Heart rate correction of the QT duration in rats

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 187-192

  Kmecova, Jana ^a,b   Klimas, Jan ^a  

^a Physics and Informatics   (Slovakia)

^b State Institute of Drug Control   (Slovakia)

Author keywords

(Rat); Bisoprolol; Clarithromycin; Electrocardiographic interval; Isoproterenol; Ivabradine

Indexed keywords

BISOPROLOL; CLARITHROMYCIN; ISOPRENALINE; IVABRADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; CORRELATIONAL STUDY; DOSE RESPONSE; ELECTROCARDIOGRAPHY; EXPERIMENTAL RAT; HEART CYCLE; HEART RATE; MALE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RAT; REPEATED DRUG DOSE; RR INTERVAL; SHORT QT INTERVAL; SINGLE DRUG DOSE;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; BISOPROLOL; BRADYCARDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEASIBILITY STUDIES; HEART RATE; MALE; RATS; RATS, WISTAR;

EID: 77954090017     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.038     Document Type: Article

References (34)

1. Ahnve S. Correction of the QT interval for heart rate: review of different formulas and the use of Bazett's formula in myocardial infarction. Am. Heart J. 1985, 109:568-574.
2. Allon N., Rabinovitz I., Manistersky E., Weissman B.A., Grauer E. Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats. Toxicol. Sci. 2005, 87:385-390.
3. Arnold L., Page J., Attwell D., Cannell M., Eisner D.A. The dependence on heart rate of the human ventricular action potential duration. Cardiovasc. Res. 1982, 16:547-551.
4. Baillard C., Mansier P., Ennezat P.V., Mangin L., Medigue C., Swynghedauw B., Chevalier B. Converting enzyme inhibition normalizes QT interval in spontaneously hypertensive rats. Hypertension 2000, 36:350-354.
5. Buschmann G., Schumacher W., Budden R., Kuhl U.G. Evaluation of the effect of dopamine and other catecholamines on the electrocardiogram and blood pressure of rats by means of on-line biosignal processing. J. Cardiovasc. Pharmacol. 1980, 2:777-795.
6. Camm A.J., Lau C.P. Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology. Drugs R. D. 2003, 4:83-89.
7. Carr R.A., Edmonds A., Shi H., Locke C.S., Gustavson L.E., Craft J.C., Harris S.I., Palmer R. Steady-state pharmacokinetics and electrocardiographic pharmacodynamics of clarithromycin and loratadine after individual or concomitant administration. Antimicrob. Agents Chemother. 1998, 42:1176-1180.
8. Clementy J., Samoyeau R., Coste P., Bricaud H. Study of the electrophysiological properties of intravenous bisoprolol in patients with and without coronary-artery disease by programmed stimulation. J. Cardiovasc. Pharmacol. 1990, 16:S169-S174.
9. Crouch M.A., Limon L., Cassano A.T. Clinical relevance and management of drug-related QT interval prolongation. Pharmacotherapy 2003, 23:881-908.
10. Davey P. How to correct the QT interval for the effects of heart rate in clinical studies. J. Pharmacol. Toxicol. Meth. 2002, 48:3-9.
11. Demolis J.L., Vacheron F., Cardus S., Funck-Brentano C. Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects. Clin. Pharmacol. Ther. 2003, 73:242-252.
12. Fossa A.A., Wisialowski T., Magnano A., Wolfgang E., Winslow R., Gorczyca W., Crimin K., Raunig D.L. Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. J. Pharmacol. Exp. Ther. 2005, 312:1-11.
13. Goldenberg I., Moss A.J., Zareba W. QT interval: how to measure it and what is "normal". J. Cardiovasc. Electrophysiol. 2006, 17:333-336.
14. Hamlin R.L., Kijtawornrat A., Keene B.W., Hamlin D.M. QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles. Toxicol. Sci. 2003, 76:437-442.
15. Hansen O., Johansson B.W., Gullberg B. Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics. Angiology 1991, 42:990-1001.
16. Hansen O., Johansson B.W., Nilsson-Ehle P. Metabolic, electrocardiographic, and hemodynamic responses to increased circulating adrenaline: effects of selective and nonselective beta adrenoceptor blockade. Angiology 1990, 41:175-188.
17. Hanton G., Nahas K., Priou C., Rabemampianina Y., Baneux P. The QT interval in the dog ECG: importance in preclinical toxicology and relationship to heart rate. Toxicol. Methods 2001, 11:21-40.
18. Hayes E., Pugsley M.K., Penz W.P., Adaikan G., Walker M.J. Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates. J. Pharmacol. Toxicol. Meth. 1994, 32:201-207.
19. Howden R., Hanlon P.R., Petranka J.G., Kleeberger S., Bucher J., Dunnick J., Nyska A., Murphy E. Ephedrine plus caffeine causes age-dependent cardiovascular responses in Fischer 344 rats. Am. J. Physiol. Heart Circ. Physiol. 2005, 288:H2219-H2224.
20. Imani A., Faghihi M., Sadr S.S., Keshavarz M., Niaraki S.S. Noradrenaline reduces ischemia-induced arrhythmia in anesthetized rats: involvement of alpha1-adrenoceptors and mitochondrial K ATP channels. J. Cardiovasc. Electrophysiol. 2008, 19:309-315.
21. Klimas J., Stankovicova T., Kyselovic J., Bacharova L. Prolonged QT interval is associated with blood pressure rather than left ventricular mass in spontaneously hypertensive rats. Clin. Exp. Hypertens. 2008, 30:475-485.
22. Krenek P., Kmecova J., Kucerova D., Bajuszova Z., Musil P., Gazova A., Ochodnicky P., Klimas J., Kyselovic J. Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function. Eur. J. Heart Fail. 2009, 11:140-146.
23. Malik M. The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes. Pacing Clin. Electrophysiol. 2002, 25:209-216.
24. Mitchell G.F., Jeron A., Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am. J. Physiol. 1998, 274:H747-H751.
25. Mougenot N., Mediani O., Lechat P. Bisoprolol and hydrochlorothiazide effects on cardiovascular remodeling in spontaneously hypertensive rats. Pharmacol. Res. 2005, 51:359-365.
26. Mulder P., Barbier S., Chagraoui A., Richard V., Henry J.P., Lallemand F., Renet S., Lerebours G., Mahlberg-Gaudin F., Thuillez C. Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation 2004, 109:1674-1679.
27. Roth D.M., Swaney J.S., Dalton N.D., Gilpin E.A., Ross J. Impact of anesthesia on cardiac function during echocardiography in mice. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H2134-H2140.
28. Sarma J.S., Venkataraman K., Samant D.R., Gadgil U.G. Effect of propranolol on the QT intervals of normal individuals during exercise: a new method for studying interventions. Br. Heart J. 1988, 60:434-439.
29. Savelieva I., Camm A.J. I(f) inhibition with ivabradine: electrophysiological effects and safety. Drug Saf. 2008, 31:95-107.
30. Shi R.Q., Lee J.K., Hayashi Y., Takeuchi Y., Kambe F., Futaki S., Seo H., Murata Y., Kodama I. Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. Eur. J. Pharmacol. 2008, 578:270-278.
31. Tavakoli S., Hajrasouliha A.R., Jabehdar-Maralani P., Ebrahimi F., Solhpour A., Sadeghipour H., Ghasemi M., Dehpour A.R. Reduced susceptibility to epinephrine-induced arrhythmias in cirrhotic rats: the roles of nitric oxide and endogenous opioid peptides. J. Hepatol. 2007, 46:432-439.
32. Vaupel D.B., Tella S.R., Huso D.L., Wagner V.O., Mukhin A.G., Chefer S.I., Horti A.G., London E.D., Koren A.O., Kimes A.S. Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography. J. Pharmacol. Exp. Ther. 2005, 312:355-365.
33. Vilaine J.P. The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease. Pharmacol. Res. 2006, 53:424-434.
34. + currents among the left ventricular free wall of rats with ascending aortic stenosis. J. Physiol. 2001, 530:443-455.