Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

DMM Disease Models and Mechanisms

Volumn 9, Issue 10, 2016, Pages 1169-1179

  Lambert, Laura J ^a   Challa, Anil K ^a   Niu, Aidi ^b   Zhou, Lihua ^b   Tucholski, Janusz ^b   Johnson, Maria S ^c   Nagy, Tim R ^c   Eberhardt, Alan W ^d   Estep, Patrick N ^d   Kesterson, Robert A ^a   Grams, Jayleen M ^b,e  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d and Radiation Oncology   (United States)

^e BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Bone strength; Bone structure; Genetic animal models; Osteocalcin; Osteocalcin knockout

Indexed keywords

GUIDE RNA; MESSENGER RNA; OSTEOCALCIN; INSULIN;

ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY COMPOSITION; BONE DENSITY; BONE MASS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; EMBRYO; FEMALE; FRAMESHIFT MUTATION; GENE LOCUS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; INSULIN TOLERANCE TEST; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RAT; RAT MODEL; RAT MUTANT; SYNTENY; TRABECULAR BONE; ANIMAL; CHEMISTRY; CRISPR CAS SYSTEM; DEFICIENCY; DIAGNOSTIC IMAGING; FEMUR; FOUNDER EFFECT; GENETIC PROCEDURES; GENETICS; INDEL MUTATION; METABOLISM; NUCLEOTIDE SEQUENCE; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; SPECIES DIFFERENCE;

ABSORPTIOMETRY, PHOTON; ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BIOMECHANICAL PHENOMENA; BODY COMPOSITION; CANCELLOUS BONE; CRISPR-CAS SYSTEMS; FEMUR; FOUNDER EFFECT; GENETIC TECHNIQUES; GLUCOSE TOLERANCE TEST; INDEL MUTATION; INSULIN; MALE; MODELS, ANIMAL; OSTEOCALCIN; RATS; SPECIES SPECIFICITY; X-RAY MICROTOMOGRAPHY;

EID: 84993967407     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.025247     Document Type: Article

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