Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Mucosal Immunology

Volumn 10, Issue 4, 2017, Pages 957-970

  Arimura, K ^a   Takagi, H ^a,b   Uto, T ^a,b   Fukaya, T ^a,b   Nakamura, T ^a   Choijookhuu, N ^a   Hishikawa, Y ^a   Yamashita, Y ^a   Sato, K ^a,b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CC CHEMOKINE RECEPTOR 2 LIGAND; CHEMOKINE; INTERFERON; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR; CCR2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR2; IFNAR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MIGRATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DISEASE COURSE; DISEASE EXACERBATION; ENTERITIS; FEMALE; HOMEOSTASIS; IMMUNE DEFICIENCY; IN VIVO STUDY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PHAGOCYTE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH MUCOSA INJURY; T LYMPHOCYTE; UPREGULATION; ACUTE DISEASE; ANIMAL; C57BL MOUSE; CELL CULTURE; COLON; DENDRITIC CELL; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; KNOCKOUT MOUSE; METABOLISM;

ACUTE DISEASE; ANIMALS; CELLS, CULTURED; COLITIS; COLON; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; HOMEOSTASIS; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTERFERON TYPE I; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTES; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, CCR2;

EID: 85019547250     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2016.96     Document Type: Article

References (46)

1. Villadangos, J. A. & Schnorrer, P. Intrinsic and cooperative antigenpresenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7, 543-555 (2007).
2. Watowich, S. S. & Liu, Y. J. Mechanisms regulating dendritic cell specification and development. Immunol. Rev. 238, 76-92 (2010).
3. Guilliams, M. et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14, 571-578 (2014).
4. Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8a dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100 (2008).
5. Dresch, C., Leverrier, Y., Marvel, J. & Shortman, K. Development of antigen cross-presentation capacity in dendritic cells. Trends Immunol. 33, 381-388 (2012).
6. Uto, T. et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat. Commun. 7, 11273 (2016).
7. Gilliet, M., Cao, W. & Liu, Y. J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8, 594-606 (2008).
8. Swiecki, M. & Colonna, M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 234, 142-162 (2010).
9. Reizis, B. Regulation of plasmacytoid dendritic cell development. Curr. Opin. Immunol. 22, 206-211 (2010).
10. Gilliet, M. & Lande, R. Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr. Opin. Immunol. 20, 401-407 (2008).
11. Glitzner, E. et al. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO Mol. Med. 6, 1312-1327 (2014).
12. Sisirak, V. et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J. Exp. Med. 211, 1969-1976 (2014).
13. Rowland, S. L. et al. Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model. J. Exp. Med. 211, 1977-1991 (2014).
14. Davison, L. M. & Jørgensen, T. N. SiglecH plasmacytoid dendritic cells drive spontaneous lupus-like disease development in B6. Nba2 mice. Arthritis Rheumatol. 67, 1012-1022 (2015).
15. Ohno, H. Intestinal M cells. J. Biochem. 159, 151-160 (2016).
16. Lepage, P. et al. A metagenomic insight into our gut'smicrobiome. Gut 62, 146-165 (2013).
17. Tsuji, N. M. & Kosaka, A. Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol. 29, 532-540 (2008).
18. Fukaya, T. et al. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4Foxp3 regulatory T cells in the establishment of oral tolerance. Blood 116, 2266-2276 (2010).
19. Shanahan, F. Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology 120, 622-635 (2001).
20. Hooper, L. V. & Gordon, J. I. Commensal host-bacterial relationships in the gut. Science 292, 1115-1118 (2001).
21. Podolsky, D. K. Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429 (2002).
22. Round, J. L. & Mazmanian, S. K. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol. 9, 313-323 (2009).
23. Strober, W., Fuss, I. J. & Blumberg, R. S. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20, 495-549 (2002).
24. Wirtz, S., Neufert, C., Weigmann, B. & Neurath, M. F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546 (2007).
25. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
26. Abe, K. et al. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc. Natl Acad. Sci. USA 104, 17022-17027 (2007).
27. Nakanishi, Y., Sato, T. & Ohteki, T. Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization. Mucosal Immunol. 8, 152-160 (2015).
28. Asano, K. et al. Intestinal CD169 macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes. Nat. Commun. 21, 7802 (2015).
29. Baumgart, D. C. et al. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloiddendritic cells. Gut 54, 228-236 (2005).
30. Baumgart, D. C. et al. Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis. Clin. Exp. Immunol. 166, 46-54 (2011).
31. Takagi, H. et al. Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity 35, 958-971 (2011).
32. Takagi, H. et al. Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation. Sci. Rep. 6, 24477 (2016).
33. Jung, S. et al. In vivo depletion of CD11c dendritic cells abrogates priming of CD8 T cells by exogenous cell-associated antigens. Immunity 17, 211-220 (2002).
34. Müller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918-1921 (1994).
35. Lombardi, V. C. & Khaiboullina, S. F. Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology. Clin. Immunol. 153, 165-177 (2014).
36. Gao, Y., Majchrzak-Kita, B., Fish, E. N. & Gommerman, J. L. Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-b. Blood 114, 2623-2631 (2009).
37. Muzaki, A. R. et al. IntestinalCD103CD11b- dendritic cells restrain colitis via IFN-g-induced anti-inflammatory response in epithelial cells. Mucosal Immunol. 9, 336-351 (2016).
38. Edelson, B. T. et al. Peripheral CD103 dendritic cells form a unified subset developmentally related to CD8a conventional dendritic cells. J. Exp. Med. 207, 823-836 (2010).
39. Mizuno, S. et al. CCR9 plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice. Immunol. Lett. 146, 64-69 (2012).
40. Tezuka, H. et al. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independentole for plasmac. Immunity 34, 247-257 (2011).
41. González-Navajas, J. M., Lee, J., David, M. & Raz, E. Immunomodulatory functions of type I interferons. Nat. Rev. Immunol. 12, 25-135 (2012).
42. Katakura, K. et al. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J. Clin. Invest. 115, 695-702 (2005).
43. Rauch, I. et al. Type I interferons have opposing effects during the emergence and recovery phases of colitis. Eur. J. Immunol. 44, 2749-2760 (2014).
44. Tamoutounour, S. et al. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur. J. Immunol. 42, 3150-3166 (2012).
45. Cooper, H. S., Murthy, S. N., Shah, R. S. & Sedergran, D. J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab. Invest. 69, 238-249 (1993).
46. Dieleman, L. A. et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 114, 385-391 (1998).