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Journal of Experimental Medicine
Volumn 211, Issue 10, 2014, Pages 2103-2118
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits
Author keywords

[No Author keywords available]
Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; 5 (6) CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; 5-(6)-CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; FLUORESCEIN DERIVATIVE; PRDM1 PROTEIN, MOUSE; SUCCINIMIDE DERIVATIVE; TRANSCRIPTION FACTOR;
EID: 84907212728     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132613     Document Type: Article
Times cited : (173)
References (58)
  • 1
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen, C.D., T. Okada, and J.G. Cyster. 2007. Germinal-center organization and cellular dynamics. Immunity. 27:190-202. http://dx.doi.org/10.1016/j.immuni.2007.07.009
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 2
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata, C.M., R.E. Davis, Y. Demchenko, W. Bellamy, A. Gabrea, F. Zhan, G. Lenz, I. Hanamura, G. Wright, W. Xiao, et al. 2007. Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 12:115-130. http://dx.doi.org/10.1016/j.ccr.2007.07.004
    • (2007) Cancer Cell , vol.12 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3    Bellamy, W.4    Gabrea, A.5    Zhan, F.6    Lenz, G.7    Hanamura, I.8    Wright, G.9    Xiao, W.10
  • 3
    • 84890233027 scopus 로고    scopus 로고
    • Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection
    • Bannard, O., R.M. Horton, C.D. Allen, J. An, T. Nagasawa, and J.G. Cyster. 2013. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 39:912-924. http://dx.doi.org/10.1016/j.immuni.2013.08.038
    • (2013) Immunity , vol.39 , pp. 912-924
    • Bannard, O.1    Horton, R.M.2    Allen, C.D.3    An, J.4    Nagasawa, T.5    Cyster, J.G.6
  • 5
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
    • Beg, A.A., W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature. 376:167-170. http://dx.doi.org/10.1038/376167a0
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 7
    • 0032489825 scopus 로고    scopus 로고
    • Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein
    • Carrasco, D., J. Cheng, A. Lewin, G. Warr, H. Yang, C. Rizzo, F. Rosas, C. Snapper, and R. Bravo. 1998. Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein. J. Exp. Med. 187:973-984. http://dx.doi.org/10.1084/jem.187.7.973
    • (1998) J. Exp. Med , vol.187 , pp. 973-984
    • Carrasco, D.1    Cheng, J.2    Lewin, A.3    Warr, G.4    Yang, H.5    Rizzo, C.6    Rosas, F.7    Snapper, C.8    Bravo, R.9
  • 10
    • 77950022062 scopus 로고    scopus 로고
    • Single round of antigen receptor signaling programs naive B cells to receive T cell help
    • Damdinsuren, B., Y. Zhang, A. Khalil, W.H. Wood III, K.G. Becker, M.J. Shlomchik, and R. Sen. 2010. Single round of antigen receptor signaling programs naive B cells to receive T cell help. Immunity. 32:355-366. http://dx.doi.org/10.1016/j.immuni.2010.02.013
    • (2010) Immunity , vol.32 , pp. 355-366
    • Damdinsuren, B.1    Zhang, Y.2    Khalil, A.3    Wood III, W.H.4    Becker, K.G.5    Shlomchik, M.J.6    Sen, R.7
  • 11
    • 84859713325 scopus 로고    scopus 로고
    • The diverse roles of IRF4 in late germinal center B-cell differentiation
    • De Silva, N.S., G. Simonetti, N. Heise, and U. Klein. 2012. The diverse roles of IRF4 in late germinal center B-cell differentiation. Immunol. Rev. 247:73-92. http://dx.doi.org/10.1111/j.1600-065X.2012.01113.x
    • (2012) Immunol. Rev , vol.247 , pp. 73-92
    • De Silva, N.S.1    Simonetti, G.2    Heise, N.3    Klein, U.4
  • 12
    • 0030999057 scopus 로고    scopus 로고
    • NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    • Doi, T.S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 185:953-962. http://dx.doi.org/10.1084/jem.185.5.953
    • (1997) J. Exp. Med , vol.185 , pp. 953-962
    • Doi, T.S.1    Takahashi, T.2    Taguchi, O.3    Azuma, T.4    Obata, Y.5
  • 14
    • 0742304482 scopus 로고    scopus 로고
    • The role of Rel/NF-κB transcription factors in B lymphocyte survival
    • Gerondakis, S., and A. Strasser. 2003. The role of Rel/NF-κB transcription factors in B lymphocyte survival. Semin. Immunol. 15:159-166. http://dx.doi.org/10.1016/S1044-5323(03)00036-8
    • (2003) Semin. Immunol , vol.15 , pp. 159-166
    • Gerondakis, S.1    Strasser, A.2
  • 15
    • 77955288093 scopus 로고    scopus 로고
    • Roles of the NF-κB pathway in lymphocyte development and function
    • Gerondakis, S., and U. Siebenlist. 2010. Roles of the NF-κB pathway in lymphocyte development and function. Cold Spring Harb. Perspect. Biol. 2:a000182. http://dx.doi.org/10.1101/cshperspect.a000182
    • (2010) Cold Spring Harb. Perspect. Biol , vol.2 , pp. a000182
    • Gerondakis, S.1    Siebenlist, U.2
  • 16
    • 0033596128 scopus 로고    scopus 로고
    • Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel
    • Gilmore, T.D. 1999. Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene. 18:6925-6937. http://dx.doi.org/10.1038/sj.onc.1203222
    • (1999) Oncogene , vol.18 , pp. 6925-6937
    • Gilmore, T.D.1
  • 17
    • 84901644301 scopus 로고    scopus 로고
    • Clonal selection in the germinal centre by regulated proliferation and hypermutation
    • Gitlin, A.D., Z. Shulman, and M.C. Nussenzweig. 2014. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature. 509:637-640. http://dx.doi.org/10.1038/nature13300
    • (2014) Nature , vol.509 , pp. 637-640
    • Gitlin, A.D.1    Shulman, Z.2    Nussenzweig, M.C.3
  • 19
    • 0036928333 scopus 로고    scopus 로고
    • B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription
    • Grumont, R.J., A. Strasser, and S. Gerondakis. 2002. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription. Mol. Cell. 10:1283-1294. http://dx.doi.org/10.1016/S1097-2765(02)00779-7
    • (2002) Mol. Cell , vol.10 , pp. 1283-1294
    • Grumont, R.J.1    Strasser, A.2    Gerondakis, S.3
  • 20
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
    • Han, S., K. Hathcock, B. Zheng, T.B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155:556-567.
    • (1995) J. Immunol. , vol.155 , pp. 556-567
    • Han, S.1    Hathcock, K.2    Zheng, B.3    Kepler, T.B.4    Hodes, R.5    Kelsoe, G.6
  • 21
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden, M.S., and S. Ghosh. 2004. Signaling to NF-κB. Genes Dev. 18: 2195-2224. http://dx.doi.org/10.1101/gad.1228704
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 22
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acety III. The kinetics of V region mutation and selection in germinal center B cells.
    • Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178:1293-1307. http://dx.doi.org/10.1084/jem.178.4.1293
    • (1993) J. Exp. Med , vol.178 , pp. 1293-1307
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 23
    • 84858712873 scopus 로고    scopus 로고
    • NF-κB function in B lymphocytes
    • Kaileh, M., and R. Sen. 2012. NF-κB function in B lymphocytes. Immunol. Rev. 246:254-271. http://dx.doi.org/10.1111/j.1600-065X.2012.01106.x
    • (2012) Immunol. Rev , vol.246 , pp. 254-271
    • Kaileh, M.1    Sen, R.2
  • 25
    • 84861692916 scopus 로고    scopus 로고
    • B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity
    • Khalil, A.M., J.C. Cambier, and M.J. Shlomchik. 2012. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 336:1178-1181. http://dx.doi.org/10.1126/science.1213368
    • (2012) Science , vol.336 , pp. 1178-1181
    • Khalil, A.M.1    Cambier, J.C.2    Shlomchik, M.J.3
  • 26
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: role in B-cell physiology and malignancy.
    • Klein, U., and R. Dalla-Favera. 2008. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8:22-33.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 27
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein, U., Y. Tu, G.A. Stolovitzky, M. Mattioli, G. Cattoretti, H. Husson, A. Freedman, G. Inghirami, L. Cro, L. Baldini, et al. 2001. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J. Exp. Med. 194:1625-1638. http://dx.doi.org/10.1084/jem.194.11.1625
    • (2001) J. Exp. Med , vol.194 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3    Mattioli, M.4    Cattoretti, G.5    Husson, H.6    Freedman, A.7    Inghirami, G.8    Cro, L.9    Baldini, L.10
  • 29
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Ko¨ntgen, F., R.J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965-1977. http://dx.doi.org/10.1101/gad.9.16.1965
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Ko¨ntgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 30
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • Le, A., A.N. Lane, M. Hamaker, S. Bose, A. Gouw, J. Barbi, T. Tsukamoto, C.J. Rojas, B.S. Slusher, H. Zhang, et al. 2012. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 15:110-121. http://dx.doi.org/10.1016/j.cmet.2011.12.009
    • (2012) Cell Metab , vol.15 , pp. 110-121
    • Le, A.1    Lane, A.N.2    Hamaker, M.3    Bose, S.4    Gouw, A.5    Barbi, J.6    Tsukamoto, T.7    Rojas, C.J.8    Slusher, B.S.9    Zhang, H.10
  • 33
    • 0028324816 scopus 로고
    • Germinal centers
    • MacLennan, I.C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117-139. http://dx.doi.org/10.1146/annurev.iy.12.040194.001001
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 117-139
    • MacLennan, I.C.1
  • 34
    • 84886720433 scopus 로고    scopus 로고
    • The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
    • Man, K., M. Miasari, W. Shi, A. Xin, D.C. Henstridge, S. Preston, M. Pellegrini, G.T. Belz, G.K. Smyth, M.A. Febbraio, et al. 2013. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat. Immunol. 14:1155-1165. http://dx.doi.org/10.1038/ni.2710
    • (2013) Nat. Immunol , vol.14 , pp. 1155-1165
    • Man, K.1    Miasari, M.2    Shi, W.3    Xin, A.4    Henstridge, D.C.5    Preston, S.6    Pellegrini, M.7    Belz, G.T.8    Smyth, G.K.9    Febbraio, M.A.10
  • 36
    • 0024521441 scopus 로고
    • bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell, T.J., N. Deane, F.M. Platt, G. Nunez, U. Jaeger, J.P. McKearn, and S.J. Korsmeyer. 1989. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79-88. http://dx.doi.org/10.1016/0092-8674(89)90174-8
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6    Korsmeyer, S.J.7
  • 38
    • 0037007143 scopus 로고    scopus 로고
    • The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
    • Pohl, T., R. Gugasyan, R.J. Grumont, A. Strasser, D. Metcalf, D. Tarlinton, W. Sha, D. Baltimore, and S. Gerondakis. 2002. The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc. Natl. Acad. Sci. USA. 99:4514-4519. http://dx.doi.org/10.1073/pnas.072071599
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4514-4519
    • Pohl, T.1    Gugasyan, R.2    Grumont, R.J.3    Strasser, A.4    Metcalf, D.5    Tarlinton, D.6    Sha, W.7    Baltimore, D.8    Gerondakis, S.9
  • 39
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758. http://dx.doi.org/10.1038/381751a0
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 40
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific, Cre-mediated mutagenesis in mice
    • Rickert, R.C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318. http://dx.doi.org/10.1093/nar/25.6.1317
    • (1997) Nucleic Acids Res , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 41
    • 34548237299 scopus 로고    scopus 로고
    • A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
    • Saito, M., J. Gao, K. Basso, Y. Kitagawa, P.M. Smith, G. Bhagat, A. Pernis, L. Pasqualucci, and R. Dalla-Favera. 2007. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell. 12:280-292. http://dx.doi.org/10.1016/j.ccr.2007.08.011
    • (2007) Cancer Cell , vol.12 , pp. 280-292
    • Saito, M.1    Gao, J.2    Basso, K.3    Kitagawa, Y.4    Smith, P.M.5    Bhagat, G.6    Pernis, A.7    Pasqualucci, L.8    Dalla-Favera, R.9
  • 43
    • 33747133955 scopus 로고    scopus 로고
    • Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
    • Sciammas, R., A.L. Shaffer, J.H. Schatz, H. Zhao, L.M. Staudt, and H. Singh. 2006. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 25:225-236. http://dx.doi.org/10.1016/j.immuni.2006.07.009
    • (2006) Immunity , vol.25 , pp. 225-236
    • Sciammas, R.1    Shaffer, A.L.2    Schatz, J.H.3    Zhao, H.4    Staudt, L.M.5    Singh, H.6
  • 44
    • 77956065473 scopus 로고    scopus 로고
    • Selectivity of the NF-κB response
    • Sen, R., and S.T. Smale. 2010. Selectivity of the NF-κB response. Cold Spring Harb. Perspect. Biol. 2:a000257. http://dx.doi.org/10.1101/cshperspect. a000257
    • (2010) Cold Spring Harb. Perspect. Biol , vol.2 , pp. a000257
    • Sen, R.1    Smale, S.T.2
  • 45
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • Shaffer, A.L., X. Yu, Y. He, J. Boldrick, E.P. Chan, and L.M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity. 13:199-212. http://dx.doi.org/10.1016/S1074-7613(00)00020-0
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1    Yu, X.2    He, Y.3    Boldrick, J.4    Chan, E.P.5    Staudt, L.M.6
  • 47
    • 84859388765 scopus 로고    scopus 로고
    • Pathogenesis of human B cell lymphomas
    • Shaffer, A.L. III, R.M. Young, and L.M. Staudt. 2012. Pathogenesis of human B cell lymphomas. Annu. Rev. Immunol. 30:565-610. http://dx.doi.org/10.1146/annurev-immunol-020711-075027
    • (2012) Annu. Rev. Immunol , vol.30 , pp. 565-610
    • Shaffer III, A.L.1    Young, R.M.2    Staudt, L.M.3
  • 48
    • 0142219442 scopus 로고    scopus 로고
    • Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    • Shapiro-Shelef, M., K.I. Lin, L.J. McHeyzer-Williams, J. Liao, M.G. McHeyzer-Williams, and K. Calame. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity. 19:607-620. http://dx.doi.org/10.1016/S1074-7613(03)00267-X
    • (2003) Immunity , vol.19 , pp. 607-620
    • Shapiro-Shelef, M.1    Lin, K.I.2    McHeyzer-Williams, L.J.3    Liao, J.4    McHeyzer-Williams, M.G.5    Calame, K.6
  • 49
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair, L.V., J. Rolf, E. Emslie, Y.B. Shi, P.M. Taylor, and D.A. Cantrell. 2013. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14:500-508. http://dx.doi.org/10.1038/ni.2556
    • (2013) Nat. Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1    Rolf, J.2    Emslie, E.3    Shi, Y.B.4    Taylor, P.M.5    Cantrell, D.A.6
  • 50
    • 0034614896 scopus 로고    scopus 로고
    • bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
    • Smith, K.G., A. Light, L.A. O'Reilly, S.M. Ang, A. Strasser, and D. Tarlinton. 2000. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J. Exp. Med. 191:475-484. http://dx.doi.org/10.1084/jem.191.3.475
    • (2000) J. Exp. Med , vol.191 , pp. 475-484
    • Smith, K.G.1    Light, A.2    O'Reilly, L.A.3    Ang, S.M.4    Strasser, A.5    Tarlinton, D.6
  • 52
    • 0031771224 scopus 로고    scopus 로고
    • c-Rel is essential for B lymphocyte survival and cell cycle progression
    • Tumang, J.R., A. Owyang, S. Andjelic, Z. Jin, R.R. Hardy, M.L. Liou, and H.C. Liou. 1998. c-Rel is essential for B lymphocyte survival and cell cycle progression. Eur. J. Immunol. 28:4299-4312. http://dx.doi.org/10.1002/(SICI)1521-4141(199812)28:12<4299::AID-IMMU4299> 3.0.CO;2-Y
    • (1998) Eur. J. Immunol , vol.28 , pp. 4299-4312
    • Tumang, J.R.1    Owyang, A.2    Andjelic, S.3    Jin, Z.4    Hardy, R.R.5    Liou, M.L.6    Liou, H.C.7
  • 53
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu, S., and M. Karin. 2009. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733. http://dx.doi.org/10.1146/annurev.immunol.021908.132641
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 54
    • 84865285455 scopus 로고    scopus 로고
    • Metabolic switching and fuel choice during T-cell differentiation and memory development
    • van der Windt, G.J., and E.L. Pearce. 2012. Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol. Rev. 249:27-42. http://dx.doi.org/10.1111/j.1600-065X.2012.01150.x
    • (2012) Immunol. Rev , vol.249 , pp. 27-42
    • van der Windt, G.J.1    Pearce, E.L.2
  • 55
    • 84859381450 scopus 로고    scopus 로고
    • Germinal centers
    • Victora, G.D., and M.C. Nussenzweig. 2012. Germinal centers. Annu. Rev. Immunol. 30:429-457. http://dx.doi.org/10.1146/annurev-immunol-020711-075032
    • (2012) Annu. Rev. Immunol , vol.30 , pp. 429-457
    • Victora, G.D.1    Nussenzweig, M.C.2
  • 56
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora, G.D., T.A. Schwickert, D.R. Fooksman, A.O. Kamphorst, M. Meyer-Hermann, M.L. Dustin, and M.C. Nussenzweig. 2010. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 143:592-605. http://dx.doi.org/10.1016/j.cell.2010.10.032
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1    Schwickert, T.A.2    Fooksman, D.R.3    Kamphorst, A.O.4    Meyer-Hermann, M.5    Dustin, M.L.6    Nussenzweig, M.C.7

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.