Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

Cell Reports

Volumn 19, Issue 4, 2017, Pages 785-797

  Horn, Sebastian ^a   Hughes, Michelle A ^b   Schilling, Ramon ^a   Sticht, Carsten ^a   Tenev, Tencho ^c   Ploesser, Michaela ^a   Meier, Pascal ^c   Sprick, Martin R ^d   MacFarlane, Marion ^b   Leverkus, Martin ^a,e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MRC TOXICOLOGY UNIT   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d Exp Hematology Group Heidelberg Institute for Stem Cell Technology and Experimental Medicine GGmbH   (Germany)

^e RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

caspase 10; caspase 8; CD95; cell death; cFLIP; DISC; NF B

Indexed keywords

CASPASE 10; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; BENZYLOXYCARBONYL-VALYL-ALANYL-ASPARTIC ACID; FADD PROTEIN, HUMAN; I KAPPA B KINASE ALPHA; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; INTERLEUKIN 8; MESSENGER RNA; NECROSTATIN-1; OLIGOPEPTIDE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6;

ARTICLE; CELL DEATH; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; GENE INDUCTION; HUMAN; HUMAN CELL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL LINE; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DRUG EFFECTS; GENETICS; HELA CELL LINE; METABOLISM; RNA INTERFERENCE;

APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 10; CASPASE 8; CELL LINE; CELL SURVIVAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; FAS LIGAND PROTEIN; FAS RECEPTOR; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HELA CELLS; HUMANS; IMIDAZOLES; INDOLES; INTERLEUKIN-8; NF-KAPPA B; NF-KAPPAB INHIBITOR ALPHA; OLIGOPEPTIDES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 85018717539     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.04.010     Document Type: Article

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