Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5

Cell

Volumn 169, Issue 3, 2017, Pages 407-421.e16

  Komolov, Konstantin E ^a   Du, Yang ^b   Duc, Nguyen Minh ^c   Betz, Robin M ^b,d,e   Rodrigues, João P G L M ^b,d   Leib, Ryan D ^b   Patra, Dhabaleswar ^f   Skiniotis, Georgios ^f   Adams, Christopher M ^b   Dror, Ron O ^b,d,e   Chung, Ka Young ^c   Kobilka, Brian K ^b   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Sungkyunkwan University   (South Korea)

^d Stanford University   (United States)

^e STANFORD UNIVERSITY   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

cross linking; G protein coupled receptor; G protein coupled receptor kinases; mass spectrometry; molecular dynamics; phosphorylation; 2 adrenergic receptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; GUANINE NUCLEOTIDE BINDING PROTEIN; RETINA S ANTIGEN; PROTEIN BINDING;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CROSS LINKING; DEUTERIUM HYDROGEN EXCHANGE; ELECTRON MICROSCOPY; ENZYME ACTIVE SITE; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR UPREGULATION; REGULATORY MECHANISM; ANIMAL; BOVINE; CHEMISTRY; GENETICS; HUMAN; MAMMAL; METABOLISM; MOLECULAR MODEL; NEW WORLD CAMELID; RAT;

ANIMALS; CAMELIDS, NEW WORLD; CATTLE; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HUMANS; MAMMALS; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; RATS; RECEPTORS, ADRENERGIC, BETA-2;

EID: 85018467289     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.03.047     Document Type: Article

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