Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells

BMC Complementary and Alternative Medicine

Volumn 17, Issue 1, 2017, Pages

  Ramkumar, Muthu ^a   Rajasankar, Srinivasagam ^b   Gobi, Veerappan Venkatesh ^a   Dhanalakshmi, Chinnasamy ^c   Manivasagam, Thamilarasan ^c   Justin Thenmozhi, Arokiasamy ^c   Essa, Musthafa Mohamed ^d,e   Kalandar, Ameer ^f   Chidambaram, Ranganathan ^g  

^a BHARATH UNIVERSITY   (India)

^b VELAMMAL MEDICAL COLLEGE HOSPITAL AND RESEARCH INSTITUTE   (India)

^c ANNAMALAI UNIVERSITY   (India)

^d SULTAN QABOOS UNIVERSITY   (Oman)

^e Food and Brain Research Foundation   (India)

^f HARAMAYA UNIVERSITY   (Ethiopia)

^g Affiliated to Bharath University   (India)

Author keywords

Apoptosis; Demethoxycurcumin; Neurodegenerative diseases; Oxidative stress; Rotenone

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 8; CASPASE 9; CYTOCHROME C; DEMETHOXYCURCUMIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; ROTENONE; CURCUMIN; INSECTICIDE; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

APOPTOSIS; ARTICLE; BAD GENE; BAX GENE; BCL 2 GENE; BCL XL GENE; CASPASE 3 GENE; CASPASE 6 GENE; CASPASE 8 GENE; CASPASE 9 GENE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYT C GENE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; ANALOGS AND DERIVATIVES; CELL DEATH; CHEMISTRY; CURCUMA; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; METABOLISM; NEUROTOXICITY SYNDROMES; PARKINSON DISEASE; PHYTOTHERAPY; TUMOR CELL LINE;

CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMA; CURCUMIN; CYTOCHROMES C; DOPAMINERGIC NEURONS; HUMANS; INSECTICIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PARKINSON DISEASE; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; ROTENONE;

EID: 85018385142     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-017-1720-5     Document Type: Article

References (54)

1. Hirsch E, Graybiel AM, Agid YA. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature. 1988;334(6180):345-8.
2. Greenamyre JT, Hastings TG. Biomedicine. Parkinson's-divergent causes, convergent mechanisms. Science. 2004;304(5674):1120-2.
3. Hancock DB, Martin ER, Mayhew GM, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK. Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BMC Neurol. 2008;8:6.
4. Priyadarshi A, Khuder SA, Schaub EA, Shrivastava A. A meta analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology. 2000;21(4):435-40.
5. Dhanalakshmi C, Manivasagam T, Nataraj J, Thenmozhi AJ, Essa MM. Neurosupportive role of vanillin, a natural phenolic compound, on rotenone induced neurotoxicity in SH-SY5Y neuroblastoma cells. Evid Based Complement Alternat Med. 2015;2015:626028.
6. Kavitha M, Manivasagam T, Essa MM, Tamilselvam K, Selvakumar GP, Karthikeyan S, Thenmozhi AJ, Subash S. Mangiferin antagonizes rotenone: induced apoptosis through attenuating mitochondrial dysfunction and oxidative stress in SK-N-SH neuroblastoma cells. Neurochem Res. 2014;39(4):668-76.
7. Tamilselvam K, Braidy N, Manivasagam T, Essa MM, Prasad NR, Karthikeyan S, Thenmozhi AJ, Selvaraju S, Guillemin GJ. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxidative Med Cell Longev. 2013;2013:102741.
8. Cannon JR, Tapias VM, Na HM, Honick AS, Drolet RE, Greenamyre JT. A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis. 2009;34(2):279-90.
9. Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron. 2003;39(6):889-909.
10. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
11. Ganguli M, Chandra V, Kamboh MI, Johnston JM, Dodge HH, Thelma BK, Juyal RC, Pandav R, Belle SH, DeKosky ST. Apolipoprotein E polymorphism and Alzheimer disease: the indo-US cross national dementia study. Arch Neurol. 2000;57(6):824-30.
12. Alladi PA, Mahadevan A, Yasha TC, Raju TR, Shankar SK, Muthane U. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lowerincidence of Parkinson's disease. Neuroscience. 2009;159:236-45.
13. Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr. 2004;44(2):97-111.
14. Fang X, Fang L, Gou S, Cheng L. Design and synthesis of dimethylaminomethyl substituted curcumin derivatives/analogues: potentantitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin. Bioorg Med Chem Lett. 2013;23:1297-301.
15. Wang J, Du XX, Jiang H, Xie JX. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem Pharmacol. 2009;78(2):178-83.
16. Fetoni AR, Paciello F, Mezzogori D, Rolesi R, Eramo SL, Paludetti G, Troiani D. Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling. Br J Cancer. 2015;113(10):1434-44.
17. Sirisidthi K, Kosai P, Jiraungkoorskul K, Jiraungkoorskul W. Antithrombotic activity of turmeric (Curcuma longa): a review. Indian J Agric Res. 2016;50(2):101-6.
18. Abe Y, Hashimoto S, Horie T. Curcumin inhibition inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res. 1999;39(1):41-7.
19. Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkaya S, Camalier RF, Hollingshead MG, Kaur G, Sausville EA, Rickles FR, Snyder JP, Liotta DC, Shoji M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg Med Chem. 2004;12(14):3871-83.
20. Madhavi D, Kagan D. Bioavailability of a sustained release formulation of Curcumin. Integr Med. 2014;13(3):24-30.
21. Kim DS, Park SY, Kim JK. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA(1-42) insult. Neurosci Lett. 2001;303(1):57-61.
22. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007;28(8):1765-73.
23. Zhang LJ, Wu CF, Meng XL, Yuan D, Cai XD, Wang QL, Yang JY. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neurosci Lett. 2008;447(1):48-53.
24. Lee JW, Hong HM, Kwon DD, Pae HO, Jeong HJ. Demethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3. Korean J Urol. 2010;51(12):870-88.
25. Kim H, Park BS, Lee KG, Choi CY, Jang SS, Ki YH, Lee SE. Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid. J Agric Food Chem. 2005;53(22):8537-41.
26. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1-2):55-63.
27. Jayaraj RL, Tamilselvam K, Manivasagam T, Elangovan N. Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease. J Mol Neurosci. 2013;51(3):863-70.
28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265-75.
29. Dhanalakshmi C, Janakiraman U, Manivasagam T, Thenmozhi AJ, Essa MM, Kalandar A, Khan MA, Guillemin GA. Vanillin attenuated behavioural impairments, neurochemical deficts, oxidative stress and apoptosis against rotenone induced rat model of Parkinson's disease. Neurochem Res. 2016;41(8):1899-910.
30. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci. 1973;20:415-55.
31. Collier TJ, Kanaan NM, Kordower JH. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nat Rev Neurosci. 2011;12(6):359-66.
32. Yong-Kee CJ, Sidorova E, Hanif A, Perera G, Nash JE. Mitochondrial dysfunction precedes other sub-cellular abnormalities in an in vitro model linked with cell death in Parkinson's disease. Neurotox Res. 2012;21:185-94.
33. Marella M, Seo BB, Matsuno-Yagi A, Yagi T. Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line. J Biol Chem. 2007;282(33):24146-56.
34. Ding HQ, Gao J, Zhu ZR, Xiong Y, Liu J. Mitochondrial dysfunction enhances susceptibility to oxidative stress by down-regulation of thioredoxin in human neuroblastoma cells. Neurochem Res. 2008;33:43-50.
35. Moon Y, Lee KH, Park JH, Geum D, Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q (10). J Neurochem. 2005;93(5):1199-208.
36. Isenberg JS, Klaunig JE. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol Sci. 2000;53(2):340-51.
37. Doran E, Halestrap AP. Cytochrome c release from isolated rat liver mitochondria can occur independently of outer membrane rupture: possible role of contact sites. Biochem J. 2000;348:343-50.
38. Kim HY, Chung JM, Chung K. Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci Lett. 2008;447:87-91.
39. Clark J, Clore EL, Zheng K, Adame A, Masliah E, Simon DK. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PLoS One. 2010;5(8):e12333.
40. Dairam A, Limson JL, Watkins GM, Antunes E, Daya S. Curcuminoids, Curcumin, and Demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric Food Chem. 2007;55(3):1039-44.
41. Borra SK, Gurumurthy P, Mahendra J, Jayamathi KM, Cherian CN, Ram chand. Antioxidant and free radical scavenging activity of curcumin determined by using different in vitro and ex vivo models. J Med Plant Res. 2013;7(36):2680-2690.
42. Testa CM, Sherer TB, Greenamyre JT. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res. 2005;134(1):109-18.
43. Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 2000;5:415-8.
44. Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C. Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol. 2003;160(1):53-64.
45. Jiang X, Wang X. Cytochrome-C mediated apoptosis. Annu Rev Biochem. 2004;73:87-106.
46. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9(1):47-59.
47. Zha JH, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of Harada death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 1996;87(4):619-28.
48. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997;278(5338):687-9.
49. Bonni A, Brunet A, Wes AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science. 1997;286(5443):1358-62.
50. Fang X, Yu S, Eder A, Mao M, Bast Jr RC, Boyd D, Mills GB. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene. 1999;18(48):6635-40.
51. Ahmed T, Gilani A. A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an A-β plus ibotenic acid-infused rat model of Alzheimer's disease. Brain Res. 2011;1400:1-18.
52. Liao KK, Wu MJ, Chen PY, Huang SW, Chiu SJ, Ho CT, Yen JH. Curcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK- and PKC-dependent pathways. J Agric Food Chem. 2012;60(1):433-43.
53. Tatton WG, Chalmers-Redman R, Brown D, Tatton N. Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann Neurol. 2003;53(Suppl 3:S61-70):61-70.
54. Ruwanpura SM, McLachlan RI, Meachem SJ. Hormonal regulation of male germ cell development. J Endocrinol. 2010;205(2):117-31.