Recombinant factor VIIa is effective at reversing coagulopathy in a lactic acidosis model

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 1, 2012, Pages 123-129

  Lesperance, Richard N ^a   Lehmann, Ryan K ^a   Harold, Dawn M ^a   Beekley, Alec C ^b   Sebesta, James A ^a   Martin, Matthew J ^a  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Coagulopathy; Hemorrhage; Lactate; Metabolic acidosis; Recombinant factor VII; ROTEM; Trauma

Indexed keywords

BICARBONATE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; BLOOD PH; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; IN VITRO STUDY; INTERNATIONAL NORMALIZED RATIO; LACTIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; SWINE; THROMBOELASTOGRAPHY; ANIMAL; ARTICLE; DISEASE MODEL; HEMORRHAGIC SHOCK;

ACIDOSIS, LACTIC; ANIMALS; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; DISEASE MODELS, ANIMAL; FACTOR VIIA; RECOMBINANT PROTEINS; SHOCK, HEMORRHAGIC; SWINE;

EID: 84859638523     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318224e24a     Document Type: Conference Paper

References (24)

1. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127-1130.
2. Niles SE, McLaughlin DF, Perkins JG, et al. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma. 2008;64:1459-1463; discussion 1463-1465.
3. Howes DW, Stratford A, Stirling M, Ferri CC, Bardell T. Administration of recombinant factor VIIa decreases blood loss after blunt trauma in noncoagulopathic pigs. J Trauma. 2007;62:311-314; discussion 314-315.
4. McMullin NR, Hedner U, Ezban M, et al. Recombinant factor VIIa reduces rebleed hemorrhage volume in a swine aortotomy model: a randomized double-blinded study. Shock. 2008;29:703-708.
5. Boffard KD, Riou B, Warren B, et al; NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebocontrolled, double-blind clinical trials. J Trauma. 2005;59:8-15; discussion 15-18.
6. Hauser CJ, Boffard K, Dutton R, et al; CONTROL Study Group. Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010;69:489-500.
7. Barletta JF, Ahrens CL, Tyburski JG, Wilson RF. A review of recombinant factor VII for refractory bleeding in nonhemophilic trauma patients. J Trauma. 2005;58:646-651.
8. Hall K, Forrest P, Sawyer C. The effects of acidosis and hypothermia on blood transfusion requirements following factor VII administration. Anaesth Intensive Care. 2007;35:494-497.
9. Rizoli SB, Nascimento B Jr, Osman F, et al. Recombinant activated coagulation factor VII and bleeding trauma patients. J Trauma. 2006; 61:1419-1425.
10. Martinowitz U, Michaelson M; Israeli Multidisciplinary rFVIIa Task Force. Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost. 2005;3:640-648.
11. Stein DM, Dutton RP, O'Connor J, Alexander M, Scalea TM. Determinants of futility of administration of recombinant factor VIIa in trauma. J Trauma. 2005;59:609-615.
12. Meng ZH, Wolberg AS, Monroe DM III, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma. 2003;55:886-891.
13. Viuff D, Lauritzen B, Pusateri AE, Andersen S, Rojkjaer R, Johansson PI. Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven). Br J Anaesth. 2008;101:324-331.
14. Martini WZ, Dubick MA, Pusateri AE, Park MS, Ryan KL, Holcomb JB. Does bicarbonate correct coagulation function impaired by acidosis in swine? J Trauma. 2006;61:99-106.
15. Martini WZ, Dubick MA, Wade CE, Holcomb JB. Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med. 2007;35:1568-1574.
16. Martini WZ, Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007;246:831-835.
17. Douzinas EE, Pitaridis MT, Patsouris E, et al. Myocardial ischemia in intestinal postischemic shock: the effect of hypoxemic reperfusion. Crit Care Med. 2003;31:2183-2189.
18. Kheirabadi BS, Crissey JM, Deguzman R, Holcomb JB. In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time. J Trauma. 2007;62:1352-1359; discussion 1359-1361.
19. Levrat A, Gros A, Rugeri L, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100:792-797.
20. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB. Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma. 2008;65: 535-543.
21. Plotkin AJ, Wade CE, Jenkins DH, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008;64(2 suppl):S64-S68.
22. Ding W, Wu X, Gong G, Meng Q, Ni L, Li J. Establishment of an acute superior mesenteric artery injury model for damage control surgery. J Surg Res. 2009;152:249-257.
23. Rugeri L, Levrat A, David JS, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007;5:289-295.
24. Lin Y, Stanworth S, Birchall J, et al. Use of recombinant factor VIIa for the prevention and treatment of bleeding in patients without hemophilia: a systematic review and meta-analysis. CMAJ. 2011;183:E9-E19.