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Volumn 51, Issue 12, 2010, Pages 870-878

Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma Caki cells through the production of reactive oxygen species, the release of cytochrome c, and the activation of caspase-3

Author keywords

Antineoplastic agents; Apoptosis; Curcumin; Dimethoxycurcumin; Renal cell carcinoma

Indexed keywords

ANTIOXIDANT; CASPASE 3; CURCUMIN; CYTOCHROME; CYTOCHROME C; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; REACTIVE OXYGEN METABOLITE; TETRAZOLIUM;

EID: 78650905938     PISSN: 20056737     EISSN: 20056745     Source Type: Journal    
DOI: 10.4111/kju.2010.51.12.870     Document Type: Article
Times cited : (56)

References (29)
  • 1
    • 77149179813 scopus 로고    scopus 로고
    • Curcumin as an anti-cancer agent: Review of the gap between basic and clinical applications
    • Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr Med Chem 2010;17:190-7.
    • (2010) Curr Med Chem , vol.17 , pp. 190-197
    • Bar-Sela, G.1    Epelbaum, R.2    Schaffer, M.3
  • 2
    • 0026540445 scopus 로고
    • Curcumin as an inhibitor of cancer
    • Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr 1992;11:192-8.
    • (1992) J Am Coll Nutr , vol.11 , pp. 192-198
    • Nagabhushan, M.1    Bhide, S.V.2
  • 3
    • 0031903668 scopus 로고    scopus 로고
    • Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene
    • DOI 10.1093/carcin/19.6.1039
    • Singletary K, MacDonald C, Iovinelli M, Fisher C, Wallig M. Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[α]anthracene. Carcinogenesis 1998;19:1039-43. (Pubitemid 28375399)
    • (1998) Carcinogenesis , vol.19 , Issue.6 , pp. 1039-1043
    • Singletary, K.1    MacDonald, C.2    Iovinelli, M.3    Fisher, C.4    Wallig, M.5
  • 5
    • 0030872976 scopus 로고    scopus 로고
    • Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines
    • Mehta K, Pantazis P, McQueen T, Aggarwal BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 1997;8:470-81.
    • (1997) Anticancer Drugs , vol.8 , pp. 470-481
    • Mehta, K.1    Pantazis, P.2    McQueen, T.3    Aggarwal, B.B.4
  • 6
    • 77449090086 scopus 로고    scopus 로고
    • Apoptosis by dietary agents for prevention and treatment of prostate cancer
    • Khan N, Adhami VM, Mukhtar H. Apoptosis by dietary agents for prevention and treatment of prostate cancer. Endocr Relat Cancer 2010;17:R39-52.
    • (2010) Endocr Relat Cancer , vol.17
    • Khan, N.1    Adhami, V.M.2    Mukhtar, H.3
  • 7
    • 55949095821 scopus 로고    scopus 로고
    • Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells
    • Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 2008;76:1340-51.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1340-1351
    • Reuter, S.1    Eifes, S.2    Dicato, M.3    Aggarwal, B.B.4    Diederich, M.5
  • 8
    • 76649091631 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway
    • Chen Q, Wang Y, Xu K, Lu G, Ying Z, Wu L, et al. Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Oncol Rep 2010;23:397-403.
    • (2010) Oncol Rep , vol.23 , pp. 397-403
    • Chen, Q.1    Wang, Y.2    Xu, K.3    Lu, G.4    Ying, Z.5    Wu, L.6
  • 9
    • 54349099181 scopus 로고    scopus 로고
    • Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells
    • Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic Biol Med 2008;45:1403-12.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1403-1412
    • Thayyullathil, F.1    Chathoth, S.2    Hago, A.3    Patel, M.4    Galadari, S.5
  • 12
    • 0032815637 scopus 로고    scopus 로고
    • Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates
    • Bhaumik S, Anjum R, Rangaraj N, Pardhasaradhi BV, Khar A. Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 1999;456:311-4.
    • (1999) FEBS Lett , vol.456 , pp. 311-314
    • Bhaumik, S.1    Anjum, R.2    Rangaraj, N.3    Pardhasaradhi, B.V.4    Khar, A.5
  • 13
    • 0034515783 scopus 로고    scopus 로고
    • Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds
    • Hadi SM, Asad SF, Singh S, Ahmad A. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life 2000;50:167-71.
    • (2000) IUBMB Life , vol.50 , pp. 167-171
    • Hadi, S.M.1    Asad, S.F.2    Singh, S.3    Ahmad, A.4
  • 14
    • 38349042198 scopus 로고    scopus 로고
    • Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis
    • Hsu YC, Weng HC, Lin S, Chien YW. Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis. J Agric Food Chem 2007;55:8213-22.
    • (2007) J Agric Food Chem , vol.55 , pp. 8213-8222
    • Hsu, Y.C.1    Weng, H.C.2    Lin, S.3    Chien, Y.W.4
  • 15
    • 0035114277 scopus 로고    scopus 로고
    • Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production
    • Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, et al. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 2001;61:1058-64.
    • (2001) Cancer Res , vol.61 , pp. 1058-1064
    • Ireson, C.1    Orr, S.2    Jones, D.J.3    Verschoyle, R.4    Lim, C.K.5    Luo, J.L.6
  • 18
    • 77958015051 scopus 로고    scopus 로고
    • Perspectives in drug development for metastatic renal cell cancer
    • Basu B, Eisen T. Perspectives in drug development for metastatic renal cell cancer. Target Oncol 2010;5:139-56.
    • (2010) Target Oncol , vol.5 , pp. 139-156
    • Basu, B.1    Eisen, T.2
  • 19
    • 77955880263 scopus 로고    scopus 로고
    • Emerging drugs for renal cell carcinoma
    • Varella L, Rini BI. Emerging drugs for renal cell carcinoma. Expert Opin Emerg Drugs 2010;15:343-53.
    • (2010) Expert Opin Emerg Drugs , vol.15 , pp. 343-353
    • Varella, L.1    Rini, B.I.2
  • 20
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003;24:1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3    Kim, D.G.4    Lee, K.S.5    Bae, J.H.6
  • 21
    • 78650902297 scopus 로고    scopus 로고
    • Curcumin induces apoptosis and inhibits metalloproteinase activity in renal cancer cell Line
    • Kim DG, Kwon TK, Park JW, Lee KS. Curcumin induces apoptosis and inhibits metalloproteinase activity in renal cancer cell Line. Korean J Urol 2002;43:423-30.
    • (2002) Korean J Urol , vol.43 , pp. 423-430
    • Kim, D.G.1    Kwon, T.K.2    Park, J.W.3    Lee, K.S.4
  • 22
    • 33748694314 scopus 로고    scopus 로고
    • Comparative effects of curcuminoids on endothelial heme oxygenase- 1 expression: Ortho-methoxy groups are essential to enhance heme oxygenase activity and protection
    • Jeong GS, Oh GS, Pae HO, Jeong SO, Kim YC, Shin MK, et al. Comparative effects of curcuminoids on endothelial heme oxygenase- 1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection. Exp Mol Med 2006;38:393-400.
    • (2006) Exp Mol Med , vol.38 , pp. 393-400
    • Jeong, G.S.1    Oh, G.S.2    Pae, H.O.3    Jeong, S.O.4    Kim, Y.C.5    Shin, M.K.6
  • 23
    • 54949090388 scopus 로고    scopus 로고
    • Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS
    • Pae HO, Jeong SO, Kim HS, Kim SH, Song YS, Kim SK, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res 2008;52:1082-91.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 1082-1091
    • Pae, H.O.1    Jeong, S.O.2    Kim, H.S.3    Kim, S.H.4    Song, Y.S.5    Kim, S.K.6
  • 24
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;48:749-62.
    • (2010) Free Radic Biol Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 25
    • 84934444244 scopus 로고    scopus 로고
    • Clinical studies with curcumin
    • Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol 2007;595:471-80.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 471-480
    • Hsu, C.H.1    Cheng, A.L.2
  • 27
    • 77951279075 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer
    • Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res 2010;44:479-96.
    • (2010) Free Radic Res , vol.44 , pp. 479-496
    • Liou, G.Y.1    Storz, P.2
  • 29
    • 73349094986 scopus 로고    scopus 로고
    • Curcumin and cancer cells: How many ways can curry kill tumor cells selectively?
    • Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 2009;11:495-510.
    • (2009) AAPS J , vol.11 , pp. 495-510
    • Ravindran, J.1    Prasad, S.2    Aggarwal, B.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.