Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: The role of curcumin on pSTAT3 and Nrf-2 signalling

British Journal of Cancer

Volumn 113, Issue 10, 2015, Pages 1434-1444

  Fetoni, A R ^a   Paciello, F ^a   Mezzogori, D ^a   Rolesi, R ^a   Eramo, S L M ^a   Paludetti, G ^a   Troiani, D ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

chemotherapeutic adjuvant; cochlea; heme oxigenase 1; human oral squamous cell carcinoma; otoprotection; polyphenols; pro antioxidant effect

Indexed keywords

CISPLATIN; CURCUMIN; PROTEIN BAX; STAT3 PROTEIN; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CANCER SURVIVAL; CELL LOSS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORTI ORGAN; DISTORTION PRODUCT OTOACOUSTIC EMISSION; DNA FRAGMENTATION; EVOKED BRAIN STEM AUDITORY RESPONSE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HEARING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOTHERAPY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVIEW; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CARCINOMA, SQUAMOUS CELL; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG RESISTANCE; HEAD AND NECK NEOPLASMS; HEARING LOSS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; CURCUMIN; DRUG RESISTANCE, NEOPLASM; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEAD AND NECK NEOPLASMS; HEARING LOSS; HUMANS; MALE; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84947484631     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.359     Document Type: Review

References (59)

1. Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME, Carey TE (2011) Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Arch Otolaryngol Head Neck Surg 137(5): 499-507.
2. Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB (2004) Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signalling. Int J Cancer 111(5): 679-692.
3. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharmacol 4(6): 807-818.
4. Armstrong DK, Bundy B,Wenzel L, Huang HQ, Baergen R, Lele S, Copeland LJ, Walker JL, Burger RA. Gynecologic Oncology Group (2006) Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med 354(1): 34-43.
5. Berndtsson M, Hagg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S (2007) Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int J Cancer 120: 175-180.
6. Calabrese V, Bates TE, Mancuso C, Cornelius C, Ventimiglia B, Cambria MT, Di Renzo L, De Lorenzo A, Dinkova-Kostova AT (2008) Curcumin and the cellular stress response in free radical-related diseases. Mol Nutr Food Res 52(9): 1062-1073.
7. Camacho-Alonso F, López-Jornet P, Tudela-Mulero MR (2013) Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells. Oral Dis 19: 465-472.
8. Cole GM, Teter B, Frautschy SA (2007) Neuroprotective effects of curcumin. Adv Exp Med Biol 595: 197-212.
9. Cullen KJ, Newkirk KA, Schumaker LM, Aldosari N, Rone JD, Haddad BR (2003) Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors. Cancer Res 63(23): 8097-8102.
10. Demirovic D, Rattan SI (2013) Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol 48(1): 94-98.
11. Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99(18): 11908-11913.
12. Fetoni AR, De Bartolo P, Eramo SL, Rolesi R, Paciello F, Bergamini C, Fato R, Paludetti G, Petrosini L, Troiani D (2013) Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defence. J Neurosci 33(9): 4011-4023.
13. Fetoni AR, Eramo SL, Paciello F, Rolesi R, Podda MV, Troiani D, Paludetti G (2014) Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction. Otol Neurotol 35(5): e169-e177.
14. Fetoni AR, Paciello F, Rolesi R, Eramo SL, Mancuso C, Troiani D, Paludetti G (2015) Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea. Free Radic Biol Med 85: 269-281.
15. Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M, Kroemer G (2012) Molecular mechanisms of cisplatin resistance. Oncogene 31(15): 1869-1883.
16. Ghalandarlaki N, Alizadeh AM, Ashkani-Esfahani S (2014) Nanotechnologyapplied curcumin for different diseases therapy. Biomed Res Int 2014: 394264.
17. Goel A, Aggarwal BB (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 62(7): 919-930.
18. Grandis JR, Drenning SD, Zeng Q,Watkins SC, MelhemMF, Endo S, Johnson DE, Huang L, He Y, Kim JD (2000) Constitutive activation of Stat3 signalling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci USA 97(8): 4227-4232.
19. Gu F, Ma Y, Zhang Z, Zhao J, Kobayashi H, Zhang L, Fu L (2010) Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep 23(3): 671-676.
20. Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34(4): 176-188.
21. Hollborn M, Chen R, Wiedemann P, Reichenbach A, Bringmann A, Kohen L (2013) Cytotoxic effects of curcumin in human retinal pigment epithelial cells. PLoS One 8(3): e59603.
22. Huang CF, Zhang L,Ma SR, Zhao ZL,WangWM, He KF, Zhao YF, ZhangWF, Liu B, Sun ZJ (2013) Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma. PLoS One 8(12): e83479.
23. Jacobs C, Lyman G, Velez-García E, Sridhar KS, Knight W, Hochster H, Goodnough LT, Mortimer JE, Einhorn LH, Schacter L (1992) A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 10(2): 257-263.
24. Jing N, Tweardy DJ (2005) Targeting Stat3 in cancer therapy. Anticancer Drugs 16(6): 601-607.
25. Johnston PA, Grandis JR (2011) STAT3 signaling: anticancer strategies and challenges. Mol Interv 11(1): 18-26.
26. Karin M, Greten F (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5(10): 749-759.
27. Kelland L (2007) The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 7(8): 573-584.
28. Kumar B, Yadav A, Hideg K, Kuppusamy P, Teknos TN, Kumar P (2014) A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer. PLoS One 9(3): e93208.
29. Lai SY, Johnson FM (2010) Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches. Drug Resist Updat 13(3): 67-78.
30. Langer T, Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O (2013) Understanding platinum-induced ototoxicity. Trends Pharmacol Sci 34(8): 458-469.
31. Lee JH, Khor TO, Shu L, Su ZY, Fuentes F, Kong AN (2013) Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther 137(2): 153-171.
32. Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT, Van Waes C, Chen Z (2008) A signal network involving coactivated NFkappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 122(9): 1987-1998.
33. Leeman-Neill RJ, Wheeler SE, Singh SV, Thomas SM, Seethala RR, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M, Cai Q, Freilino ML, Li C, Johnson DE, Grandis JR (2009) Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis 30(11): 1848-1856.
34. Liu B, Ren Z, Shi Y, Guan C, Pan Z, Zong Z (2008) Activation of signal transducers and activators of transcription 3 and overexpression of its target gene CyclinD1 in laryngeal carcinomas. Laryngoscope 118(11): 1976-1980.
35. Mali SB (2015) Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer. Oral Oncol 51(6): 565-569.
36. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203): 436-444.
37. Naksuriya O, Okonogi S, Schiffelers RM, Hennink WE (2014) Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials 35(10): 3365-3383.
38. Pan Y, Zhou F, Zhang R, Claret FX (2013) Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo-and radio-sensitivity in nasopharyngeal carcinoma. PLoS One 8(1): e54565.
39. Piacentini R, Ripoli C, Leone L, Misiti F, Clementi ME, D'Ascenzo M, Giardina B, Azzena GB, Grassi C (2008) Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid beta-peptide in human neuroblastoma IMR32 cells. J Neurochem 107(4): 1070-1082.
40. Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res Treat 46(1): 2-18.
41. Rybak LP, Mukherjea D, Jajoo S, Ramkumar V (2009) Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med 219(3): 177-186.
42. Salehi P, Akinpelu OV, Waissbluth S, Peleva E, Meehan B, Rak J, Daniel SJ (2014) Attenuation of cisplatin ototoxicity by otoprotective effects of nanoencapsulated curcumin and dexamethasone in a guinea pig model. Otol Neurotol 35(7): 1131-1139.
43. Salipur FR, Reyes-Reyes EM, Xu B, Hammond GB, Bates PJ (2014) A novel small molecule that induces oxidative stress and selectively kills malignant cells. Free Radic Biol Med 68: 110-121.
44. Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, Di Giovanni J (2005) Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res 65(13): 5720-5729.
45. Shen T, Jiang T, Long M, Chen J, Ren D, Wong PK, Chapman E, Zhou B, Zhang DD (2015) A curcumin derivative that inhibits vinyl carbamateinduced lung carcinogenesis via activation of the Nrf2 protective response. Antioxid Redox Signal 23(8): 651-664.
46. Shishodia S (2013) Molecular mechanisms of curcumin action: gene expression. Biofactors 39(1): 37-55.
47. Singer E, Judkins J, Salomonis N, Matlaf L, Soteropoulos P, McAllister S, Soroceanu L (2015) Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma. Cell Death Dis 15(6): e1601.
48. Song JI, Grandis JR (2000) STAT signaling in head and neck cancer. Oncogene 19(21): 2489-2495.
49. Stacy DR, Ely K, Massion PP, Yarbrough WG, Hallahan DE, Sekhar KR, Freeman ML (2006) Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck 28(9): 813-818.
50. Strimpakos AS, Sharma RA (2008) Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 10(3): 511-545.
51. Tew KD, Townsend DM (2012) Glutathione-s-transferases as determinants of cell survival and death. Antioxid Redox Signal 17(12): 1728-1737.
52. Thangapazham RL, Sharma A, Maheshwari RK (2006) Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J 8(3): E443-E449.
53. Waissbluth S, Daniel SJ (2013) Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity. Hear Res 299: 37-45.
54. Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB (2008) Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKTindependent pathway. Clin Cancer Res 14(19): 6228-6236.
55. Wondrak GT (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 11: 3013-3069.
56. Yang H, Wang W, Zhang Y, Zhao J, Lin E, Gao J, He J (2011) The role of NFE2-related factor 2 in predicting chemoresistance and prognosis in advanced non-small-cell lung cancer. Clin Lung Cancer 12(3): 166-171.
57. Yu H, Lee H, Herrmann A, Buettner R, Jove R (2014) Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 14(11): 736-746.
58. Zhou H, Beevers CS, Huang S (2011) The targets of curcumin. Curr Drug Targets 12(3): 332-347.
59. Zhou X, Ren Y, Liu A, Jin R, Jiang Q, Huang Y, Kong L, Wang X, Zhang L (2014) WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis. Sci Rep 4: 7461.