Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

Journal of Autoimmunity

Volumn 81, Issue , 2017, Pages 56-67

  Riemann, Marc ^a   Andreas, Nico ^a   Fedoseeva, Maria ^a   Meier, Elke ^a   Weih, Debra ^a   Freytag, Helga ^a   Schmidt Ullrich, Ruth ^b   Klein, Ulf ^c,d   Wang, Zhao Qi ^a   Weih, Falk ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c Columbia University ^*  (United States)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Autoimmunity; Central immune tolerance; Conditional gene targeting; Medullary thymic epithelial cells; NF B

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; C REACTIVE PROTEIN; CASEIN; CASEIN ALPHA; CLAUDIN 3; CLAUDIN 4; EPITHELIAL CELL ADHESION MOLECULE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN 2; SALIVA PROTEIN; SALIVARY PROTEIN 1; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL LOSS; CONTROLLED STUDY; DISEASE SEVERITY; DRIVE; ENZYME ACTIVITY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC MANIPULATION; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOPRECIPITATION; MEDULLARY THYMIC EPITHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMUS; THYMUS ATROPHY; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; AUTOIMMUNITY; CELL LINE; CYTOLOGY; DENDRITIC CELL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LIVER; LUNG; METABOLISM; PATHOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL LINE; CENTRAL TOLERANCE; DENDRITIC CELLS; EPITHELIAL CELLS; GENE EXPRESSION; LIVER; LUNG; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-KAPPA B; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 85017359604     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2017.03.007     Document Type: Article

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