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Volumn 9, Issue 4, 2017, Pages

Nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments

Author keywords

Antioxidants; Astaxanthin; Chemokine; Fibrosis; Inflammation; Insulin resistance; Macrophage Kupffer cells; NAFLD NASH; cryptoxanthin

Indexed keywords

ASTAXANTHIN; BETA CAROTENE; BETA CRYPTOXANTHIN; CHEMOKINE; LYCOPENE; ANTIOXIDANT; CAROTENOID; CRYPTOXANTHIN; XANTHOPHYLL;

EID: 85018527384     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9040387     Document Type: Review
Times cited : (379)

References (103)
  • 1
    • 84930654328 scopus 로고    scopus 로고
    • Current efforts and trends in the treatment of NASH
    • Ratziu, V.; Goodman, Z.; Sanyal, A. Current efforts and trends in the treatment of NASH. J. Hepatol. 2015, 62, S65–S75. [CrossRef] [PubMed]
    • (2015) J. Hepatol. , vol.62 , pp. S65-S75
    • Ratziu, V.1    Goodman, Z.2    Sanyal, A.3
  • 2
    • 58849132440 scopus 로고    scopus 로고
    • Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
    • Yatsuji, S.; Hashimoto, E.; Tobari, M.; Taniai, M.; Tokushige, K.; Shiratori, K. Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J. Gastroenterol. Hepatol. 2009, 24, 248–254. [CrossRef] [PubMed]
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 248-254
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3    Taniai, M.4    Tokushige, K.5    Shiratori, K.6
  • 3
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio, E.; Alvarez, E.; Dominguez, N.; Landeira, G.; Longo, C. Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies. Hepatology 2004, 40, 820–826. [CrossRef] [PubMed]
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 4
    • 33748992321 scopus 로고    scopus 로고
    • Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature
    • Ono, M.; Saibara, T. Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature. J. Gastroenterol. 2006, 41, 725–732. [CrossRef] [PubMed]
    • (2006) J. Gastroenterol. , vol.41 , pp. 725-732
    • Ono, M.1    Saibara, T.2
  • 5
    • 84944397311 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease review: Diagnosis, treatment, and outcomes
    • Ahmed, A.; Wong, R.J.; Harrison, S.A. Nonalcoholic fatty liver disease review: Diagnosis, treatment, and outcomes. Clin. Gastroenterol. Hepatol. 2015, 13, 2062–2070. [CrossRef] [PubMed]
    • (2015) Clin. Gastroenterol. Hepatol. , vol.13 , pp. 2062-2070
    • Ahmed, A.1    Wong, R.J.2    Harrison, S.A.3
  • 7
    • 84958620136 scopus 로고    scopus 로고
    • Pathophysiology and mechanisms of nonalcoholic fatty liver disease
    • Haas, J.T.; Francque, S.; Staels, B. Pathophysiology and mechanisms of nonalcoholic fatty liver disease. Annu. Rev. Physiol. 2016, 78, 181–205. [CrossRef] [PubMed]
    • (2016) Annu. Rev. Physiol. , vol.78 , pp. 181-205
    • Haas, J.T.1    Francque, S.2    Staels, B.3
  • 8
    • 84865545850 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis clinical research network. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
    • Loomba, R.; Abraham, M.; Unalp, A.; Wilson, L.; Lavine, J.; Doo, E.; Bass, N.M. Nonalcoholic steatohepatitis clinical research network. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 2012, 56, 943–951. [CrossRef] [PubMed]
    • (2012) Hepatology , vol.56 , pp. 943-951
    • Loomba, R.1    Abraham, M.2    Unalp, A.3    Wilson, L.4    Lavine, J.5    Doo, E.6    Bass, N.M.7
  • 11
    • 84962343543 scopus 로고    scopus 로고
    • Diet, microbiota, obesity, and NAFLD: A dangerous quartet
    • Machado, M.V.; Cortez-Pinto, H. Diet, microbiota, obesity, and NAFLD: A dangerous quartet. Int. J. Mol. Sci. 2016, 17, 481. [CrossRef] [PubMed]
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 481
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 12
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two “hits
    • Day, C.P.; James, O.F. Steatohepatitis: A tale of two “hits”? Gastroenterology 1998, 114, 842–845. [CrossRef]
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 14
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg, H.; Moschen, A.R. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology 2010, 52, 1836–1846. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 15
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams, C.D.; Stengel, J.; Asike, M.I.; Torres, D.M.; Shaw, J.; Contreras, M.; Landt, C.L.; Harrison, S.A. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 2011, 140, 124–131. [CrossRef] [PubMed]
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3    Torres, D.M.4    Shaw, J.5    Contreras, M.6    Landt, C.L.7    Harrison, S.A.8
  • 17
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez, F.O.; Gordon, S. The M1 and M2 paradigm of macrophage activation: Time for reassessment. F1000Prime Rep. 2014, 6, 13. [CrossRef] [PubMed]
    • (2014) F1000prime Rep. , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 18
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica, A.; Mantovani, A. Macrophage plasticity and polarization: In vivo veritas. J. Clin. Investig. 2012, 122, 787–795. [CrossRef] [PubMed]
    • (2012) J. Clin. Investig. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 19
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • Gordon, S.; Martinez, F.O. Alternative activation of macrophages: Mechanism and functions. Immunity 2010, 32, 593–604. [CrossRef] [PubMed]
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 21
    • 44649095633 scopus 로고    scopus 로고
    • Review article: Current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • Younossi, Z.M. Review article: Current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther. 2008, 28, 2–12. [CrossRef] [PubMed]
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 2-12
    • Younossi, Z.M.1
  • 23
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso, G.; Gambino, R.; Cassader, M.; Pagano, G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010, 52, 79–104. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 25
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The tonic randomized controlled trial
    • Lavine, J.E.; Schwimmer, J.B.; van Natta, M.L.; Molleston, J.P.; Murray, K.F.; Rosenthal, P.; Abrams, S.H.; Scheimann, A.O.; Sanyal, A.J.; Chalasani, N.; et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The tonic randomized controlled trial. JAMA 2011, 305, 1659–1668. [CrossRef] [PubMed]
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6    Abrams, S.H.7    Scheimann, A.O.8    Sanyal, A.J.9    Chalasani, N.10
  • 26
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong, M.J.; Gaunt, P.; Aithal, G.P.; Barton, D.; Hull, D.; Parker, R.; Hazlehurst, J.M.; Guo, K.; Abouda, G.; Aldersley, M.A.; et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 2016, 387, 679–690. [CrossRef]
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3    Barton, D.4    Hull, D.5    Parker, R.6    Hazlehurst, J.M.7    Guo, K.8    Abouda, G.9    Aldersley, M.A.10
  • 29
    • 34047192773 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of nonalcoholic fatty liver disease
    • Mendez-Sanchez, N.; Arrese, M.; Zamora-Valdes, D.; Uribe, M. Current concepts in the pathogenesis of nonalcoholic fatty liver disease. Liver Int. 2007, 27, 423–433. [CrossRef] [PubMed]
    • (2007) Liver Int , vol.27 , pp. 423-433
    • Mendez-Sanchez, N.1    Arrese, M.2    Zamora-Valdes, D.3    Uribe, M.4
  • 30
    • 0023210536 scopus 로고
    • Adipose tissue as a source of hormones
    • Siiteri, P.K. Adipose tissue as a source of hormones. Am. J. Clin. Nutr. 1987, 45, 277–282. [PubMed]
    • (1987) Am. J. Clin. Nutr. , vol.45 , pp. 277-282
    • Siiteri, P.K.1
  • 31
    • 33646363759 scopus 로고    scopus 로고
    • NAFLD, obesity, and bariatric surgery
    • Angulo, P. NAFLD, obesity, and bariatric surgery. Gastroenterology 2006, 130, 1848–1852. [CrossRef] [PubMed]
    • (2006) Gastroenterology , vol.130 , pp. 1848-1852
    • Angulo, P.1
  • 32
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein ACRP30 enhances hepatic insulin action
    • Berg, A.H.; Combs, T.P.; Du, X.; Brownlee, M.; Scherer, P.E. The adipocyte-secreted protein ACRP30 enhances hepatic insulin action. Nat. Med. 2001, 7, 947–953. [CrossRef] [PubMed]
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 36
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 2006, 444, 860–867. [CrossRef] [PubMed]
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 37
    • 84899483261 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in liver homeostasis and pathology
    • Sica, A.; Invernizzi, P.; Mantovani, A. Macrophage plasticity and polarization in liver homeostasis and pathology. Hepatology 2014, 59, 2034–2042. [CrossRef] [PubMed]
    • (2014) Hepatology , vol.59 , pp. 2034-2042
    • Sica, A.1    Invernizzi, P.2    Mantovani, A.3
  • 38
    • 84922622191 scopus 로고    scopus 로고
    • A concise review of non-alcoholic fatty liver disease
    • Than, N.N.; Newsome, P.N. A concise review of non-alcoholic fatty liver disease. Atherosclerosis 2015, 239, 192–202. [CrossRef] [PubMed]
    • (2015) Atherosclerosis , vol.239 , pp. 192-202
    • Than, N.N.1    Newsome, P.N.2
  • 39
    • 84978708500 scopus 로고    scopus 로고
    • Liver innate immune cells and insulin resistance: The multiple facets of Kupffer cells
    • Jager, J.; Aparicio-Vergara, M.; Aouadi, M. Liver innate immune cells and insulin resistance: The multiple facets of Kupffer cells. J. Intern. Med. 2016, 280, 209–220. [CrossRef] [PubMed]
    • (2016) J. Intern. Med. , vol.280 , pp. 209-220
    • Jager, J.1    Aparicio-Vergara, M.2    Aouadi, M.3
  • 41
    • 37049003544 scopus 로고    scopus 로고
    • Kupffer cell heterogeneity: Functional properties of bone marrow derived and sessile hepatic macrophages
    • Klein, I.; Cornejo, J.C.; Polakos, N.K.; John, B.; Wuensch, S.A.; Topham, D.J.; Pierce, R.H.; Crispe, I.N. Kupffer cell heterogeneity: Functional properties of bone marrow derived and sessile hepatic macrophages. Blood 2007, 110, 4077–4085. [CrossRef] [PubMed]
    • (2007) Blood , vol.110 , pp. 4077-4085
    • Klein, I.1    Cornejo, J.C.2    Polakos, N.K.3    John, B.4    Wuensch, S.A.5    Topham, D.J.6    Pierce, R.H.7    Crispe, I.N.8
  • 42
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A.; Sica, A.; Sozzani, S.; Allavena, P.; Vecchi, A.; Locati, M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25, 677–686. [CrossRef] [PubMed]
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 43
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas, S.K.; Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat. Immunol. 2010, 11, 889–896. [CrossRef] [PubMed]
    • (2010) Nat. Immunol. , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 44
    • 84894798789 scopus 로고    scopus 로고
    • M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
    • Wan, J.; Benkdane, M.; Teixeira-Clerc, F.; Bonnafous, S.; Louvet, A.; Lafdil, F.; Pecker, F.; Tran, A.; Gual, P.; Mallat, A.; et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 2014, 59, 130–142. [CrossRef] [PubMed]
    • (2014) Hepatology , vol.59 , pp. 130-142
    • Wan, J.1    Benkdane, M.2    Teixeira-Clerc, F.3    Bonnafous, S.4    Louvet, A.5    Lafdil, F.6    Pecker, F.7    Tran, A.8    Gual, P.9    Mallat, A.10
  • 46
    • 33845203351 scopus 로고    scopus 로고
    • Tuning inflammation and immunity by chemokine sequestration: Decoys and more
    • Mantovani, A.; Bonecchi, R.; Locati, M. Tuning inflammation and immunity by chemokine sequestration: Decoys and more. Nat. Rev. Immunol. 2006, 6, 907–918. [CrossRef] [PubMed]
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 907-918
    • Mantovani, A.1    Bonecchi, R.2    Locati, M.3
  • 48
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu, A.; Wang, Y.; Keshaw, H.; Xu, L.Y.; Lam, K.S.; Cooper, G.J. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Investig. 2003, 112, 91–100. [CrossRef] [PubMed]
    • (2003) J. Clin. Investig. , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 50
    • 77951146612 scopus 로고    scopus 로고
    • CC chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • Obstfeld, A.E.; Sugaru, E.; Thearle, M.; Francisco, A.M.; Gayet, C.; Ginsberg, H.N.; Ables, E.V.; Ferrante, A.W., Jr. CC chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 2010, 59, 916–925. [CrossRef] [PubMed]
    • (2010) Diabetes , vol.59 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3    Francisco, A.M.4    Gayet, C.5    Ginsberg, H.N.6    Ables, E.V.7    Ferrante, A.W.8
  • 52
  • 55
    • 34548434020 scopus 로고    scopus 로고
    • Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue
    • Inouye, K.E.; Shi, H.; Howard, J.K.; Daly, C.H.; Lord, G.M.; Rollins, B.J.; Flier, J.S. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 2007, 56, 2242–2250. [CrossRef] [PubMed]
    • (2007) Diabetes , vol.56 , pp. 2242-2250
    • Inouye, K.E.1    Shi, H.2    Howard, J.K.3    Daly, C.H.4    Lord, G.M.5    Rollins, B.J.6    Flier, J.S.7
  • 56
    • 48449102722 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue
    • Kirk, E.A.; Sagawa, Z.K.; McDonald, T.O.; O’Brien, K.D.; Heinecke, J.W. Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue. Diabetes 2008, 57, 1254–1261. [CrossRef] [PubMed]
    • (2008) Diabetes , vol.57 , pp. 1254-1261
    • Kirk, E.A.1    Sagawa, Z.K.2    McDonald, T.O.3    O’Brien, K.D.4    Heinecke, J.W.5
  • 57
    • 84863223829 scopus 로고    scopus 로고
    • CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
    • Kitade, H.; Sawamoto, K.; Nagashimada, M.; Inoue, H.; Yamamoto, Y.; Sai, Y.; Takamura, T.; Yamamoto, H.; Miyamoto, K.; Ginsberg, H.N.; et al. CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes 2012, 61, 1680–1690. [CrossRef] [PubMed]
    • (2012) Diabetes , vol.61 , pp. 1680-1690
    • Kitade, H.1    Sawamoto, K.2    Nagashimada, M.3    Inoue, H.4    Yamamoto, Y.5    Sai, Y.6    Takamura, T.7    Yamamoto, H.8    Miyamoto, K.9    Ginsberg, H.N.10
  • 61
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu, H.; Ghosh, S.; Perrard, X.D.; Feng, L.; Garcia, G.E.; Perrard, J.L.; Sweeney, J.F.; Peterson, L.E.; Chan, L.; Smith, C.W.; et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007, 115, 1029–1038. [CrossRef] [PubMed]
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3    Feng, L.4    Garcia, G.E.5    Perrard, J.L.6    Sweeney, J.F.7    Peterson, L.E.8    Chan, L.9    Smith, C.W.10
  • 64
    • 84857550029 scopus 로고    scopus 로고
    • Role of cytokines and chemokines in non-alcoholic fatty liver disease
    • Braunersreuther, V.; Viviani, G.L.; Mach, F.; Montecucco, F. Role of cytokines and chemokines in non-alcoholic fatty liver disease. World J. Gastroenterol. 2012, 18, 727–735. [CrossRef] [PubMed]
    • (2012) World J. Gastroenterol. , vol.18 , pp. 727-735
    • Braunersreuther, V.1    Viviani, G.L.2    Mach, F.3    Montecucco, F.4
  • 68
    • 0036790718 scopus 로고    scopus 로고
    • Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C
    • Yadav, D.; Hertan, H.I.; Schweitzer, P.; Norkus, E.P.; Pitchumoni, C.S. Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. Am. J. Gastroenterol. 2002, 97, 2634–2639. [CrossRef] [PubMed]
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 2634-2639
    • Yadav, D.1    Hertan, H.I.2    Schweitzer, P.3    Norkus, E.P.4    Pitchumoni, C.S.5
  • 69
    • 0038281500 scopus 로고    scopus 로고
    • Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States
    • Ruhl, C.E.; Everhart, J.E. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology 2003, 124, 1821–1829. [CrossRef]
    • (2003) Gastroenterology , vol.124 , pp. 1821-1829
    • Ruhl, C.E.1    Everhart, J.E.2
  • 70
    • 84896466264 scopus 로고    scopus 로고
    • Low serum concentrations of carotenoids and vitamin E are associated with high adiposity in Mexican-American children
    • Gunanti, I.R.; Marks, G.C.; Al-Mamun, A.; Long, K.Z. Low serum concentrations of carotenoids and vitamin E are associated with high adiposity in Mexican-American children. J. Nutr. 2014, 144, 489–495. [CrossRef] [PubMed]
    • (2014) J. Nutr. , vol.144 , pp. 489-495
    • Gunanti, I.R.1    Marks, G.C.2    Al-Mamun, A.3    Long, K.Z.4
  • 71
    • 70350705964 scopus 로고    scopus 로고
    • Impact of micronutrient deficiencies on obesity
    • Garcia, O.P.; Long, K.Z.; Rosado, J.L. Impact of micronutrient deficiencies on obesity. Nutr. Rev. 2009, 67, 559–572. [CrossRef] [PubMed]
    • (2009) Nutr. Rev. , vol.67 , pp. 559-572
    • Garcia, O.P.1    Long, K.Z.2    Rosado, J.L.3
  • 72
    • 0002743175 scopus 로고    scopus 로고
    • Update on the biological characteristics of the antioxidant micronutrients: Vitamin C, vitamin E, and the carotenoids
    • Rock, C.L.; Jacob, R.A.; Bowen, P.E. Update on the biological characteristics of the antioxidant micronutrients: Vitamin C, vitamin E, and the carotenoids. J. Am. Diet. Assoc. 1996, 96, 693–702. [CrossRef]
    • (1996) J. Am. Diet. Assoc , vol.693-702 , pp. 96
    • Rock, C.L.1    Jacob, R.A.2    Bowen, P.E.3
  • 73
    • 84922400509 scopus 로고    scopus 로고
    • Carotenoids, inflammation, and oxidative stress—Implications of cellular signaling pathways and relation to chronic disease prevention
    • Kaulmann, A.; Bohn, T. Carotenoids, inflammation, and oxidative stress—Implications of cellular signaling pathways and relation to chronic disease prevention. Nutr. Res. 2014, 34, 907–929. [CrossRef] [PubMed]
    • (2014) Nutr. Res. , vol.34 , pp. 907-929
    • Kaulmann, A.1    Bohn, T.2
  • 76
    • 84923884829 scopus 로고    scopus 로고
    • Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, beta-cryptoxanthin
    • Ni, Y.; Nagashimada, M.; Zhan, L.; Nagata, N.; Kobori, M.; Sugiura, M.; Ogawa, K.; Kaneko, S.; Ota, T. Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, beta-cryptoxanthin. Endocrinology 2015, 156, 987–999. [CrossRef] [PubMed]
    • (2015) Endocrinology , vol.156 , pp. 987-999
    • Ni, Y.1    Nagashimada, M.2    Zhan, L.3    Nagata, N.4    Kobori, M.5    Sugiura, M.6    Ogawa, K.7    Kaneko, S.8    Ota, T.9
  • 77
    • 84948456496 scopus 로고    scopus 로고
    • Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E
    • Ni, Y.; Nagashimada, M.; Zhuge, F.; Zhan, L.; Nagata, N.; Tsutsui, A.; Nakanuma, Y.; Kaneko, S.; Ota, T. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci. Rep. 2015, 5, 17192. [CrossRef] [PubMed]
    • (2015) Sci. Rep. , vol.5
    • Ni, Y.1    Nagashimada, M.2    Zhuge, F.3    Zhan, L.4    Nagata, N.5    Tsutsui, A.6    Nakanuma, Y.7    Kaneko, S.8    Ota, T.9
  • 78
    • 73649085165 scopus 로고    scopus 로고
    • Synergistic interaction of cigarette smoking and alcohol drinking with serum carotenoid concentrations: Findings from a middle-aged Japanese population
    • Sugiura, M.; Nakamura, M.; Ogawa, K.; Ikoma, Y.; Matsumoto, H.; Ando, F.; Shimokata, H.; Yano, M. Synergistic interaction of cigarette smoking and alcohol drinking with serum carotenoid concentrations: Findings from a middle-aged Japanese population. Br. J. Nutr. 2009, 102, 1211–1219. [CrossRef] [PubMed]
    • (2009) Br. J. Nutr. , vol.102 , pp. 1211-1219
    • Sugiura, M.1    Nakamura, M.2    Ogawa, K.3    Ikoma, Y.4    Matsumoto, H.5    Ando, F.6    Shimokata, H.7    Yano, M.8
  • 80
  • 82
    • 70449589634 scopus 로고    scopus 로고
    • Beta-carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages
    • Katsuura, S.; Imamura, T.; Bando, N.; Yamanishi, R. Beta-carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages. Mol. Nutr. Food Res. 2009, 53, 1396–1405. [CrossRef] [PubMed]
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 1396-1405
    • Katsuura, S.1    Imamura, T.2    Bando, N.3    Yamanishi, R.4
  • 83
    • 83055196925 scopus 로고    scopus 로고
    • Mechanism of visceral fat reduction in Tsumura Suzuki obese, diabetes (TSOD) mice orally administered beta-cryptoxanthin from Satsuma mandarin oranges (Citrus unshiu Marc)
    • Takayanagi, K.; Morimoto, S.; Shirakura, Y.; Mukai, K.; Sugiyama, T.; Tokuji, Y.; Ohnishi, M. Mechanism of visceral fat reduction in Tsumura Suzuki obese, diabetes (TSOD) mice orally administered beta-cryptoxanthin from Satsuma mandarin oranges (Citrus unshiu Marc). J. Agric. Food Chem. 2011, 59, 12342–12351. [CrossRef] [PubMed]
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 12342-12351
    • Takayanagi, K.1    Morimoto, S.2    Shirakura, Y.3    Mukai, K.4    Sugiyama, T.5    Tokuji, Y.6    Ohnishi, M.7
  • 84
    • 84901396460 scopus 로고    scopus 로고
    • Beta-cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice
    • Kobori, M.; Ni, Y.; Takahashi, Y.; Watanabe, N.; Sugiura, M.; Ogawa, K.; Nagashimada, M.; Kaneko, S.; Naito, S.; Ota, T. Beta-cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice. PLoS ONE 2014, 9, e98294. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Kobori, M.1    Ni, Y.2    Takahashi, Y.3    Watanabe, N.4    Sugiura, M.5    Ogawa, K.6    Nagashimada, M.7    Kaneko, S.8    Naito, S.9    Ota, T.10
  • 85
    • 84892855353 scopus 로고    scopus 로고
    • Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review
    • Ambati, R.R.; Phang, S.M.; Ravi, S.; Aswathanarayana, R.G. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review. Mar. Drugs 2014, 12, 128–152. [CrossRef] [PubMed]
    • (2014) Mar. Drugs , vol.12 , pp. 128-152
    • Ambati, R.R.1    Phang, S.M.2    Ravi, S.3    Aswathanarayana, R.G.4
  • 86
    • 0037407158 scopus 로고    scopus 로고
    • Haematococcus astaxanthin: Applications for human health and nutrition
    • Guerin, M.; Huntley, M.E.; Olaizola, M. Haematococcus astaxanthin: Applications for human health and nutrition. Trends Biotechnol. 2003, 21, 210–216. [CrossRef]
    • (2003) Trends Biotechnol , vol.21 , pp. 210-216
    • Guerin, M.1    Huntley, M.E.2    Olaizola, M.3
  • 87
    • 0034959030 scopus 로고    scopus 로고
    • Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCL4-treated rats
    • Kang, J.O.; Kim, S.J.; Kim, H. Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCL4-treated rats. Methods Find. Exp. Clin. Pharmacol. 2001, 23, 79–84. [CrossRef] [PubMed]
    • (2001) Methods Find. Exp. Clin. Pharmacol. , vol.23 , pp. 79-84
    • Kang, J.O.1    Kim, S.J.2    Kim, H.3
  • 88
    • 84910029457 scopus 로고    scopus 로고
    • Astaxanthin prevents TGFbeta1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells
    • Yang, Y.; Kim, B.; Park, Y.K.; Koo, S.I.; Lee, J.Y. Astaxanthin prevents TGFbeta1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochim. Biophys. Acta 2015, 1850, 178–185. [CrossRef] [PubMed]
    • (2015) Biochim. Biophys. Acta , vol.1850 , pp. 178-185
    • Yang, Y.1    Kim, B.2    Park, Y.K.3    Koo, S.I.4    Lee, J.Y.5
  • 89
    • 84958182512 scopus 로고    scopus 로고
    • Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells
    • Yang, Y.; Bae, M.; Kim, B.; Park, Y.K.; Koo, S.I.; Lee, J.Y. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. J. Nutr. Biochem. 2016, 29, 21–26. [CrossRef] [PubMed]
    • (2016) J. Nutr. Biochem. , vol.29 , pp. 21-26
    • Yang, Y.1    Bae, M.2    Kim, B.3    Park, Y.K.4    Koo, S.I.5    Lee, J.Y.6
  • 93
    • 84929710474 scopus 로고    scopus 로고
    • Vitamin B12 and ω-3 fatty acids together regulate lipid metabolism in Wistar rats
    • Khaire, A.; Rathod, R.; Kale, A.; Joshi, S. Vitamin B12 and ω-3 fatty acids together regulate lipid metabolism in Wistar rats. Prostaglandins Leukot. Essent. Fatty Acids 2015, 99, 7–17. [CrossRef] [PubMed]
    • (2015) Prostaglandins Leukot. Essent. Fatty Acids , vol.99 , pp. 7-17
    • Khaire, A.1    Rathod, R.2    Kale, A.3    Joshi, S.4
  • 94
    • 77949876397 scopus 로고    scopus 로고
    • Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    • Wang, Y.; Ausman, L.M.; Greenberg, A.S.; Russell, R.M.; Wang, X.D. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int. J. Cancer 2010, 126, 1788–1796. [CrossRef] [PubMed]
    • (2010) Int. J. Cancer , vol.126 , pp. 1788-1796
    • Wang, Y.1    Ausman, L.M.2    Greenberg, A.S.3    Russell, R.M.4    Wang, X.D.5
  • 95
    • 84858175296 scopus 로고    scopus 로고
    • Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet
    • Bahcecioglu, I.H.; Kuzu, N.; Metin, K.; Ozercan, I.H.; Ustundag, B.; Sahin, K.; Kucuk, O. Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. Vet. Med. Int. 2010, 2010. [CrossRef] [PubMed]
    • (2010) Vet. Med. Int. , vol.2010
    • Bahcecioglu, I.H.1    Kuzu, N.2    Metin, K.3    Ozercan, I.H.4    Ustundag, B.5    Sahin, K.6    Kucuk, O.7
  • 96
    • 79952784603 scopus 로고    scopus 로고
    • Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH)
    • Erhardt, A.; Stahl, W.; Sies, H.; Lirussi, F.; Donner, A.; Haussinger, D. Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH). Eur. J. Med. Res. 2011, 16, 76–78. [CrossRef] [PubMed]
    • (2011) Eur. J. Med. Res. , vol.16 , pp. 76-78
    • Erhardt, A.1    Stahl, W.2    Sies, H.3    Lirussi, F.4    Donner, A.5    Haussinger, D.6
  • 99
    • 69549133570 scopus 로고    scopus 로고
    • Adherence to the Mediterranean diet is associated with lower abdominal adiposity in European men and women
    • Romaguera, D.; Norat, T.; Mouw, T.; May, A.M.; Bamia, C.; Slimani, N.; Travier, N.; Besson, H.; Luan, J.; Wareham, N.; et al. Adherence to the Mediterranean diet is associated with lower abdominal adiposity in European men and women. J. Nutr. 2009, 139, 1728–1737. [CrossRef] [PubMed]
    • (2009) J. Nutr. , vol.139 , pp. 1728-1737
    • Romaguera, D.1    Norat, T.2    Mouw, T.3    May, A.M.4    Bamia, C.5    Slimani, N.6    Travier, N.7    Besson, H.8    Luan, J.9    Wareham, N.10
  • 101
    • 0030907984 scopus 로고    scopus 로고
    • Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients
    • Velussi, M.; Cernigoi, A.M.; De Monte, A.; Dapas, F.; Caffau, C.; Zilli, M. Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J. Hepatol. 1997, 26, 871–879. [CrossRef]
    • (1997) J. Hepatol. , vol.26 , pp. 871-879
    • Velussi, M.1    Cernigoi, A.M.2    De Monte, A.3    Dapas, F.4    Caffau, C.5    Zilli, M.6
  • 102
    • 56149118230 scopus 로고    scopus 로고
    • The efficacy of silymarin in decreasing transaminase activities in nonalcoholic fatty liver disease: A randomized controlled clinical trial
    • Hajaghamohammadi, A.A.; Ziaee, A.; Raflei, R. The efficacy of silymarin in decreasing transaminase activities in nonalcoholic fatty liver disease: A randomized controlled clinical trial. Hepat. Mon. 2008, 8, 191–195.
    • (2008) Hepat. Mon. , vol.8 , pp. 191-195
    • Hajaghamohammadi, A.A.1    Ziaee, A.2    Raflei, R.3
  • 103
    • 85016027814 scopus 로고    scopus 로고
    • Metabolite profiling can change health-care delivery to obese patients with fatty liver disease: The search for biomarkers
    • Camps, J.; Joven, J. Metabolite profiling can change health-care delivery to obese patients with fatty liver disease: The search for biomarkers. Clin. Chem. Lab. Med. 2017, 55, 501–506. [CrossRef] [PubMed]
    • (2017) Clin. Chem. Lab. Med. , vol.55 , pp. 501-506
    • Camps, J.1    Joven, J.2


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