Demographic, genetic and phenotypic characteristics of centenarians in Italy: Focus on gender differences

Mechanisms of Ageing and Development

Volumn 165, Issue , 2017, Pages 68-74

  Montesanto, Alberto ^a   De Rango, Francesco ^a   Pirazzini, Chiara ^b   Guidarelli, Giulia ^c   Domma, Filippo ^a   Franceschi, Claudio ^b,c   Passarino, Giuseppe ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b IRCCS   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Centenarians; Demography; Genetics; Healthy aging

Indexed keywords

MITOCHONDRIAL DNA;

AGE DISTRIBUTION; AGED; COHORT ANALYSIS; DEMOGRAPHY; FEMALE; FUNCTIONAL STATUS; GENETIC ASSOCIATION; GENETIC RISK; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GEOGRAPHIC DISTRIBUTION; HUMAN; ITALY; LONGEVITY; MALE; PHENOTYPE; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SEX RATIO; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY; GENOTYPE; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; SEXUAL CHARACTERISTICS;

AGED, 80 AND OVER; FEMALE; GENOTYPE; HUMANS; ITALY; LONGEVITY; MALE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SEX CHARACTERISTICS;

EID: 85019028665     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2017.04.008     Document Type: Review

References (76)

1. Abraham, G., Inouye, M., Genomic risk prediction of complex human disease and its clinical application. Curr. Opin. Genet. Dev. 33 (2015), 10–16, 10.1016/j.gde.2015.06.005.
2. Altomare, K., Greco, V., Bellizzi, D., Berardelli, M., Dato, S., DeRango, F., Garasto, S., Rose, G., Feraco, E., Mari, V., Passarino, G., Franceschi, C., De Benedictis, G., The allele (A)(-110) in the promoter region of the HSP 70-1 gene is unfavorable to longevity in women. Biogerontology 4:4 (2003), 215–220.
3. Anselmi, C.V., Malovini, A., Roncarati, R., Novelli, V., Villa, F., Condorelli, G., Bellazzi, R., Puca, A.A., Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res. 12:2 (2009), 95–104, 10.1089/rej.2008.0827.
4. Beltran-Sanchez, H., Finch, C.E., Crimmins, E.M., Twentieth century surge of excess adult male mortality. Proc. Natl. Acad. Sci U. S. A. 112:29 (2015), 8993–8998, 10.1073/pnas.1421942112.
5. Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkila, J., Monti, D., Satokari, R., Franceschi, C., Brigidi, P., De Vos, W., Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One, 5(5), 2010, e10667, 10.1371/journal.pone.0010667.
6. Bonafe, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Mayegiani, F., Cardelli, M., Pieri, C., Marra, M., Antonicelli, R., Lisa, R., Rizzo, M.R., Paolisso, G., Monti, D., Franceschi, C., A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur. J. Immunol. 31:8 (2001), 2357–2361, 10.1002/1521-4141(200108)31:8<2357:AID-IMMU2357>3.0.CO;2-X.
7. Bonafe, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., Gueresi, P., Passeri, G., Berardelli, M., Paolisso, G., Barbieri, M., Tesei, S., Lisa, R., De Benedictis, G., Franceschi, C., Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Eur. J. Hum. Genet. 10:5 (2002), 292–296, 10.1038/sj.ejhg.5200806.
8. Bucci, L., Ostan, R., Giampieri, E., Cevenini, E., Pini, E., Scurti, M., Vescovini, R., Sansoni, P., Caruso, C., Mari, D., Ronchetti, F., Borghi, M.O., Ogliari, G., Grossi, C., Capri, M., Salvioli, S., Castellani, G., Franceschi, C., Monti, D., Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status. Exp. Gerontol. 54 (2014), 14–20, 10.1016/j.exger.2014.01.023.
9. Bucci, L., Ostan, R., Cevenini, E., Pini, E., Scurti, M., Vitale, G., Mari, D., Caruso, C., Sansoni, P., Fanelli, F., Pasquali, R., Gueresi, P., Franceschi, C., Monti, D., Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview. Aging (Albany NY) 8:3 (2016), 510–519, 10.18632/aging.100912.
10. Burkle, A., Caselli, G., Franceschi, C., Mariani, E., Sansoni, P., Santoni, A., Vecchio, G., Witkowski, J.M., Caruso, C., Pathophysiology of ageing, longevity and age related diseases. Immun. Ageing, 4(4), 2007, 10.1186/1742-4933-4-4.
11. Cardelli, M., Cavallone, L., Marchegiani, F., Oliveri, F., Dato, S., Montesanto, A., Lescai, F., Lisa, R., De Benedictis, G., Franceschi, C., A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. J. Gerontol. A Biol. Sci. Med. Sci. 63:5 (2008), 454–460.
12. Carrieri, G., Marzi, E., Olivieri, F., Marchegiani, F., Cavallone, L., Cardelli, M., Giovagnetti, S., Stecconi, R., Molendini, C., Trapassi, C., De Benedictis, G., Kletsas, D., Franceschi, C., The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3:6 (2004), 443–448, 10.1111/j.1474-9728.2004.00129.x.
13. Caselli, Graziella, Lipsi, Rosa Maria, Survival differences among the oldest old in Sardinia: who, what, where, and why?. Demogr. Res. 14:13 (2006), 267–294.
14. Collino, S., Montoliu, I., Martin, F.P., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., Brigidi, P., Franceschi, C., Rezzi, S., Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One, 8(3), 2013, e56564, 10.1371/journal.pone.0056564.
15. Corsonello, A., Montesanto, A., Berardelli, M., De Rango, F., Dato, S., Mari, V., Mazzei, B., Lattanzio, F., Passarino, G., A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians' relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity. Age Ageing 39:6 (2010), 723–727, 10.1093/ageing/afq116.
16. Dato, S., Passarino, G., Rose, G., Altomare, K., Bellizzi, D., Mari, V., Feraco, E., Franceschi, C., De Benedictis, G., Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur. J. Hum. Genet. 12:12 (2004), 1080–1082, 10.1038/sj.ejhg.5201278.
17. Dato, S., Carotenuto, L., De Benedictis, G., Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). Biogerontology 8:1 (2007), 31–41, 10.1007/s10522-006-9030-1.
18. Dato, S., Montesanto, A., Lagani, V., Jeune, B., Christensen, K., Passarino, G., Frailty phenotypes in the elderly based on cluster analysis: a longitudinal study of two Danish cohorts. Evidence for a genetic influence on frailty. Age (Dordrecht) 34:3 (2012), 571–582, 10.1007/s11357-011-9257-x.
19. De Benedictis, G., Carotenuto, L., Carrieri, G., De Luca, M., Falcone, E., Rose, G., Yashin, A.I., Bonafe, M., Franceschi, C., Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Ann. Hum. Genet. 62:Pt 2 (1998), 115–122, 10.1046/j.1469-1809.1998.6220115.x.
20. De Benedictis, G., Carotenuto, L., Carrieri, G., De Luca, M., Falcone, E., Rose, G., Cavalcanti, S., Corsonello, F., Feraco, E., Baggio, G., Bertolini, S., Mari, D., Mattace, R., Yashin, A.I., Bonafe, M., Franceschi, C., Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 6:6 (1998), 534–541, 10.1038/sj.ejhg.5200222.
21. De Benedictis, G., Rose, G., Carrieri, G., De Luca, M., Falcone, E., Passarino, G., Bonafe, M., Monti, D., Baggio, G., Bertolini, S., Mari, D., Mattace, R., Franceschi, C., Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 13:12 (1999), 1532–1536.
22. De Benedictis, G., Tan, Q., Jeune, B., Christensen, K., Ukraintseva, S.V., Bonafe, M., Franceschi, C., Vaupel, J.W., Yashin, A.I., Recent advances in human gene-longevity association studies. Mech. Ageing Dev. 122:9 (2001), 909–920.
23. De Rango, F., Dato, S., Bellizzi, D., Rose, G., Marzi, E., Cavallone, L., Franceschi, C., Skytthe, A., Jeune, B., Cournil, A., Robine, J.M., Gampe, J., Vaupel, J.W., Mari, V., Feraco, E., Passarino, G., Novelletto, A., De Benedictis, G., A novel sampling design to explore gene-longevity associations: the ECHA study. Eur. J. Hum. Genet. 16:2 (2008), 236–242, 10.1038/sj.ejhg.5201950.
24. De Rango, F., Montesanto, A., Berardelli, M., Mazzei, B., Mari, V., Lattanzio, F., Corsonello, A., Passarino, G., To grow old in southern Italy: a comprehensive description of the old and oldest old in Calabria. Gerontology 57:4 (2011), 327–334, 10.1159/000316941.
25. Deelen, J., Beekman, M., Uh, H.W., Helmer, Q., Kuningas, M., Christiansen, L., Kremer, D., van der Breggen, R., Suchiman, H.E., Lakenberg, N., van den Akker, E.B., Passtoors, W.M., Tiemeier, H., van Heemst, D., de Craen, A.J., Rivadeneira, F., de Geus, E.J., Perola, M., van der Ouderaa, F.J., Gunn, D.A., Boomsma, D.I., Uitterlinden, A.G., Christensen, K., van Duijn, C.M., Heijmans, B.T., Houwing-Duistermaat, J.J., Westendorp, R.G., Slagboom, P.E., Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10:4 (2011), 686–698, 10.1111/j.1474-9726.2011.00705.x.
26. Deelen, J., Beekman, M., Capri, M., Franceschi, C., Slagboom, P.E., Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays 35:4 (2013), 386–396, 10.1002/bies.201200148.
27. Deiana, L., Ferrucci, L., Pes, G.M., Carru, C., Delitala, G., Ganau, A., Mariotti, S., Nieddu, A., Pettinato, S., Putzu, P., Franceschi, C., Baggio, G., AKEntAnnos. the sardinia study of extreme longevity. Aging (Milano) 11:3 (1999), 142–149.
28. Dudbridge, F., Power and predictive accuracy of polygenic risk scores. PLoS Genet., 9(3), 2013, e1003348, 10.1371/journal.pgen.1003348.
29. Felix Caballero, F., Soulis, G., Engchuan, W., Sanchez-Niubo, A., Arndt, H., Ayuso-Mateos, J.L., Haro, J.M., Chatterji, S., Panagiotakos, D.B., Advanced analytical methodologies for measuring healthy ageing and its determinants, using factor analysis and machine learning techniques: the ATHLOS project. Sci. Rep., 7, 2017, 43955, 10.1038/srep43955.
30. Fortney, K., Dobriban, E., Garagnani, P., Pirazzini, C., Monti, D., Mari, D., Atzmon, G., Barzilai, N., Franceschi, C., Owen, A.B., Kim, S.K., Genome-wide scan informed by age-related disease identifies loci for exceptional human longevity. PLoS Genet., 11(12), 2015, e1005728, 10.1371/journal.pgen.1005728.
31. Franceschi, C., Motta, L., Valensin, S., Rapisarda, R., Franzone, A., Berardelli, M., Motta, M., Monti, D., Bonafe, M., Ferrucci, L., Deiana, L., Pes, G.M., Carru, C., Desole, M.S., Barbi, C., Sartoni, G., Gemelli, C., Lescai, F., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Gueresi, P., Cossarizza, A., Troiano, L., Pini, G., Sansoni, P., Passeri, G., Lisa, R., Spazzafumo, L., Amadio, L., Giunta, S., Stecconi, R., Morresi, R., Viticchi, C., Mattace, R., De Benedictis, G., Baggio, G., Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging (Milano) 12:2 (2000), 77–84.
32. Franceschi, C., Motta, L., Motta, M., Malaguarnera, M., Capri, M., Vasto, S., Candore, G., Caruso, C., IMUSCE, The extreme longevity: the state of the art in Italy. Exp. Gerontol. 43:2 (2008), 45–52, 10.1016/j.exger.2007.06.006.
33. Franceschi, C., Inflammaging as a major characteristic of old people: can it be prevented or cured?. Nutr. Rev. 65:12 Pt 2 (2007), S173–S176.
34. Gagnon, A., Natural fertility and longevity. Fertil. Steril. 103:5 (2015), 1109–1116, 10.1016/j.fertnstert.2015.03.030.
35. Garagnani, P., Giuliani, C., Pirazzini, C., Olivieri, F., Bacalini, M.G., Ostan, R., Mari, D., Passarino, G., Monti, D., Bonfigli, A.R., Boemi, M., Ceriello, A., Genovese, S., Sevini, F., Luiselli, D., Tieri, P., Capri, M., Salvioli, S., Vijg, J., Suh, Y., Delledonne, M., Testa, R., Franceschi, C., Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) 5:5 (2013), 373–385, 10.18632/aging.100562.
36. Garasto, S., Rose, G., Derango, F., Berardelli, M., Corsonello, A., Feraco, E., Mari, V., Maletta, R., Bruni, A., Franceschi, C., Carotenuto, L., De Benedictis, G., The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Ann. Hum. Genet. 67:Pt 1 (2003), 54–62.
37. Garasto, S., Berardelli, M., DeRango, F., Mari, V., Feraco, E., De Benedictis, G., A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians. BMC Med. Genet., 5(3), 2004, 10.1186/1471-2350-5-3.
38. Gavrilova, N.S., Gavrilov, L.A., Comments on dietary restriction, Okinawa diet and longevity. Gerontology 58:3 (2012), 221–223, 10.1159/000329894 discussion 224-6.
39. Gentilini, D., Mari, D., Castaldi, D., Remondini, D., Ogliari, G., Ostan, R., Bucci, L., Sirchia, S.M., Tabano, S., Cavagnini, F., Monti, D., Franceschi, C., Di Blasio, A.M., Vitale, G., Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordrecht) 35:5 (2013), 1961–1973, 10.1007/s11357-012-9463-1.
40. Giuliani, C., Barbieri, C., Li, M., Bucci, L., Monti, D., Passarino, G., Luiselli, D., Franceschi, C., Stoneking, M., Garagnani, P., Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing. Aging (Albany NY) 6:6 (2014), 454–467, 10.18632/aging.100661.
41. Gueresi, P., Miglio, R., Monti, D., Mari, D., Sansoni, P., Caruso, C., Bonafede, E., Bucci, L., Cevenini, E., Ostan, R., Palmas, M.G., Pini, E., Scurti, M., Franceschi, C., Does the longevity of one or both parents influence the health status of their offspring?. Exp. Gerontol. 48:4 (2013), 395–400, 10.1016/j.exger.2013.02.004.
42. Kim, J.I., Social factors associated with centenarian rate (CR) in 32 OECD countries. BMC Int. Health Hum. Rights, 13, 2013, 16, 10.1186/1472-698X-13-16.
43. Levine, M.E., Crimmins, E.M., A genetic network associated with stress resistance longevity, and cancer in humans. J. Gerontol. A Biol. Sci. Med. Sci. 71:6 (2016), 703–712, 10.1093/gerona/glv141.
44. Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafe, M., Cavallone, L., Franceschi, C., Caruso, C., Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun. 3:1 (2002), 30–33, 10.1038/sj.gene.6363827.
45. Lio, D., Malaguarnera, M., Maugeri, D., Ferlito, L., Bennati, E., Scola, L., Motta, M., Caruso, C., Laboratory parameters in centenarians of Italian ancestry. Exp. Gerontol. 43:2 (2008), 119–122, 10.1016/j.exger.2007.06.005.
46. Marioni, R.E., Ritchie, S.J., Joshi, P.K., Hagenaars, A., Okbay, K., Adams, M.J., Hill, G., Consortium Social Science Genetic Association, R, Nagy, C., Amador, K., Lall, A., Metspalu, Liewald, A., Wilson, C., Hayward, T., Porteous, D.J., Gale, C.R., Deary, I.J., Genetic variants linked to education predict longevity. Proc. Natl. Acad. Sci. U. S. A. 113:47 (2016), 13366–13371, 10.1073/pnas.1605334113.
47. Montesanto, A., Passarino, G., Senatore, A., Carotenuto, L., De Benedictis, G., Spatial analysis and surname analysis: complementary tools for shedding light on human longevity patterns. Ann. Hum. Genet. 72:Pt 2 (2008), 253–260, 10.1111/j.1469-1809.2007.00405.x.
48. Montesanto, A., Lagani, V., Martino, C., Dato, S., De Rango, F., Berardelli, M., Corsonello, A., Mazzei, B., Mari, V., Lattanzio, F., Conforti, D., Passarino, G., A novel, population-specific approach to define frailty. Age (Dordrecht) 32:3 (2010), 385–395, 10.1007/s11357-010-9136-x.
49. Montesanto, A., De Rango, F., Berardelli, M., Mari, V., Lattanzio, F., Passarino, G., Corsonello, A., Glomerular filtration rate in the elderly and in the oldest old: correlation with frailty and mortality. Age (Dordrecht), 36(3), 2014, 9641, 10.1007/s11357-014-9641-4.
50. Montesanto, A., Geracitano, S., Garasto, S., Fusco, S., Lattanzio, F., Passarino, G., Corsonello, A., The impact of the emerging genomics data on the management of agerelated phenotypes in the context of cellular senescence. Curr. Drug Targets 17:4 (2016), 428–438.
51. Montoliu, I., Scherer, M., Beguelin, F., DaSilva, L., Mari, D., Salvioli, S., Martin, F.P., Capri, M., Bucci, L., Ostan, R., Garagnani, P., Monti, D., Biagi, E., Brigidi, P., Kussmann, M., Rezzi, S., Franceschi, C., Collino, S., Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging (Albany NY) 6:1 (2014), 9–25, 10.18632/aging.100630.
52. Ostan, R., Bucci, L., Cevenini, E., Palmas, M.G., Pini, E., Scurti, M., Vescovini, R., Caruso, C., Mari, D., Vitale, G., Franceschi, C., Monti, D., Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines. Age (Dordrecht) 35:5 (2013), 1995–2007, 10.1007/s11357-012-9483-x.
53. Ostan, R., Monti, D., Gueresi, P., Bussolotto, M., Franceschi, C., Baggio, G., Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine. Clin. Sci. (Lond.) 130:19 (2016), 1711–1725, 10.1042/CS20160004.
54. Passarino, G., Calignano, C., Vallone, A., Franceschi, C., Jeune, B., Robine, J.M., Yashin, A.I., Cavalli Sforza, L.L., De Benedictis, G., Male/female ratio in centenarians: a possible role played by population genetic structure. Exp. Gerontol. 37:10–11 (2002), 1283–1289.
55. Pes, G.M., Tolu, F., Poulain, M., Errigo, A., Masala, S., Pietrobelli, A., Battistini, N.C., Maioli, M., Lifestyle and nutrition related to male longevity in Sardinia: an ecological study. Nutr. Metab. Cardiovasc. Dis. 23:3 (2013), 212–219, 10.1016/j.numecd.2011.05.004.
56. Pes, G.M., Tolu, F., Dore, M.P., Sechi, G.P., Errigo, A., Canelada, A., Poulain, M., Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factors. Eur. J. Clin. Nutr. 69:4 (2015), 411–418, 10.1038/ejcn.2014.230.
57. Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli, S., Monti, D., Benatti, S., Gibellini, L., Cotichini, R., Stazi, M.A., Trenti, T., Franceschi, C., Cossarizza, A., Circulating mitochondrial DNA increases with age and is a familiar trait: implications for inflamm-aging. Eur. J. Immunol. 44:5 (2014), 1552–1562, 10.1002/eji.201343921.
58. Poulain, M., Pes, G.M., Grasland, C., Carru, C., Ferrucci, L., Baggio, G., Franceschi, C., Deiana, L., Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp. Gerontol. 39:9 (2004), 1423–1429, 10.1016/j.exger.2004.06.016.
59. Poulain, Michel, Herm, Anne, Gianni, Pes, The Blue Zones: areas of exceptional longevity around the world. Vienna Yearbook of Population Research, 2013, 87–108 no. 11.
60. Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P.W., Brigidi, P., Functional metagenomic profiling of intestinal microbiome in extreme ageing. Aging (Albany NY) 5:12 (2013), 902–912, 10.18632/aging.100623.
61. Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J.S., Bezrukov, V., Blanche, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E.S., Kirkwood, T.B., Kristensen, P., Leon, A., Pelicci, P.G., Poulain, M., Rea, I.M., Remacle, J., Robine, J.M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J.W., Rose, G., Majamaa, K., Perola, M., Johnson, T.E., Bolund, L., Yang, H., Passarino, G., Franceschi, C., The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell 13:3 (2014), 401–407, 10.1111/acel.12186.
62. Robine, J.M., Paccaud, F., Nonagenarians and centenarians in Switzerland, 1860–2001: a demographic analysis. J. Epidemiol. Community Health 59:1 (2005), 31–37, 10.1136/jech.2003.018663.
63. Robine, J.M., Caselli, G., Rasulo, D., Cournil, A., Differentials in the femininity ratio among centenarians: variations between northern and southern Italy from 1870. Popul. Stud. (Camb.) 60:1 (2006), 99–113, 10.1080/00324720500466000.
64. Roli, G., Samoggia, A., Miglio, R., Rettaroli, R., Longevity pattern in the Italian region of Emilia Romagna: a dynamic perspective. Geospat. Health 6:2 (2012), 233–245, 10.4081/gh.2012.141.
65. Rose, G., Passarino, G., Scornaienchi, V., Romeo, G., Dato, S., Bellizzi, D., Mari, V., Feraco, E., Maletta, R., Bruni, A., Franceschi, C., De Benedictis, G., The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genom., 8, 2007, 293, 10.1186/1471-2164-8-293.
66. Rose, G., Romeo, G., Dato, S., Crocco, P., Bruni, A.C., Hervonen, A., Majamaa, K., Sevini, F., Franceschi, C., Passarino, G., Enetics of Healthy Ageing Project Consortium, G., Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. PLoS One, 5(10), 2010, e13395, 10.1371/journal.pone.0013395.
67. Skytthe, A., Valensin, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J.C., Cotichini, R., de Craen, A.J., Dato, S., Davies, K., De Benedictis, G., Deiana, L., Flachsbart, F., Gampe, J., Gilbault, C., Gonos, E.S., Haimes, E., Hervonen, A., Hurme, M.A., Janiszewska, D., Jylha, M., Kirkwood, T.B., Kristensen, P., Laiho, P., Leon, A., Marchisio, A., Masciulli, R., Nebel, A., Passarino, G., Pelicci, G., Peltonen, L., Perola, M., Poulain, M., Rea, I.M., Remacle, J., Robine, J.M., Schreiber, S., Scurti, M., Sevini, F., Sikora, E., Skouteri, A., Slagboom, P.E., Spazzafumo, L., Stazi, M.A., Toccaceli, V., Toussaint, O., Tornwall, O., Vaupel, J.W., Voutetakis, K., Franceschi, C., Geha consortium, Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Exp. Gerontol. 46:11 (2011), 934–945, 10.1016/j.exger.2011.08.005.
68. Thatcher, R., The demography of centenarians in England and Wales. Popul. Trends, 1999, 5–12.
69. Toupance, B., Godelle, B., Gouyon, P.H., Schachter, F., A model for antagonistic pleiotropic gene action for mortality and advanced age. Am. J. Hum. Genet. 62:6 (1998), 1525–1534, 10.1086/301865.
70. Vanhooren, V., Desmyter, L., Liu, X.E., Cardelli, M., Franceschi, C., Federico, A., Libert, C., Laroy, W., Dewaele, S., Contreras, R., Chen, C., N-glycomic changes in serum proteins during human aging. Rejuvenation Res. 10:4 (2007), 521–531a, 10.1089/rej.2007.0556.
71. Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., De Deyn, P.P., Toussaint, O., Debacq-Chainiaux, F., Poulain, M., Glupczynski, Y., Franceschi, C., Jaspers, K., van der Pluijm, I., Hoeijmakers, J., Chen, C.C., Serum N-glycan profile shift during human ageing. Exp. Gerontol. 45:10 (2010), 738–743, 10.1016/j.exger.2010.08.009.
72. Vaupel, James W., Jeune, Bernard, The Emergence and Proliferation of Centenarians. 1995.
73. Vitale, G., Brugts, M.P., Ogliari, G., Castaldi, D., Fatti, L.M., Varewijck, A.J., Lamberts, S.W., Monti, D., Bucci, L., Cevenini, E., Cavagnini, F., Franceschi, C., Hofland, L.J., Mari, D., Janssen, J., Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) 4:9 (2012), 580–589, 10.18632/aging.100484.
74. Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., Klemm, A., Flicek, P., Manolio, T., Hindorff, L., Parkinson, H., The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42 (2014), D1001–D1006, 10.1093/nar/gkt1229 Database issue.
75. Westendorp, R.G., Kirkwood, T.B., Human longevity at the cost of reproductive success. Nature 396:6713 (1998), 743–746, 10.1038/25519.
76. Yashin, A.I., De Benedictis, G., Vaupel, J.W., Tan, Q., Andreev, K.F., Iachine, I.A., Bonafe, M., DeLuca, M., Valensin, S., Carotenuto, L., Franceschi, C., Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. Am. J. Hum. Genet. 65:4 (1999), 1178–1193, 10.1086/302572.