Phosphorylated nuclear receptor CAR forms a homodimer to repress its constitutive activity for ligand activation

Molecular and Cellular Biology

Volumn 37, Issue 10, 2017, Pages

  Shizu, Ryota ^a,b   Osabe, Makoto ^a,b,c   Perera, Lalith ^a,b   Moore, Rick ^a,b   Sueyoshi, Tatsuya ^a,b   Negishi, Masahiko ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Cell signaling; CITCO; Constitutive androstane receptor; Homodimer; Nuclear receptors; Phenobarbital; Protein phosphorylation

Indexed keywords

CELL NUCLEUS RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HOMODIMER; LIGAND; NUCLEAR RECEPTOR CAR; PHENOBARBITAL; PHOSPHOPROTEIN PHOSPHATASE 2A; RECEPTOR; RECEPTOR FOR PROTEIN KINASE 1; UNCLASSIFIED DRUG; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; GNB2-RS1 PROTEIN, MOUSE; NEUROPEPTIDE; PHOSPHOPROTEIN PHOSPHATASE 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; LIVER CELL; LIVER TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MULTIMERIZATION; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEUROPEPTIDES; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN PHOSPHATASE 2; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 85018965136     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00649-16     Document Type: Article

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