Social defeat models in animal science: What we have learned from rodent models

Animal Science Journal

Volumn 88, Issue 7, 2017, Pages 944-952

  Toyoda, Atsushi ^a,b  

^a IBARAKI UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

depression; feed; metabolome; social defeat

Indexed keywords

ANIMAL; ANIMAL BEHAVIOR; ANIMAL WELFARE; C57BL MOUSE; DISEASE MODEL; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGY; SOCIAL ALIENATION;

ANIMAL WELFARE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; HUMANS; MICE, INBRED C57BL; MICE, INBRED ICR; SOCIAL ALIENATION; STRESS, PSYCHOLOGICAL;

EID: 85018758022     PISSN: 13443941     EISSN: 17400929     Source Type: Journal    
DOI: 10.1111/asj.12809     Document Type: Review

References (70)

1. Altamura C, Maes M, Dai J, Meltzer HY. 1995. Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. European Neuropsychopharmacology 5(Suppl), 71–75.
2. American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders (DSM-5®), 5th edn. American Psychiatric Association, Arlington, VA.
3. Aoki-Yoshida A, Aoki R, Moriya N, Goto T, Kubota Y, Toyoda A, et al. 2016. Omics studies of the murine intestinal ecosystem exposed to subchronic and mild social defeat stress. Journal of Proteome Research 15, 3126–3138.
4. Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, et al. 2015. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature Communications 6, 7062.
5. Carrillo JA, He Y, Li Y, Liu J, Erdman RA, Sonstegard TS, et al. 2016. Integrated metabolomic and transcriptome analyses reveal finishing forage affects metabolic pathways related to beef quality and animal welfare. Scientific Reports 6, 25948.
6. Carter PA, Swallow JG, Davis SJ, Garland T. 2000. Nesting behavior of house mice (Mus domesticus) selected for increased wheel-running activity. Behavior Genetics 30, 85–94.
7. Cryan JF, Holmes A. 2005. The ascent of mouse: advances in modelling human depression and anxiety. Nature Reviews Drug Discovery 4, 775–790.
8. Cryan JF, Mombereau C. 2004. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Molecular Psychiatry 9, 326–357.
9. Deacon RM, Croucher A, Rawlins JN. 2002. Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behavioural Brain Research 132, 203–213.
10. Deacon RM, Penny C, Rawlins JN. 2003. Effects of medial prefrontal cortex cytotoxic lesions in mice. Behavioural Brain Research 139, 139–155.
11. Desire S, Turner SP, D'Eath RB, Doeschl-Wilson AB, Lewis CR, Roehe R. 2015. Genetic associations of short- and long-term aggressiveness identified by skin lesion with growth, feed efficiency, and carcass characteristics in growing pigs. Journal of Animal Science 93, 3303–3312.
12. DeWilde KE, Levitch CF, Murrough JW, Mathew SJ, Iosifescu DV. 2015. The promise of ketamine for treatment-resistant depression: current evidence and future directions. Annals of the New York Academy of Sciences 1345, 47–58.
13. Dhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, et al. 2014. 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiology of Disease 67, 18–23.
14. Filali M, Lalonde R. 2009. Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Research 1292, 93–99.
15. Fritsche E, Humm A, Huber R. 1999. The ligand-induced structural changes of human l-Arginine: glycine amidinotransferase. A mutational and crystallographic study. The Journal of Biological Chemistry 274, 3026–3032.
16. Golden SA, Covington HE, Berton O, Russo SJ. 2011. A standardized protocol for repeated social defeat stress in mice. Nature Protocols 6, 1183–1191.
17. Golden SA, Christoffel DJ, Heshmati M, Hodes GE, Magida J, Davis K, et al. 2013. Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nature Medicine 19, 337–344.
18. Goto T, Toyoda A. 2015a. A mouse model of subchronic and mild social defeat stress for understanding stress-induced behavioral and physiological deficits. Journal of Visualized Experiments 105, e52973.
19. Goto T, Kubota Y, Tanaka Y, Iio W, Moriya N, Toyoda A. 2014. Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice. Behavioural Brain Research 270, 339–348.
20. Goto T, Kubota Y, Toyoda A. 2015b. Plasma and liver metabolic profiles in mice subjected to subchronic and mild social defeat stress. Journal of Proteome Research 14, 1025–1032.
21. Goto T, Kubota Y, Toyoda A. 2016a. Effects of diet quality on vulnerability to mild subchronic social defeat stress in mice. Nutritional Neuroscience 19, 284–289.
22. Goto T, Tomonaga S, Okayama T, Toyoda A. 2016b. Murine depression model and its potential applications for discovering foods and farm products with antidepressant-like effects. Frontiers in Neuroscience 10, 72.
23. Grandin T, Shivley C. 2015. How farm animals react and perceive stressful situations such as handling, restraint, and transport. Animals (Basel) 5, 1233–1251.
24. Heller HC, Salehi A, Chuluun B, Das D, Lin B, Moghadam S, et al. 2014. Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors. Neurobiology of Learning and Memory 116, 162–171.
25. Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffel DJ, Bregman D, et al. 2014. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proceedings of the National Academy of Sciences of the United States of America 111, 16136–13141.
26. Iio W, Matsukawa N, Tsukahara T, Kohari D, Toyoda A. 2011. Effects of chronic social defeat stress on MAP kinase cascade. Neuroscience Letters 504, 281–284.
27. Iio W, Tokutake Y, Matsukawa N, Tsukahara T, Chohnan S, Toyoda A. 2012a. Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats. Biochemical and Biophysical Research Communications 421, 301–304.
28. Iio W, Matsukawa N, Tsukahara T, Toyoda A. 2012b. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids 43, 2037–2046.
29. Iio W, Takagi H, Ogawa Y, Tsukahara T, Chohnan S, Toyoda A. 2014. Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions. BMC Neuroscience 15, 72.
30. Iñiguez SD, Riggs LM, Nieto SJ, Dayrit G, Zamora NN, Shawhan KL, et al. 2014. Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice. Stress 17, 247–255.
31. Kasahara T, Takata A, Kato TM, Kubota-Sakashita M, Sawada T, Kakita A, et al. 2016. Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus. Molecular Psychiatry 21, 39–48.
32. Kinder EF. 1927. A study of the nest-building activity of the albino rat. Journal of Experimental Zoology 47, 117–161.
33. Kolb B. 1984. Functions of the frontal cortex of the rat: a comparative review. Brain Research 320, 65–98.
34. Koyama N, Ueno Y, Eguchi Y, Uetake K, Tanaka T. 2012. Effects of daily management changes on behavioral patterns of a solitary female African elephant (Loxodonta africana) in a zoo. Animal Science Journal 83, 562–570.
35. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, et al. 2007. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391–404.
36. Lane MD, Wolfgang M, Cha SH, Dai Y. 2008. Regulation of food intake and energy expenditure by hypothalamic malonyl-CoA. International Journal of Obesity (London) 32(Suppl 4), S49–S54.
37. Lang UE, Beglinger C, Schweinfurth N, Walter M, Borgwardt S. 2015. Nutritional aspects of depression. Cellular Physiology and Biochemistry 37, 1029–1043.
38. Lutter M, Nestler EJ. 2009. Homeostatic and hedonic signals interact in the regulation of food intake. Journal of Nutrition 139, 629–632.
39. Marcinkiewicz J, Kontny E. 2014. Taurine and inflammatory diseases. Amino Acids 46, 7–20.
40. McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP. 2016. Neuroinflammatory dynamics underlie memory impairments after repeated social defeat. Journal of Neuroscience 36, 2590–2604.
41. Mechawar N, Savitz J. 2016. Neuropathology of mood disorders: do we see the stigmata of inflammation? Translational Psychiatry 6, e946.
42. Miczek KA. 1979. A new test for aggression in rats without aversive stimulation: differential effects of d-amphetamine and cocaine. Psychopharmacology – Berlin 60, 253–259.
43. Murakami T, Furuse M. 2010. The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects. Amino Acids 39, 427–434.
44. Nanavati SM, Silverman RB. 1989. Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators. Journal of Medicinal Chemistry 32, 2413–2421.
45. Nestler EJ, Hyman SE. 2010. Animal models of neuropsychiatric disorders. Nature Neuroscience 13, 1161–1169.
46. Okayama T, Goto T, Toyoda A. 2015. Assessing nest-building behavior of mice using a 3D depth camera. Journal of Neuroscience Methods 251, 151–157.
47. Oliveira RF, Simões JM, Teles MC, Oliveira CR, Becker JD, Lopes JS. 2016. Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain. Proceedings of the National Academy of Sciences of the United States of America 113, E654–E661.
48. Otabi H, Goto T, Okayama T, Kohari D, Toyoda A. 2016. Subchronic and mild social defeat stress alter mouse nest building behavior. Behavioural Processes 122, 21–25.
49. Otabi H, Goto T, Okayama T, Kohari D, Toyoda A. 2017. The acute social defeat stress and nest-building test paradigm: a potential new method to screen drugs for depressive-like symptoms. Behavioural Processes 135, 71–75.
50. Penn JK, Zito MF, Kravitz EA. 2010. A single social defeat reduces aggression in a highly aggressive strain of Drosophila. Proceedings of the National Academy of Sciences of the United States of America 107, 12682–12686.
51. Porsolt RD, Le Pichon M, Jalfre M. 1977. Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730–732.
52. Potegal M, Huhman K, Moore T, Meyerhoff J. 1993. Conditioned defeat in the Syrian golden hamster (Mesocricetus auratus). Behavioral and Neural Biology 60, 93–102.
53. Rillich J, Stevenson PA. 2014. A fighter's comeback: dopamine is necessary for recovery of aggression after social defeat in crickets. Hormones and Behavior 66, 696–704.
54. Ruis MA, de Groot J, te Brake JH, Dinand Ekkel E, van de Burgwal JA, Erkens JH, et al. 2001. Behavioural and physiological consequences of acute social defeat in growing gilts: effects of the social environment. Applied Animal Behaviour Science 70, 201–225.
55. Rygula R, Abumaria N, Flügge G, Fuchs E, Rüther E, Havemann-Reinecke U. 2005. Anhedonia and motivational deficits in rats: impact of chronic social stress. Behavioural Brain Research 162, 127–134.
56. Savignac HM, Finger BC, Pizzo RC, O'Leary OF, Dinan TG, Cryan JF. 2011. Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain. Neuroscience 192, 524–536.
57. Schmidt M, Oitzl MS, Levine S, de Kloet ER. 2002. The HPA system during the postnatal development of CD1 mice, the effects of maternal deprivation. Brain Research Developmental Brain Research 139, 39–49.
58. Schubring SR, Fleischer W, Lin JS, Haas HL, Sergeeva OA. 2012. The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABA(A) receptors. Neuroscience Letters 506, 322–326.
59. Selye H. 1956. The Stress of Life. McGraw-Hill, New York, USA.
60. Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE. 1999. Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Science 65, 1773–1786.
61. Sial OK, Warren BL, Alcantara LF, Parise EM, Bolaños-Guzmán CA. 2016. Vicarious social defeat stress: bridging the gap between physical and emotional stress. Journal of Neuroscience Methods 258, 94–103.
62. Solomon MB. 2017. Evaluating social defeat as a model for psychopathology in adult female rodents. Journal of Neuroscience Research 95, 763–776.
63. Steru L, Chermat R, Thierry B, Simon P. 1985. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology – Berlin 85, 367–370.
64. Stilling RM, van de Wouw M, Clarke G, Stanton C, Dinan TG, Cryan JF. 2016. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis? Neurochemistry International 99, 110–132.
65. Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, et al. 2013. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38, 1409–1425.
66. Tasaka J, Sakai S, Tosaka T, Yoshihama I. 1989. Glial uptake system of GABA distinct from that of taurine in the bullfrog sympathetic ganglia. Neurochemical Research 14, 271–277.
67. Van de Weerd HA, Van Loo PL, Van Zutphen LF, Koolhaas JM, Baumans V. 1997. Preferences for nesting material as environmental enrichment for laboratory mice. Laboratory Animals 31, 133–143.
68. Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, et al. 1996. Cross-national epidemiology of major depression and bipolar disorder. Journal of the American Medical Association 276, 293–299.
69. Willner P. 2005. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52, 90–110.
70. Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, et al. 2016. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Scientific Reports 6, 30659.