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Volumn 66, Issue 3, 2017, Pages 587-597

Brain GLUT4 knockout mice have impaired glucose tolerance, decreased insulin sensitivity, and impaired hypoglycemic counterregulation

Author keywords

[No Author keywords available]

Indexed keywords

EPINEPHRINE; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 4; INDINAVIR; INSULIN; NESTIN; GLUCOSE BLOOD LEVEL; PROTEIN C FOS; SLC2A4 PROTEIN, MOUSE;

EID: 85019585791     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0917     Document Type: Article
Times cited : (72)

References (43)
  • 1
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 glucose transporter
    • Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab 2007;5: 237-252
    • (2007) Cell Metab , vol.5 , pp. 237-252
    • Huang, S.1    Czech, M.P.2
  • 2
    • 0008385878 scopus 로고
    • Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
    • Suzuki K, Kono T. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc Natl Acad Sci U S A 1980;77:2542-2545
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 2542-2545
    • Suzuki, K.1    Kono, T.2
  • 3
    • 0035825643 scopus 로고    scopus 로고
    • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    • Abel ED, Peroni O, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001;409:729-733
    • (2001) Nature , vol.409 , pp. 729-733
    • Abel, E.D.1    Peroni, O.2    Kim, J.K.3
  • 4
    • 0033834248 scopus 로고    scopus 로고
    • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    • Zisman A, Peroni OD, Abel ED, et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 2000;6:924-928
    • (2000) Nat Med , vol.6 , pp. 924-928
    • Zisman, A.1    Peroni, O.D.2    Abel, E.D.3
  • 5
    • 1842734654 scopus 로고    scopus 로고
    • Glucose transporter expression in the central nervous system: Relationship to synaptic function
    • McEwen BS, Reagan LP. Glucose transporter expression in the central nervous system: relationship to synaptic function. Eur J Pharmacol 2004;490: 13-24
    • (2004) Eur J Pharmacol , vol.490 , pp. 13-24
    • McEwen, B.S.1    Reagan, L.P.2
  • 6
    • 0028040935 scopus 로고
    • Glucose transporters (GLUTs 1-4) and their mRNAs in regions of the rat brain: Insulin-sensitive transporter expression in the cerebellum
    • Rayner DV, Thomas ME, Trayhurn P. Glucose transporters (GLUTs 1-4) and their mRNAs in regions of the rat brain: insulin-sensitive transporter expression in the cerebellum. Can J Physiol Pharmacol 1994;72:476-479
    • (1994) Can J Physiol Pharmacol , vol.72 , pp. 476-479
    • Rayner, D.V.1    Thomas, M.E.2    Trayhurn, P.3
  • 7
    • 0030012543 scopus 로고    scopus 로고
    • Discrete brain areas express the insulin-responsive glucose transporter GLUT4
    • Leloup C, Arluison M, Kassis N, et al. Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Brain Res Mol Brain Res 1996;38: 45-53
    • (1996) Brain Res Mol Brain Res , vol.38 , pp. 45-53
    • Leloup, C.1    Arluison, M.2    Kassis, N.3
  • 8
    • 33645883249 scopus 로고    scopus 로고
    • Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase-dependent mechanism
    • Benomar Y, Naour N, Aubourg A, et al. Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase-dependent mechanism. Endocrinology 2006;147:2550-2556
    • (2006) Endocrinology , vol.147 , pp. 2550-2556
    • Benomar, Y.1    Naour, N.2    Aubourg, A.3
  • 9
    • 77956367937 scopus 로고    scopus 로고
    • Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia
    • Diggs-Andrews KA, Zhang X, Song Z, Daphna-Iken D, Routh VH, Fisher SJ. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes 2010;59:2271-2280
    • (2010) Diabetes , vol.59 , pp. 2271-2280
    • Diggs-Andrews, K.A.1    Zhang, X.2    Song, Z.3    Daphna-Iken, D.4    Routh, V.H.5    Fisher, S.J.6
  • 11
    • 1442276966 scopus 로고    scopus 로고
    • Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
    • Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 2004;53:549-559
    • (2004) Diabetes , vol.53 , pp. 549-559
    • Kang, L.1    Routh, V.H.2    Kuzhikandathil, E.V.3    Gaspers, L.D.4    Levin, B.E.5
  • 12
    • 0033393822 scopus 로고    scopus 로고
    • Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    • Abel ED, Kaulbach HC, Tian R, et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest 1999;104:1703-1714
    • (1999) J Clin Invest , vol.104 , pp. 1703-1714
    • Abel, E.D.1    Kaulbach, H.C.2    Tian, R.3
  • 13
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bröning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bröning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 14
    • 17844391064 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
    • Fisher SJ, Bröning JC, Lannon S, Kahn CR. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 2005;54:1447-1451
    • (2005) Diabetes , vol.54 , pp. 1447-1451
    • Fisher, S.J.1    Bröning, J.C.2    Lannon, S.3    Kahn, C.R.4
  • 15
    • 0032842478 scopus 로고    scopus 로고
    • Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    • Tronche F, Kellendonk C, Kretz O, et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999; 23:99-103
    • (1999) Nat Genet , vol.23 , pp. 99-103
    • Tronche, F.1    Kellendonk, C.2    Kretz, O.3
  • 16
    • 0037324750 scopus 로고    scopus 로고
    • Insulin signaling is required for insulins direct and indirect action on hepatic glucose production
    • Fisher SJ, Kahn CR. Insulin signaling is required for insulins direct and indirect action on hepatic glucose production. J Clin Invest 2003;111:463-468
    • (2003) J Clin Invest , vol.111 , pp. 463-468
    • Fisher, S.J.1    Kahn, C.R.2
  • 17
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARgamma-deficeint mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Norris AW, Chen L, Fisher SJ, et al. Muscle-specific PPARgamma-deficeint mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 2003;112:608-618
    • (2003) J Clin Invest , vol.112 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fisher, S.J.3
  • 18
    • 0017368491 scopus 로고
    • The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat
    • Sokoloff L, Reivich M, Kennedy C, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 1977; 28:897-916
    • (1977) J Neurochem , vol.28 , pp. 897-916
    • Sokoloff, L.1    Reivich, M.2    Kennedy, C.3
  • 19
    • 4544383535 scopus 로고    scopus 로고
    • Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography
    • Toyama H, Ichise M, Liow JS, et al. Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med 2004;45:1398-1405.
    • (2004) J Nucl Med , vol.45 , pp. 1398-1405
    • Toyama, H.1    Ichise, M.2    Liow, J.S.3
  • 20
    • 65549109299 scopus 로고    scopus 로고
    • Brain insulin infusion does not augment the counterregulatory response to hypoglycemia or glucoprivation
    • Ishihara KK, Haywood SC, Daphna-Iken D, Puente EC, Fisher SJ. Brain insulin infusion does not augment the counterregulatory response to hypoglycemia or glucoprivation. Metabolism 2009;58:812-820
    • (2009) Metabolism , vol.58 , pp. 812-820
    • Ishihara, K.K.1    Haywood, S.C.2    Daphna-Iken, D.3    Puente, E.C.4    Fisher, S.J.5
  • 21
    • 47849111875 scopus 로고    scopus 로고
    • The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus-potential role in modulation of glucose uptake in neurones?
    • Fernando RN, Albiston AL, Chai SY. The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus-potential role in modulation of glucose uptake in neurones? Eur J Neurosci 2008;28:588-598
    • (2008) Eur J Neurosci , vol.28 , pp. 588-598
    • Fernando, R.N.1    Albiston, A.L.2    Chai, S.Y.3
  • 22
    • 11244320362 scopus 로고    scopus 로고
    • A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity
    • Hertel J, Struthers H, Horj CB, Hruz PW. A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity. J Biol Chem 2004; 279:55147-55152
    • (2004) J Biol Chem , vol.279 , pp. 55147-55152
    • Hertel, J.1    Struthers, H.2    Horj, C.B.3    Hruz, P.W.4
  • 23
    • 0037066357 scopus 로고    scopus 로고
    • Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    • Murata H, Hruz PW, Mueckler M. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS 2002;16:859-863
    • (2002) AIDS , vol.16 , pp. 859-863
    • Murata, H.1    Hruz, P.W.2    Mueckler, M.3
  • 24
    • 12144275681 scopus 로고    scopus 로고
    • Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
    • Song Z, Routh VH. Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2005;54: 15-22
    • (2005) Diabetes , vol.54 , pp. 15-22
    • Song, Z.1    Routh, V.H.2
  • 25
    • 33751192694 scopus 로고    scopus 로고
    • Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus
    • Song Z, Routh VH. Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus. Am J Physiol Regul Integr Comp Physiol 2006;291:R1283-R1287
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.291 , pp. R1283-R1287
    • Song, Z.1    Routh, V.H.2
  • 26
    • 0022189557 scopus 로고
    • External and internal standards in the singleisotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine
    • Shah SD, Clutter WE, Cryer PE. External and internal standards in the singleisotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine. J Lab Clin Med 1985;106:624-629
    • (1985) J Lab Clin Med , vol.106 , pp. 624-629
    • Shah, S.D.1    Clutter, W.E.2    Cryer, P.E.3
  • 27
    • 78650071301 scopus 로고    scopus 로고
    • Combined neural inactivation of suppressor of cytokine signaling-3 and protein-Tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance
    • Briancon N, McNay DE, Maratos-Flier E, Flier JS. Combined neural inactivation of suppressor of cytokine signaling-3 and protein-Tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes 2010;59:3074-3084
    • (2010) Diabetes , vol.59 , pp. 3074-3084
    • Briancon, N.1    McNay, D.E.2    Maratos-Flier, E.3    Flier, J.S.4
  • 28
    • 33746810001 scopus 로고    scopus 로고
    • Neuronal PTP1B regulates body weight, adiposity and leptin action
    • Bence KK, Delibegovic M, Xue B, et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 2006;12:917-924
    • (2006) Nat Med , vol.12 , pp. 917-924
    • Bence, K.K.1    Delibegovic, M.2    Xue, B.3
  • 29
    • 77955405459 scopus 로고    scopus 로고
    • Nestin-Cre mice are affected by hypopituitarism, which is not due to significant activity of the transgene in the pituitary gland
    • Galichet C, Lovell-Badge R, Rizzoti K. Nestin-Cre mice are affected by hypopituitarism, which is not due to significant activity of the transgene in the pituitary gland. PLoS One 2010;5:e11443
    • (2010) PLoS One , vol.5 , pp. e11443
    • Galichet, C.1    Lovell-Badge, R.2    Rizzoti, K.3
  • 30
    • 84921918075 scopus 로고    scopus 로고
    • Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons
    • Ren H, Lu TY, McGraw TE, Accili D. Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes 2015;64:405-417
    • (2015) Diabetes , vol.64 , pp. 405-417
    • Ren, H.1    Lu, T.Y.2    McGraw, T.E.3    Accili, D.4
  • 32
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 34
    • 77953183468 scopus 로고    scopus 로고
    • Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo
    • Paranjape SA, Chan O, Zhu W, et al. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes 2010;59:1521-1527
    • (2010) Diabetes , vol.59 , pp. 1521-1527
    • Paranjape, S.A.1    Chan, O.2    Zhu, W.3
  • 35
    • 79952428530 scopus 로고    scopus 로고
    • Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues
    • Lin HV, Ren H, Samuel VT, et al. Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes 2011;60:700-709
    • (2011) Diabetes , vol.60 , pp. 700-709
    • Lin, H.V.1    Ren, H.2    Samuel, V.T.3
  • 36
    • 0033166168 scopus 로고    scopus 로고
    • Insulin resistance in HIV protease inhibitor-Associated diabetes
    • Yarasheski KE, Tebas P, Sigmund C, et al. Insulin resistance in HIV protease inhibitor-Associated diabetes. J Acquir Immune Defic Syndr 1999;21:209-216
    • (1999) J Acquir Immune Defic Syndr , vol.21 , pp. 209-216
    • Yarasheski, K.E.1    Tebas, P.2    Sigmund, C.3
  • 37
    • 33646536045 scopus 로고    scopus 로고
    • I.C.V. Administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration
    • Kale AY, Paranjape SA, Briski KP. I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration. Neuroscience 2006;140:555-565
    • (2006) Neuroscience , vol.140 , pp. 555-565
    • Kale, A.Y.1    Paranjape, S.A.2    Briski, K.P.3
  • 38
    • 0028865816 scopus 로고
    • Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia
    • Niimi M, Sato M, Tamaki M, Wada Y, Takahara J, Kawanishi K. Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia. Neurosci Res 1995;23:361-364
    • (1995) Neurosci Res , vol.23 , pp. 361-364
    • Niimi, M.1    Sato, M.2    Tamaki, M.3    Wada, Y.4    Takahara, J.5    Kawanishi, K.6
  • 39
    • 34248204584 scopus 로고    scopus 로고
    • Characterization of glucosensing neuron subpopulations in the arcuate nucleus: Integration in neuropeptide y and pro-opio melanocortin networks?
    • Fioramonti X, Contié S, Song Z, Routh VH, Lorsignol A, Pénicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks? Diabetes 2007; 56:1219-1227
    • (2007) Diabetes , vol.56 , pp. 1219-1227
    • Fioramonti, X.1    Contié, S.2    Song, Z.3    Routh, V.H.4    Lorsignol, A.5    Pénicaud, L.6
  • 40
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3
  • 41
    • 70349244719 scopus 로고    scopus 로고
    • AMP-Activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
    • Murphy BA, Fakira KA, Song Z, Beuve A, Routh VH. AMP-Activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. Am J Physiol Cell Physiol 2009;297:C750-C758
    • (2009) Am J Physiol Cell Physiol , vol.297 , pp. C750-C758
    • Murphy, B.A.1    Fakira, K.A.2    Song, Z.3    Beuve, A.4    Routh, V.H.5
  • 42
    • 0033944152 scopus 로고    scopus 로고
    • Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
    • Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000;3:757-758
    • (2000) Nat Neurosci , vol.3 , pp. 757-758
    • Spanswick, D.1    Smith, M.A.2    Mirshamsi, S.3    Routh, V.H.4    Ashford, M.L.5
  • 43
    • 66149083518 scopus 로고    scopus 로고
    • Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose
    • Cotero VE, Routh VH. Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. Am J Physiol Endocrinol Metab 2009;296:E1101-E1109
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E1101-E1109
    • Cotero, V.E.1    Routh, V.H.2


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