Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells

Journal of Clinical Investigation

Volumn 119, Issue 8, 2009, Pages 2143-2159

  Ivanov, Andrei ^a   Beers, Stephen A ^b   Walshe, Claire A ^b   Honeychurch, Jamie ^a   Alduaij, Waleed ^a   Cox, Kerry L ^b   Potter, Kathleen N ^b   Murray, Stephen ^a   Chan, Claude H T ^a   Klymenko, Tetyana ^a   Erenpreisa, Jekaterina ^c   Glennie, Martin J ^b   Illidge, Tim M ^a   Cragg, Mark S ^b,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE; CASPASE; CATHEPSIN B; CD20 ANTIGEN; CHOLESTEROL; FC RECEPTOR; HLA DR ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN BCL 2; RITUXIMAB; TOSITUMOMAB;

ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID MEMBRANE; LYMPHOMA CELL; LYSOSOME; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; RAJI CELL;

ACTINS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; APOPTOSIS; AUTOPHAGY; CELL ADHESION; CELL COMMUNICATION; CELL LINE; HLA-DR ANTIGENS; HUMANS; LEUKEMIA; LYMPHOMA; LYSOSOMES; MEMBRANE MICRODOMAINS; MICROVILLI;

EID: 68849108368     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37884     Document Type: Article

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