Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Project

Journal of Trauma and Acute Care Surgery

Volumn 83, Issue 4, 2017, Pages 683-689

  Black, George Edward ^a   Sokol, Kyle K ^a   Moe, Donald M ^c   Simmons, Jon D ^b   Muscat, David ^a   Pastukh, Victor ^c   Capley, Gina ^a   Gorodnya, Olena ^c   Ruchko, Mykhaylo ^c   Roth, Mark B ^d   Gillespie, Mark ^c   Martin, Matthew J ^a,e  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^c University of South   (United States)

^d USA   (United States)

^e LEGACY EMANUEL MEDICAL CENTER   (United States)

Author keywords

Damage associated molecular pattern accumulation; hemorrhage; LY294002; mitochondrial DNA; trauma

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BIOLOGICAL FACTOR; DAMAGE ASSOCIATED MOLECULAR PATTERN; MITOCHONDRIAL DNA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DNA DAMAGE; DRUG SYNTHESIS; HEMORRHAGIC SHOCK; INJURY SEVERITY; INTERNATIONAL NORMALIZED RATIO; KIDNEY FUNCTION; LAPAROTOMY; LIVER FUNCTION; LUNG FUNCTION; NONHUMAN; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTHROMBIN TIME; PULMONARY ARTERY OCCLUSION PRESSURE; REPERFUSION INJURY; RESPIRATORY QUOTIENT; RESUSCITATION; SOUTHERN BLOTTING; ANIMAL; COMPLICATION; DISEASE MODEL; ENERGY METABOLISM; MULTIPLE ORGAN FAILURE; PIG; SHOCK, TRAUMATIC;

ANIMALS; CHROMONES; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA, MITOCHONDRIAL; ENERGY METABOLISM; ENZYME INHIBITORS; MORPHOLINES; MULTIPLE ORGAN FAILURE; SHOCK, TRAUMATIC; SWINE;

EID: 85019628882     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000001593     Document Type: Article

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