: Initiation of the classical and lectin pathways of complement activation
    • Wallis, R., D. A. Mitchell, R. Schmid, W. J. Schwaeble, and A. H. Keeble. 2010. Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology 215: 1-11.
    • (2010) Immunobiology , vol.215 , pp. 1-11
    • Wallis, R.1    Mitchell, D.A.2    Schmid, R.3    Schwaeble, W.J.4    Keeble, A.H.5
  • 55
    • 84918825382 scopus 로고    scopus 로고
    • IgG subclasses and allotypes: From structure to effector functions
    • Vidarsson, G., G. Dekkers, and T. Rispens. 2014. IgG subclasses and allotypes: From structure to effector functions. Front. Immunol. 5: 520.
    • (2014) Front. Immunol. , vol.5 , pp. 520
    • Vidarsson, G.1    Dekkers, G.2    Rispens, T.3
  • 57
    • 33746114879 scopus 로고    scopus 로고
    • The kinetic-segregation model: TCR triggering and beyond
    • Davis, S. J., and P. A. van der Merwe. 2006. The kinetic-segregation model: TCR triggering and beyond. Nat. Immunol. 7: 803-809.
    • (2006) Nat. Immunol. , vol.7 , pp. 803-809
    • Davis, S.J.1    Merwe Der Van, P.A.2
  • 58
    • 23144455728 scopus 로고    scopus 로고
    • T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
    • Choudhuri, K., D. Wiseman, M. H. Brown, K. Gould, and P. A. van der Merwe. 2005. T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436: 578-582.
    • (2005) Nature , vol.436 , pp. 578-582
    • Choudhuri, K.1    Wiseman, D.2    Brown, M.H.3    Gould, K.4    Merwe Der Van, P.A.5
  • 61
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell, B., N. I. Affara, and L. M. Coussens. 2012. Differential macrophage programming in the tumor microenvironment. Trends Immunol. 33: 119-126.
    • (2012) Trends Immunol. , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3
  • 64
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh, R. S., M. J. Whitters, C. A. Piccirillo, D. A. Young, E. M. Shevach, M. Collins, and M. C. Byrne. 2002. CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16: 311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3    Young, D.A.4    Shevach, E.M.5    Collins, M.6    Byrne, M.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.