Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor

Biochemistry

Volumn 56, Issue 3, 2017, Pages 473-486

  Lingerfelt, Mary A ^a   Zhao, Pingwei ^b   Sharir, Haleli P ^b   Hurst, Dow P ^a   Reggio, Patricia H ^a   Abood, Mary E ^b  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; BODY FLUIDS; COVALENT BONDS; CRYSTAL STRUCTURE; LIGANDS;

AMINO ACID RESIDUES; DELTA-OPIOID RECEPTOR; DISCRETE INFORMATION; EXTRACELLULAR DOMAINS; G PROTEIN COUPLED RECEPTORS; METABOLIC DISORDERS; SERUM RESPONSE ELEMENTS; SERUM RESPONSE FACTORS;

SIGNALING;

1 PHENYLPIPERAZINE DERIVATIVE; 3 [4 (2,3 DIMETHYLPHENYL)PIPERAZINE 1 CARBONYL] N,N DIMETHYL 4 PYRROLIDIN 1 YLBENZENESULFONAMIDE; AMINO ACID; BENZENESULFONAMIDE DERIVATIVE; DELTA OPIATE RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR GPR55; LEVO ALPHA LYSOPHOSPHATIDYLINOSITOL; LIGAND; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL; PYRROLIDINE DERIVATIVE; RADIOLIGAND; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG; GPR55 PROTEIN, HUMAN; HYBRID PROTEIN; LYSOPHOSPHATIDYLINOSITOL; LYSOPHOSPHOLIPID; PIPERAZINE DERIVATIVE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HEK293 CELL LINE; LIGAND BINDING; LUCIFERASE ASSAY; MOLECULAR DOCKING; MOLECULAR INTERACTION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; AGONISTS; BINDING SITE; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; KINETICS; METABOLISM; PROTEIN MOTIF; SOYBEAN; STRUCTURAL HOMOLOGY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; LYSOPHOSPHOLIPIDS; MOLECULAR DOCKING SIMULATION; MUTATION; PIPERAZINES; PROTEIN BINDING; PYRROLIDINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID, DELTA; RECOMBINANT FUSION PROTEINS; SERUM RESPONSE ELEMENT; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; SOYBEANS; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS;

EID: 85017638436     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b01013     Document Type: Article

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