Use of Whole Exome Sequencing for the Identification of Ito-Based Arrhythmia Mechanism and Therapy

Journal of the American Heart Association

Volumn 4, Issue 5, 2015, Pages

  Sturm, Amy C ^a,b   Kline, Crystal F ^a,b   Glynn, Patric ^a,b   Johnson, Benjamin L ^a   Curran, Jerry ^a,b   Kilic, Ahmet ^a,b   Higgins, Robert S D ^a,b   Binkley, Philip F ^a,b   Janssen, Paul M L ^a,b   Weiss, Raul ^a,b   Raman, Subha V ^a,b   Fowler, Steven J ^e,f   Priori, Silvia G ^e,g   Hund, Thomas J ^a,b,c   Carnes, Cynthia A ^a,d   Mohler, Peter J ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c Ohio State University   (United States)

^d New York University Langone Medical Center ^*  (United States)

^e NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

arrhythmia; genetics; ion channel

Indexed keywords

CILOSTAZOL; DIPEPTIDYL PEPTIDASE; DPP6 PROTEIN, HUMAN; FAMPRIDINE; NERVE PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRAZOLE DERIVATIVE; VASODILATOR AGENT;

ACTION POTENTIAL; ADULT; CASE REPORT; COMBINATION DRUG THERAPY; DNA SEQUENCE; DRUG EFFECTS; ELECTROCARDIOGRAPHY; EXOME; GENETIC VARIATION; GENETICS; HEART RATE; HUMAN; MALE; MUTATION; PATHOPHYSIOLOGY; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION;

4-AMINOPYRIDINE; ACTION POTENTIALS; ADULT; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; EXOME; GENETIC VARIATION; HEART RATE; HUMANS; MALE; MUTATION; NERVE TISSUE PROTEINS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SEQUENCE ANALYSIS, DNA; TETRAZOLES; TREATMENT OUTCOME; VASODILATOR AGENTS; VENTRICULAR FIBRILLATION;

EID: 85018222947     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001762     Document Type: Article

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