메뉴 건너뛰기




Volumn 5, Issue 1-2, 2014, Pages 7-23

CD20 and its antibodies: Past, present, and future

Author keywords

ADCC; ADCP; CD20; Fc R; Lymphoma; Rituxan; Rituximab

Indexed keywords

BORTEZOMIB; CD20 ANTIBODY; CHLORAMBUCIL; FC RECEPTOR; OFATUMUMAB; RITUXIMAB;

EID: 84939250217     PISSN: 21518017     EISSN: 21518025     Source Type: Journal    
DOI: 10.1615/ForumImmunDisTher.2015014073     Document Type: Review
Times cited : (10)

References (125)
  • 1
    • 0018949401 scopus 로고
    • Characterization of a human B lymphocyte-specific antigen
    • Stashenko P, Nadler LM, Hardy R, Schlossman SF. Characterization of a human B lymphocyte-specific antigen. J Immunol. 1980;125(4):1678-1685.
    • (1980) J Immunol , vol.125 , Issue.4 , pp. 1678-1685
    • Stashenko, P.1    Nadler, L.M.2    Hardy, R.3    Schlossman, S.F.4
  • 2
    • 0022202908 scopus 로고
    • The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle
    • Golay JT, Clark EA, Beverley PC. The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle. J Immunol. 1985;135(6):3795-3801.
    • (1985) J Immunol , vol.135 , Issue.6 , pp. 3795-3801
    • Golay, J.T.1    Clark, E.A.2    Beverley, P.C.3
  • 3
    • 0028108050 scopus 로고
    • CD20: A regulator of cell-cycle progression of B lymphocytes
    • Tedder TF, Engel P. CD20: A regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994;15(9):450-454.
    • (1994) Immunol Today , vol.15 , Issue.9 , pp. 450-454
    • Tedder, T.F.1    Engel, P.2
  • 5
    • 77950331000 scopus 로고    scopus 로고
    • CD20 as a target for therapeutic type I and II monoclonal antibodies
    • Beers SA, Chan CH, French RR, Cragg MS, Glennie MJ. CD20 as a target for therapeutic type I and II monoclonal antibodies. Sem Hematol. 2010;47(2):107-114.
    • (2010) Sem Hematol , vol.47 , Issue.2 , pp. 107-114
    • Beers, S.A.1    Chan, C.H.2    French, R.R.3    Cragg, M.S.4    Glennie, M.J.5
  • 7
    • 0023672444 scopus 로고
    • Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes
    • Tedder TF, Streuli M, Schlossman SF, Saito H. Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 1988;85(1):208-212.
    • (1988) Proc Natl Acad Sci , vol.85 , Issue.1 , pp. 208-212
    • Tedder, T.F.1    Streuli, M.2    Schlossman, S.F.3    Saito, H.4
  • 8
    • 0032194163 scopus 로고    scopus 로고
    • Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment
    • Polyak MJ, Tailor SH, Deans JP. Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment. J Immunol. 1998;161(7):3242-3248.
    • (1998) J Immunol , vol.161 , Issue.7 , pp. 3242-3248
    • Polyak, M.J.1    Tailor, S.H.2    Deans, J.P.3
  • 9
    • 0035263570 scopus 로고    scopus 로고
    • Identification of a CD20-, FcγRIβ-, and HTm4-related gene family: Sixteen new MS4A family members expressed in human and mouse
    • Liang Y, Tedder TF. Identification of a CD20-, FcγRIβ-, and HTm4-related gene family: Sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72(2):119-127.
    • (2001) Genomics , vol.72 , Issue.2 , pp. 119-127
    • Liang, Y.1    Tedder, T.F.2
  • 10
    • 0020584077 scopus 로고
    • Further biochemical studies of the human B-cell differentiation antigens B1 and B2
    • Oettgen HC, Bayard PJ, Van Ewijk W, Nadler LM, Terhorst CP. Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983;2(1):17-28.
    • (1983) Hybridoma , vol.2 , Issue.1 , pp. 17-28
    • Oettgen, H.C.1    Bayard, P.J.2    Van Ewijk, W.3    Nadler, L.M.4    Terhorst, C.P.5
  • 11
    • 0023746626 scopus 로고
    • Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes
    • Tedder TF, Schlossman SF. Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. J Biol Chem. 1988;263(20):10009-10015.
    • (1988) J Biol Chem , vol.263 , Issue.20 , pp. 10009-10015
    • Tedder, T.F.1    Schlossman, S.F.2
  • 12
    • 0034617121 scopus 로고    scopus 로고
    • Structure of the cytoplasmic β subunit - T1 assembly of voltage-dependent K+ channels
    • Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic β subunit - T1 assembly of voltage-dependent K+ channels. Science. 2000;289(5476):123-127.
    • (2000) Science , vol.289 , Issue.5476 , pp. 123-127
    • Gulbis, J.M.1    Zhou, M.2    Mann, S.3    MacKinnon, R.4
  • 13
    • 49649128420 scopus 로고    scopus 로고
    • CD20 Homooligomers physically associate with the B cell antigen receptor: Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins
    • Polyak MJ, Li H, Shariat N, Deans JP. CD20 Homooligomers physically associate with the B cell antigen receptor: Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins. J Biol Chem. 2008;283(27):18545-18552.
    • (2008) J Biol Chem , vol.283 , Issue.27 , pp. 18545-18552
    • Polyak, M.J.1    Li, H.2    Shariat, N.3    Deans, J.P.4
  • 14
    • 0027168420 scopus 로고
    • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes
    • Bubien JK, Zhou LJ, Bell PD, Frizzell RA, Tedder TF. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol. 1993;121(5):1121-1132.
    • (1993) J Cell Biol , vol.121 , Issue.5 , pp. 1121-1132
    • Bubien, J.K.1    Zhou, L.J.2    Bell, P.D.3    Frizzell, R.A.4    Tedder, T.F.5
  • 15
    • 0142180086 scopus 로고    scopus 로고
    • Store-operated cation entry mediated by CD20 in membrane rafts
    • Li H, Ayer LM, Lytton J, Deans JP. Store-operated cation entry mediated by CD20 in membrane rafts. J Biol Chem. 2003;278(43):42427-42434.
    • (2003) J Biol Chem , vol.278 , Issue.43 , pp. 42427-42434
    • Li, H.1    Ayer, L.M.2    Lytton, J.3    Deans, J.P.4
  • 16
    • 35648940728 scopus 로고    scopus 로고
    • Lipid rafts and B cell signaling
    • Gupta N, DeFranco AL. Lipid rafts and B cell signaling. Sem Cell Devel Biol. 2007;18(5):616-626.
    • (2007) Sem Cell Devel Biol , vol.18 , Issue.5 , pp. 616-626
    • Gupta, N.1    DeFranco, A.L.2
  • 23
    • 0036566507 scopus 로고    scopus 로고
    • Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure
    • Polyak MJ, Deans JP. Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood. 2002;99(9):3256-3262.
    • (2002) Blood , vol.99 , Issue.9 , pp. 3256-3262
    • Polyak, M.J.1    Deans, J.P.2
  • 24
    • 1642306050 scopus 로고    scopus 로고
    • Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents
    • Cragg MS, Glennie MJ. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood. 2004;103(7):2738-2743.
    • (2004) Blood , vol.103 , Issue.7 , pp. 2738-2743
    • Cragg, M.S.1    Glennie, M.J.2
  • 25
    • 0031962079 scopus 로고    scopus 로고
    • Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment
    • Deans JP, Robbins SM, Polyak MJ, Savage JA. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem. 1998;273(1):344-348.
    • (1998) J Biol Chem , vol.273 , Issue.1 , pp. 344-348
    • Deans, J.P.1    Robbins, S.M.2    Polyak, M.J.3    Savage, J.A.4
  • 28
    • 34447527885 scopus 로고    scopus 로고
    • Structural basis for recognition of CD20 by therapeutic antibody rituximab
    • Du J, Wang H, Zhong C, Peng B, Zhang M, Li B, Huo S, Guo Y, Ding J. Structural basis for recognition of CD20 by therapeutic antibody rituximab. J Biol Chem. 2007;282(20):15073-15080.
    • (2007) J Biol Chem , vol.282 , Issue.20 , pp. 15073-15080
    • Du, J.1    Wang, H.2    Zhong, C.3    Peng, B.4    Zhang, M.5    Li, B.6    Huo, S.7    Guo, Y.8    Ding, J.9
  • 31
    • 79960475243 scopus 로고    scopus 로고
    • CD20 antibodies: Doing the time warp
    • Cragg MS. CD20 antibodies: Doing the time warp. Blood. 2011;118(2):219-220.
    • (2011) Blood , vol.118 , Issue.2 , pp. 219-220
    • Cragg, M.S.1
  • 34
    • 0023911111 scopus 로고
    • Reshaping human antibodies for therapy
    • Riechmann L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. Nature. 1988;332(6162):323-327.
    • (1988) Nature , vol.332 , Issue.6162 , pp. 323-327
    • Riechmann, L.1    Clark, M.2    Waldmann, H.3    Winter, G.4
  • 36
    • 67349188801 scopus 로고    scopus 로고
    • Structure of the Fab fragment of therapeutic antibody ofatumumab provides insights into the recognition mechanism with CD20
    • Du J, Yang H, Guo Y, Ding J. Structure of the Fab fragment of therapeutic antibody ofatumumab provides insights into the recognition mechanism with CD20. Molec Immunol. 2009;46(11-12):2419-2423.
    • (2009) Molec Immunol , vol.46 , Issue.11-12 , pp. 2419-2423
    • Du, J.1    Yang, H.2    Guo, Y.3    Ding, J.4
  • 38
    • 84939245591 scopus 로고    scopus 로고
    • [cited 2014 17/12/2014]. Available from
    • Inman S. Ofatumumab falls short in DLBCL trial: OncLive; 2014 [cited 2014 17/12/2014]. Available from: http://www.onclive.com/web-exclusives/Ofatumumab-Falls-Short-in-DLBCL-Trial.
    • (2014) Ofatumumab Falls Short in DLBCL Trial: OncLive
    • Inman, S.1
  • 40
    • 0034660092 scopus 로고    scopus 로고
    • Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis
    • Golay J, Zaffaroni L, Vaccari T, Lazzari M, Borleri G-M, Bernasconi S, Tedesco F, Rambaldi A, Introna M. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood. 2000;95(12):3900-3908.
    • (2000) Blood , vol.95 , Issue.12 , pp. 3900-3908
    • Golay, J.1    Zaffaroni, L.2    Vaccari, T.3    Lazzari, M.4    Borleri, G.-M.5    Bernasconi, S.6    Tedesco, F.7    Rambaldi, A.8    Introna, M.9
  • 41
    • 0021952732 scopus 로고
    • Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg
    • Marder SR, Chenoweth DE, Goldstein IM, Perez HD. Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg. J Immunol. 1985;134(5):3325-3331.
    • (1985) J Immunol , vol.134 , Issue.5 , pp. 3325-3331
    • Marder, S.R.1    Chenoweth, D.E.2    Goldstein, I.M.3    Perez, H.D.4
  • 42
    • 17644388462 scopus 로고    scopus 로고
    • Role of C5a in inflammatory responses
    • Guo R-F, Ward PA. Role of C5a in inflammatory responses. Ann Rev Immunol. 2005;23(1):821-852.
    • (2005) Ann Rev Immunol , vol.23 , Issue.1 , pp. 821-852
    • Guo, R.-F.1    Ward, P.A.2
  • 43
    • 0034999619 scopus 로고    scopus 로고
    • Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies
    • Treon SP, Mitsiades C, Mitsiades N, Young G, Doss D, Schlossman R, Anderson KC. Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies. J Immunother. 2001;24(3):263-271.
    • (2001) J Immunother , vol.24 , Issue.3 , pp. 263-271
    • Treon, S.P.1    Mitsiades, C.2    Mitsiades, N.3    Young, G.4    Doss, D.5    Schlossman, R.6    Anderson, K.C.7
  • 45
    • 0035469885 scopus 로고    scopus 로고
    • Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma
    • Weng W-K, Levy R. Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma. Blood. 2001;98(5):1352-1357.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1352-1357
    • Weng, W.-K.1    Levy, R.2
  • 47
    • 34248224220 scopus 로고    scopus 로고
    • The CCL3 family of chemokines and innate immunity cooperate in vivo in the eradication of an established lymphoma xenograft by rituximab
    • Cittera E, Leidi M, Buracchi C, Pasqualini F, Sozzani S, Vecchi A, Waterfield JD, Introna M, Golay J. The CCL3 family of chemokines and innate immunity cooperate in vivo in the eradication of an established lymphoma xenograft by rituximab. J Immunol. 2007;178(10):6616-6623.
    • (2007) J Immunol , vol.178 , Issue.10 , pp. 6616-6623
    • Cittera, E.1    Leidi, M.2    Buracchi, C.3    Pasqualini, F.4    Sozzani, S.5    Vecchi, A.6    Waterfield, J.D.7    Introna, M.8    Golay, J.9
  • 48
    • 58149162030 scopus 로고    scopus 로고
    • Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
    • Beers SA, Chan CH, James S, French RR, Attfield KE, Brennan CM, Ahuja A, Shlomchik MJ, Cragg MS, Glennie MJ. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood. 2008;112(10):4170-4177.
    • (2008) Blood , vol.112 , Issue.10 , pp. 4170-4177
    • Beers, S.A.1    Chan, C.H.2    James, S.3    French, R.R.4    Attfield, K.E.5    Brennan, C.M.6    Ahuja, A.7    Shlomchik, M.J.8    Cragg, M.S.9    Glennie, M.J.10
  • 49
    • 51649123832 scopus 로고    scopus 로고
    • Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV
    • Minard-Colin V, Xiu Y, Poe JC, Horikawa M, Magro CM, Hamaguchi Y, Haas KM, Tedder TF. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV. Blood. 2008;112(4):1205-1213.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1205-1213
    • Minard-Colin, V.1    Xiu, Y.2    Poe, J.C.3    Horikawa, M.4    Magro, C.M.5    Hamaguchi, Y.6    Haas, K.M.7    Tedder, T.F.8
  • 52
    • 0032030699 scopus 로고    scopus 로고
    • Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies
    • Shan D, Ledbetter JA, Press OW. Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies. Blood. 1998;91(5):1644-1652.
    • (1998) Blood , vol.91 , Issue.5 , pp. 1644-1652
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 54
    • 14744284704 scopus 로고    scopus 로고
    • Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis
    • Janas E, Priest R, Wilde JI, White JH, Malhotra R. Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Clin Exper Immunol. 2005;139(3):439-446.
    • (2005) Clin Exper Immunol , vol.139 , Issue.3 , pp. 439-446
    • Janas, E.1    Priest, R.2    Wilde, J.I.3    White, J.H.4    Malhotra, R.5
  • 55
    • 40949083386 scopus 로고    scopus 로고
    • Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression
    • Olejniczak SH, Hernandez-Ilizaliturri FJ, Clements JL, Czuczman MS. Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression. Clin Cancer Res. 2008;14(5):1550-1560.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1550-1560
    • Olejniczak, S.H.1    Hernandez-Ilizaliturri, F.J.2    Clements, J.L.3    Czuczman, M.S.4
  • 56
    • 40949136882 scopus 로고    scopus 로고
    • Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels
    • Czuczman MS, Olejniczak S, Gowda A, Kotowski A, Binder A, Kaur H, Knight J, Starostik P, Deans J, Hernandez-Ilizaliturri FJ. Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels. Clin Cancer Res. 2008;14(5):1561-1570.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1561-1570
    • Czuczman, M.S.1    Olejniczak, S.2    Gowda, A.3    Kotowski, A.4    Binder, A.5    Kaur, H.6    Knight, J.7    Starostik, P.8    Deans, J.9    Hernandez-Ilizaliturri, F.J.10
  • 58
    • 0141704595 scopus 로고    scopus 로고
    • CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts
    • Chan HTC, Hughes D, French RR, Tutt AL, Walshe CA, Teeling JL, Glennie MJ, Cragg MS. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts. Cancer Res. 2003;63(17):5480-5489.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5480-5489
    • Chan, H.T.C.1    Hughes, D.2    French, R.R.3    Tutt, A.L.4    Walshe, C.A.5    Teeling, J.L.6    Glennie, M.J.7    Cragg, M.S.8
  • 62
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd JC, Kitada S, Flinn IW, Aron JL, Pearson M, Lucas D, Reed JC. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood. 2002;99(3):1038-1043.
    • (2002) Blood , vol.99 , Issue.3 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3    Aron, J.L.4    Pearson, M.5    Lucas, D.6    Reed, J.C.7
  • 65
    • 37549036732 scopus 로고    scopus 로고
    • Fcγ receptors as regulators of immune responses
    • Nimmerjahn F, Ravetch JV. Fcγ receptors as regulators of immune responses. Nature Rev Immunol. 2008;8(1):34-47.
    • (2008) Nature Rev Immunol , vol.8 , Issue.1 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 66
    • 0028347321 scopus 로고
    • A 13-amino-acid motif in the cytoplasmic domain of Fcγ RIIB modulates B-cell receptor signalling
    • Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JV. A 13-amino-acid motif in the cytoplasmic domain of Fcγ RIIB modulates B-cell receptor signalling. Nature. 1994;368(6466):70-73.
    • (1994) Nature , vol.368 , Issue.6466 , pp. 70-73
    • Muta, T.1    Kurosaki, T.2    Misulovin, Z.3    Sanchez, M.4    Nussenzweig, M.C.5    Ravetch, J.V.6
  • 68
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nature Med. 2000;6(4):443-446.
    • (2000) Nature Med , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 69
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • Uchida J, Hamaguchi Y, Oliver JA, Ravetch JV, Poe JC, Haas KM, Tedder TF. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exper Med. 2004;199(12):1659-1669.
    • (2004) J Exper Med , vol.199 , Issue.12 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 71
    • 51649123832 scopus 로고    scopus 로고
    • Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV
    • Minard-Colin V, Xiu Y, Poe JC, Horikawa M, Magro CM, Hamaguchi Y, Haas KM, Tedder TF. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV. Blood. 2008;112(4):1205-1213.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1205-1213
    • Minard-Colin, V.1    Xiu, Y.2    Poe, J.C.3    Horikawa, M.4    Magro, C.M.5    Hamaguchi, Y.6    Haas, K.M.7    Tedder, T.F.8
  • 73
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood. 2002;99(3):754-758.
    • (2002) Blood , vol.99 , Issue.3 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 74
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng W-K, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol. 2003;21(21):3940-3947.
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3940-3947
    • Weng, W.-K.1    Levy, R.2
  • 75
    • 84867473636 scopus 로고    scopus 로고
    • Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma
    • Keane C, Nourse J, Crooks P, Nguyen-Van D, Mutsando H, Mollee P, Lea RA, Gandhi MK. Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma. Int Med J. 2012;42(10):1113-1119.
    • (2012) Int Med J , vol.42 , Issue.10 , pp. 1113-1119
    • Keane, C.1    Nourse, J.2    Crooks, P.3    Nguyen-Van, D.4    Mutsando, H.5    Mollee, P.6    Lea, R.A.7    Gandhi, M.K.8
  • 76
    • 84871770952 scopus 로고    scopus 로고
    • A critical review of the role of Fcγ receptor polymorphisms in the response to monoclonal antibodies in cancer
    • Mellor JD, Brown MP, Irving HR, Zalcberg JR, Dobrovic A. A critical review of the role of Fcγ receptor polymorphisms in the response to monoclonal antibodies in cancer. J Hematol Oncol. 2013;6(1):1.
    • (2013) J Hematol Oncol , vol.6 , Issue.1 , pp. 1
    • Mellor, J.D.1    Brown, M.P.2    Irving, H.R.3    Zalcberg, J.R.4    Dobrovic, A.5
  • 77
    • 0842264005 scopus 로고    scopus 로고
    • FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia
    • Farag SS, Flinn IW, Modali R, Lehman TA, Young D, Byrd JC. FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. Blood. 2004;103(4):1472-1474.
    • (2004) Blood , vol.103 , Issue.4 , pp. 1472-1474
    • Farag, S.S.1    Flinn, I.W.2    Modali, R.3    Lehman, T.A.4    Young, D.5    Byrd, J.C.6
  • 78
    • 38049103314 scopus 로고    scopus 로고
    • Mechanisms of granule-dependent killing
    • Cullen SP, Martin SJ. Mechanisms of granule-dependent killing. Cell Death Differ. 2007;15(2):251-262.
    • (2007) Cell Death Differ , vol.15 , Issue.2 , pp. 251-262
    • Cullen, S.P.1    Martin, S.J.2
  • 81
    • 48749097545 scopus 로고    scopus 로고
    • Neutrophil role in in vivo anti-lymphoma activity of rituximab: FCGR3B-NA1/NA2 polymorphism does not influence response and survival after rituximab treatment
    • Cartron G, Ohresser M, Salles G, Solal-Celigny P, Colombat P, Watier H. Neutrophil role in in vivo anti-lymphoma activity of rituximab: FCGR3B-NA1/NA2 polymorphism does not influence response and survival after rituximab treatment. Ann Oncol. 2008;19(8):1485-1487.
    • (2008) Ann Oncol , vol.19 , Issue.8 , pp. 1485-1487
    • Cartron, G.1    Ohresser, M.2    Salles, G.3    Solal-Celigny, P.4    Colombat, P.5    Watier, H.6
  • 82
    • 45749104147 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor potentiates rituximab in patients with relapsed follicular lymphoma: Results of a phase II study
    • Cartron G, Zhao-Yang L, Baudard M, Kanouni T, Rouillé V, Quittet P, Klein B, Rossi JF. Granulocyte-macrophage colony-stimulating factor potentiates rituximab in patients with relapsed follicular lymphoma: Results of a phase II study. J Clin Oncol. 2008;26(16):2725-2731.
    • (2008) J Clin Oncol , vol.26 , Issue.16 , pp. 2725-2731
    • Cartron, G.1    Zhao-Yang, L.2    Baudard, M.3    Kanouni, T.4    Rouillé, V.5    Quittet, P.6    Klein, B.7    Rossi, J.F.8
  • 83
    • 84939223502 scopus 로고    scopus 로고
    • A phase II study of the combination of rituximab and granulocyte macrophage colony stimulating factor as treatment of patients with chronic lymphocytic leukemia
    • Strati P, Tong WG, Vitale C, Wierda WG, O'Brien S, Brown JR, Weng WK, Kipps T, Keating MJ, Ferrajoli A. A phase II study of the combination of rituximab and granulocyte macrophage colony stimulating factor as treatment of patients with chronic lymphocytic leukemia. Leuk Lymph. 2014:1-3.
    • (2014) Leuk Lymph , pp. 1-3
    • Strati, P.1    Tong, W.G.2    Vitale, C.3    Wierda, W.G.4    O'Brien, S.5    Brown, J.R.6    Weng, W.K.7    Kipps, T.8    Keating, M.J.9    Ferrajoli, A.10
  • 87
    • 0037178791 scopus 로고    scopus 로고
    • Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity
    • Shields RL, Lai J, Keck R, O'Connell LY, Hong K, Meng YG, Weikert SH, Presta LG. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity. J Biological Chem. 2002;277(30):26733-26740.
    • (2002) J Biological Chem , vol.277 , Issue.30 , pp. 26733-26740
    • Shields, R.L.1    Lai, J.2    Keck, R.3    O'Connell, L.Y.4    Hong, K.5    Meng, Y.G.6    Weikert, S.H.7    Presta, L.G.8
  • 93
    • 32044464340 scopus 로고    scopus 로고
    • The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes
    • Beum PV, Kennedy AD, Williams ME, Lindorfer MA, Taylor RP. The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes. J Immunol. 2006;176(4):2600-2609.
    • (2006) J Immunol , vol.176 , Issue.4 , pp. 2600-2609
    • Beum, P.V.1    Kennedy, A.D.2    Williams, M.E.3    Lindorfer, M.A.4    Taylor, R.P.5
  • 94
    • 53149151480 scopus 로고    scopus 로고
    • Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximab-opsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving
    • Beum PV, Lindorfer MA, Taylor RP. Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximab-opsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving. J Immunol. 2008;181(4):2916-2924.
    • (2008) J Immunol , vol.181 , Issue.4 , pp. 2916-2924
    • Beum, P.V.1    Lindorfer, M.A.2    Taylor, R.P.3
  • 95
    • 84923794242 scopus 로고    scopus 로고
    • Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalisation of CD20 independent of signalling via the cytoplasmic domain
    • Vaughan AT, Chan CHT, Klein C, Glennie MJ, Beers SA, Cragg MS. Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalisation of CD20 independent of signalling via the cytoplasmic domain. J Biol Chem. 2015;290(9):5424-5437.
    • (2015) J Biol Chem , vol.290 , Issue.9 , pp. 5424-5437
    • Vaughan, A.T.1    Chan, C.H.T.2    Klein, C.3    Glennie, M.J.4    Beers, S.A.5    Cragg, M.S.6
  • 98
    • 84964315758 scopus 로고    scopus 로고
    • Expression of the inhibitory Fcγ receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98)
    • Lee CS, Ashton-Key M, Cogliatti S, Rondeau S, Schmitz S-FH, Ghielmini M, Cragg MS, Johnson P. Expression of the inhibitory Fcγ receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98). Br J Haematol. 2015;168(1):145-148.
    • (2015) Br J Haematol , vol.168 , Issue.1 , pp. 145-148
    • Lee, C.S.1    Ashton-Key, M.2    Cogliatti, S.3    Rondeau, S.4    Schmitz, S.-F.H.5    Ghielmini, M.6    Cragg, M.S.7    Johnson, P.8
  • 99
    • 77958009878 scopus 로고    scopus 로고
    • HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells
    • Shimizu R, Kikuchi J, Wada T, Ozawa K, Kano Y, Furukawa Y. HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells. Leukemia. 2010;24(10):1760-1768.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1760-1768
    • Shimizu, R.1    Kikuchi, J.2    Wada, T.3    Ozawa, K.4    Kano, Y.5    Furukawa, Y.6
  • 101
  • 104
    • 84861830510 scopus 로고    scopus 로고
    • A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies
    • Sehn LH, Assouline SE, Stewart DA, Mangel J, Gascoyne RD, Fine G, Frances-Lasserre S, Carlile DJ, Crump M. A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies. Blood. 2012;119(22):5118-5125.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5118-5125
    • Sehn, L.H.1    Assouline, S.E.2    Stewart, D.A.3    Mangel, J.4    Gascoyne, R.D.5    Fine, G.6    Frances-Lasserre, S.7    Carlile, D.J.8    Crump, M.9
  • 112
    • 33744482623 scopus 로고    scopus 로고
    • Immunomodulating drugs for chronic lymphocytic leukaemia
    • Chanan-Khan A, Porter CW. Immunomodulating drugs for chronic lymphocytic leukaemia. Lancet Oncol. 2006;7(6):480-488.
    • (2006) Lancet Oncol , vol.7 , Issue.6 , pp. 480-488
    • Chanan-Khan, A.1    Porter, C.W.2
  • 113
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, Gorgun G, Le Dieu R, Blum W, Byrd JC, Gribben JG. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 2008;118(7):2427-2437.
    • (2008) J Clin Invest , vol.118 , Issue.7 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3    Gorgun, G.4    Le Dieu, R.5    Blum, W.6    Byrd, J.C.7    Gribben, J.G.8
  • 114
    • 36849024949 scopus 로고    scopus 로고
    • Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumor activity of rituximab in vivo
    • Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J, Wallace P, Czuczman MS. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumor activity of rituximab in vivo. Br J Haematol. 2008;140(1):36-45.
    • (2008) Br J Haematol , vol.140 , Issue.1 , pp. 36-45
    • Reddy, N.1    Hernandez-Ilizaliturri, F.J.2    Deeb, G.3    Roth, M.4    Vaughn, M.5    Knight, J.6    Wallace, P.7    Czuczman, M.S.8
  • 115
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L, Adams M, Carter T, Chen R, Muller G, Stirling D, Schafer P, Bartlett JB. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res. 2008;14(14):4650-4657.
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3    Chen, R.4    Muller, G.5    Stirling, D.6    Schafer, P.7    Bartlett, J.B.8
  • 117
    • 84905865264 scopus 로고    scopus 로고
    • Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: A multicenter clinical-translational study from the chronic lymphocytic leukemia research consortium
    • James DF, Werner L, Brown JR, Wierda WG, Barrientos JC, Castro JE, Greaves A, Johnson AJ, Rassenti LZ, Rai KR, Neuberg D, Kipps TJ. Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: A multicenter clinical-translational study from the chronic lymphocytic leukemia research consortium. J Clin Oncol. 2014;32(19):2067-2073.
    • (2014) J Clin Oncol , vol.32 , Issue.19 , pp. 2067-2073
    • James, D.F.1    Werner, L.2    Brown, J.R.3    Wierda, W.G.4    Barrientos, J.C.5    Castro, J.E.6    Greaves, A.7    Johnson, A.J.8    Rassenti, L.Z.9    Rai, K.R.10    Neuberg, D.11    Kipps, T.J.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.