A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease

Science Advances

Volumn 2, Issue 8, 2016, Pages

  Freer, Rosie ^a   Sormanni, Pietro ^a   Vecchi, Giulia ^a   Ciryam, Prajwal ^a,b   Dobson, Christopher M ^a   Vendruscolo, Michele ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; PHYSIOLOGY; PROTEINS; RISK ASSESSMENT; TISSUE;

AMYLOID PLAQUES; ENVIRONMENTAL RISKS; EXPRESSION PATTERNS; NEUROFIBRILLARY TANGLES; PROTEIN AGGREGATION; QUANTITATIVE CORRELATION; TISSUE SPECIFICS; TRANSCRIPTIONAL ANALYSIS;

TISSUE HOMEOSTASIS;

AMYLOID BETA PROTEIN; TAU PROTEIN; TRANSCRIPTOME;

ADULT; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANTIBODY SPECIFICITY; BIOSYNTHESIS; BRAIN; BRAIN MAPPING; DISEASE COURSE; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; MIDDLE AGED; NEUROFIBRILLARY TANGLE; PATHOLOGY; PROTEINOSIS;

ADULT; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BRAIN; BRAIN MAPPING; DISEASE PROGRESSION; HOMEOSTASIS; HUMANS; MIDDLE AGED; NEUROFIBRILLARY TANGLES; ORGAN SPECIFICITY; PLAQUE, AMYLOID; PROTEIN AGGREGATION, PATHOLOGICAL; TAU PROTEINS; TRANSCRIPTOME;

EID: 85019334475     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.1600947     Document Type: Article

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