Safe intake of a plant sterol-enriched beverage with milk fat globule membrane: Bioaccessibility of sterol oxides during storage

Journal of Food Composition and Analysis

Volumn 68, Issue , 2018, Pages 111-117

  Alvarez Sala, Andrea ^a   Blanco Morales, Virginia ^a   Cilla, Antonio ^a   Garcia Llatas, Guadalupe ^a   Sánchez Siles, Luis Manuel ^b   Barberá, Reyes ^a   Lagarda, María Jesús ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Research and Development Department   (Spain)

Author keywords

Bioaccessibility; Food analysis; Food composition; Functional beverages; MFGM; Oxysterols; Simulated gastrointestinal digestion; Sterol oxidation products

Indexed keywords

EID: 85017391293     PISSN: 08891575     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jfca.2017.03.011     Document Type: Article

References (45)

1. Alemany, L., Cilla, A., Garcia-Llatas, G., Rodriguez-Estrada, M.T., Cardenia, V., Alegría, A., Effect of a simulated gastrointestinal digestion on plant sterols and their oxides in enriched beverages. Food Res. Int. 52 (2013), 1–7.
2. Alemany-Costa, L., González-Larena, M., García-Llatas, G., Alegría, A., Barberá R., Sánchez-Siles, L.M., Lagarda, M.J., Sterol stability in functional fruit beverages enriched with different plant sterol sources. Food Res. Int. 48 (2012), 265–270.
3. Alvarez-Sala, A., Garcia-Llatas, G., Cilla, A., Barberá R., Sánchez-Siles, L.M., Lagarda, M.J., Impact of lipid components and emulsifiers on plant sterols bioaccessibility from milk-based fruit beverages. J. Agric. Food Chem. 64 (2016), 5686–5691.
4. Ansorena, D., Barriuso, B., Cardenia, V., Astiasarán, I., Lercker, G., Thermo-oxidation of cholesterol: effect of the unsaturation degree of the lipid matrix. Food Chem. 141 (2013), 2757–2764.
5. Armstrong, M.J., Carey, M.C., Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J. Lipid Res. 28 (1987), 1144–1155.
6. Barriuso, B., Ansorena, D., Astiasarán, I., Oxysterols formation: a review of a multifactorial process. J. Steroid Biochem. Mol. Biol., 2016, 10.1016/j.jsbmb.2016.02.027.
7. Barriuso, B., Astiasarán, I., Ansorena, D., Unsaturated lipid matrices protect plant sterols from degradation during heating treatment. Food Chem. 196 (2016), 451–458.
8. Bin Sayeed, M.S., Ameen, S.S., Beta-sitosterol: a promising but orphan nutraceutical to fight against cancer. Nutr. Cancer 67 (2015), 1214–1220.
9. Brzeska, M., Szymczyk, K., Szterk, A., Current knowledge about oxysterols: a review. J. Food Sci. 81 (2016), R2299–R2308.
10. Cercaci, L., Rodriguez-Estrada, M.T., Lercker, G., Decker, E.A., Phytosterol oxidation in oil-in-water emulsions and bulk oil. Food Chem. 102 (2007), 161–167.
11. Commission Decision 2004/336/EC of 31 March 2004 authorizing the placing on the market of yellow fat spreads, milk based fruit drinks, yoghurt type products and cheese type products with added phytosterols/phytostanols as novel foods or novel food ingredients under Regulation (EC) No 258/97 of the European Parliament and of the Council. Off. J. Eur. Comm. L105, 49–51.
12. Emanuel, H.A., Hassel, C.A., Addis, P.B., Bergmann, S.D., Zavoral, J.H., Plasma cholesterol oxidation products (oxysterols) in human subjects fed a meal rich in oxysterols. ‎ J. Food Sci. 56 (1991), 843–847.
13. García-Llatas, G., Rodríguez-Estrada, M.T., Current and new insights on phytosterol oxides in plant sterol-enriched food. Chem. Phys. Lipids 164 (2011), 607–624.
14. Garcia-Llatas, G., Cilla, A., Alegría, A., Lagarda, M.J., Bioavailability of plant sterol-enriched milk-based fruit beverages: in vivo and in vitro studies. J. Funct. Foods 14 (2015), 44–50.
15. González-Larena, M., García-Llatas, G., Vidal, M.C., Sánchez-Siles, L.M., Barberá R., Lagarda, M.J., Stability of plant sterols in ingredients used in functional foods. J. Agric. Food Chem. 59 (2011), 3624–3631.
16. González-Larena, M., Garcia-Llatas, G., Clemente, G., Barberá R., Lagarda, M.J., Plant sterol oxides in functional beverages: influence of matrix and storage. Food Chem. 173 (2015), 881–889.
17. Hovenkamp, E., Demonty, I., Plat, J., Lütjohann, D., Mensink, R.P., Trautwein, E.A., Biological effects of oxidized phytosterols: a review of the current knowledge. Prog. Lipid Res. 47 (2008), 37–49.
18. Ikeda, I., Tanabe, Y., Suganoi, M., Effects of sitosterol and sitostanol on micellar solubility of cholesterol. J. Nutr. Sci. Vitaminol. 35 (1989), 361–369.
19. Klingberg, S., Winkvist, A., Hallmans, G., Johansson, I., Evaluation of plant sterol intake estimated with the Northern Sweden FFQ. Public Health Nutr. 16 (2012), 460–467.
20. Kulig, W., Cwiklik, L., Jurkiewicz, P., Rog, T., Cholesterol oxidation products and their biological importance. Chem. Phys. Lipids 199 (2016), 144–160.
21. Lake, R.J., Scholes, P., Consumption of cholesterol oxides from fast foods fried in beef fat in New Zealand. J. Am. Oil Chem. Soc. 74 (1997), 1069–1075.
22. Laparra, J.M., Alfonso-García, A., Alegría, A., Barberá R., Cilla, A., 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epithelial (Caco-2) cells. Food Chem. Toxicol. 84 (2015), 29–36.
23. Lin, Y., Knol, D., Trautwein, E.A., Phytosterol oxidation products (POP) in foods with added phytosterols and estimation of their daily intake: a literature review. Eur. J. Lipid Sci. Technol. 118 (2016), 1423–1438.
24. Matsuoka, K., Kajimoto, E., Horiuchi, M., Honda, C., Endo, K., Competitive solubilization of cholesterol and six species of sterol/stanol in bile salt micelles. Chem. Phys. Lipids 163 (2010), 397–402.
25. Matsuoka, K., Rie, E., Yui, S., Honda, C., Endo, K., Competitive solubilization of cholesterol and β-sitosterol with changing biliary lipid compositions in model intestinal solution. Chem. Phys. Lipids 165 (2012), 7–14.
26. Nielsen, J.H., Olsen, C.E., Jensen, C., Skibsted, L.H., Cholesterol oxidation in butter and dairy spread during storage. J. Dairy Res. 63 (1996), 159–167.
27. O'Callaghan, Y., McCarthy, F.O., O'Brien, N.M., Recent advances in phytosterol oxidation products. Biochem. Biophys. Res. Commun. 446 (2014), 786–791.
28. Olkkonen, V.M., Gylling, H., Ikonen, E., Plant sterols, cholesterol precursors and oxysterols: minute concentrations- major physiological effects. J. Steroid Biochem. Mol. Biol., 2015, 10.1016/j.jsbmb.2015.12.026.
29. Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansonera, D., Astiasarán, I., Oxysterols: a world to explore. Food Chem. Toxicol. 48 (2010), 3289–3303.
30. Othman, R.A., Moghadasian, M.H., Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties. Nutr. Rev. 69 (2011), 371–382.
31. Pignoli, G., Rodríguez-Estrada, M.T., Mandrioli, M., Barbanti, L., Rizzi, L., Lercker, G., Effects of different rearing and feeding systems on lipid oxidation and antioxidant capacity of freeze-dried egg yolks. J. Agric. Food Chem. 57 (2009), 11517–11527.
32. Ramprasath, V.R., Awad, A.B., Role of phytosterols in cancer prevention and treatment. J. AOAC Int. 98 (2015), 735–738.
33. Ras, R.T., Geleijnse, J.M., Trautwein, E.A., LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br. J. Nutr. 112 (2014), 214–219.
34. Ras, R.T., van der Schouw, Y.T., Trautwein, E.A., Sioen, I., Dalmeijer, G.W., Zock, P., Beulens, J.W.J., Intake of phytosterols from natural sources and risk of cardiovascular disease in the European Prospective Investigation into Cancer and Nutrition-the Netherlands (EPIC-NL) population. Eur. J. Prev. Cardiol. 22 (2015), 1067–1075.
35. Rueda, R., The role of complex lipids in attaining metabolic health. Curr. Cardiovasc. Risk Rep., 8, 2014, 371, 10.1007/s12170-013-0371-4.
36. Ryan, E., McCarthy, F.O., Maguire, A.R., O'Brien, N.M., Phytosterol oxidation products: their formation, occurrence, and biological effects. Food Res. Int. 25 (2009), 157–174.
37. Scholz, B., Guth, S., Engel, K.H., Steinberg, P., Phytosterol oxidation products in enriched foods: occurrence, exposure, and biological effects. Mol. Nutr. Food Res. 59 (2015), 1339–1352.
38. Shahzad, N., Khan, W., Shadab, M.D., Ali, A., Saluja, S.S., Sharma, S., Al-Allaf, F.A., Abdujjaleel, Z., Ibrahim, I.A.A., Abdel-Wahab, A.F., Afify, M.A., Al-Ghamdi, S.S., Phytosterols as a natural anticancer agent: current status and future perspective. Biomed. Pharmacother. 88 (2017), 786–794.
39. Soupas, L., Juntunen, L., Lampi, A., Piironen, V., Effects of sterol structure, temperature, and lipid medium on phytosterol oxidation. J. Agric. Food Chem. 52 (2004), 6485–6491.
40. Soupas, L., Huikko, L., Lampi, A., Piironen, V., Pan-frying may induce phytosterol oxidation. Food Chem. 101 (2007), 286–297.
41. Vaghini, S., Cilla, A., Garcia-Llatas, G., Lagarda, M.J., Bioaccessibility study of plant sterol-enriched fermented milks. Food Funct. 7 (2016), 110–117.
42. Vanmierlo, T., Husche, C., Schött, H.F., Pettersson, H., Lütjohann, D., Plant sterol oxidation products – analogs to cholesterol oxidation products from plant origin?. Biochimie 95 (2013), 464–472.
43. Vesper, H., Schmelz, E.M., Nikolova-Karakashian, M.N., Dillehay, D.L., Lynch, D.V., Merrill, A.H., Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129 (1999), 1239–1250.
44. Xu, G., Sun, J., Liang, Y., Yang, C., Chen, Z., Interaction of fatty acids with oxidation of cholesterol and β-sitosterol. Food Chem. 124 (2011), 162–170.
45. van de Bovenkamp, P., Kosmeijer-Schuil, T.G., Katan, M.B., Quantification of oxysterols in Dutch foods: egg products and mixed diets. Lipids 11 (1988), 1079–1085.