Genetic identification of GnRH receptor neurons: A new model for studying neural circuits underlying reproductive physiology in the mouse brain

Endocrinology

Volumn 152, Issue 4, 2011, Pages 1515-1526

  Wen, Shuping ^a   Götze, Iris N ^b   Mai, Oliver ^a   Schauer, Christian ^b   Leinders Zufall, Trese ^b   Boehm, Ulrich ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADORELIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; FEMALE; GENE; GENETIC IDENTIFICATION; HYPOTHALAMUS; MALE; MOUSE; NERVE CELL; NONHUMAN; OLFACTORY NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPRODUCTION; ROSA26 GENE; SEXUAL BEHAVIOR;

ANIMALS; BRAIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HYPOTHALAMUS; MALE; MICE; NEURAL CONDUCTION; NEURONS; ODORS; PHEROMONES; PROTEINS; RECEPTORS, LHRH; SEXUAL BEHAVIOR, ANIMAL; SIGNAL TRANSDUCTION; THALAMUS;

EID: 79953172210     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1208     Document Type: Article

References (59)

1. Gore AC 2002 GnRH: The master molecule of reproduction. Kluwer Academic Publishers
2. Herbison AE 2006 Physiology of the gonadotropin-releasing hormone neuronal network. In: Neill JD, Plant TM, Pfaff DW, Challis JRG, de Kretser DM, Richards JS, Wassarman PM, eds. Knobil and Neill's physiology of reproduction. 3rd ed. Elsevier Academic Press: St. Louis; 1415-1482
3. Tirindelli R, Dibattista M, Pifferi S, Menini A 2009 From pheromones to behavior. Physiol Rev 89:921-956
4. Yoon H, Enquist LW, Dulac C 2005 Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 123:669-682 (Pubitemid 41608468)
5. Boehm U, Zou Z, Buck LB 2005 Feedback loops link odor and pheromone signaling with reproduction. Cell 123:683-695 (Pubitemid 41608469)
6. Childs GV 2006 Gonadotropes and lactotropes. In: Neill JD, Plant TM, Pfaff DW, Challis JRG, de Kretser DM, Richards JS, Wassarman PM, eds. Knobil and Neill's physiology of reproduction. 3rd ed. Elsevier Academic Press: St. Louis; 1483-1579
7. Jeong K-H, Kaiser UB 2006 Gonadotropin-releasing hormone regulation of gonadotropin biosynthesis and secretion. In: Neill JD, Plant TM, Pfaff DW, Challis JRG, de Kretser DM, Richards JS, Wassarman PM, eds. Knobil and Neill's physiology of reproduction. 3rd ed. Elsevier Academic Press: St. Louis; 1635-1701
8. Sherwood NM, Lovejoy DA, Coe IR 1993 Origin of mammalian gonadotropin-releasing hormones. Endocr Rev 14:241-254 (Pubitemid 23118420)
9. Sirinathsinghji DJ 1983 GnRH in the spinal subarachnoid space potentiates lordosis behavior in the female rat. Physiol Behav 31:717-723 (Pubitemid 14200452)
10. Moss RL, Foreman MM 1976 Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone. Neuroendocrinology 20:176-181
11. Moss RL, McCann SM 1973 Induction of mating behavior in rats by luteinizing hormone-releasing factor. Science 181:177-179
12. Kandel E, Schwartz J, Jessell T 2000 Principles of neural science. 4th ed. McGraw-Hill Medical: New York
13. Jennes L, Stumpf WE 1980 LHRH-systems in the brain of the golden hamster. Cell Tissue Res 209:239-256 (Pubitemid 10019515)
14. Badr M, Pelletier G 1987 Characterization and autoradiographic localization of LHRH receptors in the rat brain. Synapse 1:567-571 (Pubitemid 18007837)
15. Jennes L, Dalati B, Conn PM 1988 Distribution of gonadrotropin releasing hormone agonist binding sites in the rat central nervous system. Brain Res 452:156-164
16. Jennes L, Eyigor O, Janovick JA, Conn PM 1997 Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Prog Horm Res 52:475-490; discussion 490-491
17. Lobe CG, Koop KE, Kreppner W, Lomeli H, Gertsenstein M, Nagy A 1999 Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208:281-292 (Pubitemid 29183990)
18. Srinivas S, Watanabe T, Lin CS, William CM, Tanabe Y, Jessell TM, Costantini F 2001 Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1:4
19. Rodriguez I, Feinstein P, Mombaerts P 1999 Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell 97:199-208 (Pubitemid 29194271)
20. Paxinos G, Franklin KBJ 2001 The mouse brain in stereotaxic coordinates. 2nd ed. Elsevier Academic Press: St. Louis
21. Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny MV, Shipley MT, Zufall F 2000 Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405:792-796 (Pubitemid 30407851)
22. Leinders-Zufall T, Ishii T, Mombaerts P, Zufall F, Boehm T 2009 Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci 12:1551-1558
23. Wen S, Schwarz JR, Niculescu D, Dinu C, Bauer CK, Hirdes W, Boehm U 2008 Functional characterization of genetically labeled gonadotropes. Endocrinology 149:2701-2711 (Pubitemid 351724497)
24. Seibler J, Küter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kühn R, Brüning JC, Schwenk F 2005 Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic Acids Res 33:e67
25. Wen S, Ai W, Alim Z, Boehm U 2010 Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis. Proc Natl Acad Sci USA 107:16372-16377
26. Halpern M, Martínez-Marcos A 2003 Structure and function of the vomeronasal system: an update. Prog Neurobiol 70:245-318 (Pubitemid 37287601)
27. Kang N, Baum MJ, Cherry JA 2009 A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female mice selectively responds to volatile pheromones from males. Eur J Neurosci 29:624-634
28. Petrovich GD, Canteras NS, Swanson LW 2001 Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems. Brain Res Brain Res Rev 38:247-289 (Pubitemid 34070636)
29. Shipley MT, Ennis M, Puche A 2004 Olfactory system. In: Paxinos G ed. The rat nervous system. 3rd ed. Elsevier Academic Press: St. Louis; 923-964
30. Riskind P, Moss RL 1979 Midbrain central gray: LHRH infusion enhances lordotic behavior in estrogen-primed ovariectomized rats. Brain Res Bull 4:203-205 (Pubitemid 9215984)
31. Sakuma Y, Pfaff DW 1980 LH-RHin the mesencephalic central grey can potentiate lordosis reflex of female rats. Nature 283:566-567 (Pubitemid 10136029)
32. Simerly RB 2002 Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci 25:507-536 (Pubitemid 34748027)
33. Krsmanovic LZ, Martinez-Fuentes AJ, Arora KK, Mores N, Navarro CE, Chen HC, Stojilkovic SS, Catt KJ 1999 Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology 140:1423-1431 (Pubitemid 29104249)
34. Xu C, Xu XZ, Nunemaker CS, Moenter SM 2004 Dose-dependent switch in response of gonadotropin-releasing hormone (GnRH) neurons to GnRH mediated through the type I GnRH receptor. Endocrinology 145:728-735 (Pubitemid 38183815)
35. Todman MG, Han SK, Herbison AE 2005 Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays. Neuroscience 132:703-712
36. Naor Z 2009 Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor. Front Neuroendocrinol 30:10-29
37. Tsutsumi R, Mistry D, Webster NJ 2010 Signaling responses to pulsatile GnRH in LbetaT2 gonadotrope cells. J Biol Chem 285:20262-20272
38. Yoshioka K, Suzuki C, Arai S, Iwamura S, Hirose H 2001 Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid of the heifer during the estrous cycle. Biol Reprod 64:563-570 (Pubitemid 32109745)
39. Meredith M, Howard G 1992 Intracerebroventricular LHRH relieves behavioral deficits due to vomeronasal organ removal. Brain Res Bull 29:75-79
40. Samson WK, McCann SM, Chud L, Dudley CA, Moss RL 1980 Intra- and extrahypothalamic luteinizing hormone-releasing hormone (LHRH) distribution in the rat with special reference to mesencephalic sites which contain both LHRH and single neurons responsive to LHRH. Neuroendocrinology 31:66-72 (Pubitemid 10118265)
41. Bandler R, Depaulis A, Vergnes M 1985 Identification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids. Behav Brain Res 15:107-119 (Pubitemid 15090331)
42. Depaulis A, Vergnes M 1986 Elicitation of intraspecific defensive behaviors in the rat by microinjection of picrotoxin, a gamma-aminobutyric acid antagonist, into the midbrain periaqueductal gray matter. Brain Res 367:87-95 (Pubitemid 16011667)
43. Krieger JE, Graeff FG 1985 Defensive behavior and hypertension induced by glutamate in the midbrain central gray of the rat. Braz J Med Biol Res 18:61-67 (Pubitemid 15225623)
44. Mora S, Díaz-Véliz G 1985 Luteinizing-hormone-releasing hormone modifies retention of passive and active avoidance responses in rats. Psychopharmacology (Berl) 85:315-318 (Pubitemid 15123106)
45. Albertson AJ, Navratil A, Mignot M, Dufourny L, Cherrington B, Skinner DC 2008 Immunoreactive GnRH type I receptors in the mouse and sheep brain. J Chem Neuroanat 35:326-333
46. Granger A, Ngo-Muller V, Bleux C, Guigon C, Pincas H, Magre S, Daegelen D, Tixier-Vidal A, Counis R, Laverriere JN 2004 The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues. Endocrinology 145:983-993 (Pubitemid 38183843)
47. Maruniak JA, Bronson FH 1976 Gonadotropic responses of male mice to female urine. Endocrinology 99:963-969
48. Wirsig-Wiechmann CR 2001 Function of gonadotropin-releasing hormone in olfaction. Keio J Med 50:81-85 (Pubitemid 33611656)
49. Hummel T, Gollisch R, Wildt G, Kobal G 1991 Changes in olfactory perception during the menstrual cycle. Experientia 47:712-715
50. Krsmanovic LZ, Hu L, Leung PK, Feng H, Catt KJ 2009 The hypothalamic GnRH pulse generator: multiple regulatory mechanisms. Trends Endocrinol Metab 20:402-408
51. Spergel DJ, Kruth U, Hanley DF, Sprengel R, Seeburg PH 1999 GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice. J Neurosci 19:2037-2050 (Pubitemid 29133382)
52. Suter KJ, Song WJ, Sampson TL, Wuarin JP, Saunders JT, Dudek FE, Moenter SM 2000 Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology. Endocrinology 141:412-419 (Pubitemid 32260384)
53. Pawson AJ, Morgan K, Maudsley SR, Millar RP 2003 Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology. Reproduction 126:271-278 (Pubitemid 37185227)
54. Morgan K, Millar RP 2004 Evolution of GnRH ligand precursors and GnRH receptors in protochordate and vertebrate species. Gen Comp Endocrinol 139:191-197 (Pubitemid 39550345)
55. Stewart AJ, Katz AA, Millar RP, Morgan K 2009 Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals. Neuroendocrinology 90:416-432
56. Dyer RG, Dyball RE 1974 Proceedings: Inhibition of hypothalamic unit activity by iontophoretically applied luteinizing hormone releasing factor and thyrotrophin releasing factor. J Endocrinol 63:35P
57. Pan JT, Kow LM, Pfaff DW 1988 Modulatory actions of luteinizing hormone-releasing hormone on electrical activity of preoptic neurons in brain slices. Neuroscience 27:623-628
58. Renaud LP, Martin JB, Brazeau P 1975 Depressant action of TRH, LH-RH and somatostatin on activity of central neurones. Nature 255:233-235
59. Rothfeld JM, Carstens E, Gross DS 1985 Neuronal responsiveness to gonadotropin-releasing hormone and its correlation with sexual receptivity in the rat. Peptides 6:603-608 (Pubitemid 16195038)