Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species

Nutritional Neuroscience

Volumn 21, Issue 6, 2018, Pages 447-454

  Clementi, Maria Elisabetta ^a   Pani, Giovambattista ^a   Sampaolese, Beatrice ^a   Tringali, Giuseppe ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Apoptosis; Mitochondrial dysfunction; Neurodegeneration; Oxidative stress; Punicalagin

Indexed keywords

CASPASE 3; FLAVONOID; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; TERPENOID; ANTIOXIDANT; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; ELLAGITANNIN; NEUROPROTECTIVE AGENT; PROTEIN BAX; PUNICALAGIN; TANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL SURVIVAL; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MTS ASSAY; NERVE DEGENERATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL LINE; POLYMERASE CHAIN REACTION; POMEGRANATE JUICE; PRIORITY JOURNAL; RNA ISOLATION; ANIMAL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; NERVE CELL; PC12 CELL LINE; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL SURVIVAL; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; HYDROLYZABLE TANNINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES;

EID: 85017378430     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2017.1306935     Document Type: Article

References (31)

1. Kojadinovic MI, Arsic AC, Debeljak-Martacic JD, Konic-Ristic AI, Kardum ND, Popovic TB, et al. Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. J Sci Food Agric 2017 Apr;97(6):1798–804. doi:10.1002/jsfa.7977
2. Sohrab G, Ebrahimof S, Sotoudeh G, Neyestani TR, Angoorani P, Hedayati M, et al. Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial. Int J Food Sci Nutr 2017;68(2):249–55. doi:10.1080/09637486.2016.1229760
3. Gómez-Caravaca AM, Verardo V, Toselli M, Segura-Carretero A, Fernández- Gutiérrez A, Caboni MF. Determination of the major phenolic compounds in pomegranate juices by HPLC−DAD−ESI-MS. J Agric Food Chem 2013;61(22):5328–37. doi:10.1021/jf400684n
4. Wang SG, Huang MH, Li JH, Lai FI, Lee HM, Hsu YN. Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells. Acta Pharmacol Sin 2013;34(11):1411–9. doi:10.1038/aps.2013.98
5. Clementi ME, Sampaolese B, Lazzarino G, Giardina B. Effect of Punicalagin and resveratrol on Methionine Sulfoxide Reductase: A Possible Protective Contribution against Alzheimer's disease. J Prevent Alzheimers Dis 2015;2(1):33–37. doi:10.14283/jpad.2015.40
6. Yan C, Sun W, Wang X, Long J, Liu X, Feng Z, et al. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res 2016;60(5):1139–49. doi:10.1002/mnfr.201500490
7. Flynn JM, Melov S. SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med 2013;62:4–12. doi:10.1016/j.freeradbiomed.2013.05.027
8. Borza LR. A review on the cause–effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases. Rev Med Chir Soc Med Nat Iasi 2014;118(1):19–27.
9. Huang WJ, Zhang X, Chen WW. Role of oxidative stress in Alzheimer's disease. Biomed Rep 2016;4(5):519–22. doi:10.3892/br.2016.630
10. Ciofani G, Genchi GG, Mazzolai B, Mattoli V. Transcriptional profile of genes involved in oxidative stress and antioxidant defense in PC12 cells following treatment with cerium oxide nanoparticles. Biochim Biophys Acta 2014;1840(1):495–506. doi:10.1016/j.bbagen.2013
11. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44–84. doi:10.1016/j.biocel.2006.07.001
12. Williams RJ, Mohanakumar KP, Beart PM. Neuro-nutraceuticals: Further insights into their promise for brain health. Neurochem Int 2016;95:1–3. doi:10.1016/j.neuint.2016.03.016
13. Islam MT. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res 2017;39(1):73–82. doi:10.1080/01616412.2016.1251711
14. Pradelli LA, Bénéteau M, Ricci JE. Mitochondrial control of Caspase- dependent and -independent cell death. Cell Mol Life Sci 2010;67(10):1589–97. doi:10.1007/s00018-010-0285-y
15. Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders–a step towards mitochondria based therapeutic strategies. Biochim Biophys Acta 2016. doi:10.1016/j.bbadis.2016.11.010
16. Vercesi AE, Kowaltowski AJ, Oliveira HC, Castilho RF. Mitochondrial Ca2+ transport, permeability transition and oxidative stress in cell death: implications in cardiotoxicity, neurodegeneration and dyslipidemias. Front Biosci 2006;1(11):2554–64. doi: 10.2741/1990
17. Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 2016;1863(12):2977–92. doi:10.1016/j.bbamcr.2016.09.012
18. Akbar M, Essa MM, Daradkeh G, Abdelmegeed MA, Choi Y, Mahmood L, et al. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res 2016;1637:34–55. doi:10.1016/j.brainres.2016.02.016
19. Clementi ME, Tringali G, Triggiani D, Giardina B. Aloe arborescens extract protects IMR-32 Cells against Alzheimer amyloid beta peptide via inhibition of radical peroxide production. Nat Prod Commun 2015;10(11):1993–5.
20. Basiri S. Evaluation of antioxidant and antiradical properties of Pomegranate (Punica granatum L.) seed and defatted seed extracts. J Food Sci Technol 2015;52(2):1117–23. doi:10.1007/s13197-013-1102-z
21. Fouad AA, Qutub HO, Al-Melhim WN. Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury. Toxicol Mech Methods 2016;26(7):538–43. doi:10.1080/15376516.2016.1211207
22. Houston DM, Robins B, Bugert JJ, Denyer SP, Heard CM. In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection. Eur J Pharm Sci 2016;96(1):99–106. doi:10.1016/j.ejps.2016.08.013
23. Shao J, Wang P, Liu A, Du X, Bai J, Chen M. Punicalagin prevents hypoxic pulmonary hypertension via anti-oxidant effects in rats. Am J Chin Med 2016;44(4):785–801. doi:10.1142/S0192415X16500439
24. Chen B, Longtine MS, Nelson DM. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. Am J Physiol Endocrinol Metab 2013;305(10):E1274–80. doi:10.1152/ajpendo.00218.2013
25. Wu XJ, Zheng YJ, Cui YY, Zhu L, Lu Y, Chen HZ. Propofol attenuates oxidative stress-induced PC12 cell injury via p38 MAP kinase dependent pathway. Acta Pharmacol Sin 2007;28(8):1123–8. doi:10.1111/j.1745-7254.2007.00610.x
26. Chaturvedi RK, Flint Beal M. Mitochondrial diseases of the brain. Free Radic Biol Med 2013;63:1–29. doi:10.1016/j.freeradbiomed.2013.03.018
27. Knudson CM, Brown NM. Mitochondria potential, bax “activation,” and programmed cell death. Methods Mol Biol 2008;414:95–108.
28. Shalini S, Dorstyn L, Dawar S, Kumar S., Old, new and emerging functions of caspases. Cell Death Differ 2015;22(4):526–39. doi:10.1038/cdd.2014.216
29. D'Amelio M, Cavallucci V, Cecconi F. Neuronal Caspase-3 signaling: not only cell death. Cell Death Differ 2010;17(7):1104–14. doi:10.1038/cdd.2009.180
30. Eberhardt MV, Jeffery EH. When dietary antioxidants perturb the thiol redox. J Sci Food Agric 2006;86(13):1996–8. doi:10.1002/jsfa.2617
31. Cerda B, Llorach R, Ceron JJ, Espin JC, Tomas-Barberan FA. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr 2003;42(1):18–28. doi:10.1007/s00394-003-0396-4