메뉴 건너뛰기




Volumn 37, Issue 14, 2017, Pages 3875-3886

Leptin signaling in AgRP neurons modulates puberty onset and adult fertility in mice

Author keywords

AgRP; Fertility; GnRH; Leptin; Puberty; Reproduction

Indexed keywords

AGOUTI RELATED PROTEIN; GONADORELIN; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE;

EID: 85019158248     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3138-16.2017     Document Type: Article
Times cited : (89)

References (40)
  • 2
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • CrossRef Medline
    • Bates SH, Myers MG Jr (2003) The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14:447-452. CrossRef Medline
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 447-452
    • Bates, S.H.1    Myers, M.G.2
  • 5
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • CrossRef Medline
    • Bouret SG, Draper SJ, Simerly RB (2004) Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304:108-110. CrossRef Medline
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 6
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • CrossRef Medline
    • Broberger C, Johansen J, Johansson C, Schalling M, Hökfelt T (1998) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A 95:15043-15048. CrossRef Medline
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hökfelt, T.5
  • 7
    • 0036553037 scopus 로고    scopus 로고
    • The melanocortin receptors: Lessons from knockout models
    • CrossRef Medline
    • Butler AA, Cone RD (2002) The melanocortin receptors: lessons from knockout models. Neuropeptides 36:77-84. CrossRef Medline
    • (2002) Neuropeptides , vol.36 , pp. 77-84
    • Butler, A.A.1    Cone, R.D.2
  • 8
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
    • CrossRef Medline
    • Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, Rivier JE, Sizonenko PC, Aubert ML (1993) Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132:224-234. CrossRef Medline
    • (1993) Endocrinology , vol.132 , pp. 224-234
    • Catzeflis, C.1    Pierroz, D.D.2    Rohner-Jeanrenaud, F.3    Rivier, J.E.4    Sizonenko, P.C.5    Aubert, M.L.6
  • 9
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • CrossRef Medline
    • Chehab FF, Lim ME, Lu R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12:318-320. CrossRef Medline
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 11
    • 84925538202 scopus 로고    scopus 로고
    • Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding
    • CrossRef Medline
    • Dietrich MO, Zimmer MR, Bober J, Horvath TL (2015) Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell 160:1222-1232. CrossRef Medline
    • (2015) Cell , vol.160 , pp. 1222-1232
    • Dietrich, M.O.1    Zimmer, M.R.2    Bober, J.3    Horvath, T.L.4
  • 12
    • 79951674090 scopus 로고    scopus 로고
    • Hypothalamic sites of leptin action linking metabolism and reproduction
    • CrossRef Medline
    • Donato J Jr, Cravo RM, Frazão R, Elias CF (2011a) Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology 93:9-18. CrossRef Medline
    • (2011) Neuroendocrinology , vol.93 , pp. 9-18
    • Donato, J.1    Cravo, R.M.2    Frazão, R.3    Elias, C.F.4
  • 14
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • CrossRef Medline
    • Erickson JC, Hollopeter G, Palmiter RD (1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704-1707. CrossRef Medline
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 15
    • 85012195855 scopus 로고    scopus 로고
    • Neuroendocrineintegrationofnutritionalsignals on reproduction
    • CrossRef
    • Evans MC, Anderson GM (2017) Neuroendocrineintegrationofnutritionalsignals on reproduction. J Mol Endocrinol 58:R107-R128. CrossRef
    • (2017) J Mol Endocrinol , vol.58 , pp. R107-R128
    • Evans, M.C.1    Anderson, G.M.2
  • 16
    • 84908046858 scopus 로고    scopus 로고
    • Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice
    • CrossRef Medline
    • Evans MC, Rizwan MZ, Anderson GM (2014) Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology 155:4368-4379. CrossRef Medline
    • (2014) Endocrinology , vol.155 , pp. 4368-4379
    • Evans, M.C.1    Rizwan, M.Z.2    Anderson, G.M.3
  • 17
    • 0032931966 scopus 로고    scopus 로고
    • Effect of the genetic background on the reproduction of leptin-deficient obese mice*
    • CrossRef Medline
    • Ewart-Toland A, Mounzih K, Qiu J, Chehab FF (1999) Effect of the genetic background on the reproduction of leptin-deficient obese mice*. Endocrinology 140:732-738. CrossRef Medline
    • (1999) Endocrinology , vol.140 , pp. 732-738
    • Ewart-Toland, A.1    Mounzih, K.2    Qiu, J.3    Chehab, F.F.4
  • 19
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • CrossRef Medline
    • Hahn TM, Breininger JF, Baskin DG, Schwartz MW (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1:271-272. CrossRef Medline
    • (1998) Nat Neurosci , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 20
    • 0030990363 scopus 로고    scopus 로고
    • Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus:GABAergic and non-GABAergic subpopulations
    • CrossRef Medline
    • Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus:GABAergic and non-GABAergic subpopulations. Brain Res 756:283-286. CrossRef Medline
    • (1997) Brain Res , vol.756 , pp. 283-286
    • Horvath, T.L.1    Bechmann, I.2    Naftolin, F.3    Kalra, S.P.4    Leranth, C.5
  • 22
    • 84861479803 scopus 로고    scopus 로고
    • G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight
    • CrossRef
    • Kloukina V, Herzer S, Karlsson N, Perez M, Daraio T, Meister B (2012) G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight. J Chem Neuroanat 44:14-23. CrossRef
    • (2012) J Chem Neuroanat , vol.44 , pp. 14-23
    • Kloukina, V.1    Herzer, S.2    Karlsson, N.3    Perez, M.4    Daraio, T.5    Meister, B.6
  • 23
    • 78651102603 scopus 로고    scopus 로고
    • Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons
    • CrossRef Medline
    • Mayer C, Acosta-Martinez M, Dubois SL, Wolfe A, Radovick S, Boehm U, Levine JE (2010) Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A 107:22693-22698. CrossRef Medline
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 22693-22698
    • Mayer, C.1    Acosta-Martinez, M.2    Dubois, S.L.3    Wolfe, A.4    Radovick, S.5    Boehm, U.6    Levine, J.E.7
  • 24
    • 4344713706 scopus 로고    scopus 로고
    • An allelic series for the leptin receptor gene generated by CRE and FLP recombinase
    • CrossRef Medline
    • McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr (2004) An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome 15:677-685. CrossRef Medline
    • (2004) Mamm Genome , vol.15 , pp. 677-685
    • McMinn, J.E.1    Liu, S.M.2    Dragatsis, I.3    Dietrich, P.4    Ludwig, T.5    Eiden, S.6    Chua, S.C.7
  • 25
    • 0036184221 scopus 로고    scopus 로고
    • Leptin and reproduction: A review
    • CrossRef Medline
    • Moschos S, Chan JL, Mantzoros CS (2002) Leptin and reproduction: a review. Fertil Steril 77:433-444. CrossRef Medline
    • (2002) Fertil Steril , vol.77 , pp. 433-444
    • Moschos, S.1    Chan, J.L.2    Mantzoros, C.S.3
  • 26
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • CrossRef Medline
    • Mounzih K, Lu R, Chehab FF (1997) Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138:1190-1193. CrossRef Medline
    • (1997) Endocrinology , vol.138 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 28
    • 84867764901 scopus 로고    scopus 로고
    • Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice
    • CrossRef Medline
    • Roa J, Herbison AE (2012) Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice. Endocrinology 153:5587-5599. CrossRef Medline
    • (2012) Endocrinology , vol.153 , pp. 5587-5599
    • Roa, J.1    Herbison, A.E.2
  • 29
    • 45349098372 scopus 로고    scopus 로고
    • Molecular and neural mediators of leptin action
    • CrossRef Medline
    • Robertson SA, Leinninger GM, Myers MG Jr (2008) Molecular and neural mediators of leptin action. Physiol Behav 94:637-642. CrossRef Medline
    • (2008) Physiol Behav , vol.94 , pp. 637-642
    • Robertson, S.A.1    Leinninger, G.M.2    Myers, M.G.3
  • 31
    • 84890397199 scopus 로고    scopus 로고
    • Agouti-related peptide plays a critical role in leptin’s effects on female puberty and reproduction
    • CrossRef Medline
    • Sheffer-Babila S, Sun Y, Israel DD, Liu, S-M, Neal-Perry G, Chua SC (2013) Agouti-related peptide plays a critical role in leptin’s effects on female puberty and reproduction. Am J Physiol Endocrinol Metab 305:E1512-E1520. CrossRef Medline
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E1512-E1520
    • Sheffer-Babila, S.1    Sun, Y.2    Israel, D.D.3    Liu, S.-M.4    Neal-Perry, G.5    Chua, S.C.6
  • 32
    • 77950925742 scopus 로고    scopus 로고
    • The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis
    • CrossRef Medline
    • Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ (2010) The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis. Physiol Behav 100:165-172. CrossRef Medline
    • (2010) Physiol Behav , vol.100 , pp. 165-172
    • Shi, H.1    Sorrell, J.E.2    Clegg, D.J.3    Woods, S.C.4    Seeley, R.J.5
  • 33
    • 84879304955 scopus 로고    scopus 로고
    • Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin’s effects on fertility in mice
    • CrossRef Medline
    • Singireddy AV, Inglis MA, Zuure WA, Kim JS, Anderson GM (2013) Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin’s effects on fertility in mice. Endocrinology 154:2434-2445. CrossRef Medline
    • (2013) Endocrinology , vol.154 , pp. 2434-2445
    • Singireddy, A.V.1    Inglis, M.A.2    Zuure, W.A.3    Kim, J.S.4    Anderson, G.M.5
  • 34
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • CrossRef Medline
    • Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB (2008) Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11:998-1000. CrossRef Medline
    • (2008) Nat Neurosci , vol.11 , pp. 998-1000
    • Tong, Q.1    Ye, C.P.2    Jones, J.E.3    Elmquist, J.K.4    Lowell, B.B.5
  • 36
    • 12344274258 scopus 로고    scopus 로고
    • Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey
    • CrossRef Medline
    • Vulliémoz NR, Xiao E, Xia-Zhang L, Wardlaw SL, Ferin M (2005) Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. Endocrinology 146:784-789. CrossRef Medline
    • (2005) Endocrinology , vol.146 , pp. 784-789
    • Vulliémoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Wardlaw, S.L.4    Ferin, M.5
  • 38
    • 79953172210 scopus 로고    scopus 로고
    • Genetic identification of GnRH receptor neurons: A new model for studying neural circuits underlying reproductive physiology in the mouse brain
    • CrossRef
    • Wen S, Go Tze IN, Mai O, Schauer C, Leinders-Zufall T, Boehm U (2011) Genetic identification of GnRH receptor neurons: a new model for studying neural circuits underlying reproductive physiology in the mouse brain. Endocrinology 152:1515-1526. CrossRef
    • (2011) Endocrinology , vol.152 , pp. 1515-1526
    • Wen, S.1    Go Tze, I.N.2    Mai, O.3    Schauer, C.4    Leinders-Zufall, T.5    Boehm, U.6
  • 39
    • 84857374972 scopus 로고    scopus 로고
    • Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    • CrossRef Medline
    • Wu Q, Whiddon BB, Palmiter RD (2012) Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci U S A 109:3155-3160. CrossRef Medline
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3155-3160
    • Wu, Q.1    Whiddon, B.B.2    Palmiter, R.D.3
  • 40
    • 84887064714 scopus 로고    scopus 로고
    • Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function
    • CrossRef Medline
    • Zuure WA, Roberts AL, Quennell JH, Anderson GM (2013) Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function. J Neurosci 33:17874-17883. CrossRef Medline
    • (2013) J Neurosci , vol.33 , pp. 17874-17883
    • Zuure, W.A.1    Roberts, A.L.2    Quennell, J.H.3    Anderson, G.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.