Premature aging in persons with Down syndrome: MR findings

American Journal of Neuroradiology

Volumn 17, Issue 7, 1996, Pages 1283-1289

  Roth, Gerald M ^a,d   Sun, Belinda ^c   Greensite, Fred S ^a   Lott, Ira T ^b   Dietrich, Rosalind B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Age and aging; Brain magnetic resonance; Down syndrome

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; BRAIN ATROPHY; CONTROLLED STUDY; DISEASE SEVERITY; DOWN SYNDROME; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVER VARIATION; PREMATURE AGING; PREVALENCE; WHITE MATTER;

ADULT; AGING; ATROPHY; BASAL GANGLIA; BRAIN; DOWN SYNDROME; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED;

EID: 0029840079     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. LeMay M. Radiologic changes of the aging brain and skull. AJNR Am J Neuroradiol 1984;5:269-275
2. Bradley WO, Waluch V, Brant-Zawadzki M, Yadley RA, Wycoff RR. Patchy, periventricular white matter lesions in the elderly: a common observation during NMR imaging. Noninvas Med Imaging 1984;1:35-41
3. Drayer B, Burger P, Darwin R, Riederer S, Herfkens R, Johnson GA. Magnetic resonance imaging of brain iron. AJNR Am J Neuroradiol 1986;7:373-380
4. Milton WJ, Atlas SW, Lexa FJ, Mozley PD, Gur RE. Deep gray matter hypointensity patterns with aging in healthy adults: MR imaging at 1.5 T. Radiology 1991;181: 715-719
5. Davis PC, Mirra SS, Alazraki N. The brain in older persons with and without dementia: findings on MR, PET and SPECT images. AJR Am J Roentgenol 1994;162:1267-1278
6. Drayer BP. Imaging of the aging brain, I: normal findings. Radiology 1988;166:785-796
7. LeMay M, Alvarez N. The relationship between enlargement of the temporal horns of the lateral ventricles and dementia in aging patients with Down syndrome, Neuroradiology 1990;32:104-107
8. Lott IT. The neurology of Alzheimer disease in Down syndrome. Prog Clin Biol Res 1992;379:1-14
9. Thase, ME. Longevity and mortality in Down's syndrome. J Ment Defic Res 1982;26:177-192
10. Kumar AJ, Naidich TP, Stetten G, et al. Chromosomal disorders: background and neuroradiology. AJNR Am J Neuroradiol 1992; 13:577-593
11. Wisniewski KE, French JH, Rosen JF, Kozlowski PB, Tenner M, Wisniewski HM. Basal ganglia calcification (BGC) in Down's syndrome (DS): another manifestation of premature aging. Ann N Y Acad Sci 1982;396:179-189
12. Schapiro MB, Creasey H, Schwartz M, et al. Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages. Neurology 1987;37;1424-1427
13. Schapiro MB, Luxenburg JS, Kaye JA, Haxby JV, Friedland RP, Rapoport SI. Serial quantitative CT analysis of brain morphometrics in adult Down's syndrome at different ages. Neurology 1989; 39:1349-1353
14. Pearlson GD, Warren AC, Starkstein SE, et al. Brain atrophy in 18 patients with Down syndrome: a CT study. AJNR Am J Neuroradiol 1990;11:811-816
15. Pelz DM, Karlik SJ, Fox AJ, Vinuela F. Magnetic resonance imaging in Down's syndrome. Can J Neurol Sci 1986;13:566-569
16. Tamraz JC, Rethore M-O, Iba-Zizen M-T, Lejeune J, Cabanis EA. Contribution of magnetic resonance imaging to the knowledge of CNS malformations related to chromosomal aberrations. Hum Genet 1987;76:265-273
17. Weis S, Weber G, Neuhold A, Rett A. Down syndrome: MR quantification of brain structures and comparison with normal control subjects. AJNR Am J Neuroradiol 1991;12:1207-1211
18. Weis S. Morphometry and magnetic resonance imaging of the human brain in normal controls and Down's syndrome. Anat Rec 1991;231:593-598
19. Kesslak JP, Nagata SF, Lott I, Nalcioglu O. Magnetic resonance imaging analysis of age-related changes in the brains of persons with Down's syndrome. Neurology 1994;44:1039-1045
20. Mann DM. Calcification of the basal ganglia in Down's syndrome and Alzheimer's disease. Acta Neuropathol 1988;76:595-598
21. Takashima S, Becker LE. Basal ganglia calcification in Down's syndrome. J Neurol Neurosurg Psychiatry 1985;48:61-64
22. Ieshima A, Kisa T, Yoshino K, Takashima S, Takeshita K. A morphometric CT study of Down's syndrome showing small posterior fossa and calcification of basal ganglia. Neuroradiology 1984;26:493-498
23. Drayer BP, Olanow W, Burger P, Johnson GA, Herfkens R, Riederer S. Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology 1986;159:493-498
24. Drayer B, Burger P, Hurwitz B, Dawson D, Cain J. Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content? AJNR Am J Neuroradiol 1987; 8:413-419
25. Cross PA, Atlas SW, Grossman RI. MR evaluation of brain iron in children with cerebral infarction. AJNR Am J Neuroradiol 1990; 10:341-348
26. Dietrich RB, Bradley WG. Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. Radiology 1988;168:203-206