Cardiometabolic Traits and Systolic Mechanics in the Community

Circulation: Heart Failure

Volumn 10, Issue 5, 2017, Pages

  Ho, Jennifer E ^a,b   McCabe, Elizabeth L ^b   Wang, Thomas J ^c   Larson, Martin G ^b,d   Levy, Daniel ^b   Tsao, Connie ^b,e   Aragam, Jayashri ^f,g   Mitchell, Gary F ^h   Benjamin, Emelia J ^b,d,i   Vasan, Ramachandran S ^b,d,i   Cheng, Susan ^a,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h CARDIOVASCULAR ENGINEERING INC   (United States)

ⁱ BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

adipokine; echocardiography; epidemiology; left ventricular function; obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALDOSTERONE; C REACTIVE PROTEIN; LEPTIN RECEPTOR; TRIACYLGLYCEROL;

ADULT; ARTICLE; BIOMECHANICS; BODY MASS; CARDIOMETABOLIC RISK; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FRAMINGHAM RISK SCORE; GLUCOSE BLOOD LEVEL; HEART FAILURE; HEART VENTRICLE REMODELING; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; PRIORITY JOURNAL; SPECKLE TRACKING ECHOCARDIOGRAPHY; BLOOD; CLINICAL TRIAL; COMPLICATION; ECHOCARDIOGRAPHY; FOLLOW UP; HEART LEFT VENTRICLE FUNCTION; HYPERTROPHY, LEFT VENTRICULAR; INCIDENCE; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY; RISK FACTOR; SYSTOLE; UNITED STATES;

ADIPOKINES; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INCIDENCE; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; RISK FACTORS; SYSTOLE; UNITED STATES; VENTRICULAR FUNCTION, LEFT;

EID: 85019636814     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.116.003536     Document Type: Article

References (43)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation. 2014;129:e28-e292. doi: 10.1161/01. cir.0000441139.02102.80.
2. Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D'Agostino RB Sr. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006;113:2914-2918. doi: 10.1161/CIRCULATIONAHA.106.613828.
3. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362-2374. doi: 10.1056/NEJMoa031049.
4. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305-313. doi: 10.1056/NEJMoa020245.
5. Sundström J, Risérus U, Byberg L, Zethelius B, Lithell H, Lind L. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ. 2006;332:878-882. doi: 10.1136/bmj.38766.624097.1F.
6. Wang YC, Liang CS, Gopal DM, Ayalon N, Donohue C, Santhanakrishnan R, Sandhu H, Perez AJ, Downing J, Gokce N, Colucci WS, Ho JE. Preclinical systolic and diastolic dysfunctions in metabolically healthy and unhealthy obese individuals. Circ Heart Fail. 2015;8:897-904. doi: 10.1161/CIRCHEARTFAILURE.114.002026.
7. Ayalon N, Gopal DM, Mooney DM, Simonetti JS, Grossman JR, Dwivedi A, Donohue C, Perez AJ, Downing J, Gokce N, Miller EJ, Liang CS, Apovian CM, Colucci WS, Ho JE. Preclinical left ventricular diastolic dysfunction in metabolic syndrome. Am J Cardiol. 2014;114:838-842. doi: 10.1016/j.amjcard.2014.06.013.
8. Aurigemma GP, de Simone G, Fitzgibbons TP. Cardiac remodeling in obesity. Circ Cardiovasc Imaging. 2013;6:142-152. doi: 10.1161/CIRCIMAGING.111.964627.
9. Cavalera M, Wang J, Frangogiannis NG. Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities. Transl Res. 2014;164:323-335. doi: 10.1016/j.trsl.2014.05.001.
10. Park M, Sweeney G. Direct effects of adipokines on the heart: focus on adiponectin. Heart Fail Rev. 2013;18:631-644. doi: 10.1007/s10741-012-9337-8.
11. Abel ED, Sweeney G. Modulation of the cardiovascular system by leptin. Biochimie. 2012;94:2097-2103.
12. Hung CL, Verma A, Uno H, Shin SH, Bourgoun M, Hassanein AH, McMurray JJ, Velazquez EJ, Kober L, Pfeffer MA, Solomon SD; VALIANT investigators. Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction. J Am Coll Cardiol. 2010;56:1812-1822. doi: 10.1016/j. jacc.2010.06.044.
13. Cheng S, McCabe EL, Larson MG, Merz AA, Osypiuk E, Lehman BT, Stantchev P, Aragam J, Solomon SD, Benjamin EJ, Vasan RS. Distinct aspects of left ventricular mechanical function are differentially associated with cardiovascular outcomes and all-cause mortality in the community. J Am Heart Assoc. 2015;4:e002071. doi: 10.1161/JAHA.115.002071.
14. Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL. Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. J Am Soc Echocardiogr. 2011;24:277-313. doi: 10.1016/j.echo.2011.01.015.
15. Donal E, Bergerot C, Thibault H, Ernande L, Loufoua J, Augeul L, Ovize M, Derumeaux G. Influence of afterload on left ventricular radial and longitudinal systolic functions: a two-dimensional strain imaging study. Eur J Echocardiogr. 2009;10:914-921. doi: 10.1093/ejechocard/jep095.
16. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol. 1979;110:281-290.
17. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D'Agostino RB Sr, Fox CS, Larson MG, Murabito JM, O'Donnell CJ, Vasan RS, Wolf PA, Levy D. The third generation cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol. 2007;165:1328-1335. doi: 10.1093/aje/kwm021.
18. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735-2752. doi: 10.1161/CIRCULATIONAHA.105.169404.
19. Meigs JB, Mittleman MA, Nathan DM, Tofler GH, Singer DE, Murphy- Sheehy PM, Lipinska I, D'Agostino RB, Wilson PW. Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study. JAMA. 2000;283:221-228.
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
21. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976;37:7-11.
22. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450-458.
23. Cheng S, McCabe EL, Larson MG, Chen MH, Osypiuk E, Lehman BT, Stantchev P, Aragam J, Solomon SD, Benjamin EJ, Vasan RS. Left ventricular mechanical function: clinical correlates, heritability, and association with parental heart failure. Eur J Heart Fail. 2015;17:44-50. doi: 10.1002/ejhf.202.
24. Cheng S, Larson MG, McCabe EL, Osypiuk E, Lehman BT, Stanchev P, Aragam J, Benjamin EJ, Solomon SD, Vasan RS. Reproducibility of speckle-tracking-based strain measures of left ventricular function in a community-based study. J Am Soc Echocardiogr. 2013;26:1258-1266. e2. doi: 10.1016/j.echo.2013.07.002.
25. Turkbey EB, McClelland RL, Kronmal RA, Burke GL, Bild DE, Tracy RP, Arai AE, Lima JA, Bluemke DA. The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging. 2010;3:266-274. doi: 10.1016/j.jcmg.2009.10.012.
26. Russo C, Sera F, Jin Z, Palmieri V, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR. Abdominal adiposity, general obesity, and subclinical systolic dysfunction in the elderly: a population-based cohort study. Eur J Heart Fail. 2016;18:537-544. doi: 10.1002/ejhf.521.
27. Selvaraj S, Martinez EE, Aguilar FG, Kim K-YA, Peng J, Sha J, Irvin MR, Lewis CE, Hunt SC, Arnett DK, Shah SJ. Association of central adiposity with adverse cardiac mechanics: findings from the Hypertension Genetic Epidemiology Network Study. Circ Cardiovasc Imaging. 2016;9.e004396. doi: 10.1161/CIRCIMAGING.115.004396.
28. Kishi S, Armstrong AC, Gidding SS, Colangelo LA, Venkatesh BA, Jacobs DR Jr, Carr JJ, Terry JG, Liu K, Goff DC Jr, Lima JA. Association of obesity in early adulthood and middle age with incipient left ventricular dysfunction and structural remodeling: the CARDIA study (Coronary Artery Risk Development in Young Adults). JACC Heart Fail. 2014;2:500-508. doi: 10.1016/j.jchf.2014.03.001.
29. Donal E, Roulaud M, Raud-Raynier P, De Bisschop C, Leclercq C, Derumeaux G, Daubert JC, Mabo P, Denjean A. Echocardiographic right ventricular strain analysis in chronic heart failure. Eur J Echocardiogr. 2007;8:449-456. doi: 10.1016/j.euje.2006.07.011.
30. Baltabaeva A, Marciniak M, Bijnens B, Moggridge J, He FJ, Antonios TF, MacGregor GA, Sutherland GR. Regional left ventricular deformation and geometry analysis provides insights in myocardial remodelling in mild to moderate hypertension. Eur J Echocardiogr. 2008;9:501-508. doi: 10.1016/j.euje.2007.08.004.
31. Hasegawa H, Little WC, Ohno M, Brucks S, Morimoto A, Cheng HJ, Cheng CP. Diastolic mitral annular velocity during the development of heart failure. J Am Coll Cardiol. 2003;41:1590-1597.
32. Skali H, Shah A, Gupta DK, Cheng S, Claggett B, Liu J, Bello N, Aguilar D, Vardeny O, Matsushita K, Selvin E, Solomon S. Cardiac structure and function across the glycemic spectrum in elderly men and women free of prevalent heart disease: the Atherosclerosis Risk In the Community study. Circ Heart Fail. 2015;8:448-454. doi: 10.1161/CIRCHEARTFAILURE.114.001990.
33. Short KR, Vittone JL, Bigelow ML, Proctor DN, Nair KS. Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol Endocrinol Metab. 2004;286:E92-101. doi: 10.1152/ajpendo.00366.2003.
34. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun. 2001;283:982-988. doi: 10.1006/bbrc.2001.4885.
35. Huby AC, Antonova G, Groenendyk J, Gomez-Sanchez CE, Bollag WB, Filosa JA, Belin de Chantemèle EJ. Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis. Circulation. 2015;132:2134-2145. doi: 10.1161/CIRCULATIONAHA.115.018226.
36. Fontes-Carvalho R, Pimenta J, Bettencourt P, Leite-Moreira A, Azevedo A. Association between plasma leptin and adiponectin levels and diastolic function in the general population. Expert Opin Ther Targets. 2015;19:1283-1291. doi: 10.1517/14728222.2015.1019468.
37. Li RJ, Yang J, Yang Y, Ma N, Jiang B, Sun QW, Li YJ. Speckle tracking echocardiography in the diagnosis of early left ventricular systolic dysfunction in type II diabetic mice. BMC Cardiovasc Disord. 2014;14:141. doi: 10.1186/1471-2261-14-141.
38. Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, Sattar N. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104:3052-3056.
39. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. The association of serum leptin with mortality in older adults. PLoS One. 2015;10:e0140763. doi: 10.1371/journal. pone.0140763.
40. Martin SS, Blaha MJ, Muse ED, Qasim AN, Reilly MP, Blumenthal RS, Nasir K, Criqui MH, McClelland RL, Hughes-Austin JM, Allison MA. Leptin and incident cardiovascular disease: the Multi-ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015;239:67-72.
41. Koshino Y, Villarraga HR, Somers VK, Miranda WR, Garza CA, Hsiao JF, Yu Y, Saleh HK, Lopez-Jimenez F. Changes in myocardial mechanics in patients with obesity following major weight loss after bariatric surgery. Obesity (Silver Spring). 2013;21:1111-1118. doi: 10.1002/oby.20168.
42. Schuster I, Vinet A, Karpoff L, Startun A, Jourdan N, Dauzat M, Nottin S, Perez-Martin A. Diastolic dysfunction and intraventricular dyssynchrony are restored by low intensity exercise training in obese men. Obesity (Silver Spring). 2012;20:134-140. doi: 10.1038/oby.2011.270.
43. Kosmala W, Przewlocka-Kosmala M, Szczepanik-Osadnik H, Mysiak A, O'Moore-Sullivan T, Marwick TH. A randomized study of the beneficial effects of aldosterone antagonism on LV function, structure, and fibrosis markers in metabolic syndrome. JACC Cardiovasc Imaging. 2011;4:1239-1249. doi: 10.1016/j.jcmg.2011.08.014.