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Volumn 61, Issue 5, 2017, Pages

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial

Author keywords

Cardiometabolic; EFSA; Gut microbiota; Metabotype; Urolithins

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; COUMARIN DERIVATIVE; PLANT EXTRACT; POLYPHENOL; TANNIN;

EID: 85018992803     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600830     Document Type: Article
Times cited : (165)

References (53)
  • 1
    • 85044864955 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: friend or foe?
    • Kim, S. H., Després, J. P., Koh, K. K., Obesity and cardiovascular disease: friend or foe? Eur. Heart J. 2015, doi:10.1093/eurheartj/ehv509.
    • (2015) Eur. Heart J.
    • Kim, S.H.1    Després, J.P.2    Koh, K.K.3
  • 2
    • 84982113684 scopus 로고    scopus 로고
    • 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C. et al., 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur. Heart J. 2016, 37, 2315–2381.
    • (2016) Eur. Heart J. , vol.37 , pp. 2315-2381
    • Piepoli, M.F.1    Hoes, A.W.2    Agewall, S.3    Albus, C.4
  • 3
    • 84879882627 scopus 로고    scopus 로고
    • Toward new biomarkers of cardiometabolic diseases
    • Roberts, L. D., Gerszten, R. E., Toward new biomarkers of cardiometabolic diseases. Cell Metab. 2013, 18, 43–50.
    • (2013) Cell Metab , vol.18 , pp. 43-50
    • Roberts, L.D.1    Gerszten, R.E.2
  • 4
    • 84905189482 scopus 로고    scopus 로고
    • Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials
    • Boekholdt, S. M., Hovingh, G. K., Mora, S., Arsenault, B. J. et al., Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J. Am. Coll. Cardiol. 2014, 64, 485–494.
    • (2014) J. Am. Coll. Cardiol. , vol.64 , pp. 485-494
    • Boekholdt, S.M.1    Hovingh, G.K.2    Mora, S.3    Arsenault, B.J.4
  • 5
    • 0036924183 scopus 로고    scopus 로고
    • Personalized medicine
    • Jain, K. K., Personalized medicine. Curr. Opin. Mol. Ther. 2002, 4, 548–558.
    • (2002) Curr. Opin. Mol. Ther. , vol.4 , pp. 548-558
    • Jain, K.K.1
  • 6
    • 30744445986 scopus 로고    scopus 로고
    • High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart
    • Frankenfeld, C. L., Atkinson, C., Thomas, W. K., Gonzalez, A. et al., High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart. Br. J. Nutr. 2005, 94, 873–876.
    • (2005) Br. J. Nutr. , vol.94 , pp. 873-876
    • Frankenfeld, C.L.1    Atkinson, C.2    Thomas, W.K.3    Gonzalez, A.4
  • 7
    • 84898009943 scopus 로고    scopus 로고
    • Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein
    • Frankenfeld, C. L., Atkinson, C., Wähälä, K., Lampe, J. W., Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. Eur. J. Clin. Nutr. 2014, 68, 526–530.
    • (2014) Eur. J. Clin. Nutr. , vol.68 , pp. 526-530
    • Frankenfeld, C.L.1    Atkinson, C.2    Wähälä, K.3    Lampe, J.W.4
  • 8
    • 84926473017 scopus 로고    scopus 로고
    • A critical evaluation of the clinical evidence for pomegranate preparations in the prevention and treatment of cardiovascular diseases
    • Vlachojannis, C., Erne, P., Schoenenberger, A. W., Chrubasik-Hausmann, S., A critical evaluation of the clinical evidence for pomegranate preparations in the prevention and treatment of cardiovascular diseases. Phytother. Res. 2015, 29, 501–508.
    • (2015) Phytother. Res. , vol.29 , pp. 501-508
    • Vlachojannis, C.1    Erne, P.2    Schoenenberger, A.W.3    Chrubasik-Hausmann, S.4
  • 9
    • 84942834400 scopus 로고    scopus 로고
    • Effect of daily intake of pomegranate juice on fecal microbiota and feces metabolites from healthy volunteers
    • Mosele, J. I., Gosalbes, M. J., Macià, A., Rubió, L. et al., Effect of daily intake of pomegranate juice on fecal microbiota and feces metabolites from healthy volunteers. Mol. Nutr. Food Res. 2015, 59, 1942–1953.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 1942-1953
    • Mosele, J.I.1    Gosalbes, M.J.2    Macià, A.3    Rubió, L.4
  • 10
    • 84927665991 scopus 로고    scopus 로고
    • Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients
    • Banihani, S. A., Makahleh, S. M., El-Akawi, Z., Al-Fashtaki, R. A. et al., Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutr. Res. 2014, 34, 862–867.
    • (2014) Nutr. Res. , vol.34 , pp. 862-867
    • Banihani, S.A.1    Makahleh, S.M.2    El-Akawi, Z.3    Al-Fashtaki, R.A.4
  • 11
    • 84958213085 scopus 로고    scopus 로고
    • Effects of concentrated pomegranate juice on subclinical inflammation and cardiometabolic risk factors for type 2 diabetes: a quasi-experimental study
    • Shishehbor, F., Mohammad Shahi, M., Zarei, M., Saki, A. et al., Effects of concentrated pomegranate juice on subclinical inflammation and cardiometabolic risk factors for type 2 diabetes: a quasi-experimental study. Int. J. Endocrinol. Metab. 2016, 14:e33835.
    • (2016) Int. J. Endocrinol. Metab. , vol.14
    • Shishehbor, F.1    Mohammad Shahi, M.2    Zarei, M.3    Saki, A.4
  • 12
    • 85015160939 scopus 로고    scopus 로고
    • Pomegranate juice consumption decrease blood lipid peroxidation and level of arachidonic acid in women with metabolic syndrome
    • Kojadinovic, M. I., Arsic, A. C., Debeljak-Martacic, J. D., Konic-Ristic, A. I. et al., Pomegranate juice consumption decrease blood lipid peroxidation and level of arachidonic acid in women with metabolic syndrome. J. Sci. Food Agric. 2016, doi: 10.1002/jsfa.7977.
    • (2016) J. Sci. Food Agric.
    • Kojadinovic, M.I.1    Arsic, A.C.2    Debeljak-Martacic, J.D.3    Konic-Ristic, A.I.4
  • 13
    • 84982227970 scopus 로고    scopus 로고
    • Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials
    • Sahebkar, A., Simental-Mendía, L. E., Giorgini, P., Ferri, C. et al., Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials. Phytomedicine 2016, 23, 1103–1112.
    • (2016) Phytomedicine , vol.23 , pp. 1103-1112
    • Sahebkar, A.1    Simental-Mendía, L.E.2    Giorgini, P.3    Ferri, C.4
  • 14
    • 84874959821 scopus 로고    scopus 로고
    • Gut metabotypes govern health effects of dietary polyphenols
    • Bolca, S., Van de Wiele, T., Possemiers, S., Gut metabotypes govern health effects of dietary polyphenols. Curr. Opin. Biotechnol. 2013, 24, 220–225.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 220-225
    • Bolca, S.1    Van de Wiele, T.2    Possemiers, S.3
  • 15
    • 84904437984 scopus 로고    scopus 로고
    • Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status
    • Tomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V. et al., Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. J. Agric. Food Chem. 2014, 62, 6535–6538.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 6535-6538
    • Tomás-Barberán, F.A.1    García-Villalba, R.2    González-Sarrías, A.3    Selma, M.V.4
  • 16
    • 85003674360 scopus 로고    scopus 로고
    • Addressing the inter-individual variation in response to consumption of plant food bioactives—towards a better understanding of their role in healthy ageing and cardiometabolic risk reduction
    • Manach, C., Milenkovic, D., Van de Wiele, T., Rodríguez-Mateos, A. et al., Addressing the inter-individual variation in response to consumption of plant food bioactives—towards a better understanding of their role in healthy ageing and cardiometabolic risk reduction. Mol. Nutr. Food Res. 2016, doi: 10.1002/mnfr.201600557.
    • (2016) Mol. Nutr. Food Res.
    • Manach, C.1    Milenkovic, D.2    Van de Wiele, T.3    Rodríguez-Mateos, A.4
  • 17
    • 84977563497 scopus 로고    scopus 로고
    • Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status
    • Tomás-Barberán, F. A., González-Sarrías, A., García-Villalba, R., Núñez-Sánchez, M. A. et al., Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status. Mol. Nutr. Food Res. 2016, doi: 10.1002/mnfr.201500901.
    • (2016) Mol. Nutr. Food Res.
    • Tomás-Barberán, F.A.1    González-Sarrías, A.2    García-Villalba, R.3    Núñez-Sánchez, M.A.4
  • 18
    • 84966393306 scopus 로고    scopus 로고
    • The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism
    • Selma, M. V., Romo-Vaquero, M., García-Villalba, R., González-Sarrías, A. et al., The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food Funct. 2016, 7, 1769–1774.
    • (2016) Food Funct. , vol.7 , pp. 1769-1774
    • Selma, M.V.1    Romo-Vaquero, M.2    García-Villalba, R.3    González-Sarrías, A.4
  • 19
    • 84959858829 scopus 로고    scopus 로고
    • Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid
    • García-Villalba, R., Espín, J. C., Tomás-Barberán, F. A., Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid. J. Chromatogr. A. 2016, 1428, 162–175.
    • (2016) J. Chromatogr. A. , vol.1428 , pp. 162-175
    • García-Villalba, R.1    Espín, J.C.2    Tomás-Barberán, F.A.3
  • 20
    • 84938323859 scopus 로고    scopus 로고
    • Validated method for the characterization and quantification of extractable and nonextractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts
    • García-Villalba, R., Espín, J. C., Aaby, K., Alasalvar, C. et al., Validated method for the characterization and quantification of extractable and nonextractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts. J. Agric. Food Chem. 2015, 63,6555–6566.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 6555-6566
    • García-Villalba, R.1    Espín, J.C.2    Aaby, K.3    Alasalvar, C.4
  • 21
    • 77249122543 scopus 로고    scopus 로고
    • Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL
    • De la Torre-Carbot, K., Chávez-Servín, J. L., Jaúregui, O., Castellote, A. I. et al., Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J. Nutr. 2010, 140, 501–508.
    • (2010) J. Nutr. , vol.140 , pp. 501-508
    • De la Torre-Carbot, K.1    Chávez-Servín, J.L.2    Jaúregui, O.3    Castellote, A.I.4
  • 22
    • 84871435182 scopus 로고    scopus 로고
    • Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach
    • Nieman, D.C., Cialdella-Kam, L., Knab, A. M., Shanely, R. A., Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach. Plant Foods Hum. Nutr. 2012, 67, 415–421.
    • (2012) Plant Foods Hum. Nutr. , vol.67 , pp. 415-421
    • Nieman, D.C.1    Cialdella-Kam, L.2    Knab, A.M.3    Shanely, R.A.4
  • 23
    • 84861697559 scopus 로고    scopus 로고
    • Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial
    • Tomé-Carneiro, J., Gonzálvez, M., Larrosa, M., García-Almagro, F. J. et al., Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol. Nutr. Food Res. 2012, 56, 810–821.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 810-821
    • Tomé-Carneiro, J.1    Gonzálvez, M.2    Larrosa, M.3    García-Almagro, F.J.4
  • 24
    • 70449346889 scopus 로고    scopus 로고
    • Macronutrient intakes and cardio metabolic risk factors in high BMI African American children
    • Sharma, S., Roberts, L. S., Hudes, M. L., Lustig, R. H. et al., Macronutrient intakes and cardio metabolic risk factors in high BMI African American children. Nutr. Metab. 2009, 6, 1–8.
    • (2009) Nutr. Metab. , vol.6 , pp. 1-8
    • Sharma, S.1    Roberts, L.S.2    Hudes, M.L.3    Lustig, R.H.4
  • 25
    • 0037446467 scopus 로고    scopus 로고
    • Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    • Vega, G. L., Ma, P. T. S., Cater, N. B., Filipchuk, N. et al., Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am. J. Cardiol. 2003, 91, 956–960.
    • (2003) Am. J. Cardiol. , vol.91 , pp. 956-960
    • Vega, G.L.1    Ma, P.T.S.2    Cater, N.B.3    Filipchuk, N.4
  • 26
    • 65549150087 scopus 로고    scopus 로고
    • Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR
    • Furet, J. P., Firmesse, O., Gourmelon, M., Bridonneau, C. et al., Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR. FEMS Microbiol. Ecol. 2009, 68, 451–462.
    • (2009) FEMS Microbiol. Ecol. , vol.68 , pp. 451-462
    • Furet, J.P.1    Firmesse, O.2    Gourmelon, M.3    Bridonneau, C.4
  • 27
    • 84938848667 scopus 로고    scopus 로고
    • Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production
    • Romo-Vaquero, M., García-Villalba, R., González-Sarrías, A., Beltrán, D., Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production. J. Funct. Foods 2015, 17, 785–791.
    • (2015) J. Funct. Foods , vol.17 , pp. 785-791
    • Romo-Vaquero, M.1    García-Villalba, R.2    González-Sarrías, A.3    Beltrán, D.4
  • 28
    • 84928789447 scopus 로고    scopus 로고
    • Personalized medicine: time for one-person trials
    • Schork, N. J., Personalized medicine: time for one-person trials. Nature 2015, 520, 609–611.
    • (2015) Nature , vol.520 , pp. 609-611
    • Schork, N.J.1
  • 31
    • 84885188985 scopus 로고    scopus 로고
    • miRNA as molecular target of polyphenols underlying their biological effects
    • Milenkovic, D., Jude, B., Morand, C., miRNA as molecular target of polyphenols underlying their biological effects. Free Radic. Biol. Med. 2013, 64, 40–51.
    • (2013) Free Radic. Biol. Med. , vol.64 , pp. 40-51
    • Milenkovic, D.1    Jude, B.2    Morand, C.3
  • 32
    • 84977622019 scopus 로고    scopus 로고
    • Diet-microbiota interactions as moderators of human metabolism
    • Sonnenburg, J. L., Bäckhed, F., Diet-microbiota interactions as moderators of human metabolism. Nature. 2016, 535, 56–64.
    • (2016) Nature. , vol.535 , pp. 56-64
    • Sonnenburg, J.L.1    Bäckhed, F.2
  • 33
    • 84982860470 scopus 로고    scopus 로고
    • Interactions of gut microbiota with dietary polyphenols and consequences to human health
    • Tomás-Barberán, F. A., Selma, M. V., Espín, J. C., Interactions of gut microbiota with dietary polyphenols and consequences to human health. Curr. Opin. Clin. Nutr. Metab. Care 2016, doi:10.1097/MCO.0000000000000314.
    • (2016) Curr. Opin. Clin. Nutr. Metab. Care
    • Tomás-Barberán, F.A.1    Selma, M.V.2    Espín, J.C.3
  • 34
    • 85027935272 scopus 로고    scopus 로고
    • At the interface of antioxidant signalling and cellular function: key polyphenol effects
    • Kerimi, A., Williamson, G., At the interface of antioxidant signalling and cellular function: key polyphenol effects. Mol. Nutr. Food Res. 2016, 60, 1770–1788.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 1770-1788
    • Kerimi, A.1    Williamson, G.2
  • 36
    • 84934444773 scopus 로고    scopus 로고
    • Dietary phenolics against colorectal cancer—from promising preclinical results to poor translation into clinical trials: pitfalls and future needs
    • Núñez-Sánchez, M. A., González-Sarrías, A., Romo-Vaquero, M., García-Villalba, R. et al., Dietary phenolics against colorectal cancer—from promising preclinical results to poor translation into clinical trials: pitfalls and future needs. Mol. Nutr. Food Res. 2015, 59, 1274–1291.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 1274-1291
    • Núñez-Sánchez, M.A.1    González-Sarrías, A.2    Romo-Vaquero, M.3    García-Villalba, R.4
  • 37
    • 84922706350 scopus 로고    scopus 로고
    • Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial
    • Ye, Y. B., Chen, A. L., Lu, W., Zhuo, S. Y. et al., Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial. Mol. Nutr. Food Res. 2015, 59, 240–249.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 240-249
    • Ye, Y.B.1    Chen, A.L.2    Lu, W.3    Zhuo, S.Y.4
  • 39
    • 84959925870 scopus 로고    scopus 로고
    • Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
    • Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M. et al., Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial. Am. J. Clin. Nutr. 2016, 103, 694–702.
    • (2016) Am. J. Clin. Nutr. , vol.103 , pp. 694-702
    • Hazim, S.1    Curtis, P.J.2    Schär, M.Y.3    Ostertag, L.M.4
  • 40
    • 68249114506 scopus 로고    scopus 로고
    • Interaction between phenolics and gut microbiota: role in human health
    • Selma, M. V., Espín, J. C., Tomás-Barberán, F. A., Interaction between phenolics and gut microbiota: role in human health. J. Agric. Food Chem. 2009, 57, 6485–6501.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 6485-6501
    • Selma, M.V.1    Espín, J.C.2    Tomás-Barberán, F.A.3
  • 41
    • 85072403432 scopus 로고    scopus 로고
    • Scientific Opinion on the substantiation of health claims related to pomegranate/pomegranate juice and maintenance of normal blood cholesterol concentrations (ID 1162, 1320, 2107, 2167), maintenance of normal erectile function (ID 1163), protection of lipids from oxidative damage (ID 1201, 1319, 2123), “antioxidant and anti-aging properties” (ID 1901), increase in appetite after unintentional weight loss leading to an increase in energy intake (ID 2122) and maintenance of normal blood glucose concentrations (ID 4471) pursuant to Article 13of Regulation (EC) No 1924/2006., EFSA J, 2010,, 8, 1750 []
    • EFSA. Scientific Opinion on the substantiation of health claims related to pomegranate/pomegranate juice and maintenance of normal blood cholesterol concentrations (ID 1162, 1320, 2107, 2167), maintenance of normal erectile function (ID 1163), protection of lipids from oxidative damage (ID 1201, 1319, 2123), “antioxidant and anti-aging properties” (ID 1901), increase in appetite after unintentional weight loss leading to an increase in energy intake (ID 2122) and maintenance of normal blood glucose concentrations (ID 4471) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J., 2010, 8, 1750 [22 pp.].
    • , Issue.1
  • 42
    • 85078388055 scopus 로고    scopus 로고
    • Scientific opinion on the substantiation of a health claim related to a combination of pomegranate pomace extract and greater galangal rhizome powder and an increase in the number of motile spermatozoa in semen pursuant to Article 13of Regulation (EC) No 1924/2006., EFSA J, 2015,, 13, 4097 []
    • EFSA. Scientific opinion on the substantiation of a health claim related to a combination of pomegranate pomace extract and greater galangal rhizome powder and an increase in the number of motile spermatozoa in semen pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA J., 2015, 13, 4097 [16 pp.].
    • , Issue.5
  • 43
    • 79953163759 scopus 로고    scopus 로고
    • Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    • Emerging Risk Factors Collaboration, Wormser, D., Kaptoge, S., Di Angelantonio, E. et al., Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 2011, 377, 1085–1095.
    • (2011) Lancet , vol.377 , pp. 1085-1095
    • Wormser, D.1    Kaptoge, S.2    Di Angelantonio, E.3
  • 44
    • 85007566482 scopus 로고    scopus 로고
    • Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes
    • Frankenfeld, C. L., Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes. Mol. Nutr. Food Res 2016, doi: 10.1002/mnfr.201500900.
    • (2016) Mol. Nutr. Food Res
    • Frankenfeld, C.L.1
  • 45
    • 84980316457 scopus 로고    scopus 로고
    • Metabolomics reveals differences between three daidzein metabolizing phenotypes in adults with cardiometabolic risk factors
    • Reverri, E. J., Slupsky, C. M., Mishchuk, D. O., Steinberg, F. M., Metabolomics reveals differences between three daidzein metabolizing phenotypes in adults with cardiometabolic risk factors. Mol. Nutr. Food Res. 2016, doi: 10.1002/mnfr.201600132.
    • (2016) Mol. Nutr. Food Res.
    • Reverri, E.J.1    Slupsky, C.M.2    Mishchuk, D.O.3    Steinberg, F.M.4
  • 46
    • 12344282206 scopus 로고    scopus 로고
    • Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability
    • Cerdá, B., Tomás-Barberán, F. A., Espín, J. C., Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227–235.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 227-235
    • Cerdá, B.1    Tomás-Barberán, F.A.2    Espín, J.C.3
  • 47
    • 77954657360 scopus 로고    scopus 로고
    • Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
    • Larrosa, M., González-Sarrías, A., Yáñez-Gascón, M. J., Selma, M. V. et al., Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J. Nutr. Biochem. 2010, 21, 717–725.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 717-725
    • Larrosa, M.1    González-Sarrías, A.2    Yáñez-Gascón, M.J.3    Selma, M.V.4
  • 48
    • 80052596190 scopus 로고    scopus 로고
    • In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A
    • Ishimoto, H., Shibata, M., Myojin, Y., Ito, H. et al., In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg. Med. Chem. Lett. 2011, 21, 5901–5904.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5901-5904
    • Ishimoto, H.1    Shibata, M.2    Myojin, Y.3    Ito, H.4
  • 49
    • 84978136448 scopus 로고    scopus 로고
    • Urolithin A induces mitophagy and prolongs lifespan in Celegans and increases muscle function in rodents
    • Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E. et al., Urolithin A induces mitophagy and prolongs lifespan in Celegans and increases muscle function in rodents. Nat. Med. 2016, 22, 879–888.
    • (2016) Nat. Med. , vol.22 , pp. 879-888
    • Ryu, D.1    Mouchiroud, L.2    Andreux, P.A.3    Katsyuba, E.4
  • 50
    • 84942834606 scopus 로고    scopus 로고
    • MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts
    • Nuñez-Sánchez, M.A., Dávalos, A., González-Sarrías, A., Casas-Agustench, P. et al., MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts. Mol. Nutr. Food Res. 2015, 59, 1973—1986.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 1973-1986
    • Nuñez-Sánchez, M.A.1    Dávalos, A.2    González-Sarrías, A.3    Casas-Agustench, P.4
  • 51
    • 77953122894 scopus 로고    scopus 로고
    • The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota
    • Bialonska, D., Ramnani, P., Kasimsetty, S. G., Muntha, K. R. et al., The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int. J. Food Microbiol. 2010, 140, 175–182.
    • (2010) Int. J. Food Microbiol. , vol.140 , pp. 175-182
    • Bialonska, D.1    Ramnani, P.2    Kasimsetty, S.G.3    Muntha, K.R.4
  • 52
    • 84938782551 scopus 로고    scopus 로고
    • Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers
    • Li, Z., Henning, S. M., Lee, R. P., Lu, Q. Y. et al., Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct. 2015, 6, 2487–2495.
    • (2015) Food Funct. , vol.6 , pp. 2487-2495
    • Li, Z.1    Henning, S.M.2    Lee, R.P.3    Lu, Q.Y.4
  • 53
    • 0036877706 scopus 로고    scopus 로고
    • Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study)
    • Sigurdardottir, V., Fagerberg, B., Hulthe, J., Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study). J. Intern. Med. 2002, 252, 440–447.
    • (2002) J. Intern. Med. , vol.252 , pp. 440-447
    • Sigurdardottir, V.1    Fagerberg, B.2    Hulthe, J.3


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