Unique cardiac Purkinje fiber transient outward current β-subunit composition: A potential molecular link to idiopathic ventricular fibrillation

Circulation Research

Volumn 112, Issue 10, 2013, Pages 1310-1322

  Xiao, Ling ^a   Koopmann, Tamara T ^b   Ördög, Balázs ^a   Postema, Pieter G ^b   Verkerk, Arie O ^b   Iyer, Vivek ^c   Sampson, Kevin J ^c   Boink, Gerard J J ^b   Mamarbachi, Maya A ^a   Varro, Andras ^d   Jordaens, Luc ^e   Res, Jan ^e   Kass, Robert S ^c   Wilde, Arthur A ^b   Bezzina, C R ^b   Nattel, Stanley ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^d UNIVERSITY OF SZEGED   (Hungary)

^e ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Cardiac arrhythmia mechanisms; ECG; Genetic arrhythmia syndromes; Molecular electrophysiology; Potassium channels; Sudden death; Ventricular tachycardia arrhythmia

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE LIKE PROTEIN 6; NEURONAL CALCIUM SENSOR; POTASSIUM CHANNEL; TETRYLAMMONIUM; UNCLASSIFIED DRUG; DPP6 PROTEIN, HUMAN; KV CHANNEL INTERACTING PROTEIN; NERVE PROTEIN; POTASSIUM CHANNEL BLOCKING AGENT; SHAL POTASSIUM CHANNEL;

ARTICLE; CLINICAL ARTICLE; DOG; HEART ARRHYTHMIA; HEART MUSCLE FIBER MEMBRANE CONDUCTANCE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; MATHEMATICAL ANALYSIS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE FIBER MEMBRANE POTENTIAL; ADULT; ANIMAL; CARDIAC ARRHYTHMIA MECHANISMS; CELL CULTURE; CHO CELL; CRICETULUS; DISEASE MODEL; DRUG EFFECT; ELECTROCARDIOGRAM; FEMALE; GENE SILENCING; GENETIC ARRHYTHMIA SYNDROMES; GENETIC TRANSFECTION; GENETICS; HAMSTER; HEART VENTRICLE; IN VITRO STUDY; MALE; MIDDLE AGED; MOLECULAR ELECTROPHYSIOLOGY; PATCH CLAMP; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PURKINJE FIBER; SUDDEN DEATH; THEORETICAL MODEL; VENTRICULAR TACHYCARDIA ARRHYTHMIA;

CARDIAC ARRHYTHMIA MECHANISMS; ECG; GENETIC ARRHYTHMIA SYNDROMES; MOLECULAR ELECTROPHYSIOLOGY; POTASSIUM CHANNELS; SUDDEN DEATH; VENTRICULAR TACHYCARDIA ARRHYTHMIA;

ADULT; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEART VENTRICLES; HUMANS; KV CHANNEL-INTERACTING PROTEINS; MALE; MIDDLE AGED; MODELS, THEORETICAL; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PURKINJE FIBERS; SHAL POTASSIUM CHANNELS; TETRAETHYLAMMONIUM; TRANSFECTION; VENTRICULAR FIBRILLATION;

MLCS; MLOWN;

EID: 84879846193     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.300227     Document Type: Article

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