5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy

Neurobiology of Disease

Volumn 67, Issue , 2014, Pages 18-23

  Dhaher, Roni ^a   Damisah, Eyiyemisi C ^a   Wang, Helen ^a   Gruenbaum, Shaun E ^a   Ong, Caroline ^a   Zaveri, Hitten P ^a   Gruenbaum, Benjamin F ^a   Eid, Tore ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; Epileptogenesis; GABA; Gliosis; Glutamate; Glutamine; Glutamine synthetase; Hippocampus

Indexed keywords

5 AMINOVALERIC ACID; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; METHIONINE SULFOXIMINE; 5-AMINOVALERIC ACID; AMINO ACID;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ASTROCYTE; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; ENZYME INACTIVATION; EPILEPTOGENESIS; GABAERGIC SYSTEM; HIPPOCAMPUS; MALE; MESIAL TEMPORAL LOBE EPILEPSY; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; ANIMAL; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; EPILEPSY, TEMPORAL LOBE; PATHOPHYSIOLOGY; SEIZURES; SPRAGUE DAWLEY RAT;

AMINO ACIDS, NEUTRAL; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; MALE; METHIONINE SULFOXIMINE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 84897078527     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.03.006     Document Type: Article

References (34)

1. Albrecht J., Jones E.A. Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome. J. Neurol. Sci. 1999, 170:138-146.
2. Allan R.D., Dickenson H.W. Evidence that antagonism by delta-aminovaleric acid of GABAB receptors in the guinea-pig ileum may be due to an interaction between GABAA and GABAB receptors. Eur. J. Pharmacol. 1986, 120:119-122.
3. Annegers J.F., et al. Causes of epilepsy: contributions of the Rochester epidemiology project. Mayo Clin. Proc. 1996, 71:570-575.
4. Avoli M., Gloor P. Pathophysiology of focal and generalized convulsive seizures versus that of generalized non-convulsive seizures. Epileptic Seizures and Syndromes 1994, 547-561. John Libby Eurotext Ltd., Montrouge, France. P. Wolf (Ed.).
5. Bertram E.H., et al. Design and construction of a long-term continuous video-EEG monitoring unit for simultaneous recording of multiple small animals. Brain Res. Brain Res. Protocol. 1997, 2:85-97.
6. Cohen I., et al. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 2002, 298:1418-1421.
7. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 2001, 65:1-105.
8. Dudek F.E., Staley K.J. The time course and circuit mechanisms of acquired epileptogenesis. Jasper's Basic Mechanisms of the Epilepsies, Bethesda (MD) 2012, J.L. Noebels (Ed.).
9. Eid T., et al. Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet 2004, 363:28-37.
10. Fritsche E., et al. The ligand-induced structural changes of human l-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. J. Biol. Chem. 1999, 274:3026-3032.
11. Gastaut H. Clinical and electroencephalographical classification of epileptic seizures. Epilepsia 1970, 11:102-113.
12. Hauser W.A., et al. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia 1991, 32:429-445.
13. Holopainen I., et al. Proposed antagonists at GABAB receptors that inhibit adenylyl cyclase in cerebellar granule cell cultures of rat. Eur. J. Pharmacol. 1992, 227:225-228.
14. Hwang A.S., Wilcox G.L. Baclofen, gamma-aminobutyric acidB receptors and substance P in the mouse spinal cord. J. Pharmacol. Exp. Ther. 1989, 248:1026-1033.
15. Manocha A., et al. Possible mechanism of anticonvulsant effect of ketamine in mice. Indian J. Exp. Biol. 2001, 39:1002-1008.
16. Manocha A., et al. Studies on the anticonvulsant effect of U50488H on maximal electroshock seizure in mice. Pharmacol. Biochem. Behav. 2003, 76:111-117.
17. Manocha A., et al. Possible mechanism involved in the anticonvulsant action of butorphanol in mice. Pharmacol. Biochem. Behav. 2003, 74:343-350.
18. Manocha A., et al. On the mechanism of anticonvulsant effect of tramadol in mice. Pharmacol. Biochem. Behav. 2005, 82:74-81.
19. Martinez-Hernandez A., et al. Glutamine synthetase: glial localization in brain. Science 1977, 195:1356-1358.
20. Muhyaddin M., et al. Presynaptic gamma-aminobutyric acid receptors in the rat anococcygeus muscle and their antagonism by 5-aminovaleric acid. Br. J. Pharmacol. 1982, 77:163-168.
21. Nagao T., et al. Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. Neurosci. Lett. 1994, 174:160-164.
22. Nanavati S.M., Silverman R.B. Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators. J. Med. Chem. 1989, 32:2413-2421.
23. Otis T.S., Jahr C.E. Anion currents and predicted glutamate flux through a neuronal glutamate transporter. J. Neurosci. 1998, 18:7099-7110.
24. Petroff O.A., et al. Glutamate-glutamine cycling in the epileptic human hippocampus. Epilepsia 2002, 43:703-710.
25. Racine R.J., et al. Rates of motor seizure development in rats subjected to electrical brain stimulation: strain and inter-stimulation interval effects. Electroencephalogr. Clin. Neurophysiol. 1973, 35:553-556.
26. Robinson T.N., et al. Effects of the putative antagonists phaclofen and delta-aminovaleric acid on GABAB receptor biochemistry. Br. J. Pharmacol. 1989, 98:833-840.
27. Samuels S., et al. Anticonvulsant activity of glycylglycine and delta-aminovaleric acid: evidence for glutamine exchange in amino acid transport. J. Neurochem. 1983, 40:1063-1068.
28. Santicioli P., et al. The postganglionic excitatory innervation of the mouse urinary bladder and its modulation by prejunctional GABAB receptors. J. Auton. Pharmacol. 1986, 6:53-66.
29. Sawynok J. Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum. Neuropharmacology 1986, 25:795-798.
30. 2+]i in rat brain synaptosomes. Neuropharmacology 1989, 28:699-704.
31. Sutula T.P., Ockuly J. Kindling, spontaneous seizures, and the consequences of epilepsy: more than a model. Models of Seizures and Epilepsy 2006, 395-406. Elsevier Academic Press, Burlington, MA San Diego, CA London. A. Pitkanen (Ed.).
32. Tasaka J., et al. Glial uptake system of GABA distinct from that of taurine in the bullfrog sympathetic ganglia. Neurochem. Res. 1989, 14:271-277.
33. van der Hel W.S., et al. Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy. Neurology 2005, 64:326-333.
34. Wang Y., et al. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. Exp. Neurol. 2009, 220:293-302.