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Volumn 6, Issue 5, 2017, Pages 1340-1355

First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential

Author keywords

Apoptosis; Exosomes; Extracellular vesicles; Fetal stem cells; MiRNA; Paracrine communication; Proliferation; Tissue regeneration

Indexed keywords

MICRORNA; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR NANOG;

EID: 85019488997     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.1002/sctm.16-0297     Document Type: Article
Times cited : (106)

References (88)
  • 1
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi M, Zhang Z, Ni A et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008;103:1204–1219.
    • (2008) Circ Res , vol.103 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3
  • 2
    • 79151471175 scopus 로고    scopus 로고
    • Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
    • Mirotsou M, Jayawardena TM, Schmeckpeper J et al. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol 2011;50:280–289.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 280-289
    • Mirotsou, M.1    Jayawardena, T.M.2    Schmeckpeper, J.3
  • 3
    • 84903705293 scopus 로고    scopus 로고
    • The regenerative role of the fetal and adult stem cell secretome
    • Bollini S, Gentili C, Tasso R et al. The regenerative role of the fetal and adult stem cell secretome. J Clin Med J Clin Med 2013;2: 302–327.
    • (2013) J Clin Med J Clin Med , vol.2 , pp. 302-327
    • Bollini, S.1    Gentili, C.2    Tasso, R.3
  • 4
    • 84881139801 scopus 로고    scopus 로고
    • Extracellular vesicles as an emerging mechanism of cell-to-cell communication
    • Tetta C, Ghigo E, Silengo L et al. Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine 2012; 44:11–19.
    • (2012) Endocrine , vol.44 , pp. 11-19
    • Tetta, C.1    Ghigo, E.2    Silengo, L.3
  • 5
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles
    • Lotvall J, Hill AF, Hochberg F et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 2014;3:26913.
    • (2014) J Extracell Vesicles , vol.3
    • Lotvall, J.1    Hill, A.F.2    Hochberg, F.3
  • 6
    • 84957603483 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Therapeutic potential of stem cell-derived extracellular vesicles
    • Zhang B, Yeo R, Tan K et al. Focus on extracellular vesicles: Therapeutic potential of stem cell-derived extracellular vesicles. Int J Mol Sci 2016;17:pii: E174.
    • (2016) Int J Mol Sci , vol.17
    • Zhang, B.1    Yeo, R.2    Tan, K.3
  • 7
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan F, Lai RC, Smeets MB et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res 2013;10:301–312.
    • (2013) Stem Cell Res , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3
  • 8
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai RC, Arslan F, Lee MM et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 2010;4: 214–222.
    • (2010) Stem Cell Res , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3
  • 9
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • Bian S, Zhang L, Duan L et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl) 2014;92:387–397.
    • (2014) J Mol Med (Berl) , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3
  • 10
    • 84931578273 scopus 로고    scopus 로고
    • HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing
    • ELLS 2015; 33:2158–2168.
    • (2015) ells , vol.33 , pp. 2158-2168
    • Xu, W.1    Qian, H.2    Zhang, B.3
  • 11
    • 84898039042 scopus 로고    scopus 로고
    • MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease
    • Kordelas L, Rebmann V, Ludwig A-K et al. MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 2014;28:970–973.
    • (2014) Leukemia , vol.28 , pp. 970-973
    • Kordelas, L.1    Rebmann, V.2    Ludwig, A.-K.3
  • 12
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • Bruno S, Grange C, Collino F et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 2012;7:e33115.
    • (2012) Plos One , vol.7
    • Bruno, S.1    Grange, C.2    Collino, F.3
  • 13
    • 84905237972 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
    • Tan CY, Lai RC, Wong W et al. Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models. Stem Cell Res Ther 2014;5:76.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 76
    • Tan, C.Y.1    Lai, R.C.2    Wong, W.3
  • 14
    • 84862867271 scopus 로고    scopus 로고
    • Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
    • ELLS 2012;30:1556–1564.
    • (2012) ells , vol.30 , pp. 1556-1564
    • Xin, H.1    Li, Y.2    Buller, B.3
  • 15
    • 84940467274 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived microvesicles transmit RNAs and proteins to recipient mature heart cells modulating cell fate and behavior
    • ELLS 2015;33: 2748–2761.
    • (2015) ells , vol.33 , pp. 2748-2761
    • Bobis-Wozowicz, S.1    Kmiotek, K.2    Sekula, M.3
  • 16
    • 33846120651 scopus 로고    scopus 로고
    • Isolation of amniotic stem cell lines with potential for therapy
    • De Coppi P, BartschG Jr., Siddiqui MM et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 2007;25: 100–106.
    • (2007) Nat Biotechnol , vol.25 , pp. 100-106
    • De Coppi, P.1
  • 18
    • 84945895817 scopus 로고    scopus 로고
    • Endothelial properties of third-trimester amniotic fluid stem cells cultured in hypoxia
    • Schiavo AA, Franzin C, Albiero M et al. Endothelial properties of third-trimester amniotic fluid stem cells cultured in hypoxia. Stem Cell Res Ther 2015;6:209.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 209
    • Schiavo, A.A.1    Franzin, C.2    Albiero, M.3
  • 19
    • 84857083796 scopus 로고    scopus 로고
    • Amniotic fluid stem cells are cardioprotective following acute myocardial infarction
    • Bollini S, Cheung KK, Riegler J et al. Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem Cells Dev 2011;20:1985–1994.
    • (2011) Stem Cells Dev , vol.20 , pp. 1985-1994
    • Bollini, S.1    Cheung, K.K.2    Riegler, J.3
  • 20
    • 79959819263 scopus 로고    scopus 로고
    • De novo cardiomyocytes from within the activated adult heart after injury 2011
    • Smart N, Bollini S, Dubàe KN et al. De novo cardiomyocytes from within the activated adult heart after injury 2011. Nature 2011;474:640–644.
    • (2011) Nature , vol.474 , pp. 640-644
    • Smart, N.1    Bollini, S.2    Dubàe, K.N.3
  • 21
    • 84891698587 scopus 로고    scopus 로고
    • Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism
    • Zani A, Cananzi M, Fascetti-Leon F et al. Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut 2014;63:300–309.
    • (2014) Gut , vol.63 , pp. 300-309
    • Zani, A.1    Cananzi, M.2    Fascetti-Leon, F.3
  • 22
    • 84864373143 scopus 로고    scopus 로고
    • Amniotic fluid stem cells restore the muscle cell niche in a HSA-Cre, SmnF7/F7 mouse model
    • ELLS 2012;30:1675–1684.
    • (2012) ells , vol.30 , pp. 1675-1684
    • Piccoli, M.1    Franzin, C.2    Bertin, E.3
  • 23
    • 84864643054 scopus 로고    scopus 로고
    • Proangiogenic soluble factors from amniotic fluid stem cells mediate the recruitment of endothelial progenitors in a model of ischemic fasciocutaneous flap
    • Mirabella T, Hartinger J, Lorandi C et al. Proangiogenic soluble factors from amniotic fluid stem cells mediate the recruitment of endothelial progenitors in a model of ischemic fasciocutaneous flap. Stem Cells Dev 2012;21: 2179–2188.
    • (2012) Stem Cells Dev , vol.21 , pp. 2179-2188
    • Mirabella, T.1    Hartinger, J.2    Lorandi, C.3
  • 24
    • 79952744450 scopus 로고    scopus 로고
    • Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model
    • Mirabella T, Cilli M, Carlone S et al. Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model. Biomaterials 2011;32:3689–3699.
    • (2011) Biomaterials , vol.32 , pp. 3689-3699
    • Mirabella, T.1    Cilli, M.2    Carlone, S.3
  • 25
    • 79955087102 scopus 로고    scopus 로고
    • Recruitment of host’s progenitor cells to sites of human amniotic fluid stem cells implantation
    • Mirabella T, Poggi A, Scaranari M et al. Recruitment of host’s progenitor cells to sites of human amniotic fluid stem cells implantation. Biomaterials 2011;32:4218–4227.
    • (2011) Biomaterials , vol.32 , pp. 4218-4227
    • Mirabella, T.1    Poggi, A.2    Scaranari, M.3
  • 26
    • 84855393283 scopus 로고    scopus 로고
    • Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes
    • Bekeredjian-Ding I, Foermer S, Kirschning CJ et al. Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes. PLoS One 2012;7:e29806.
    • (2012) Plos One , vol.7
    • Bekeredjian-Ding, I.1    Foermer, S.2    Kirschning, C.J.3
  • 27
    • 84870807127 scopus 로고    scopus 로고
    • Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo
    • Zhang H-C, Liu X-B, Huang S et al. Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev 2012;21:3289–3297.
    • (2012) Stem Cells Dev , vol.21 , pp. 3289-3297
    • Zhang, H.-C.1    Liu, X.-B.2    Huang, S.3
  • 28
    • 84951987732 scopus 로고    scopus 로고
    • Dynamic microvesicle release and clearance within the cardiovascular system: Triggers and mechanisms
    • Ayers L, Nieuwland R, Kohler M et al. Dynamic microvesicle release and clearance within the cardiovascular system: Triggers and mechanisms. Clin Sci (Lond) 2015;129:915– 931.
    • (2015) Clin Sci (Lond) , vol.129
    • Ayers, L.1    Nieuwland, R.2    Kohler, M.3
  • 29
    • 84922105441 scopus 로고    scopus 로고
    • Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology
    • Gray WD, French KM, Ghosh-Choudhary S et al. Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology. Circ Res 2015;116:255–263.
    • (2015) Circ Res , vol.116 , pp. 255-263
    • Gray, W.D.1    French, K.M.2    Ghosh-Choudhary, S.3
  • 30
    • 84858268342 scopus 로고    scopus 로고
    • Third trimester amniotic fluid cells with the capacity to develop neural phenotypes and with heterogeneity among sub-populations
    • Bottai D, Cigognini D, Nicora E et al. Third trimester amniotic fluid cells with the capacity to develop neural phenotypes and with heterogeneity among sub-populations. Restor Neurol Neurosci 2012;30:55–68.
    • (2012) Restor Neurol Neurosci , vol.30 , pp. 55-68
    • Bottai, D.1    Cigognini, D.2    Nicora, E.3
  • 31
    • 34047236704 scopus 로고    scopus 로고
    • Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 2006
    • Chiavegato A, Bollini S, Pozzobon M et al. Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 2006. J Mol Cell Cardiol 2007;42:746–759.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 746-759
    • Chiavegato, A.1    Bollini, S.2    Pozzobon, M.3
  • 32
    • 84907337461 scopus 로고    scopus 로고
    • Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction
    • Barile L, Lionetti V, Cervio E et al. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. Cardiovasc Res 2014;103:530– 541.
    • (2014) Cardiovasc Res , vol.103
    • Barile, L.1    Lionetti, V.2    Cervio, E.3
  • 33
    • 84924958677 scopus 로고    scopus 로고
    • Reproducibility and efficiency of serum-derived exosome extraction methods
    • Caradec J, Kharmate G, Hosseini-Beheshti E et al. Reproducibility and efficiency of serum-derived exosome extraction methods. Clin Biochem 2014;47:1286–1292.
    • (2014) Clin Biochem , vol.47 , pp. 1286-1292
    • Caradec, J.1    Kharmate, G.2    Hosseini-Beheshti, E.3
  • 34
    • 84993937713 scopus 로고    scopus 로고
    • Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipo-genesis
    • Connolly KD, Guschina IA, Yeung V et al. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipo-genesis. J Extracell Vesicles 2015;24;4:29159.
    • J Extracell Vesicles 2015;24 , vol.4 , pp. 29159
    • Connolly, K.D.1    Guschina, I.A.2    Yeung, V.3
  • 35
    • 84927539091 scopus 로고    scopus 로고
    • Detection of microparticles from human red blood cells by multiparametric flow cytometry
    • Grisendi G, Finetti E, Manganaro D et al. Detection of microparticles from human red blood cells by multiparametric flow cytometry. Blood Transfus 2015;13:274–280.
    • (2015) Blood Transfus , vol.13 , pp. 274-280
    • Grisendi, G.1    Finetti, E.2    Manganaro, D.3
  • 36
    • 0033557716 scopus 로고    scopus 로고
    • The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
    • Judge TA, Wu Z, Zheng XG et al. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol 1999;162:1947–1951.
    • (1999) J Immunol , vol.162 , pp. 1947-1951
    • Judge, T.A.1    Wu, Z.2    Zheng, X.G.3
  • 37
    • 84957603867 scopus 로고    scopus 로고
    • Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta
    • Mareschi K, Castiglia S, Sanavio F et al. Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. Exp Hematol 2016;44:138–150.
    • (2016) Exp Hematol , vol.44 , pp. 138-150
    • Mareschi, K.1    Castiglia, S.2    Sanavio, F.3
  • 38
    • 84924043876 scopus 로고    scopus 로고
    • Purification and immunophenotypic characterization of human B cells with regulatory functions
    • de Masson A, Le Buanec H, Bouaziz J-D. Purification and immunophenotypic characterization of human B cells with regulatory functions. Methods Mol Biol 2014;1190:45–52.
    • (2014) Methods Mol Biol , vol.1190 , pp. 45-52
    • De Masson, A.1    Le Buanec, H.2    Bouaziz, J.-D.3
  • 39
    • 84876274371 scopus 로고    scopus 로고
    • Type 2 innate signals stimulate fibro/adipo-genic progenitors to facilitate muscle regeneration
    • Heredia JE, Mukundan L, Chen FM et al. Type 2 innate signals stimulate fibro/adipo-genic progenitors to facilitate muscle regeneration. Cell 2013;153:376–388.
    • (2013) Cell , vol.153 , pp. 376-388
    • Heredia, J.E.1    Mukundan, L.2    Chen, F.M.3
  • 40
    • 0033753570 scopus 로고    scopus 로고
    • Update on the genetics of the idiopathic inflammatory myopathies
    • Shamim EA, Rider LG, Miller FW. Update on the genetics of the idiopathic inflammatory myopathies. Curr Opin Rheumatol 2000;12:482–491.
    • (2000) Curr Opin Rheumatol , vol.12 , pp. 482-491
    • Shamim, E.A.1    Rider, L.G.2    Miller, F.W.3
  • 41
    • 84976600360 scopus 로고    scopus 로고
    • MircoRNA-regulated proinflammatory cytokines in sarco-penia
    • Fan J, Kou X, Yang Y et al. MircoRNA-regulated proinflammatory cytokines in sarco-penia. Mediators Inflamm 2016;2016: 1438686.
    • (2016) Mediators Inflamm , vol.2016 , pp. 1438686
    • Fan, J.1    Kou, X.2    Yang, Y.3
  • 42
    • 84962866749 scopus 로고    scopus 로고
    • Skeletal muscle inflammation following repeated bouts of lengthening contractions in humans
    • Deyhle MR, Gier AM, Evans KC et al. Skeletal muscle inflammation following repeated bouts of lengthening contractions in humans. Front Physiol 2016;6:624.
    • (2016) Front Physiol , vol.6 , pp. 624
    • Deyhle, M.R.1    Gier, A.M.2    Evans, K.C.3
  • 43
    • 77951700255 scopus 로고    scopus 로고
    • Regulatory interactions between muscle and the immune system during muscle regeneration
    • Tidball JG, Villalta SA. Regulatory interactions between muscle and the immune system during muscle regeneration. AJP Regul Integr Comp Physiol 2010;298:R1173–R1187.
    • (2010) AJP Regul Integr Comp Physiol , vol.298 , pp. R1173-R1187
    • Tidball, J.G.1    Villalta, S.A.2
  • 44
    • 69749107748 scopus 로고    scopus 로고
    • MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
    • Zhang Z, Sun H, Dai H et al. MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle 2009;8:2756–2768.
    • (2009) Cell Cycle , vol.8 , pp. 2756-2768
    • Zhang, Z.1    Sun, H.2    Dai, H.3
  • 45
    • 70450240736 scopus 로고    scopus 로고
    • Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting Caspase-8-associated protein 2
    • Won Kim H, Haider HK, Jiang S et al. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting Caspase-8-associated protein 2. J Biol Chem 2009;284:33161–33168.
    • (2009) J Biol Chem , vol.284 , pp. 33161-33168
    • Won Kim, H.1    Haider, H.K.2    Jiang, S.3
  • 46
    • 84959288708 scopus 로고    scopus 로고
    • ExoCarta: A web-based compendium of exosomal cargo
    • Keerthikumar S, Chisanga D, Ariyaratne D et al. ExoCarta: A web-based compendium of exosomal cargo. J Mol Biol 2016;428:688–692.
    • (2016) J Mol Biol , vol.428 , pp. 688-692
    • Keerthikumar, S.1    Chisanga, D.2    Ariyaratne, D.3
  • 47
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications
    • Rani S, Ryan AE, Griffin MD et al. Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications. Mol Ther 2015;23:812–823.
    • (2015) Mol Ther , vol.23 , pp. 812-823
    • Rani, S.1    Ryan, A.E.2    Griffin, M.D.3
  • 48
    • 84892843829 scopus 로고    scopus 로고
    • The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; A dream for tendon repair?
    • Tetta C, Consiglio AL, Bruno S et al. The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; A dream for tendon repair? Muscles Ligaments Tendons J 2012;2:212–221.
    • (2012) Muscles Ligaments Tendons J , vol.2 , pp. 212-221
    • Tetta, C.1    Consiglio, A.L.2    Bruno, S.3
  • 49
    • 84873116088 scopus 로고    scopus 로고
    • Role of stem-cell-derived microvesicles in the paracrine action of stem cells
    • Camussi G, Deregibus MC, Cantaluppi V. Role of stem-cell-derived microvesicles in the paracrine action of stem cells. Biochem Soc Trans 2013;41:283–287.
    • (2013) Biochem Soc Trans , vol.41 , pp. 283-287
    • Camussi, G.1    Deregibus, M.C.2    Cantaluppi, V.3
  • 50
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • EL Andaloussi S, M€ager I, Breakefield XO et al. Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat Rev Drug Discov 2013;12:347–357.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 347-357
    • El Andaloussi, S.1
  • 51
    • 77956224494 scopus 로고    scopus 로고
    • Qui~nones-Hinojosa A. Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A, Garzàon-Muvdi T, Qui~nones-Hinojosa A. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 2010;7:150–161.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzàon-Muvdi, T.2
  • 52
    • 84879976839 scopus 로고    scopus 로고
    • Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis
    • Salomon C, Ryan J, Sobrevia L et al. Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. PLoS One 2013;8:e68451.
    • (2013) Plos One , vol.8
    • Salomon, C.1    Ryan, J.2    Sobrevia, L.3
  • 53
    • 84869081799 scopus 로고    scopus 로고
    • Mechanism of TNF-a autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1a, presented by exosomes
    • Yu X, Deng L, Wang D et al. Mechanism of TNF-a autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1a, presented by exosomes. J Mol Cell Cardiol 2012;53:848–857.
    • (2012) J Mol Cell Cardiol , vol.53 , pp. 848-857
    • Yu, X.1    Deng, L.2    Wang, D.3
  • 54
    • 84891795530 scopus 로고    scopus 로고
    • Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-b/ SMAD2 and PI3K/Akt pathways
    • Jun EK, Zhang Q, Yoon BS et al. Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-b/ SMAD2 and PI3K/Akt pathways. Int J Mol Sci 2014;15:605–628.
    • (2014) Int J Mol Sci , vol.15 , pp. 605-628
    • Jun, E.K.1    Zhang, Q.2    Yoon, B.S.3
  • 55
    • 84929649938 scopus 로고    scopus 로고
    • Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction
    • Kang K, Ma R, Cai W et al. Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction. Stem Cells Int 2015;2015:659890.
    • (2015) Stem Cells Int , vol.2015
    • Kang, K.1    Ma, R.2    Cai, W.3
  • 56
    • 84961253699 scopus 로고    scopus 로고
    • Adipose-derived stem cells induce angiogenesis via microvesicle transport of miRNA-31
    • ED 2016;5:440–450.
    • (2016) ed , vol.5 , pp. 440-450
    • Kang, T.1    Jones, T.M.2    Naddell, C.3
  • 57
    • 84919807905 scopus 로고    scopus 로고
    • Immune regulatory properties of CD117(Pos) amniotic fluid stem cells vary according to gestational age
    • Di Trapani M, Bassi G, Fontana E et al. Immune regulatory properties of CD117(pos) amniotic fluid stem cells vary according to gestational age. Stem Cells Dev 2015;24:132– 143.
    • (2015) Stem Cells Dev , vol.24
    • Di Trapani, M.1    Bassi, G.2    Fontana, E.3
  • 58
    • 80055049727 scopus 로고    scopus 로고
    • Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response
    • Moorefield EC, McKee EE, Solchaga L et al. Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response. PLoS One 2011;6:e26535.
    • (2011) Plos One , vol.6
    • Moorefield, E.C.1    McKee, E.E.2    Solchaga, L.3
  • 59
    • 84975214996 scopus 로고    scopus 로고
    • Mesenchymal stem cells and immunomodulation: Current status and future prospects
    • Gao F, Chiu SM, Motan DAL et al. Mesenchymal stem cells and immunomodulation: Current status and future prospects. Cell Death Dis 2016;7:e2062.
    • (2016) Cell Death Dis , vol.7
    • Gao, F.1    Chiu, S.M.2    Motan, D.A.L.3
  • 60
    • 84941802098 scopus 로고    scopus 로고
    • The immunomodulatory function of mesenchymal stem cells: Mode of action and pathways
    • Uccelli A, de Rosbo NK. The immunomodulatory function of mesenchymal stem cells: Mode of action and pathways. Ann NY Acad Sci 2015;1351:114–126.
    • (2015) Ann NY Acad Sci , vol.1351 , pp. 114-126
    • Uccelli, A.1    De Rosbo, N.K.2
  • 61
    • 84865355844 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling
    • Mokarizadeh A, Delirezh N, Morshedi A et al. Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling. Immunol Lett 2012; 147:47–54.
    • (2012) Immunol Lett , vol.147 , pp. 47-54
    • Mokarizadeh, A.1    Delirezh, N.2    Morshedi, A.3
  • 62
    • 84919421853 scopus 로고    scopus 로고
    • Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells
    • Blazquez R, Sanchez-Margallo FM, de la Rosa O et al. Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells. Front Immunol 2014;5:556.
    • (2014) Front Immunol , vol.5 , pp. 556
    • Blazquez, R.1    Sanchez-Margallo, F.M.2    De La Rosa, O.3
  • 63
    • 84896453064 scopus 로고    scopus 로고
    • Mesenchymal stem cells secrete immunologically active exosomes
    • Zhang B, Yin Y, Lai RC et al. Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev 2014;23:1233–1244.
    • (2014) Stem Cells Dev , vol.23 , pp. 1233-1244
    • Zhang, B.1    Yin, Y.2    Lai, R.C.3
  • 64
    • 84913605925 scopus 로고    scopus 로고
    • Microvescicles derived from mesenchymal stromal cells are not as effective as their cellular counterpart in the ability to modulate immune responses in vitro
    • Conforti A, Scarsella M, Starc N et al. Microvescicles derived from mesenchymal stromal cells are not as effective as their cellular counterpart in the ability to modulate immune responses in vitro. Stem Cells Dev 2014;23:2591–2599.
    • (2014) Stem Cells Dev , vol.23 , pp. 2591-2599
    • Conforti, A.1    Scarsella, M.2    Starc, N.3
  • 65
    • 84874443222 scopus 로고    scopus 로고
    • The immunosuppressive effect of mesenchymal stromal cells on B lymphocytes is mediated by membrane vesicles
    • Budoni M, Fierabracci A, Luciano R et al. The immunosuppressive effect of mesenchymal stromal cells on B lymphocytes is mediated by membrane vesicles. Cell Transplant 2013;22:369–379.
    • (2013) Cell Transplant , vol.22 , pp. 369-379
    • Budoni, M.1    Fierabracci, A.2    Luciano, R.3
  • 66
    • 0038273864 scopus 로고    scopus 로고
    • Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle
    • Nicole S, Desforges B, Millet G et al. Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle. J Cell Biol 2003;161: 571–582.
    • (2003) J Cell Biol , vol.161 , pp. 571-582
    • Nicole, S.1    Desforges, B.2    Millet, G.3
  • 67
    • 84936766922 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
    • Nakamura Y, Miyaki S, Ishitobi H et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett 2015;589:1257–1265.
    • (2015) FEBS Lett , vol.589 , pp. 1257-1265
    • Nakamura, Y.1    Miyaki, S.2    Ishitobi, H.3
  • 68
    • 84930944230 scopus 로고    scopus 로고
    • Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action
    • Dutt V, Gupta S, Dabur R et al. Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action. Pharmacol Res 2015;99:86–100.
    • (2015) Pharmacol Res , vol.99 , pp. 86-100
    • Dutt, V.1    Gupta, S.2    Dabur, R.3
  • 69
    • 84930924311 scopus 로고    scopus 로고
    • Extracellular vesicle microRNA transfer in cardiovascular disease
    • Das S, Halushka MK. Extracellular vesicle microRNA transfer in cardiovascular disease. Cardiovasc Pathol 2015;24:199–206.
    • (2015) Cardiovasc Pathol , vol.24 , pp. 199-206
    • Das, S.1    Halushka, M.K.2
  • 70
    • 84971408010 scopus 로고    scopus 로고
    • Exosome-mediated small RNA delivery for gene therapy
    • Zhou Y, Zhou G, Tian C et al. Exosome-mediated small RNA delivery for gene therapy. Wiley Interdiscip Rev RNA 2016;7:758–771.
    • (2016) Wiley Interdiscip Rev RNA , vol.7 , pp. 758-771
    • Zhou, Y.1    Zhou, G.2    Tian, C.3
  • 71
    • 84906078197 scopus 로고    scopus 로고
    • MiR-210 promotes IPF fibroblast proliferation in response to hypoxia
    • Bodempudi V, Hergert P, Smith K et al. miR-210 promotes IPF fibroblast proliferation in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 2014;307:L283–L294.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.307 , pp. L283-L294
    • Bodempudi, V.1    Hergert, P.2    Smith, K.3
  • 72
    • 84871442001 scopus 로고    scopus 로고
    • Functional screening identifies miRNAs inducing cardiac regeneration
    • Eulalio A, Mano M, Ferro MD et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature 2012;492:376–381.
    • (2012) Nature , vol.492 , pp. 376-381
    • Eulalio, A.1    Mano, M.2    Ferro, M.D.3
  • 73
    • 84891746974 scopus 로고    scopus 로고
    • MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain
    • Zeng L, He X, Wang Y et al. MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain. Gene Ther 2014;21:37–43.
    • (2014) Gene Ther , vol.21 , pp. 37-43
    • Zeng, L.1    He, X.2    Wang, Y.3
  • 74
    • 84866770765 scopus 로고    scopus 로고
    • Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD341 cells enhances cell-mediated angiogenesis
    • Alaiti MA, Ishikawa M, Masuda H et al. Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD341 cells enhances cell-mediated angiogenesis. J Cell Mol Med 2012;16:2413–2421.
    • (2012) J Cell Mol Med , vol.16 , pp. 2413-2421
    • Alaiti, M.A.1    Ishikawa, M.2    Masuda, H.3
  • 75
    • 84930636929 scopus 로고    scopus 로고
    • Exosomes for intramyocardial intercellular communication
    • Cervio E, Barile L, Moccetti T et al. Exosomes for intramyocardial intercellular communication. Stem Cells Int 2015;2015:482171.
    • (2015) Stem Cells Int , vol.2015 , pp. 482171
    • Cervio, E.1    Barile, L.2    Moccetti, T.3
  • 76
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang S, Aurora AB, Johnson BA et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008;15:261–271.
    • (2008) Dev Cell , vol.15 , pp. 261-271
    • Wang, S.1    Aurora, A.B.2    Johnson, B.A.3
  • 77
    • 68649114571 scopus 로고    scopus 로고
    • AngiomiRs--Key regulators of angiogenesis
    • Wang S, Olson EN. AngiomiRs--Key regulators of angiogenesis. Curr Opin Genet Dev 2009;19:205–211.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 205-211
    • Wang, S.1    Olson, E.N.2
  • 78
    • 84975267334 scopus 로고    scopus 로고
    • Mesenchymal stem cells deliver exogenous micro-RNA let7c via exosomes to attenuate renal fibrosis
    • Wang B, Yao K, Huuskes BM et al. Mesenchymal stem cells deliver exogenous micro-RNA let7c via exosomes to attenuate renal fibrosis. Mol Ther 2016; 24:1290–1301.
    • (2016) Mol Ther , vol.24 , pp. 1290-1301
    • Wang, B.1    Yao, K.2    Huuskes, B.M.3
  • 79
    • 77956842581 scopus 로고    scopus 로고
    • MicroRNA-21 is a key determinant in IL-11/ Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts
    • Haider KH, Idris NM, Kim HW et al. MicroRNA-21 is a key determinant in IL-11/ Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts. Cardiovasc Res 2010;88:168–178.
    • (2010) Cardiovasc Res , vol.88 , pp. 168-178
    • Haider, K.H.1    Idris, N.M.2    Kim, H.W.3
  • 80
    • 84899980641 scopus 로고    scopus 로고
    • Exosomes as critical agents of cardiac regeneration triggered by cell therapy
    • Ibrahim AG, Cheng K, Marbàan E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Rep 2014;2:606–619.
    • (2014) Stem Cell Rep , vol.2 , pp. 606-619
    • Ibrahim, A.G.1    Cheng, K.2    Marbàan, E.3
  • 81
    • 79551625082 scopus 로고    scopus 로고
    • MicroRNAs in resolution of Acute inflammation: Identification of novel resolvin D1-miRNA circuits
    • Recchiuti A, Krishnamoorthy S, Fredman G et al. MicroRNAs in resolution of acute inflammation: Identification of novel resolvin D1-miRNA circuits. FASEB J 2011;25: 544–560.
    • (2011) FASEB J , vol.25 , pp. 544-560
    • Recchiuti, A.1    Krishnamoorthy, S.2    Fredman, G.3
  • 82
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    • Sheedy FJ, Palsson-McDermott E, Hennessy EJ et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol 2010;11:141–147.
    • (2010) Nat Immunol , vol.11 , pp. 141-147
    • Sheedy, F.J.1    Palsson-McDermott, E.2    Hennessy, E.J.3
  • 83
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (MiR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intrav-asation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SAK, Nikolova DA et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intrav-asation and metastasis in colorectal cancer. Oncogene 2008;27:2128–2136.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.K.2    Nikolova, D.A.3
  • 84
    • 84960192985 scopus 로고    scopus 로고
    • Mirna-mediated macrophage polarization and its potential role in the regulation of inflammatory response
    • Essandoh K, Li Y, Huo J et al. Mirna-mediated macrophage polarization and its potential role in the regulation of inflammatory response. Shock 2016 46:122–131.
    • (2016) Shock , vol.46 , pp. 122-131
    • Essandoh, K.1    Li, Y.2    Huo, J.3
  • 85
    • 84934444323 scopus 로고    scopus 로고
    • MiR-210: Fine-tuning the hypoxic response
    • Ivan M, Huang X. miR-210: Fine-tuning the hypoxic response. Adv Exp Med Biol 2014; 772:205–227.
    • (2014) Adv Exp Med Biol , vol.772 , pp. 205-227
    • Ivan, M.1    Huang, X.2
  • 86
    • 84964894933 scopus 로고    scopus 로고
    • Equine amniotic microvesicles and their anti-inflammatory potential in a tenocyte model in vitro
    • Lange-Consiglio A, Perrini C, Tasquier R et al. Equine amniotic microvesicles and their anti-inflammatory potential in a tenocyte model in vitro. Stem Cells Dev 2016;25:610– 621.
    • (2016) Stem Cells Dev , vol.25
    • Lange-Consiglio, A.1    Perrini, C.2    Tasquier, R.3
  • 87
    • 84865052759 scopus 로고    scopus 로고
    • Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro
    • Iglesias DM, El-Kares R, Taranta A et al. Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro. PLoS One 2012;7.
    • (2012) Plos One , vol.7
    • Iglesias, D.M.1    El-Kares, R.2    Taranta, A.3
  • 88
    • 84898655806 scopus 로고    scopus 로고
    • The anti-oxidative role of micro-vesicles derived from human Wharton-Jelly mesenchymal stromal cells through NOX2/gp91(Phox) suppression in alleviating renal ischemia-reperfusion injury in rats
    • Zhang G, Zou X, Miao S et al. The anti-oxidative role of micro-vesicles derived from human Wharton-Jelly mesenchymal stromal cells through NOX2/gp91(phox) suppression in alleviating renal ischemia-reperfusion injury in rats. PLoS One 2014;9:e92129.
    • (2014) Plos One , vol.9
    • Zhang, G.1    Zou, X.2    Miao, S.3


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