The osteocyte: Key player in regulating bone turnover

RMD Open

Volumn 1, Issue , 2015, Pages

  Goldring, Steven R ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85018193394     PISSN: None     EISSN: 20565933     Source Type: Journal    
DOI: 10.1136/rmdopen-2015-000049     Document Type: Review

References (40)

1. Eriksen EF. Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord 2010;11:219-27.
2. Cardoso L, Herman BC, Verborgt O, et al. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res 2009;24:597-605.
3. Martin RB. Targeted bone remodeling involves BMU steering as well as activation. Bone 2007;40:1574-80.
4. Nistala H, Lee-Arteaga S, Siciliano G, et al. Extracellular regulation of transforming growth factor beta and bone morphogenetic protein signaling in bone. Ann N Y Acad Sci 2010;1192:253-6.
5. Wu X, Shi W, Cao X. Multiplicity of BMP signaling in skeletal development. Ann N Y Acad Sci 2007;1116:29-49.
6. Purdue PE, Crotti TN, Shen Z, et al. Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate. Sci Rep 2014;4:7595.
7. Pederson L, Ruan M, Westendorf JJ, et al. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci USA 2008;105:20764-9.
8. Negishi-Koga T, Shinohara M, Komatsu N, et al. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med 2011;17:1473-80.
9. Rodan GA, Martin TJ. Role of osteoblasts in hormonal control of bone resorption-a hypothesis. Calcif Tissue Int 1982;34:311.
10. Corral DA, Amling M, Priemel M, et al. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci U S A 1998;95:13835-40.
11. Galli C, Fu Q, Wang W, et al. Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem 2009;284:12654-62.
12. Bonewald LF. The amazing osteocyte. J Bone Miner Res 2011;26:229-38.
13. Schaffler MB, Cheung WY, Majeska R, et al. Osteocytes: master orchestrators of bone. Calcif Tissue Int 2014;94:5-24.
14. Xiong J, Onal M, Jilka RL, et al. Matrix-embedded cells control osteoclast formation. Nat Med 2011;17:1235-41.
15. Nakashima T, Hayashi M, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 2011;17:1231-4.
16. Tatsumi S, Ishii K, Amizuka N, et al. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab 2007;5:464-75.
17. Kramer I, Halleux C, Keller H, et al. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol 2010;30:3071-85.
18. Cheng B, Kato Y, Zhao S, et al. PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. Endocrinology 2001;142:3464-73.
19. Caballero-Alias AM, Loveridge N, Pitsillides A, et al. Osteocytic expression of constitutive NO synthase isoforms in the femoral neck cortex: a case-control study of intracapsular hip fracture. J Bone Miner Res 2005;20:268-73.
20. Sheng MH, Lau KH, Baylink DJ. Role of osteocyte-derived insulin-like growth factor I in developmental growth, modeling, remodeling, and regeneration of the bone. J Bone Metab 2014;21:41-54.
21. Kennedy OD, Laudier DM, Majeska RJ, et al. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone 2014;64:132-7.
22. Lau KH, Baylink DJ, Zhou XD, et al. Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity. Am J Physiol Endocrinol Metab 2013;305:E271-81.
23. Yin J, Hao Z, Ma Y, et al. Concomitant activation of the PI3K/Akt and ERK1/2 signalling is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells. Cell Biol Int 2014;38:591-8.
24. Heino J, Hentunen TA, Vaananen HK. Osteocytes inhibit osteoclastic bone resorption through transforming factor-beta; enhancement by estrogen. J Cell Biochem 2002;85:185-97.
25. Quarles LD. Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. Nat Rev Endocrinol 2012;8:276-86.
26. Baron R, Kneissel M.WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 2013;19:179-92.
27. Robling AG, Bellido T, Turner CH. Mechanical stimulation in vivo reduces osteocyte expression of sclerostin. J Musculoskelet Neuronal Interact 2006;6:354.
28. Robling AG, Niziolek PJ, Baldridge LA, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008;283:5866-75.
29. Tu X, Rhee Y, Condon KW, et al. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone 2012;50:209-17.
30. Bellido T, Saini V, Pajevic PD. Effects of PTH on osteocyte function. Bone 2013;54:250-7.
31. Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone 2005;37:148-58.
32. Rhee Y, Allen MR, Condon K, et al. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res 2011;26:1035-46.
33. Ben-Awadh AN, Delgado-Calle J, Tu X, et al. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology 2014;155:2797-809.
34. Morse A, McDonald M, Kelly N, et al. Mechanical load increases in bone formation via a sclerostin-independent pathway. J Bone Miner Res 2014;29:2456-67.
35. Kennedy OD, Herman BC, Laudier DM, et al. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone 2012;50:1115-22.
36. Schaffler MB, Kennedy OD. Osteocyte signaling in bone. Curr Osteoporos Rep 2012;10:118-25.
37. Appel H, Maier R, Loddenkemper C, et al. Immunohistochemical analysis of osteoblasts in zygapophyseal joints of patients with ankylosing spondylitis reveal repair mechanisms similar to osteoarthritis. J Rheumatol 2010;37:823-8.
38. Chan BY, Fuller ES, Russell AK, et al. Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage 2011;19:874-85.
39. Funck-Brentano T, Bouaziz W, Marty C, et al. Dkk1-mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis. Arthritis Rheumatol 2014;66:3028-39.
40. Roudier M, Li X, Niu QT, et al. Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury. Arthritis and Rheum 2013;65:721-31.