Mitochondrial DNA damage-associated molecular patterns mediate a feedforward cycle of bacteria-induced vascular injury in perfused rat lungs

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 308, Issue 10, 2015, Pages L1078-L1085

  Kuck, Jamie L ^a   Obiako, Boniface O ^a   Gorodnya, Olena M ^a   Pastukh, Viktor M ^a   Kua, Justin ^a   Simmons, Jon D ^a   Gillespie, Mark N ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Damage associated molecular patterns; Lung injury; Mitochondrial DNA; Ogg1; Oxidant stress

Indexed keywords

HYBRID PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRION DEOXYRIBONUCLEIC ACID DAMAGE ASSOCIATED MOLECULAR PATTERN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN OGG1; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE I; DNA GLYCOSYLTRANSFERASE; OGG1 PROTEIN, RAT; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA SEQUENCE; LUNG INJURY; LUNG PARENCHYMA; LUNG PERFUSION; MALE; MITOCHONDRIAL GENOME; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; ACUTE LUNG INJURY; AGONISTS; ANIMAL; DRUG EFFECTS; LUNG; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PERFUSION; PSEUDOMONAS INFECTION; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ACUTE LUNG INJURY; ANIMALS; DEOXYRIBONUCLEASE I; DNA DAMAGE; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; LUNG; MALE; OLIGODEOXYRIBONUCLEOTIDES; OXIDATIVE STRESS; PERFUSION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RATS; RATS, SPRAGUE-DAWLEY; TOLL-LIKE RECEPTOR 9;

EID: 84930829907     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00015.2015     Document Type: Article

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