Peripheral glucose homeostasis: Does brain insulin matter?

Journal of Clinical Investigation

Volumn 121, Issue 9, 2011, Pages 3392-3395

  Levin, Barry E ^a,b   Sherwin, Robert S ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

CALORIC INTAKE; DRUG EFFECT; ENERGY EXPENDITURE; GENETIC TRANSCRIPTION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HYPERINSULINEMIA; HYPOTHALAMUS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; LEARNING; MEMORY; NERVE CELL PLASTICITY; NEUROENDOCRINE SYSTEM; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PRIORITY JOURNAL; REWARD; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; DOGS; GLUCONEOGENESIS; GLUCOSE; GLYCOGEN; HUMANS; INSULIN; LIVER;

EID: 80052362993     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59653     Document Type: Note

References (22)

1. Perseghin G., et al. Regulation of glucose homeostasis in humans with denervated livers. J Clin Invest. 1997;100(4):931-941. (Pubitemid 27371712)
2. Edgerton D.S., et al. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest. 2006;116(2):521-527. (Pubitemid 43228370)
3. Obici S., Zhang B.B., Karkanias G., Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med. 2002;8(12):1376-1382. (Pubitemid 36019422)
4. Pocai A., et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature. 2005; 434(7036):1026-1031.
5. Ramnanan C.J., et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest. 2011;121(9):3713-3723.
6. Woods S.C., Lotter E.C., McKay L.D., Porte D. Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature. 1979;282(5738):503-505. (Pubitemid 10126541)
7. Paranjape S.A., et al. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes. 2010;59(6):1521-1527.
8. Unger J.W., Moss A.M., Livingston J.N. Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat. NeuroScience. 1991;42(3):853-861.
9. Werther G.A., et al. Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology. 1987;121(4):1562-1570. (Pubitemid 17155909)
10. Spanswick D., Smith M.A., Mirshamsi S., Routh V.H., Ashford M.L. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci. 2000;3(8):757-758. (Pubitemid 30485698)
11. Levin B.E., Kang L., Sanders N.M., Dunn-Meynell A.A. Role of neuronal glucosensing in the regulation of energy homeostasis. Diabetes. 2006;55(suppl 2):S122-S130. (Pubitemid 44927042)
12. Lautt W.W. Autonomic neural control of liver glycogen metabolism. Med Hypotheses. 1979; 5(12):1287-1296.
13. Sakaguchi T., Bray G.A. Sympathetic activity following paraventricular injections of glucose and insulin. Brain Res Bull. 1988;21(1):25-29. (Pubitemid 19268442)
14. Spanswick D., Smith M.A., Mirshamsi S., Routh V.H., Ashford M.L. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nature Neurosci. 2000;3(8):757-758. (Pubitemid 30485698)
15. Kang L., Routh V.H., Kuzhikandathil E.V., Gaspers L., Levin B.E. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes. 2004;53(3):549-559. (Pubitemid 38270622)
16. Lin H.V., et al. Diabetes in mice with selective impairment of insulin action in glut4-expressing tissues. Diabetes. 2011;60(3):700-709.
17. Konner A.C., et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab. 2007;5(6):438-449. (Pubitemid 46825497)
18. Lin H.V., et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes. 2010;59(2):337-346.
19. Bruning J.C., et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289(5487):2122-2125.
20. Mullier A., Bouret S.G., Prevot V., Dehouck B. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J Comp Neurol. 2010;518(7):943-962.
21. Gerozissis K., Rouch C., Lemierre S., Nicolaidis S., Orosco M. A potential role of central insulin in learning and memory related to feeding. Cell Mol Neurobiol. 2001;21(4):389-401. (Pubitemid 34002945)
22. Sindelar D.K., Balcom J.H., Chu C.A., Neal D.W., Cherrington A.D. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes. 1996;45(11):1594-1604. (Pubitemid 26357554)