Perforin expression by CD8 T cells is sufficient to cause fatal brain edema during experimental cerebral malaria

Infection and Immunity

Volumn 85, Issue 5, 2017, Pages

  Huggins, Matthew A ^a   Johnson, Holly L ^b   Jin, Fang ^a   N'Songo, Aurelie ^b   Hanson, Lisa M ^a   LaFrance, Stephanie J ^a   Butler, Noah S ^c   Harty, John T ^d   Johnson, Aaron J ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Blood brain barrier; CD8 T cell; Experimental cerebral malaria; Perforin

Indexed keywords

CLAUDIN 5; GADOLINIUM; OCCLUDIN; PERFORIN; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; BRAIN STEM; CD8+ T LYMPHOCYTE; CEREBRAL MALARIA; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYTOLYSIS; ENDOTHELIUM CELL; INTRACRANIAL HYPERTENSION; LATERAL BRAIN VENTRICLE; LYMPHOCYTIC INFILTRATION; MOUSE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLFACTORY BULB; PLASMODIUM BERGHEI INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RODENT MALARIA; TIGHT JUNCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPLICATION; DIAGNOSTIC IMAGING; DISEASE MODEL; GENE EXPRESSION; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY;

ANIMALS; BRAIN EDEMA; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; MAGNETIC RESONANCE IMAGING; MALARIA, CEREBRAL; MICE, INBRED C57BL; MICE, KNOCKOUT; PORE FORMING CYTOTOXIC PROTEINS;

EID: 85018634230     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00985-16     Document Type: Article

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