Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline

Neurobiology of Aging

Volumn 56, Issue , 2017, Pages 41-49

  Cole, James H ^a   Annus, Tiina ^b   Wilson, Liam R ^b   Remtulla, Ridhaa ^c   Hong, Young T ^b   Fryer, Tim D ^b   Acosta Cabronero, Julio ^d   Cardenas Blanco, Arturo ^d   Smith, Robert ^b   Menon, David K ^b   Zaman, Shahid H ^b   Nestor, Peter J ^d   Holland, Anthony J ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Amyloid PET; Brain aging; Cognitive decline; Down syndrome; Machine learning; MRI

Indexed keywords

AMYLOID BETA PROTEIN; PITTSBURGH COMPOUND B;

ADULT; AGE DETERMINATION; AGING; AMYLOIDOSIS; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN SYNDROME; FEMALE; HUMAN; MACHINE LEARNING; MALE; NEUROIMAGING; ONSET AGE; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; AGED; BRAIN; COGNITION; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY;

ADULT; AGED; AGING; AMYLOID BETA-PEPTIDES; BRAIN; COGNITION; DOWN SYNDROME; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY;

EID: 85018245576     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2017.04.006     Document Type: Article

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