Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

Journal of Pineal Research

Volumn 63, Issue 1, 2017, Pages

  Zhou, Hao ^a   Zhang, Ying ^a   Hu, Shunying ^a   Shi, Chen ^b   Zhu, Pingjun ^a   Ma, Qiang ^a   Jin, Qinhua ^a   Cao, Feng ^a   Tian, Feng ^a   Chen, Yundai ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

AMP activated protein kinase ; cardiac microcirculation endothelial cells; hexokinase 22; melatonin; microvascular IR injury; mitochondrial fission; mitochondrial permeability transition pore opening; voltage dependent anion channel 1

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEXOKINASE; HEXOKINASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MELATONIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PARKIN; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; CARDIOTONIC AGENT; CARRIER PROTEIN; HEXOKINASE 2, MOUSE; VDAC1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CELL DEATH; CELL INFILTRATION; CELL SURVIVAL; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; INFLAMMATORY CELL; MALE; MICROCIRCULATION; MICROVASCULAR ISCHEMIA; MICROVASCULATURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; MOUSE; NONHUMAN; OLIGOMERIZATION; PERCUTANEOUS CORONARY INTERVENTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CARDIAC MUSCLE; CYTOLOGY; DRUG EFFECTS; HEART; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRIAL DYNAMICS; MYOCARDIAL ISCHEMIA REPERFUSION INJURY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARDIOTONIC AGENTS; HEART; HEXOKINASE; IMMUNOHISTOCHEMISTRY; MALE; MELATONIN; MICE; MICE, KNOCKOUT; MICROVESSELS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 85018289179     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12413     Document Type: Article

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