Phosphorylation of farnesoid X receptor at serine 154 links ligand activation with degradation

Molecular Endocrinology

Volumn 30, Issue 10, 2016, Pages 1070-1080

  Hashiguchi, Takuyu ^a   Arakawa, Shingo ^a   Takahashi, Shogo ^b   Gonzalez, Frank J ^b   Sueyoshi, Tatsuya ^a   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ACTIVATION FUNCTION 1 PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; COMPLEMENTARY DNA; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; GLUTATHIONE TRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIGAND; LIVER EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN; PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE SHP; RETINOID RELATED ORPHAN RECEPTOR ALPHA; SERINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VACCINIA RELATED KINASE 1; AMINO ACID; CELL RECEPTOR; DNA BINDING PROTEIN; FARNESOID X-ACTIVATED RECEPTOR; PROTEASOME; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; COS 1 CELL LINE; CYTOSOLIC FRACTION; DNA MICROARRAY; ECTOPIC EXPRESSION; GEL MOBILITY SHIFT ASSAY; GENE MUTATION; GENE SILENCING; HINGE REGION; IMMUNOPRECIPITATION; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSACTIVATION; TRANSIENT EXPRESSION; UBIQUITINATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

AMINO ACID MOTIFS; AMINO ACIDS; ANIMALS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; GENES, REPORTER; HEPATOCYTES; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SERINE;

EID: 84990046749     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2016-1105     Document Type: Article

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