Association of FcγRIIa (CD32a) with lipid rafts regulates ligand binding activity

Journal of Immunology

Volumn 182, Issue 12, 2009, Pages 8026-8036

  Bournazos, Stylianos ^a,b   Hart, Simon P ^c   Chamberlain, Luke H ^d   Glennie, Martin J ^e   Dransfield, Ian ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF HULL   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD32 ANTIGEN; FC RECEPTOR IIA; IMMUNOGLOBULIN G; FC RECEPTOR; LIGAND; PANCREATIC ELASTASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL TYPE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIGAND BINDING; LIPID MEMBRANE; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; ENZYMOLOGY; GENETICS; HAMSTER; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NEUTROPHIL;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CRICETINAE; HUMANS; IMMUNOGLOBULIN G; LIGANDS; MEMBRANE MICRODOMAINS; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PANCREATIC ELASTASE; PROTEIN BINDING; RECEPTORS, IGG;

EID: 67649213025     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900107     Document Type: Article

References (49)

1. Nathan, C. 2006. Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6: 173-182.
2. Dale, D. C., L. Boxer, and W. C. Liles. 2008. The phagocytes: neutrophils and monocytes. Blood 112: 935-945.
3. Janssens, S., and R. Beyaert. 2003. Role of Toll-like receptors in pathogen recognition. Clin. Microbiol. Rev. 16: 637-646.
4. Daeron, M. 1997. Fc receptor biology. Annu. Rev. Immunol. 15: 203-234.
5. Ravetch, J. V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19: 275-290.
6. Huizinga, T. W., D. Roos, and A. E. dem Borne. 1990. Neutrophil Fcγ receptors: a two-way bridge in the immune system. Blood 75: 1211-1214.
7. Barabe, F., E. Rollet-Labelle, C. Gilbert, M. J. Fernandes, S. N. Naccache, and P. H. Naccache. 2002. Early events in the activation of FcγRIIA in human neutrophils: stimulated insolubilization, translocation to detergent-resistant domains, and degradation of FcγRIIaA. J. Immunol. 168: 4042-4049.
8. Rollet-Labelle, E., S. Marois, K. Barbeau, S. E. Malawista, and P. H. Naccache. 2004. Recruitment of the cross-linked opsonic receptor CD32A (FcγRIIA) to high-density detergent-resistant membrane domains in human neutrophils. Biochem. J. 381: 919-928.
9. Kwiatkowska, K., J. Frey, and A. Sobota. 2003. Phosphorylation of FcγRIIA is required for the receptor-induced actin rearrangement and capping: the role of membrane rafts. J. Cell Sci. 116: 537-550.
10. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature 387: 569-572.
11. Cheng, P. C., B. K. Brown, W. Song, and S. K. Pierce. 2001. Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J. Immunol. 166: 3693-3701. (Pubitemid 32224891)
12. Xavier, R., T. Brennan, Q. Li, C. McCormack, and B. Seed. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8: 723-732.
13. Abbal, C., M. Lambelet, D. Bertaggia, C. Gerbex, M. Martinez, A. Arcaro, M. Schapira, and O. Spertini. 2006. Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions. Blood 108: 3352-3359.
14. Setiadi, H., and R. P. McEver. 2008. Clustering endothelial E-selectin in clathrincoated pits and lipid rafts enhances leukocyte adhesion under flow. Blood 111: 1989-1998.
15. Cambi, A., B. Joosten, M. Koopman, L. F. de Lange, I. Beeren, R. Torensma, J. A. Fransen, M. Garcia-Parajo, F. N. van Leeuwen, and C. G. Figdor. 2006. Organization of the integrin LFA-1 in nanoclusters regulates its activity. Mol. Biol. Cell 17: 4270-4281.
16. Marwali, M. R., J. Rey-Ladino, L. Dreolini, D. Shaw, and F. Takei. 2003. Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity. Blood 102: 215-222.
17. Wysoczynski, M., R. Reca, J. Ratajczak, M. Kucia, N. Shirvaikar, M. Honczarenko, M. Mills, J. Wanzeck, A. Janowska-Wieczorek, and M. Z. Ratajczak. 2005. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient. Blood 105: 40-48.
18. Marmor, M. D., and M. Julius. 2001. Role for lipid rafts in regulating interleukin- 2 receptor signaling. Blood 98: 1489-1497.
19. Niv, H., O. Gutman, Y. Kloog, and Y. I. Henis. 2002. Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J. Cell Biol. 157: 865-872.
20. Jahn, T., E. Leifheit, S. Gooch, S. Sindhu, and K. Weinberg. 2007. Lipid rafts are required for Kit survival and proliferation signals. Blood 110: 1739-1747.
21. Young, R. M., D. Holowka, and B. Baird. 2003. A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation. J. Biol. Chem. 278: 20746-20752.
22. Katsumata, O., M. Hara-Yokoyama, C. Sautes-Fridman, Y. Nagatsuka, T. Katada, Y. Hirabayashi, K. Shimizu, J. Fujita-Yoshigaki, H. Sugiya, and S. Furuyama. 2001. Association of FcγRII with low-density detergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine phosphorylation pathway and superoxide generation. J. Immunol. 167: 5814-5823.
23. Kwiatkowska, K., and A. Sobota. 2001. The clustered Fcγ receptor II is recruited to Lyn-containing membrane domains and undergoes phosphorylation in a cholesterol-dependent manner. Eur. J. Immunol. 31: 989-998.
24. Garcia-Garcia, E., E. J. Brown, and C. Rosales. 2007. Transmembrane mutations to FcγRIIA alter its association with lipid rafts: implications for receptor signaling. J. Immunol. 178: 3048-3058. (Pubitemid 46333185)
25. Walker, B. A., B. E. Hagenlocker, E. B. Stubbs, Jr., R. R. Sandborg, B. W. Agranoff, and P. A. Ward. 1991. Signal transduction events and FcγR engagement in human neutrophils stimulated with immune complexes. J. Immunol. 146: 735-741.
26. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320: 365-376.
27. Wipke, B. T., and P. M. Allen. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J. Immunol. 167: 1601-1608.
28. Qasim, F. J., P. W. Mathieson, F. Sendo, S. Thiru, and D. B. Oliveira. 1996. Role of neutrophils in the pathogenesis of experimental vasculitis. Am. J. Pathol. 149: 81-89.
29. Hart, S. P., K. M. Alexander, and I. Dransfield. 2004. Immune complexes bind preferentially to FcγRIIA (CD32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cytokines. J. Immunol. 172: 1882-1887.
30. van de Winkel, J. G., O. R. van Ommen, T. W. Huizinga, M. A. de Raad, W. B. Tuijnman, P. J. Groenen, P. J. Capel, R. A. Koene, and W. J. Tax. 1989. Proteolysis induces increased binding affinity of the monocyte type II FcR for human IgG. J. Immunol. 143: 571-578.
31. Bournazos, S., J. Rennie, S. P. Hart, K. A. Fox, and I. Dransfield. 2008. Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arterioscler. Thromb. Vasc. Biol. 28: 1491-1498.
32. Green, J. M., A. D. Schreiber, and E. J. Brown. 1997. Role for a glycan phosphoinositol anchor in Fcγ receptor synergy. J. Cell Biol. 139: 1209-1217.
33. Eisenhaber, B., P. Bork, and F. Eisenhaber. 1999. Prediction of potential GPI-modification sites in proprotein sequences. J. Mol. Biol. 292: 741-758.
34. Coeytaux, K., and A. Poupon. 2005. Prediction of unfolded segments in a protein sequence based on amino acid composition. Bioinformatics 21: 1891-1900.
35. Harder, T., P. Scheiffele, P. Verkade, and K. Simons. 1998. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141: 929-942.
36. Tuijnman, W. B., F. W. van Dam, J. G. van de Winkel, and P. J. Capel. 1990. PMN-derived proteases enhance the affinity of Fcγ receptor II on myeloid cells, but not on B cells. Mol. Immunol. 27: 1229-1236.
37. Barnes, N. C., M. S. Powell, H. M. Trist, A. L. Gavin, B. D. Wines, and P. M. Hogarth. 2006. Raft localisation of FcγRIIa and efficient signaling are dependent on palmitoylation of cysteine 208. Immunol. Lett. 104: 118-123.
38. Rajendran, L., and K. Simons. 2005. Lipid rafts and membrane dynamics. J. Cell Sci. 118: 1099-1102.
39. Anderson, R. G., and K. Jacobson. 2002. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296: 1821-1825.
40. Simons, K., and D. Toomre. 2000. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1: 31-39.
41. Linder, M. E., and R. J. Deschenes. 2007. Palmitoylation: policing protein stability and traffic. Nat. Rev. Mol. Cell Biol. 8: 74-84.
42. Viola, A., and N. Gupta. 2007. Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins. Nat. Rev. Immunol. 7: 889-896.
43. Allenspach, E. J., P. Cullinan, J. Tong, Q. Tang, A. G. Tesciuba, J. L. Cannon, S. M. Takahashi, R. Morgan, J. K. Burkhardt, and A. I. Sperling. 2001. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-750.
44. Boesze-Battaglia, K., and R. Schimmel. 1997. Cell membrane lipid composition and distribution: implications for cell function and lessons learned from photoreceptors and platelets. J. Exp. Biol. 200: 2927-2936.
45. Sandhoff, R., B. Brügger, D. Jeckel, W. D. Lehmann, and F. T. Wieland. 1999. Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J. Lipid Res. 40: 126-132.
46. Beekman, J. M., J. A. van der Linden, J. G. van de Winkel, and J. H. Leusen. 2008. FcγRI (CD64) resides constitutively in lipid rafts. Immunol. Lett. 116: 149-155.
47. Kondadasula, S. V., J. M. Roda, R. Parihar, J. Yu, A. Lehman, M. A. Caligiuri, S. Tridandapani, R. W. Burry, and W. E. Carson, III. 2008. Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon γ. Blood 111: 4173-4183.
48. 232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum. Mol. Genet. 14: 2881-2892.
49. Floto, R. A., M. R. Clatworthy, K. R. Heilbronn, D. R. Rosner, P. A. MacAry, A. Rankin, P. J. Lehner, W. H. Ouwehand, J. M. Allen, N. A. Watkins, and K. G. Smith. 2005. Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts. Nat. Med. 11: 1056-1058.