Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Iglesias, Diana M ^a   El Kares, Reyhan ^a   Taranta, Anna ^b   Bellomo, Francesco ^b   Emma, Francesco ^b   Besouw, Martine ^c   Levtchenko, Elena ^c   Toelen, Jaan ^c   van den Heuvel, Lambertus ^c   Chu, LeeLee ^a   Zhao, Jing ^d   Young, Yoon Kow ^d   Eliopoulos, Nicoletta ^d,e   Goodyer, Paul ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d MCGILL UNIVERSITY   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTINE; CYSTINOSIN; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL ISOLATION; CELL VACUOLE; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYSTINOSIN GENE; CYSTINOSIS; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MESENCHYMAL STEM CELL; MICROVESICLE; ORGANELLE SIZE; PARACRINE SIGNALING; PROTEIN TRANSPORT; WILD TYPE;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; CYSTINE; CYSTINOSIS; EXOSOMES; FIBROBLASTS; HUMANS; LYSOSOMES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MUTATION; PROTEIN TRANSPORT; RNA, MESSENGER;

EID: 84865052759     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042840     Document Type: Article

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