Fine-scale mapping of the FGFR2 breast cancer risk locus: Putative functional variants differentially bind FOXA1 and E2F1

American Journal of Human Genetics

Volumn 93, Issue 6, 2013, Pages 1046-1060

  Meyer, Kerstin B ^a   O'Reilly, Martin ^a   Michailidou, Kyriaki ^a   Carlebur, Saskia ^a   Edwards, Stacey L ^b,c   French, Juliet D ^b,c   Prathalingham, Radhika ^a   Dennis, Joe ^a   Bolla, Manjeet K ^a   Wang, Qin ^a   De Santiago, Ines ^a   Hopper, John L ^d   Tsimiklis, Helen ^d   Apicella, Carmel ^d   Southey, Melissa C ^d   Schmidt, Marjanka K ^e   Broeks, Annegien ^e   Van 't Veer, Laura J ^e   Hogervorst, Frans B ^e   Muir, Kenneth ^f,co   Lophatananon, Artitaya ^f   Stewart Brown, Sarah ^f   Siriwanarangsan, Pornthep ^g   Fasching, Peter A ^h,i   Lux, Michael P ^h   Ekici, Arif B ⁱ   Beckmann, Matthias W ⁱ   Peto, Julian ^j   Dos Santos Silva, Isabel ^j   Fletcher, Olivia ^k   Johnson, Nichola ^k   Sawyer, Elinor J ^l   Tomlinson, Ian ^m   Kerin, Michael J ⁿ   Miller, Nicola ⁿ   Marme, Federick ^o   Schneeweiss, Andreas ^o   Sohn, Christof ^o   Burwinkel, Barbara ^o,p   Guénel, Pascal ^q   Truong, Thérèse ^q   Laurent Puig, Pierre ^r   Menegaux, Florence ^q   Bojesen, Stig E ^s   Nordestgaard, Børge G ^s   Nielsen, Sune F ^s   Flyger, Henrik ^t   Milne, Roger L ^u   Zamora, M Pilar ^v   Arias, Jose I ^w   Benitez, Javier ^u,cp   Neuhausen, Susan ^x   Anton Culver, Hoda ^y   Ziogas, Argyrios ^y   Dur, Christina C ^z   Brenner, Hermann ^p   Müller, Heiko ^p   Arndt, Volker ^p   Stegmaier, Christa ^aa   Meindl, Alfons ^ab   Schmutzler, Rita K ^ac   Engel, Christoph ^ad   Ditsch, Nina ^ae   Brauch, Hiltrud ^af,cq   Brüning, Thomas ^ag   Ko, Yon Dschun ^ah   Nevanlinna, Heli ^ai   Muranen, Taru A ^ai   Aittomäki, Kristiina ^ai   Blomqvist, Carl ^ai   Matsuo, Keitaro ^aj   Ito, Hidemi ^ak   Iwata, Hiroji ^ak   Yatabe, Yasushi ^ak   Dörk, Thilo ^al   Helbig, Sonja ^al   Bogdanova, Natalia V ^al   Lindblom, Annika ^am   Margolin, Sara ^am   Mannermaa, Arto ^an   Kataja, Vesa ^an   Kosma, Veli Matti ^an   Hartikainen, Jaana M ^an   Chenevix Trench, Georgia ^b   Wu, Anna H ^ao   Tseng, Chiu C ^ao   Van Den Berg, David ^ao   Stram, Daniel O ^ao   Lambrechts, Diether ^ap,aq   Thienpont, Bernard ^ap,aq   Christiaens, Marie Rose ^ar   Smeets, Ann ^ar   Chang Claude, Jenny ^p   Rudolph, Anja ^p   Seibold, Petra ^p   Flesch Janys, Dieter ^as   Radice, Paolo ^at   Peterlongo, Paolo ^au   Bonanni, Bernardo ^av   Bernard, Loris ^av,cr   Couch, Fergus J ^aw   Olson, Janet E ^aw   Wang, Xianshu ^aw   Purrington, Kristen ^ax   Giles, Graham G ^d,ay   Severi, Gianluca ^d,ay   Baglietto, Laura ^ay   Mclean, Catriona ^az   Haiman, Christopher A ^ao   Henderson, Brian E ^ao   Schumacher, Fredrick ^ao   Le Marchand, Loic ^ba   Simard, Jacques ^bb   Goldberg, Mark S ^bc,cs   Labrèche, France ^bd   Dumont, Martine ^bb   Teo, Soo Hwang ^be,bf   Yip, Cheng Har ^bf   Phuah, Sze Yee ^be,bf   Kristensen, Vessela ^bg,bh   Grenaker Alnæs, Grethe ^bg   Børresen Dale, Anne Lise ^bg,bh   Zheng, Wei ^bi   Deming Halverson, Sandra ^bi   Shrubsole, Martha ^bi   Long, Jirong ^bi   Winqvist, Robert ^bj   Pylkäs, Katri ^bj   Jukkola Vuorinen, Arja ^bk   Kauppila, Saila ^bk   Andrulis, Irene L ^bl,bm   Knight, Julia A ^bl,bn   Glendon, Gord ^bl   Tchatchou, Sandrine ^bl   Devilee, Peter ^bo   Tollenaar, Robert A E M ^bo   Seynaeve, Caroline M ^bp   García Closas, Montserrat ^k   Figueroa, Jonine ^bq   Chanock, Stephen J ^bq   Lissowska, Jolanta ^br   Czene, Kamila ^am   Darabi, Hartef ^am   Eriksson, Kimael ^am   Hooning, Maartje J ^bp   Martens, John W M ^bp   Van Den Ouweland, Ans M W ^bs   Van Deurzen, Carolien H M ^bs   Hall, Per ^am   Li, Jingmei ^bt   Liu, Jianjun ^bt   Humphreys, Keith ^am   Shu, Xiao Ou ^bi   Lu, Wei ^bu   Gao, Yu Tang ^bv   Cai, Hui ^bi   Cox, Angela ^bw   Reed, Malcolm W R ^bw   Blot, William ^bi,bw   Signorello, Lisa B ^bi,bx   Cai, Qiuyin ^bi   Pharoah, Paul D P ^a   Ghoussaini, Maya ^a   Harrington, Patricia ^a   Tyrer, Jonathan ^a   Kang, Daehee ^by,bz   Choi, Ji Yeob ^bz   Park, Sue K ^by   Noh, Dong Young ^by   Hartman, Mikael ^ca,cb   Hui, Miao ^ca,cb   Lim, Wei Yen ^ca,cb   Buhari, Shaik A ^cb   Hamann, Ute ^p   Försti, Asta ^cc   Rüdiger, Thomas ^cd   Ulmer, Hans Ulrich ^ce   Jakubowska, Anna ^cf   Lubinski, Jan ^cf   Jaworska, Katarzyna ^cf,cg   Durda, Katarzyna ^cf   Sangrajrang, Suleeporn ^ch   Gaborieau, Valerie ^ci   Brennan, Paul ^ci   Mckay, James ^ci   Vachon, Celine ^aw   Slager, Susan ^aw   Fostira, Florentia ^cj   Pilarski, Robert ^ck   Shen, Chen Yang ^cl,cm   Hsiung, Chia Ni ^cl   Wu, Pei Ei ^cm   Hou, Ming Feng ^cn   Swerdlow, Anthony ^k,br   Ashworth, Alan ^k   Orr, Nick ^k   Schoemaker, Minouk J ^br   Ponder, Bruce A J ^a   Dunning, Alison M ^a   Easton, Douglas F ^a   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^f UNIVERSITY OF WARWICK   (United Kingdom)

^g MINISTRY OF PUBLIC HEALTH   (Thailand)

^h UNIVERSITY HOSPITAL ERLANGEN   (Germany)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^k INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^l KING'S COLLEGE LONDON   (United Kingdom)

^m UNIVERSITY OF OXFORD   (United Kingdom)

ⁿ UNIVERSITY HOSPITAL GALWAY   (Ireland)

^o UNIVERSITY OF HEIDELBERG   (Germany)

^p GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^q NATIONAL INSTITUTES OF HEALTH   (United States)

^r Therapeutic Implications Laboratoire d'Excellence GR Ex   (France)

^s Mental Health Services CPH   (Denmark)

^t GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^u Centro Nacional de Investigaciones Oncológicas   (Spain)

^v HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^w HOSPITAL MONTE NARANCO   (Spain)

^x CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^aa Saarland Cancer Registry   (Germany)

^ab TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ac UNIVERSITY OF COLOGNE   (Germany)

^ad UNIVERSITY OF LEIPZIG   (Germany)

^ae UNIVERSITY OF MUNICH   (Germany)

^af DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^ag RUHR UNIVERSITY BOCHUM   (Germany)

^ah Johanniter Krankenhaus   (Germany)

^ai HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^aj KYUSHU UNIVERSITY   (Japan)

^ak AICHI CANCER CENTER HOSPITAL   (Japan)

^al HANNOVER MEDICAL SCHOOL   (Germany)

^am KAROLINSKA INSTITUTE   (Sweden)

^an KUOPIO UNIVERSITY HOSPITAL   (Finland)

^ao UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^ap DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^aq UNIVERSITY OF LEUVEN   (Belgium)

^ar UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^as UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^at NATIONAL CANCER INSTITUTE   (Italy)

^au FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^av EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^aw MAYO CLINIC   (United States)

^ax KARMANOS CANCER INSTITUTE   (United States)

^ay CANCER EPIDEMIOLOGY CENTRE   (Australia)

^az ALFRED HOSPITAL   (Australia)

^ba UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^bb LAVAL UNIVERSITY   (Canada)

^bc MCGILL UNIVERSITY   (Canada)

^bd UNIVERSITÉ DE MONTRÉAL   (Canada)

^be CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

^bf UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^bg OSLO UNIVERSITY HOSPITAL   (Norway)

^bh UNIVERSITY OF OSLO   (Norway)

^bi VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^bj UNIVERSITY OF OULU   (Finland)

^bk OULU UNIVERSITY HOSPITAL   (Finland)

^bl MOUNT SINAI HOSPITAL   (Canada)

^bm UNIVERSITY OF TORONTO   (Canada)

^bn UNIVERSITY OF TORONTO   (Canada)

^bo LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^bp ERASMUS MC CANCER INSTITUTE   (Netherlands)

^bq NATIONAL CANCER INSTITUTE   (United States)

^br INSTITUTE OF ONCOLOGY   (Poland)

^bs ERASMUS MEDICAL CENTER   (Netherlands)

^bt GENOME INSTITUTE OF SINGAPORE   (Singapore)

^bu Shanghai Center for Disease Control and Prevention   (China)

^bv SHANGHAI CANCER INSTITUTE   (China)

^bw UNIVERSITY OF SHEFFIELD   (United Kingdom)

^bx INTERNATIONAL EPIDEMIOLOGY INSTITUTE   (United States)

^by Seoul National University College of Medicine   (South Korea)

^bz Seoul National University   (South Korea)

^ca NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^cb NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^cc LUND UNIVERSITY HOSPITAL   (Sweden)

^cd STÄDTISCHES KLINIKUM KARLSRUHE   (Germany)

^ce Baden Baden   (Germany)

^cf POMERANIAN MEDICAL UNIVERSITY   (Poland)

^cg MEDICAL UNIVERSITY OF WARSAW   (Poland)

^ch NATIONAL CANCER INSTITUTE   (Thailand)

^ci INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^cj INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^ck OHIO STATE UNIVERSITY   (United States)

^cl INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^cm CHINA MEDICAL UNIVERSITY   (Taiwan)

^cn KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^co UNIVERSITY OF MANCHESTER   (United Kingdom)

^cp CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^cq UNIVERSITY OF TÜBINGEN   (Germany)

^cr Chung Ho Memorial Hospital ^*  (Italy)

^cs ROYAL VICTORIA HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; RNA POLYMERASE II; TRANSCRIPTION FACTOR E2F1;

ALLELE; ARTICLE; BREAST CANCER; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORESIS; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; INDEL MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DNA BINDING; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BINDING SITES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME MAPPING; E2F1 TRANSCRIPTION FACTOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; HAPLOTYPES; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HUMANS; POSITION-SPECIFIC SCORING MATRICES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RNA INTERFERENCE;

EID: 84890310753     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2013.10.026     Document Type: Article

References (35)

1. D.F. Easton, K.A. Pooley, A.M. Dunning, P.D. Pharoah, D. Thompson, D.G. Ballinger, J.P. Struewing, J. Morrison, H. Field, R. Luben SEARCH collaborators kConFab AOCS Management Group Genome-wide association study identifies novel breast cancer susceptibility loci Nature 447 2007 1087 1093
2. D.J. Hunter, P. Kraft, K.B. Jacobs, D.G. Cox, M. Yeager, S.E. Hankinson, S. Wacholder, Z. Wang, R. Welch, and A. Hutchinson A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer Nat. Genet. 39 2007 870 874
3. J. Liang, P. Chen, Z. Hu, X. Zhou, L. Chen, M. Li, Y. Wang, J. Tang, H. Wang, and H. Shen Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women Carcinogenesis 29 2008 2341 2346
4. J.S. Barnholtz-Sloan, P.B. Shetty, X. Guan, S.J. Nyante, J. Luo, D.J. Brennan, and R.C. Millikan FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women Carcinogenesis 31 2010 1417 1423
5. N. Orr, R. Cooke, M. Jones, O. Fletcher, F. Dudbridge, S. Chilcott-Burns, K. Tomczyk, P. Broderick, R. Houlston, A. Ashworth, and A. Swerdlow Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men PLoS Genet. 7 2011 e1002290
6. K. Michailidou, P. Hall, A. Gonzales-Neira, M. Ghoussaini, J. Dennis, R. Milne, M.K. Schmidt, J. Chang-Claude, S.E. Bojesen, and M.K. Bolla Large-scale genotyping identifies 41 novel breast cancer susceptibility loci Nat. Genet. 45 2013 353 361
7. M. Garcia-Closas, P. Hall, H. Nevanlinna, K. Pooley, J. Morrison, D.A. Richesson, S.E. Bojesen, B.G. Nordestgaard, C.K. Axelsson, J.I. Arias Australian Ovarian Cancer Management Group Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics PLoS Genet. 4 2008 e1000054
8. M.S. Udler, K.B. Meyer, K.A. Pooley, E. Karlins, J.P. Struewing, J. Zhang, D.R. Doody, S. MacArthur, J. Tyrer, P.D. Pharoah SEARCH Collaborators FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation Hum. Mol. Genet. 18 2009 1692 1703
9. F. Chen, G.K. Chen, R.C. Millikan, E.M. John, C.B. Ambrosone, L. Bernstein, W. Zheng, J.J. Hu, R.G. Ziegler, and S.L. Deming Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans Hum. Mol. Genet. 20 2011 4491 4503
10. K.B. Meyer, A.T. Maia, M. O'Reilly, A.E. Teschendorff, S.F. Chin, C. Caldas, and B.A. Ponder Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer PLoS Biol. 6 2008 e108
11. X. Zhu, S.L. Asa, and S. Ezzat Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer Mol. Endocrinol. 23 2009 1397 1405
12. P.E. Huijts, M. van Dongen, M.C. de Goeij, A.J. van Moolenbroek, F. Blanken, M.P. Vreeswijk, E.M. de Kruijf, W.E. Mesker, E.W. van Zwet, and R.A. Tollenaar Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10 Breast Cancer Res. 13 2011 R72
13. C. Sun, O.I. Olopade, and A. Di Rienzo rs2981582 is associated with FGFR2 expression in normal breast Cancer Genet. Cytogenet. 197 2010 193 194
14. D. Schmidt, M.D. Wilson, C. Spyrou, G.D. Brown, J. Hadfield, and D.T. Odom ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions Methods 48 2009 240 248
15. J.S. Carroll, C.A. Meyer, J. Song, W. Li, T.R. Geistlinger, J. Eeckhoute, A.S. Brodsky, E.K. Keeton, K.C. Fertuck, and G.F. Hall Genome-wide analysis of estrogen receptor binding sites Nat. Genet. 38 2006 1289 1297
16. A. Hurtado, K.A. Holmes, C.S. Ross-Innes, D. Schmidt, and J.S. Carroll FOXA1 is a key determinant of estrogen receptor function and endocrine response Nat. Genet. 43 2011 27 33
17. P.G. Giresi, J. Kim, R.M. McDaniell, V.R. Iyer, and J.D. Lieb FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin Genome Res. 17 2007 877 885
18. J. French, M. Ghoussaini, S. Edwards, K. Meyer, K. Michailidou, S. Ahmed, S. Kahn, M. Maranian, M. O'Reilly, and K. Hillman Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers Am. J. Hum. Genet. 92 2013 489 503
19. J.L. Robinson, S. Macarthur, C.S. Ross-Innes, W.D. Tilley, D.E. Neal, I.G. Mills, and J.S. Carroll Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1 EMBO J. 30 2011 3019 3027
20. C. Curtis, S.P. Shah, S.F. Chin, G. Turashvili, O.M. Rueda, M.J. Dunning, D. Speed, A.G. Lynch, S. Samarajiwa, Y. Yuan METABRIC Group The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature 486 2012 346 352
21. M.T. Maurano, R. Humbert, E. Rynes, R.E. Thurman, E. Haugen, H. Wang, A.P. Reynolds, R. Sandstrom, H. Qu, and J. Brody Systematic localization of common disease-associated variation in regulatory DNA Science 337 2012 1190 1195
22. C.S. Ross-Innes, R. Stark, A.E. Teschendorff, K.A. Holmes, H.R. Ali, M.J. Dunning, G.D. Brown, O. Gojis, I.O. Ellis, and A.R. Green Differential oestrogen receptor binding is associated with clinical outcome in breast cancer Nature 481 2012 389 393
23. J. Odawara, A. Harada, T. Yoshimi, K. Maehara, T. Tachibana, S. Okada, K. Akashi, and Y. Ohkawa The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach BMC Genomics 12 2011 516
24. H. Nakshatri, and S. Badve FOXA1 in breast cancer Expert Rev. Mol. Med. 11 2009 e8
25. S.E. Bojesen, K.A. Pooley, S.E. Johnatty, J. Beesley, K. Michailidou, J.P. Tyrer, S.L. Edwards, H.A. Pickett, H.C. Shen, C.E. Smart Australian Cancer Study Australian Ovarian Cancer Study Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) Gene Environment Interaction and Breast Cancer (GENICA) Swedish Breast Cancer Study (SWE-BRCA) Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE) Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO) Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer Nat. Genet. 45 2013 371 384 e1-e2
26. R. Cowper-Sal lari, X. Zhang, J.B. Wright, S.D. Bailey, M.D. Cole, J. Eeckhoute, J.H. Moore, and M. Lupien Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression Nat. Genet. 44 2012 1191 1198
27. M.N.C. Fletcher, C.A.A. Mauro, S.-F. Chin, C. Caldas, B.A.J. Ponder, F. Markowetz, and K.B. Meyer Master regulators of the FGFR2 response in breast cancer Nat. Commun. 4 2013 10.1038/ncomms3464 Published online September 17, 2013
28. K.S. Zaret, and J.S. Carroll Pioneer transcription factors: establishing competence for gene expression Genes Dev. 25 2011 2227 2241
29. S.L. Kong, G. Li, S.L. Loh, W.K. Sung, and E.T. Liu Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state Mol. Syst. Biol. 7 2011 526
30. V. Vuaroqueaux, P. Urban, M. Labuhn, M. Delorenzi, P. Wirapati, C.C. Benz, R. Flury, H. Dieterich, F. Spyratos, U. Eppenberger, and S. Eppenberger-Castori Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome Breast Cancer Res. 9 2007 R33
31. N. Ferrari, L. McDonald, J. Morris, E. Cameron, and K. Blyth RUNX2 in mammary gland development and breast cancer J. Cell. Physiol. 228 2013 1137 1142
32. M. Riaz, E.M. Berns, A.M. Sieuwerts, K. Ruigrok-Ritstier, V. de Weerd, A. Groenewoud, A.G. Uitterlinden, M.P. Look, J.G. Klijn, and S. Sleijfer Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes Breast Cancer Res. Treat. 133 2012 843 851
33. Q. Li, J.H. Seo, B. Stranger, A. McKenna, I. Pe'er, T. Laframboise, M. Brown, S. Tyekucheva, and M.L. Freedman Integrative eQTL-based analyses reveal the biology of breast cancer risk loci Cell 152 2013 633 641
34. P. Lu, A.J. Ewald, G.R. Martin, and Z. Werb Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis Dev. Biol. 321 2008 77 87
35. N. Reintjes, Y. Li, A. Becker, E. Rohmann, R. Schmutzler, and B. Wollnik Activating somatic FGFR2 mutations in breast cancer PLoS ONE 8 2013 e60264