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Volumn 193, Issue 10, 2016, Pages 1168-1175

Higher estradiol and lower dehydroepiandrosterone-sulfate levels are associated with pulmonary arterial hypertension in men

Author keywords

DHEA; Estradiol; Pulmonary hypertension; Sex hormones

Indexed keywords

ESTRADIOL; PRASTERONE SULFATE;

EID: 84987608841     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201509-1785OC     Document Type: Article
Times cited : (101)

References (49)
  • 1
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • HumbertM, Sitbon O, Chaouat A, BertocchiM, Habib G, Gressin V, Yaïci A, Weitzenblum E, Cordier J-F, Chabot F, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010; 122: 156-163.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M1    Sitbon, O2    Chaouat, A3    Bertocchi, M4    Habib, G5    Gressin, V6    Yaïci, A7    Weitzenblum, E8    Cordier, J-F9    Chabot, F10
  • 2
    • 77954759389 scopus 로고    scopus 로고
    • Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
    • Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, Frost A, Barst RJ, Badesch DB, Elliott CG, et al. Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 2010; 122:164-172.
    • (2010) Circulation , vol.122 , pp. 164-172
    • Benza, RL1    Miller, DP2    Gomberg-Maitland, M3    Frantz, RP4    Foreman, AJ5    Coffey, CS6    Frost, A7    Barst, RJ8    Badesch, DB9    Elliott, CG10
  • 3
    • 65549105008 scopus 로고    scopus 로고
    • Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease
    • Pulmonary Vascular Complications of Liver Disease Study Group
    • Roberts KE, Fallon MB, Krowka MJ, Brown RS, Trotter JF, Peter I, Tighiouart H, Knowles JA, Rabinowitz D, Benza RL, et al.; Pulmonary Vascular Complications of Liver Disease Study Group. Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med 2009; 179: 835-842.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 835-842
    • Roberts, KE1    Fallon, MB2    Krowka, MJ3    Brown, RS4    Trotter, JF5    Peter, I6    Tighiouart, H7    Knowles, JA8    Rabinowitz, D9    Benza, RL10
  • 5
    • 84879186805 scopus 로고    scopus 로고
    • Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension
    • Alzoubi A, Toba M, Abe K, O'Neill KD, Rocic P, Fagan KA, McMurtry IF, Oka M. Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 2013; 304:H1708-H1718.
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H1708-H1718
    • Alzoubi, A1    Toba, M2    Abe, K3    O'Neill, KD4    Rocic, P5    Fagan, KA6    McMurtry, IF7    Oka, M.8
  • 7
    • 84865446457 scopus 로고    scopus 로고
    • Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension
    • White K, Johansen AK, Nilsen M, Ciuclan L, Wallace E, Paton L, Campbell A, Morecroft I, Loughlin L, McClure JD, et al. Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation 2012; 126:1087-1098.
    • (2012) Circulation , vol.126 , pp. 1087-1098
    • White, K1    Johansen, AK2    Nilsen, M3    Ciuclan, L4    Wallace, E5    Paton, L6    Campbell, A7    Morecroft, I8    Loughlin, L9    McClure, JD10
  • 9
    • 49049100968 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in protection against monocrotalineinduced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone
    • Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in protection against monocrotalineinduced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol 2008; 295:L71-L78.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L71-L78
    • Homma, N1    Nagaoka, T2    Karoor, V3    Imamura, M4    Taraseviciene-Stewart, L5    Walker, LA6    Fagan, KA7    McMurtry, IF8    Oka, M.9
  • 11
    • 78751644250 scopus 로고    scopus 로고
    • Estrogens and development of pulmonary hypertension: Interaction of estradiol metabolism and pulmonary vascular disease
    • Tofovic SP. Estrogens and development of pulmonary hypertension: Interaction of estradiol metabolism and pulmonary vascular disease. J Cardiovasc Pharmacol 2010; 56:696-708.
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 696-708
    • Tofovic, SP.1
  • 12
    • 0015905051 scopus 로고
    • Cardiopulmonary responses of male and female swine to simulated high altitude
    • McMurtry IF, Frith CH, Will DH. Cardiopulmonary responses of male and female swine to simulated high altitude. J Appl Physiol 1973; 35: 459-462.
    • (1973) J Appl Physiol , vol.35 , pp. 459-462
    • McMurtry, IF1    Frith, CH2    Will, DH.3
  • 13
    • 0035995324 scopus 로고    scopus 로고
    • Effects of sex hormones and their balance on the proliferation of rat vascular endothelial cells
    • Liu J, Wu S, Wei H, Zhou K, Ruan Y, Lai W. Effects of sex hormones and their balance on the proliferation of rat vascular endothelial cells. Horm Res 2002; 58:16-20.
    • (2002) Horm Res , vol.58 , pp. 16-20
    • Liu, J1    Wu, S2    Wei, H3    Zhou, K4    Ruan, Y5    Lai, W.6
  • 14
    • 84879332558 scopus 로고    scopus 로고
    • Testosterone negatively regulates right ventricular load stress responses in mice
    • Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ 2012; 2:352-358.
    • (2012) Pulm Circ , vol.2 , pp. 352-358
    • Hemnes, AR1    Maynard, KB2    Champion, HC3    Gleaves, L4    Penner, N5    West, J6    Newman, JH.7
  • 18
    • 34548417939 scopus 로고    scopus 로고
    • Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden
    • Tivesten A, Mellström D, Jutberger H, Fagerberg B, Lernfelt B, Orwoll E, Karlsson MK, Ljunggren O, Ohlsson C. Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden. J Am Coll Cardiol 2007; 50:1070-1076.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1070-1076
    • Tivesten, A1    Mellström, D2    Jutberger, H3    Fagerberg, B4    Lernfelt, B5    Orwoll, E6    Karlsson, MK7    Ljunggren, O8    Ohlsson, C.9
  • 22
    • 79958778458 scopus 로고    scopus 로고
    • Sex and race differences in right ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis-Right Ventricle Study
    • Kawut SM, Lima JA, Barr RG, Chahal H, Jain A, Tandri H, Praestgaard A, Bagiella E, Kizer JR, Johnson WC, et al. Sex and race differences in right ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis-Right Ventricle Study. Circulation 2011; 123: 2542-2551.
    • (2011) Circulation , vol.123 , pp. 2542-2551
    • Kawut, SM1    Lima, JA2    Barr, RG3    Chahal, H4    Jain, A5    Tandri, H6    Praestgaard, A7    Bagiella, E8    Kizer, JR9    Johnson, WC10
  • 24
    • 0028908861 scopus 로고
    • Laboratory methods and quality assurance in the Cardiovascular Health Study
    • Cushman M, Cornell ES, Howard PR, Bovill EG, Tracy RP. Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem 1995; 41:264-270.
    • (1995) Clin Chem , vol.41 , pp. 264-270
    • Cushman, M1    Cornell, ES2    Howard, PR3    Bovill, EG4    Tracy, RP.5
  • 25
    • 85016901455 scopus 로고    scopus 로고
    • Using SAS to perform individual matching in design of case control studies
    • SAS Global Forum Seattle, WA, Coders Corner 2010: Paper 061-2010
    • Grandits G, Neuhaus J. Using SAS to perform individual matching in design of case control studies. SAS Global Forum 2010, Seattle, WA, Coders' Corner 2010: Paper 061-2010.
    • (2010)
    • Grandits, G1    Neuhaus, J.2
  • 27
    • 20344362689 scopus 로고    scopus 로고
    • Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
    • Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 2005; 96:1053-1063.
    • (2005) Circ Res , vol.96 , pp. 1053-1063
    • Yang, X1    Long, L2    Southwood, M3    Rudarakanchana, N4    Upton, PD5    Jeffery, TK6    Atkinson, C7    Chen, H8    Trembath, RC9    Morrell, NW.10
  • 28
    • 0034681831 scopus 로고    scopus 로고
    • Gene expression in distinct regions of the heart
    • Thum T, Borlak J. Gene expression in distinct regions of the heart. Lancet 2000; 355:979-983.
    • (2000) Lancet , vol.355 , pp. 979-983
    • Thum, T1    Borlak, J.2
  • 29
    • 84903641935 scopus 로고    scopus 로고
    • Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension
    • Fessel JP, Chen X, Frump A, Gladson S, Blackwell T, Kang C, Johnson J, Loyd JE, Hemnes A, Austin E, et al. Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension. Pulm Circ 2013; 3:564-577.
    • (2013) Pulm Circ , vol.3 , pp. 564-577
    • Fessel, JP1    Chen, X2    Frump, A3    Gladson, S4    Blackwell, T5    Kang, C6    Johnson, J7    Loyd, JE8    Hemnes, A9    Austin, E10
  • 31
    • 0038056185 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats
    • Hampl V, BíbováJ, PovýsilováV, Herget J. Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats. Eur Respir J 2003; 21:862-865.
    • (2003) Eur Respir J , vol.21 , pp. 862-865
    • Hampl, V1    Bíbová, J2    Povýsilová, V3    Herget, J.4
  • 32
    • 80355128997 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension
    • Paulin R, Meloche J, Jacob MH, Bisserier M, Courboulin A, Bonnet S. Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 2011; 301:H1798-H1809.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. H1798-H1809
    • Paulin, R1    Meloche, J2    Jacob, MH3    Bisserier, M4    Courboulin, A5    Bonnet, S.6
  • 34
    • 57649213384 scopus 로고    scopus 로고
    • Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion
    • Chen H, Lin AS, Li Y, Reiter CEN, VerMR, QuonMJ. Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion. J Biol Chem2008; 283: 29228-29238.
    • J Biol Chem2008 , vol.283 , pp. 29228-29238
    • Chen, H1    Lin, AS2    Li, Y3    Reiter, CEN4    Ver, MR5    Quon, MJ.6
  • 35
    • 0037077286 scopus 로고    scopus 로고
    • Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2, 3)
    • Liu D, Dillon JS. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2, 3). J Biol Chem 2002; 277:21379-21388.
    • (2002) J Biol Chem , vol.277 , pp. 21379-21388
    • Liu, D1    Dillon, JS.2
  • 40
    • 0036086413 scopus 로고    scopus 로고
    • Estrogen alters thresholds for B cell apoptosis and activation
    • Grimaldi CM, Cleary J, Dagtas AS, Moussai D, Diamond B. Estrogen alters thresholds for B cell apoptosis and activation. J Clin Invest 2002; 109:1625-1633.
    • (2002) J Clin Invest , vol.109 , pp. 1625-1633
    • Grimaldi, CM1    Cleary, J2    Dagtas, AS3    Moussai, D4    Diamond, B.5
  • 41
    • 77953287830 scopus 로고    scopus 로고
    • Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice
    • Behrens M, Trejo T, Luthra H, Griffiths M, David CS, Taneja V. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice. J Autoimmun 2010; 35:1-9.
    • (2010) J Autoimmun , vol.35 , pp. 1-9
    • Behrens, M1    Trejo, T2    Luthra, H3    Griffiths, M4    David, CS5    Taneja, V.6
  • 43
    • 79955540987 scopus 로고    scopus 로고
    • Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: Evidence for a direct role of testosterone on regulatory T cell expansion
    • Fijak M, Schneider E, Klug J, Bhushan S, Hackstein H, Schuler G, Wygrecka M, Gromoll J, Meinhardt A. Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: Evidence for a direct role of testosterone on regulatory T cell expansion. J Immunol 2011; 186:5162-5172.
    • (2011) J Immunol , vol.186 , pp. 5162-5172
    • Fijak, M1    Schneider, E2    Klug, J3    Bhushan, S4    Hackstein, H5    Schuler, G6    Wygrecka, M7    Gromoll, J8    Meinhardt, A.9
  • 44
    • 84876326351 scopus 로고    scopus 로고
    • Negative association between testosterone concentration and inflammatory markers in young men: A nested cross-sectional study
    • Bobjer J, Katrinaki M, Tsatsanis C, Lundberg Giwercman Y, Giwercman A. Negative association between testosterone concentration and inflammatory markers in young men: A nested cross-sectional study. PLoS One 2013; 8:e61466.
    • (2013) PLoS One , vol.8 , pp. e61466
    • Bobjer, J1    Katrinaki, M2    Tsatsanis, C3    Lundberg Giwercman, Y4    Giwercman, A.5
  • 45
    • 0242524396 scopus 로고    scopus 로고
    • Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: High correlation between serum estradiol and current degree of inflammation
    • Tengstrand B, Carlström K, Felländer-Tsai L, Hafström I. Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: High correlation between serum estradiol and current degree of inflammation. J Rheumatol 2003; 30: 2338-2343.
    • (2003) J Rheumatol , vol.30 , pp. 2338-2343
    • Tengstrand, B1    Carlström, K2    Felländer-Tsai, L3    Hafström, I.4
  • 46
    • 32044449855 scopus 로고    scopus 로고
    • Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease
    • Joffe HV, Ridker PM, Manson JE, Cook NR, Buring JE, Rexrode KM. Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Ann Epidemiol 2006; 16: 105-112.
    • (2006) Ann Epidemiol , vol.16 , pp. 105-112
    • Joffe, HV1    Ridker, PM2    Manson, JE3    Cook, NR4    Buring, JE5    Rexrode, KM.6
  • 48
    • 84862819053 scopus 로고    scopus 로고
    • Low serum sex hormone-binding globulin: Marker of inflammation?
    • Liao CH, Li HY, Yu HJ, Chiang HS, Lin MS, Hua CH, Ma WY. Low serum sex hormone-binding globulin: Marker of inflammation? Clin Chim Acta 2012; 413:803-807.
    • (2012) Clin Chim Acta , vol.413 , pp. 803-807
    • Liao, CH1    Li, HY2    Yu, HJ3    Chiang, HS4    Lin, MS5    Hua, CH6    Ma, WY.7


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