Abdominal adiposity, general obesity, and subclinical systolic dysfunction in the elderly: A population-based cohort study

European Journal of Heart Failure

Volumn 18, Issue 5, 2016, Pages 537-544

  Russo, Cesare ^a   Sera, Fusako ^a   Jin, Zhezhen ^a   Palmieri, Vittorio ^b   Homma, Shunichi ^a   Rundek, Tatjana ^c   Elkind, Mitchell S V ^a   Sacco, Ralph L ^c   Di Tullio, Marco R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Headache Center SGMoscati   (Italy)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Abdominal adiposity; Echocardiography; Global longitudinal strain; Obesity; Systolic dysfunction

Indexed keywords

ABDOMINAL OBESITY; AGE DISTRIBUTION; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BODY SIZE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GERIATRIC PATIENT; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MALE; OBESITY; POPULATION RESEARCH; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SPECKLE TRACKING ECHOCARDIOGRAPHY; SYSTOLIC DYSFUNCTION; TWO DIMENSIONAL ECHOCARDIOGRAPHY; WAIST CIRCUMFERENCE; WAIST HIP RATIO; DIAGNOSTIC IMAGING; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; MIDDLE AGED; OBESITY, ABDOMINAL; ODDS RATIO; OVERWEIGHT; SYSTOLE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BODY MASS INDEX; ECHOCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OBESITY, ABDOMINAL; ODDS RATIO; OVERWEIGHT; RISK FACTORS; STROKE VOLUME; SYSTOLE; VENTRICULAR DYSFUNCTION, LEFT; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84964806776     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.521     Document Type: Article

References (49)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM,. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014; 311: 806-814.
2. Hubert HB, Feinleib M, McNamara PM, Castelli WP,. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983; 67: 968-977.
3. Bahrami H, Bluemke DA, Kronmal R, Bertoni AG, Lloyd-Jones DM, Shahar E, Szklo M, Lima JA,. Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J Am Coll Cardiol 2008; 51: 1775-1783.
4. Flegal KM, Graubard BI, Williamson DF, Gail MH,. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005; 293: 1861-1867.
5. Russo C, Jin Z, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR,. Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort. J Am Coll Cardiol 2011; 57: 1368-1374.
6. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS,. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305-313.
7. Despres JP, Lemieux I,. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-887.
8. Lee CM, Huxley RR, Wildman RP, Woodward M,. Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol 2008; 61: 646-653.
9. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L,. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 937-952.
10. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, Tanomsup S, Wangai P Jr, Razak F, Sharma AM, Anand SS,. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 2005; 366: 1640-1649.
11. Loehr LR, Rosamond WD, Poole C, McNeill AM, Chang PP, Folsom AR, Chambless LE, Heiss G,. Association of multiple anthropometrics of overweight and obesity with incident heart failure: the Atherosclerosis Risk in Communities study. Circ Heart Fail 2009; 2: 18-24.
12. de Koning L, Merchant AT, Pogue J, Anand SS,. Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies. Eur Heart J 2007; 28: 850-856.
13. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, van der Schouw YT, Spencer E, Moons KG, Tjonneland A, Halkjaer J, Jensen MK, Stegger J, Clavel-Chapelon F, Boutron-Ruault MC, Chajes V, Linseisen J, Kaaks R, Trichopoulou A, Trichopoulos D, Bamia C, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Peeters PH, May AM, Bueno-de-Mesquita HB, van Duijnhoven FJ, Hallmans G, Weinehall L, Manjer J, Hedblad B, Lund E, Agudo A, Arriola L, Barricarte A, Navarro C, Martinez C, Quiros JR, Key T, Bingham S, Khaw KT, Boffetta P, Jenab M, Ferrari P, Riboli E,. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 359: 2105-2120.
14. Hu G, Jousilahti P, Antikainen R, Katzmarzyk PT, Tuomilehto J,. Joint effects of physical activity, body mass index, waist circumference, and waist-to-hip ratio on the risk of heart failure. Circulation 2010; 121: 237-244.
15. Sahakyan KR, Somers VK, Rodriguez-Escudero JP, Hodge DO, Carter RE, Sochor O, Coutinho T, Jensen MD, Roger VL, Singh P, Lopez-Jimenez F,. Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality. Ann Intern Med 2015; 163: 827-835.
16. Turkbey EB, McClelland RL, Kronmal RA, Burke GL, Bild DE, Tracy RP, Arai AE, Lima JA, Bluemke DA,. The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging 2010; 3: 266-274.
17. Pascual M, Pascual DA, Soria F, Vicente T, Hernandez AM, Tebar FJ, Valdes M,. Effects of isolated obesity on systolic and diastolic left ventricular function. Heart 2003; 89: 1152-1156.
18. de Simone G, Devereux RB, Mureddu GF, Roman MJ, Ganau A, Alderman MH, Contaldo F, Laragh JH,. Influence of obesity on left ventricular midwall mechanics in arterial hypertension. Hypertension 1996; 28: 276-283.
19. Russo C, Jin Z, Elkind MS, Rundek T, Homma S, Sacco RL, Di Tullio MR,. Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort. Eur J Heart Fail 2014; 16: 1301-1309.
20. Peterson LR, Waggoner AD, Schechtman KB, Meyer T, Gropler RJ, Barzilai B, vila-Roman VG,. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 2004; 43: 1399-1404.
21. Wong CY, O'Moore-Sullivan T, Leano R, Byrne N, Beller E, Marwick TH,. Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 2004; 110: 3081-3087.
22. Kishi S, Armstrong AC, Gidding SS, Colangelo LA, Venkatesh BA, Jacobs DR Jr, Carr JJ, Terry JG, Liu K, Goff DC Jr, Lima JA,. Association of obesity in early adulthood and middle age with incipient left ventricular dysfunction and structural remodeling: the CARDIA study (Coronary Artery Risk Development in Young Adults). JACC Heart Fail 2014; 2: 500-508.
23. Sacco RL, Khatri M, Rundek T, Xu Q, Gardener H, Boden-Albala B, Di Tullio MR, Homma S, Elkind MS, Paik MC,. Improving global vascular risk prediction with behavioral and anthropometric factors the Multiethnic NOMAS (Northern Manhattan Cohort Study). J Am Coll Cardiol 2009; 54: 2303-2311.
24. World Health Organization. Waist circumference and waist-hip ratio. Report of a WHO Expert Consultation, Geneva, 8-11 December 2008. Geneva: WHO; 2011.
25. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ,. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440-1463.
26. Devereux RB, Reichek N,. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977; 55: 613-618.
27. Russo C, Jin Z, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR,. Effect of diabetes and hypertension on left ventricular diastolic function in a high-risk population without evidence of heart disease. Eur J Heart Fail 2010; 12: 454-461.
28. Russo C, Jin Z, Palmieri V, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR,. Arterial stiffness and wave reflection: sex differences and relationship with left ventricular diastolic function. Hypertension 2012; 60: 362-368.
29. Russo C, Jin Z, Sera F, Lee ES, Homma S, Rundek T, Elkind MS, Sacco RL, Di Tullio MR,. Left ventricular systolic dysfunction by longitudinal strain is an independent predictor of incident atrial fibrillation: a community-based cohort study. Circ Cardiovasc Imaging 2015; 8:e003520.
30. Levitan EB, Yang AZ, Wolk A, Mittleman MA,. Adiposity and incidence of heart failure hospitalization and mortality: a population-based prospective study. Circ Heart Fail 2009; 2: 202-208.
31. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr., Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999; 341: 1097-1105.
32. Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R, Hollenbeck A, Leitzmann MF,. Overweight, obesity, and mortality in a large prospective cohort of persons 50-71 years old. N Engl J Med 2006; 355: 763-778.
33. Nazare JA, Smith J, Borel AL, Aschner P, Barter P, Van GL, Tan CE, Wittchen HU, Matsuzawa Y, Kadowaki T, Ross R, Brulle-Wohlhueter C, Almeras N, Haffner SM, Balkau B, Despres JP,. Usefulness of measuring both body mass index and waist circumference for the estimation of visceral adiposity and related cardiometabolic risk profile (from the INSPIRE ME IAA Study). Am J Cardiol 2015; 115: 307-315.
34. Nicklas BJ, Cesari M, Penninx BW, Kritchevsky SB, Ding J, Newman A, Kitzman DW, Kanaya AM, Pahor M, Harris TB,. Abdominal obesity is an independent risk factor for chronic heart failure in older people. J Am Geriatr Soc 2006; 54: 413-420.
35. Djousse L, Bartz TM, Ix JH, Zieman SJ, Delaney JA, Mukamal KJ, Gottdiener JS, Siscovick DS, Kizer JR,. Adiposity and incident heart failure in older adults: the cardiovascular health study. Obesity (Silver Spring) 2012; 20: 1936-1941.
36. Wormser D, Kaptoge S, Di AE, Wood AM, Pennells L, Thompson A, Sarwar N, Kizer JR, Lawlor DA, Nordestgaard BG, Ridker P, Salomaa V, Stevens J, Woodward M, Sattar N, Collins R, Thompson SG, Whitlock G, Danesh J,. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 2011; 377: 1085-1095.
37. Bella JN, Devereux RB, Roman MJ, O'Grady MJ, Welty TK, Lee ET, Fabsitz RR, Howard BV,. Relations of left ventricular mass to fat-free and adipose body mass. The Strong Heart Study Investigators. Circulation 1998; 98: 2538-2544.
38. Collis T, Devereux RB, Roman MJ, de Simone G, Yeh JL, Howard BV, Fabsitz RR, Welty TK,. Relations of stroke volume and cardiac output to body composition: the Strong Heart Study. Circulation 2001; 103: 820-825.
39. Palmieri V, de Simone G, Arnett DK, Bella JN, Kitzman DW, Oberman A, Hopkins PN, Province MA, Devereux RB,. Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study). Am J Cardiol 2001; 88: 1163-1168.
40. Rider OJ, Lewandowski A, Nethononda R, Petersen SE, Francis JM, Pitcher A, Holloway CJ, Dass S, Banerjee R, Byrne JP, Leeson P, Neubauer S,. Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging. Eur Heart J 2013; 34: 292-299.
41. Kosmala W, Jedrzejuk D, Derzhko R, Przewlocka-Kosmala M, Mysiak A, Bednarek-Tupikowska G,. Left ventricular function impairment in patients with normal-weight obesity: contribution of abdominal fat deposition, profibrotic state, reduced insulin sensitivity, and proinflammatory activation. Circ Cardiovasc Imaging 2012; 5: 349-356.
42. Visscher TL, Seidell JC, Molarius A, van der Kuip D, Hofman A, Witteman JC,. A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord 2001; 25: 1730-1735.
43. de Hollander EL, Bemelmans WJ, Boshuizen HC, Friedrich N, Wallaschofski H, Guallar-Castillon P, Walter S, Zillikens MC, Rosengren A, Lissner L, Bassett JK, Giles GG, Orsini N, Heim N, Visser M, de Groot LC,. The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. Int J Epidemiol 2012; 41: 805-817.
44. Wang YC, Liang CS, Gopal DM, Ayalon N, Donohue C, Santhanakrishnan R, Sandhu H, Perez AJ, Downing J, Gokce N, Colucci WS, Ho JE,. Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals. Circ Heart Fail 2015; 8: 897-904.
45. Russo C, Jin Z, Takei Y, Hasegawa T, Koshaka S, Palmieri V, Elkind MS, Homma S, Sacco RL, Di Tullio MR,. Arterial wave reflection and subclinical left ventricular systolic dysfunction. J Hypertens 2011; 29: 574-582.
46. Fernandes VR, Polak JF, Edvardsen T, Carvalho B, Gomes A, Bluemke DA, Nasir K, O'Leary DH, Lima JA,. Subclinical atherosclerosis and incipient regional myocardial dysfunction in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Coll Cardiol 2006; 47: 2420-2428.
47. Russo C, Jin Z, Homma S, Elkind MS, Rundek T, Yoshita M, DeCarli C, Wright CB, Sacco RL, Di Tullio MR,. Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study. Circulation 2013; 128: 1105-1111.
48. Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD, Kisrieva-Ware Z, Dence C, Klein S, Marsala J, Meyer T, Gropler RJ,. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 2004; 109: 2191-2196.
49. Kosmala W, Plaksej R, Przewlocka-Kosmala M, Kuliczkowska-Plaksej J, Bednarek-Tupikowska G, Mazurek W,. Matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in premenopausal obese women: relationship to cardiac function. Int J Obes (Lond) 2008; 32: 763-771.