CpG in combination with an inhibitor of notch signaling suppresses formalin-inactivated respiratory syncytial virus-enhanced airway hyperresponsiveness and inflammation by inhibiting Th17 memory responses and promoting tissue-resident memory cells in lungs

Journal of Virology

Volumn 91, Issue 10, 2017, Pages

  Zhang, Lei ^a   Li, Hongyong ^a,c   Hai, Yan ^a   Yin, Wei ^a   Li, Wenjian ^a   Zheng, Boyang ^a   Du, Xiaomin ^a,c   Li, Na ^a,c   Zhang, Zhengzheng ^a   Deng, Yuqing ^a   Zeng, Ruihong ^a   Wei, Lin ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province   (China)

^c Xingtai Medical College   (China)

Author keywords

CpG; FI RSV enhanced respiratory disease; Inhibitor of Notch signaling; Th17; Tissue resident memory cells

Indexed keywords

ALUMINUM HYDROXIDE; ANTIVIRUS AGENT; CPG; EOTAXIN; METHACHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; NOTCH RECEPTOR; NOTCH RECEPTOR INHIBITOR; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; CPG-OLIGONUCLEOTIDE; DIPEPTIDE; FORMALDEHYDE; IMMUNOLOGICAL ADJUVANT; INACTIVATED VACCINE; L 685458; OLIGODEOXYRIBONUCLEOTIDE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; TOLL LIKE RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CELLULAR IMMUNITY; CONTROLLED STUDY; DYNAMIC COMPLIANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HISTOLOGY; IMMUNOLOGICAL MEMORY; INFLAMMATION; LEUKOCYTE DIFFERENTIAL COUNT; LUNG; LUNG RESISTANCE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT PARAMETERS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH17 CELL; ANIMAL; BAGG ALBINO MOUSE; BRONCHUS HYPERREACTIVITY; CD8+ T LYMPHOCYTE; CHEMICALLY INDUCED; CHEMISTRY; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION; VIROLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BRONCHIAL HYPERREACTIVITY; CARBAMATES; CD8-POSITIVE T-LYMPHOCYTES; DIPEPTIDES; FORMALDEHYDE; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; LUNG; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, NOTCH; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS VACCINES; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; SIGNAL TRANSDUCTION; TH17 CELLS; TOLL-LIKE RECEPTOR 1; VACCINES, INACTIVATED;

EID: 85018328749     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02111-16     Document Type: Article

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