Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese

Circulation: Cardiovascular Genetics

Volumn 6, Issue 6, 2013, Pages 598-607

  He, Jiang ^a,b   Kelly, Tanika N ^a   Zhao, Qi ^a   Li, Hongfan ^c,e   Huang, Jianfeng ^c   Wang, Laiyuan ^e   Jaquish, Cashell E ^f   Sung, Yun Ju ^g   Shimmin, Lawrence C ^h   Lu, Fanghong ⁱ   Mu, Jianjun ^k   Hu, Dongsheng ^l   Ji, Xu ^m   Shen, Chong ^c   Guo, Dongshuang ^o   Ma, Jixiang ^j   Wang, Renping ^p   Shen, Jinjin ^q   Li, Shengxu ^a   Chen, Jing ^a,b   Mei, Hao ^a   Chen, Chung Shiuan ^a   Chen, Shufeng ⁿ   Chen, Jichun ^c   Li, Jianxin ^c   Cao, Jie ^c   Lu, Xiangfeng ^c   Wu, Xigui ^c   Rice, Treva K ^g   Gu, C Charles ^g   Schwander, Karen ^g   Hamm, L Lee ^a,b   Liu, Depei ^d   Rao, Dabeeru C ^g   Hixson, James E ^h   Gu, Dongfeng ^c   more..

^a TULANE UNIVERSITY   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FUWAI HOSPITAL   (China)

^d INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^e CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^j Shandong Center for Disease Control and Prevention   (China)

^k XI'AN JIAOTONG UNIVERSITY   (China)

^l SHENZHEN UNIVERSITY   (China)

^m Xinle Traditional Chinese Medicine Hospital   (China)

ⁿ NANJING MEDICAL UNIVERSITY   (China)

^o Yuxian Hospital   (China)

^p Hebei Changcheng Hospital   (China)

^q Center for Disease Control and Prevention of Yancheng   (China)

more..

Author keywords

Blood pressure; Genomics; Potassium; Sodium

Indexed keywords

POTASSIUM; SODIUM;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CHINESE; COLD PRESSOR TEST; DIET SUPPLEMENTATION; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIGH POTASSIUM INTAKE; HIGH SODIUM INTAKE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHENOTYPE; POTASSIUM INTAKE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM INTAKE; SODIUM RESTRICTION;

BLOOD PRESSURE; GENOMICS; POTASSIUM; SODIUM;

ADP-RIBOSYLATION FACTORS; ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CHINA; F-BOX PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NUCLEAR PROTEINS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM, DIETARY; PREGNANCY PROTEINS; PROTEIN-ARGININE N-METHYLTRANSFERASES; SODIUM, DIETARY; SUPPRESSOR FACTORS, IMMUNOLOGIC; TRANSCRIPTION FACTORS; TRPM CATION CHANNELS;

EID: 84892418762     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000307     Document Type: Article

References (48)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-223.
2. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747-1757.
3. Adrogué HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med. 2007;356:1966-1978.
4. He J, Gu D, Chen J, Jaquish CE, Rao DC, Hixson JE, et al; GenSalt Collaborative Research Group. Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens. 2009;27:48-54.
5. Kelly TN, He J. Genomic epidemiology of blood pressure salt sensitivity. J Hypertens. 2012;30:861-873.
6. Kasagi F, Akahoshi M, Shimaoka K. Relation between cold pressor test and development of hypertension based on 28-year follow-up. Hypertension. 1995;25:71-76.
7. Chen J, Gu D, Jaquish CE, Chen CS, Rao DC, Liu D, et al; GenSalt Collaborative Research Group. Association between blood pressure responses to the cold pressor test and dietary sodium intervention in a Chinese population. Arch Intern Med. 2008;168:1740-1746.
8. Mei H, Gu D, Rice TK, Hixson JE, Chen J, Jaquish CE, et al. Heritability of blood pressure responses to cold pressor test in a Chinese population. Am J Hypertens. 2009;22:1096-1100.
9. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, et al Wellcome Trust Case Control Consortium. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009;41:666-676.
10. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41:677-687.
11. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, et al. Meta-analysis identifies five novel loci associated with blood pressure in East Asians. Nat Genet. 2011;43:531-538.
12. International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-109.
13. Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, et al; LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium; CHARGE Consortium Heart Failure Working Group; KidneyGen consortium; CKDGen consortium; Cardiogenics consortium; CardioGram. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011;43:1005-1011.
14. GenSalt Collaborative Research Group. GenSalt: rationale, design, methods and baseline characteristics of study participants. J Hum Hypertens. 2007;21:639-646.
15. Zhao Q, Wang Y, Cao Y, Chen A, Ren M, Ge Y, et al. Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Sci Total Environ. 2013;470-471C:340-347.
16. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559-575.
17. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet. 1998;63:259-266.
18. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol. 2010;34:816-834.
19. Sharma AM, Schattenfroh S, Kribben A, Distler A. Reliability of salt-sensitivity testing in normotensive subjects. Klin Wochenschr. 1989;67:632-634.
20. Gu D, Zhao Q, Chen J, Chen JC, Huang J, Bazzano LA, et al. Reproducibility of blood pressure responses to dietary sodium and potassium interventions: the GenSalt study. Hypertension. 2013;62:499-505.
21. Hassellund SS, Flaa A, Sandvik L, Kjeldsen SE, Rostrup M. Long-term stability of cardiovascular and catecholamine responses to stress tests: an 18-year follow-up study. Hypertension. 2010;55:131-136.
22. Zhao Q, Bazzano LA, Cao J, Li J, Chen J, Huang J, et al. Reproducibility of blood pressure response to the cold pressor test: the GenSalt Study. Am J Epidemiol. 2012;176 (Suppl 7):S91-S98.
23. Barba G, Galletti F, Cappuccio FP, Siani A, Venezia A, Versiero M, et al. Incidence of hypertension in individuals with different blood pressure salt-sensitivity: results of a 15-year follow-up study. J Hypertens. 2007;25:1465-1471.
24. Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension. 2001;37(2 Pt 2):429-432.
25. Knox SS, Hausdorff J, Markovitz JH; Coronary Artery Risk Development in Young Adults Study. Reactivity as a predictor of subsequent blood pressure: racial differences in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Hypertension. 2002;40:914-919.
26. Szekeres-Bartho J, Falkay G, Török A, Pacsa AS. The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: II. Relationship between cytotoxicity and the cyclooxygenase pathway of arachidonic acid metabolism. Am J Reprod Immunol Microbiol. 1985;9:19-22.
27. Miko E, Halasz M, Jericevic-Mulac B, Wicherek L, Arck P, Arató G, et al. Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness. J Reprod Immunol. 2011;90:50-57.
28. Stelzer G, Dalah I, Stein TI, Satanower Y, Rosen N, Nativ N, et al. In-silico human genomics with GeneCards. Hum Genomics. 2011;5:709-717.
29. Muller DN, Dechend R, Mervaala EM, Park JK, Schmidt F, Fiebeler A, et al. NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension. 2000;35(1 Pt 2):193-201.
30. Rodríguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Mezzano S, Vaziri ND. Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats. J Pharmacol Exp Ther. 2005;315:51-57.
31. Farhang-Fallah J, Yin X, Trentin G, Cheng AM, Rozakis-Adcock M. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J Biol Chem. 2000;275:40492-40497.
32. Ueda T, Furusawa T, Kurahashi T, Tessarollo L, Bustin M. The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol. 2009;29:5264-5276.
33. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet. 2008;40:1092-1097.
34. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet. 2008;40:1098-1102.
35. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42:579-589.
36. Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, Stefansdottir H, et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet. 2010;42:117-122.
37. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, Estrada K, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009;41:399-406.
38. Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, Fuchsberger C, et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009;41:407-414.
39. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003;299:251-254.
40. Engel T, Lueken A, Bode G, Hobohm U, Lorkowski S, Schlueter B, et al. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. FEBS Lett. 2004;566:241-246.
41. Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res. 2011;52:531-539.
42. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, et al. Metaanalysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011;123:731-738.
43. Engels S, Kohlhase J, McGaughran J. A SALL1 mutation causes a branchio-oto-renal syndrome-like phenotype. J Med Genet. 2000;37:458-460.
44. Chasman DI, Schürks M, Anttila V, de Vries B, Schminke U, Launer LJ, et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet. 2011;43:695-698.
45. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature. 2004;430:748-754.
46. Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol. 2006;16:1591-1605.
47. Cirulli ET, Goldstein DB. Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet. 2010;11:415-425.
48. Chen J, Gu D, Huang J, Rao DC, Jaquish CE, Hixson JE, et al; GenSalt Collaborative Research Group. Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study. Lancet. 2009;373:829-835.