Melatonin inhibits thermal injuryYinduced hyperpermeability in microvascular endothelial cells

Journal of Trauma and Acute Care Surgery

Volumn 77, Issue 6, 2014, Pages 899-905

  Wiggins Dohlvik, Katie ^a   Han, Min Suk ^a   Stagg, Hayden W ^a   Alluri, Himakarnika ^a   Shaji, Chinchusha Anasooya ^a   Tech, B ^a   Oakley, Ryan P ^a   Davis, Matthew L ^a   Tharakan, Binu ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Burn shock; Melatonin; MMP 9; Rats; Vascular permeability

Indexed keywords

ACTIN; BOVINE SERUM ALBUMIN; FLUORESCEIN ISOTHIOCYANATE; MELATONIN; REACTIVE OXYGEN METABOLITE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD VESSEL PERMEABILITY; BURN SHOCK; CAPILLARY ENDOTHELIAL CELL; CELL DAMAGE; CELL JUNCTION; CONFERENCE PAPER; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; IMMUNOFLUORESCENCE; INTRAVITAL MICROSCOPY; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; RAT; STRESS FIBER; VASCULAR HYPERPERMEABILITY; VENULE; ANIMAL; BURNS; CAPILLARY PERMEABILITY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; MICROVASCULATURE; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM;

ADHERENS JUNCTIONS; ANIMALS; BURNS; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; MELATONIN; MICROSCOPY, FLUORESCENCE; MICROVESSELS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84918544336     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000346     Document Type: Conference Paper

References (35)

1. Alvarado R, Chung K, Cancio L,Wolf S. Burn resuscitation. Burns. 2009; 35:4-14.
2. PhamT, Cancio L,GibranN.American BurnAssociation practice guidelines burn shock resuscitation. J Burn Care Res. 2008;1:257-266.
3. Dries D. Management of burn injuriesVrecent developments in resuscitation, infection control and outcomes research. Scand J Trauma Resusc Emerg Med. 2009;14:1-13.
4. Greenhalgh D. Burn resuscitation. J Burn Care Res. 2007;555-565.
5. Demling R. The burn edema process: current concepts. J BurnCare Rehabil. 2005;3:207-227.
6. Stagg H, Whaley J, Tharakan B, Hunter F, Jupiter D, Little D, et al. Doxycycline attenuates burn-induced microvascular hyperpermeability. J Trauma Acute Care Surg. 2013;75(6):1040-1046.
7. Mehta D, Malik A. Signaling mechanisms regulating endothelial permeability. Physiology. 2006;86:279-367.
8. Vandenbroucke E, Mehta D, Minshall R, Malik A. Regulation of endothelial junctional permeability. Ann N Y Acad Sci. 2008;1123:134-145.
9. Whaley J, Tharakan B, Smith B, Hunter F, Childs E. (-)-Deprenyl inhibits thermal injuryYinduced apoptotic signaling and hyperpermeability in microvascular endothelial cells. J Burn Care Res. 2009;30:1018-1027.
10. Tharakan B, Whaley J, Hunter F, Childs E. (-)-Deprenyl inhibits vascular hyperpermeability after hemorrhagic shock. Shock. 2010;33:56-63.
11. Orman M, Nguyen T, Ierapetritou M, Berthiaume F, Androulakis I. Comparison of the cytokine and chemokine dynamics of the early inflammatory response in models of burn injury and infection. Cytokine. 2011;55: 362-371.
12. Farina J, Rosique M, Rosique R. Curbing inflammation in burn patients. Int J Inflam. 2013; 2013:1-9.
13. QinW, LuW, Li H, Yuan X, Li B, Zhang Q, et al. Melatonin inhibits IL1binduced MMP-9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kB activation. J Endocrinol. 2012;214: 145-153.
14. Sternlicht M, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516.
15. Vandooren J, Steen PV, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol. 2013;48(3):222-272.
16. Opdenakker G, Steen PV, Damme J. Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol. 2001;22(10):571-579.
17. Luplerdlop N, Misse D, Bray D, Deleuze V, Gonzalez J, Leardkamolkarn V, et al. Dengue-virusYinfected dendritic cells trigger vascular leakage through metalloproteinase overproduction. EMBO Rep. 2006;7:1176-1181.
18. Klein M, Hayden D, Elson C, Nathens A, Gamelli R, Gibran N, et al. The association between fluid administration and outcome following major burn. Ann Surg. 2007;245:622-628.
19. Tai S, Chen H, Lee E, Chen T, Lin H, Hung Y, et al. Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia. J Pineal Res. 2010;49:332-341.
20. Ordonez R, Carbajo-Pescador S, Prieto-Dominguez N, Garcia-Palomo A, Gonzalez-Gallego J, Mauriz J. Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells. J Pineal Res. 2013;56:20-30.
21. Esposito E, Genovese T, Caminiti R, Bramanti P, Meli R, Cuzzocrea S. Melatonin regulates matrix metalloproteinases after traumatic experimental spinal cord injury. J Pineal Res. 2008;45:149-156.
22. Wang J, Gui W, Chen W, Yu W, Tian Y, Fu L, et al. Melatonin potentiates the antiproliferative and pro-Apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways. J Pineal Res. 2013;54:406-416.
23. Trivedi P, Jena G. Melatonin reduces ulcerative colitisYassociated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci. 2013;58(12):3460-3474.
24. Paul S, Sharma A, Mahapatra P, Bhattacharya P, Reiter R, Swarnakar S. Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. J Pineal Res. 2008;44:439-449.
25. MishraA, Paul S,Swarnakar S.Downregulation ofmatrixmetalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice. Biochimie. 2011;93:854-866.
26. Rudra D, Pal U, Maiti N, Reiter R, Swarnakar S. Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site. J Pineal Res. 2013;54:398-405.
27. Reiter R, Tan D, Fuentes-Broto L. Melatonin: a multitasking molecule. Prog Brain Res. 2010;181:127-151.
28. Walker H, Mason A. A standard animal burn. J Trauma. 1968;8:1049-1051.
29. American BurnAssociation. NationalBurnRepository 2013 Report.Version 9.0. Chicago, IL: American Burn Association; 2013.
30. Azzopardi E, McWilliams B, Iyer S, Whitaker I. Fluid resuscitation in adults with severe burns at risk of secondary abdominal compartment syndromeVan evidence based systematic review. Burns. 2009;35: 912-920.
31. NelsonW. Regulation of cellYcell adhesion by the cadherinYcatenin complex. Biochem Soc Trans. 2008;36:149-155.
32. Tojkander S, Gateva G, Lappalainen P. Actin stress fibersVassembly, dynamics and biological roles. J Cell Sci. 2012;125:1855-1864.
33. Huang Q, XuW, Ustinova E,Wu M, Childs E, Hunter F, et al. Myosin light chain kinase-dependent microvascular hyperpermeability in thermal injury. Shock. 2003;20:363-368.
34. Zhang H, Wang Z, Wu H, Li Z, Li L, Hu X, et al. Transforming growth factor-b1 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cells via ROS-dependent ERKYNF-jB pathways. Mol Cell Biochem. 2013;375:11-21.
35. Burggraf D, Trinkl A, Dichgans M, Harmann G. Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol Dis. 2007;25:506-513.