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Volumn 33, Issue 2, 2017, Pages 248-255

Improved methods for multi-trait fine mapping of pleiotropic risk loci

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; CHROMOSOMAL MAPPING; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC DISORDER; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMAN; LIPID METABOLISM; PLEIOTROPY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; SOFTWARE;

EID: 85019665555     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/btw615     Document Type: Article
Times cited : (98)

References (34)
  • 1
    • 84975795680 scopus 로고    scopus 로고
    • An integrated map of genetic variation from 1,092 human genomes
    • 1000 Genomes Project Consortium. et al.
    • 1000 Genomes Project Consortium. et al. (2012) An integrated map of genetic variation from 1,092 human genomes. Nature, 491, 56-65.
    • (2012) Nature , vol.491 , pp. 56-65
  • 2
    • 84961884115 scopus 로고    scopus 로고
    • Finemap: Efficient variable selection using summary data from genome-wide association studies
    • Benner,C. et al. (2015) Finemap: efficient variable selection using summary data from genome-wide association studies. bioRxiv, 027342.
    • (2015) BioRxiv , pp. 027342
    • Benner, C.1
  • 3
    • 85000692305 scopus 로고    scopus 로고
    • An atlas of genetic correlations across human diseases and traits
    • Bulik-Sullivan,B. et al. (2015) An atlas of genetic correlations across human diseases and traits. Nat. Genet., 47, 1236-1241.
    • (2015) Nat. Genet. , vol.47 , pp. 1236-1241
    • Bulik-Sullivan, B.1
  • 4
    • 0001024874 scopus 로고
    • The likelihood ratio, Wald, and Lagrange multiplier tests: An expository note
    • Buse,A. (1982) The likelihood ratio, Wald, and Lagrange multiplier tests: an expository note. Am. Stat., 36, 153-157.
    • (1982) Am. Stat. , vol.36 , pp. 153-157
    • Buse, A.1
  • 5
    • 84937035185 scopus 로고    scopus 로고
    • Fine mapping causal variants with an approximate Bayesian method using marginal test statistics
    • Chen,W. et al. (2015) Fine mapping causal variants with an approximate Bayesian method using marginal test statistics. Genetics, 200, 719-736.
    • (2015) Genetics , vol.200 , pp. 719-736
    • Chen, W.1
  • 6
    • 84912117315 scopus 로고    scopus 로고
    • GPA: A statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation
    • Chung,D. et al. (2014) GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet., 10, e1004787.
    • (2014) PLoS Genet. , vol.10 , pp. e1004787
    • Chung, D.1
  • 7
    • 84940830979 scopus 로고    scopus 로고
    • FTO obesity variant circuitry and adipocyte browning in humans
    • Claussnitzer,M. et al. (2015) FTO obesity variant circuitry and adipocyte browning in humans. N. Engl. J. Med., 373, 895-907.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 895-907
    • Claussnitzer, M.1
  • 8
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Encode Project Consortium
    • ENCODE Project Consortium. et al. (2012) An integrated encyclopedia of DNA elements in the human genome. Nature, 489, 57-74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 9
    • 84878020180 scopus 로고    scopus 로고
    • Meta-analysis methods for genomewide association studies and beyond
    • Evangelou,E. and Ioannidis,J.P. (2013) Meta-analysis methods for genomewide association studies and beyond. Nat. Rev. Genet., 14, 379-389.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 379-389
    • Evangelou, E.1    Ioannidis, J.P.2
  • 10
    • 85000443086 scopus 로고    scopus 로고
    • Partitioning heritability by functional annotation using genome-wide association summary statistics
    • Finucane,H.K. et al. (2015) Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet., 47, 1228-1235.
    • (2015) Nat. Genet. , vol.47 , pp. 1228-1235
    • Finucane, H.K.1
  • 11
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Global Lipids Genetics Consortium. et al. (2013) Discovery and refinement of loci associated with lipid levels. Nat. Genet., 45, 1274-1283.
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
  • 12
    • 0001240715 scopus 로고
    • Importance sampling for stochastic simulations
    • Glynn,P.W. and Iglehart,D.L. (1989) Importance sampling for stochastic simulations. Manag. Sci., 35, 1367-1392.
    • (1989) Manag. Sci. , vol.35 , pp. 1367-1392
    • Glynn, P.W.1    Iglehart, D.L.2
  • 13
    • 84922273141 scopus 로고    scopus 로고
    • Partitioning heritability of regulatory and cell-typespecific variants across 11 common diseases
    • Gusev,A. et al. (2014) Partitioning heritability of regulatory and cell-typespecific variants across 11 common diseases. Am. J. Hum. Genet., 95, 535-552.
    • (2014) Am. J. Hum. Genet. , vol.95 , pp. 535-552
    • Gusev, A.1
  • 14
    • 84908042860 scopus 로고    scopus 로고
    • Identifying causal variants at loci with multiple signals of association
    • Hormozdiari,F. et al. (2014) Identifying causal variants at loci with multiple signals of association. Genetics, 198, 497-508.
    • (2014) Genetics , vol.198 , pp. 497-508
    • Hormozdiari, F.1
  • 15
    • 84938982145 scopus 로고    scopus 로고
    • Leveraging functional-annotation data in trans-ethnic fine-mapping studies
    • Kichaev,G. and Pasaniuc,B. (2015) Leveraging functional-annotation data in trans-ethnic fine-mapping studies. Am. J. Hum. Genet., 97, 260-271.
    • (2015) Am. J. Hum. Genet. , vol.97 , pp. 260-271
    • Kichaev, G.1    Pasaniuc, B.2
  • 16
    • 84908324508 scopus 로고    scopus 로고
    • Integrating functional data to prioritize causal variants in statistical fine-mapping studies
    • Kichaev,G. et al. (2014) Integrating functional data to prioritize causal variants in statistical fine-mapping studies. PLoS Genet., 10, e1004722.
    • (2014) PLoS Genet. , vol.10 , pp. e1004722
    • Kichaev, G.1
  • 17
    • 84878451270 scopus 로고    scopus 로고
    • Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression
    • Kote-Jarai,Z. et al. (2013) Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Hum. Mol. Genet., 22, 2520-2528.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 2520-2528
    • Kote-Jarai, Z.1
  • 18
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Kundaje,A. et al. (2015) Integrative analysis of 111 reference human epigenomes. Nature, 518, 317-330.
    • (2015) Nature , vol.518 , pp. 317-330
    • Kundaje, A.1
  • 19
    • 84923349434 scopus 로고    scopus 로고
    • Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
    • Lindström,S. et al. (2014) Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat. Commun., 5, 5303.
    • (2014) Nat. Commun. , vol.5 , pp. 5303
    • Lindström, S.1
  • 20
    • 84940771118 scopus 로고    scopus 로고
    • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
    • Liu,J.Z. et al. (2015) Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet., 47, 979-986.
    • (2015) Nat. Genet. , vol.47 , pp. 979-986
    • Liu, J.Z.1
  • 21
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke,A.E. et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature, 518, 197-206.
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1
  • 22
    • 84870502629 scopus 로고    scopus 로고
    • Bayesian refinement of association signals for 14 loci in 3 common diseases
    • Maller,J.B. et al. (2012) Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet., 44, 1294-1301.
    • (2012) Nat. Genet. , vol.44 , pp. 1294-1301
    • Maller, J.B.1
  • 23
    • 84890310753 scopus 로고    scopus 로고
    • Fine-scale mapping of the fgfr2 breast cancer risk locus: Putative functional variants differentially bind foxa1 and e2f1
    • Meyer,K.B. et al. (2013) Fine-scale mapping of the fgfr2 breast cancer risk locus: putative functional variants differentially bind foxa1 and e2f1. Am. J. Hum. Genet., 93, 1046-1060.
    • (2013) Am. J. Hum. Genet. , vol.93 , pp. 1046-1060
    • Meyer, K.B.1
  • 24
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via sort1 at the 1p13 cholesterol locus
    • Musunuru,K. et al. (2010) From noncoding variant to phenotype via sort1 at the 1p13 cholesterol locus. Nature, 466, 714-719.
    • (2010) Nature , vol.466 , pp. 714-719
    • Musunuru, K.1
  • 25
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada,Y. et al. (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506, 376-381.
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1
  • 26
    • 84921782559 scopus 로고    scopus 로고
    • Fast and accurate imputation of summary statistics enhances evidence of functional enrichment
    • Pasaniuc,B. et al. (2014) Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics, btu416.
    • (2014) Bioinformatics , pp. btu416
    • Pasaniuc, B.1
  • 27
    • 84879419343 scopus 로고    scopus 로고
    • Pleiotropy in complex traits: Challenges and strategies
    • Solovieff,N. et al. (2013) Pleiotropy in complex traits: challenges and strategies. Nat. Rev. Genet., 14, 483-495.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 483-495
    • Solovieff, N.1
  • 28
    • 79961193174 scopus 로고    scopus 로고
    • Hapgen2: Simulation of multiple disease SNPs
    • Su,Z. et al. (2011) Hapgen2: simulation of multiple disease SNPs. Bioinformatics., 27, 2304-2305.
    • (2011) Bioinformatics. , vol.27 , pp. 2304-2305
    • Su, Z.1
  • 29
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • Type,A.G.E.N. et al. (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet., 46, 234-244.
    • (2014) Nat. Genet. , vol.46 , pp. 234-244
    • Type, A.G.E.N.1
  • 30
    • 84862909349 scopus 로고    scopus 로고
    • Five years of GWAS discovery
    • Visscher,P.M. et al. (2012) Five years of GWAS discovery. Am. J. Hum. Genet., 90, 7-24.
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 7-24
    • Visscher, P.M.1
  • 31
    • 84908890496 scopus 로고    scopus 로고
    • Defining the role of common variation in the genomic and biological architecture of adult human height
    • Wood,A.R. et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet., 46, 1173-1186.
    • (2014) Nat. Genet. , vol.46 , pp. 1173-1186
    • Wood, A.R.1
  • 32
    • 84875996758 scopus 로고    scopus 로고
    • Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained
    • Wu,Y. et al. (2013) Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet., 9, e1003379.
    • (2013) PLoS Genet. , vol.9 , pp. e1003379
    • Wu, Y.1
  • 33
    • 79957588287 scopus 로고    scopus 로고
    • Genome partitioning of genetic variation for complex traits using common SNPs
    • Yang,J. et al. (2011) Genome partitioning of genetic variation for complex traits using common SNPs. Nat. Genet., 43, 519-525.
    • (2011) Nat. Genet. , vol.43 , pp. 519-525
    • Yang, J.1
  • 34
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou,V.W. et al. (2011) Charting histone modifications and the functional organization of mammalian genomes. Nat. Rev. Genet., 12, 7-18.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 7-18
    • Zhou, V.W.1


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