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Volumn 25, Issue 5, 2017, Pages 1095-1106

Cardiovascular Gene Therapy: Past, Present, and Future

Author keywords

cardiovascular gene therapy; clinical trials; endpoints; heart failure; hyperlipidemias; ischemia; trial design

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SCATTER FACTOR; VASCULOTROPIN D; FGF4 PROTEIN, HUMAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 85017348801     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2017.03.027     Document Type: Review
Times cited : (133)

References (84)
  • 1
    • 0025132571 scopus 로고
    • Site-specific gene expression in vivo by direct gene transfer into the arterial wall
    • 1 Nabel, E.G., Plautz, G., Nabel, G.J., Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 249 (1990), 1285–1288.
    • (1990) Science , vol.249 , pp. 1285-1288
    • Nabel, E.G.1    Plautz, G.2    Nabel, G.J.3
  • 5
    • 84973375350 scopus 로고    scopus 로고
    • Gene therapy for the treatment of heart failure: promise postponed
    • 5 Hulot, J.S., Ishikawa, K., Hajjar, R.J., Gene therapy for the treatment of heart failure: promise postponed. Eur. Heart J. 37 (2016), 1651–1658.
    • (2016) Eur. Heart J. , vol.37 , pp. 1651-1658
    • Hulot, J.S.1    Ishikawa, K.2    Hajjar, R.J.3
  • 6
    • 85018231660 scopus 로고    scopus 로고
    • Angiogenic gene therapy in cardiovascular diseases: dream or vision?
    • 6 Ylä-Herttuala, S., Bridges, C., Katz, M.G., Korpisalo, P., Angiogenic gene therapy in cardiovascular diseases: dream or vision?. Eur. Heart J., 2017, 2017, 10.
    • (2017) Eur. Heart J. , vol.2017 , pp. 10
    • Ylä-Herttuala, S.1    Bridges, C.2    Katz, M.G.3    Korpisalo, P.4
  • 7
    • 84866899464 scopus 로고    scopus 로고
    • Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union
    • 7 Ylä-Herttuala, S., Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union. Mol. Ther. 20 (2012), 1831–1832.
    • (2012) Mol. Ther. , vol.20 , pp. 1831-1832
    • Ylä-Herttuala, S.1
  • 9
    • 84989261706 scopus 로고    scopus 로고
    • Intramyocardial gene therapy directed to hibernating heart muscle using a combination of electromechanical mapping and positron emission tomography
    • 9 Hassinen, I., Kivelä, A., Hedman, A., Saraste, A., Knuuti, J., Hartikainen, J.E., Ylä-Herttuala, S., Intramyocardial gene therapy directed to hibernating heart muscle using a combination of electromechanical mapping and positron emission tomography. Hum. Gene Ther. 27 (2016), 830–834.
    • (2016) Hum. Gene Ther. , vol.27 , pp. 830-834
    • Hassinen, I.1    Kivelä, A.2    Hedman, A.3    Saraste, A.4    Knuuti, J.5    Hartikainen, J.E.6    Ylä-Herttuala, S.7
  • 10
    • 0037968240 scopus 로고    scopus 로고
    • Gene transfer as a tool to induce therapeutic vascular growth
    • 10 Ylä-Herttuala, S., Alitalo, K., Gene transfer as a tool to induce therapeutic vascular growth. Nat. Med. 9 (2003), 694–701.
    • (2003) Nat. Med. , vol.9 , pp. 694-701
    • Ylä-Herttuala, S.1    Alitalo, K.2
  • 11
    • 84893659397 scopus 로고    scopus 로고
    • Treatment of refractory angina in patients not suitable for revascularization
    • 11 Henry, T.D., Satran, D., Jolicoeur, E.M., Treatment of refractory angina in patients not suitable for revascularization. Nat. Rev. Cardiol. 11 (2014), 78–95.
    • (2014) Nat. Rev. Cardiol. , vol.11 , pp. 78-95
    • Henry, T.D.1    Satran, D.2    Jolicoeur, E.M.3
  • 12
    • 84929003354 scopus 로고    scopus 로고
    • Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data
    • 12 Gyöngyösi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marban, E., Assmus, B., Henry, T.D., Traverse, J.H., et al., ACCRUE Investigators. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ. Res. 116 (2015), 1346–1360.
    • (2015) Circ. Res. , vol.116 , pp. 1346-1360
    • Gyöngyösi, M.1    Wojakowski, W.2    Lemarchand, P.3    Lunde, K.4    Tendera, M.5    Bartunek, J.6    Marban, E.7    Assmus, B.8    Henry, T.D.9    Traverse, J.H.10
  • 14
    • 20144386684 scopus 로고    scopus 로고
    • Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial
    • 14 Kastrup, J., Jørgensen, E., Rück, A., Tägil, K., Glogar, D., Ruzyllo, W., Bøtker, H.E., Dudek, D., Drvota, V., Hesse, B., et al., Euroinject One Group. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial. J. Am. Coll. Cardiol. 45 (2005), 982–988.
    • (2005) J. Am. Coll. Cardiol. , vol.45 , pp. 982-988
    • Kastrup, J.1    Jørgensen, E.2    Rück, A.3    Tägil, K.4    Glogar, D.5    Ruzyllo, W.6    Bøtker, H.E.7    Dudek, D.8    Drvota, V.9    Hesse, B.10
  • 15
    • 0038210219 scopus 로고    scopus 로고
    • Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT)
    • 15 Hedman, M., Hartikainen, J., Syvänne, M., Stjernvall, J., Hedman, A., Kivelä, A., Vanninen, E., Mussalo, H., Kauppila, E., Simula, S., et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). Circulation 107 (2003), 2677–2683.
    • (2003) Circulation , vol.107 , pp. 2677-2683
    • Hedman, M.1    Hartikainen, J.2    Syvänne, M.3    Stjernvall, J.4    Hedman, A.5    Kivelä, A.6    Vanninen, E.7    Mussalo, H.8    Kauppila, E.9    Simula, S.10
  • 16
    • 33748155036 scopus 로고    scopus 로고
    • Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment
    • 16 Stewart, D.J., Hilton, J.D., Arnold, J.M., Gregoire, J., Rivard, A., Archer, S.L., Charbonneau, F., Cohen, E., Curtis, M., Buller, C.E., et al. Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment. Gene Ther. 13 (2006), 1503–1511.
    • (2006) Gene Ther. , vol.13 , pp. 1503-1511
    • Stewart, D.J.1    Hilton, J.D.2    Arnold, J.M.3    Gregoire, J.4    Rivard, A.5    Archer, S.L.6    Charbonneau, F.7    Cohen, E.8    Curtis, M.9    Buller, C.E.10
  • 17
    • 67349287066 scopus 로고    scopus 로고
    • VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial
    • 17 Stewart, D.J., Kutryk, M.J.B., Fitchett, D., Freeman, M., Camack, N., Su, Y., Siega, A.D., Bilodeau, L., Burton, J.R., Proulx, G., et al. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial. Mol. Ther. 17 (2009), 1109–1115.
    • (2009) Mol. Ther. , vol.17 , pp. 1109-1115
    • Stewart, D.J.1    Kutryk, M.J.B.2    Fitchett, D.3    Freeman, M.4    Camack, N.5    Su, Y.6    Siega, A.D.7    Bilodeau, L.8    Burton, J.R.9    Proulx, G.10
  • 18
    • 79954490234 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial
    • 18 Kastrup, J., Jørgensen, E., Fuchs, S., Nikol, S., Bøtker, H.E., Gyöngyösi, M., Glogar, D., Kornowski, R., A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial. EuroIntervention 6 (2011), 813–818.
    • (2011) EuroIntervention , vol.6 , pp. 813-818
    • Kastrup, J.1    Jørgensen, E.2    Fuchs, S.3    Nikol, S.4    Bøtker, H.E.5    Gyöngyösi, M.6    Glogar, D.7    Kornowski, R.8
  • 19
    • 33748044611 scopus 로고    scopus 로고
    • Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease
    • 19 Ripa, R.S., Wang, Y., Jørgensen, E., Johnsen, H.E., Hesse, B., Kastrup, J., Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease. Eur. Heart J. 27 (2006), 1785–1792.
    • (2006) Eur. Heart J. , vol.27 , pp. 1785-1792
    • Ripa, R.S.1    Wang, Y.2    Jørgensen, E.3    Johnsen, H.E.4    Hesse, B.5    Kastrup, J.6
  • 20
    • 85018237578 scopus 로고    scopus 로고
    • Corautus Genetics (2006). Corautus announces termination of patient enrollment in GENASIS severe angina clinical trial.
    • 20 Corautus Genetics (2006). Corautus announces termination of patient enrollment in GENASIS severe angina clinical trial. http://www.corautus.com.
  • 21
    • 0033520056 scopus 로고    scopus 로고
    • Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
    • 21 Rosengart, T.K., Lee, L.Y., Patel, S.R., Sanborn, T.A., Parikh, M., Bergman, G.W., Hachamovitch, R., Szulc, M., Kligfield, P.D., Okin, P.M., et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 100 (1999), 468–474.
    • (1999) Circulation , vol.100 , pp. 468-474
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3    Sanborn, T.A.4    Parikh, M.5    Bergman, G.W.6    Hachamovitch, R.7    Szulc, M.8    Kligfield, P.D.9    Okin, P.M.10
  • 22
    • 77951738011 scopus 로고    scopus 로고
    • Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -
    • 22 Kilian, E.G., Sadoni, S., Vicol, C., Kelly, R., van Hulst, K., Schwaiger, M., Kupatt, C., Boekstegers, P., Pillai, R., Channon, K., et al. Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -. Circ. J. 74 (2010), 916–924.
    • (2010) Circ. J. , vol.74 , pp. 916-924
    • Kilian, E.G.1    Sadoni, S.2    Vicol, C.3    Kelly, R.4    van Hulst, K.5    Schwaiger, M.6    Kupatt, C.7    Boekstegers, P.8    Pillai, R.9    Channon, K.10
  • 24
    • 84874096269 scopus 로고    scopus 로고
    • Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease
    • 24 Rosengart, T.K., Bishawi, M.M., Halbreiner, M.S., Fakhoury, M., Finnin, E., Hollmann, C., Shroyer, A.L., Crystal, R.G., Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease. Hum. Gene Ther. 24 (2013), 203–208.
    • (2013) Hum. Gene Ther. , vol.24 , pp. 203-208
    • Rosengart, T.K.1    Bishawi, M.M.2    Halbreiner, M.S.3    Fakhoury, M.4    Finnin, E.5    Hollmann, C.6    Shroyer, A.L.7    Crystal, R.G.8
  • 25
    • 84859591761 scopus 로고    scopus 로고
    • 10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb
    • 25 Muona, K., Mäkinen, K., Hedman, M., Manninen, H., Ylä-Herttuala, S., 10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb. Gene Ther. 19 (2012), 392–395.
    • (2012) Gene Ther. , vol.19 , pp. 392-395
    • Muona, K.1    Mäkinen, K.2    Hedman, M.3    Manninen, H.4    Ylä-Herttuala, S.5
  • 26
    • 36348967096 scopus 로고    scopus 로고
    • Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model
    • 26 Koponen, J.K., Kekarainen, T., Heinonen, S.E., Laitinen, A., Nystedt, J., Laine, J., Ylä-Herttuala, S., Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model. Mol. Ther. 15 (2007), 2172–2177.
    • (2007) Mol. Ther. , vol.15 , pp. 2172-2177
    • Koponen, J.K.1    Kekarainen, T.2    Heinonen, S.E.3    Laitinen, A.4    Nystedt, J.5    Laine, J.6    Ylä-Herttuala, S.7
  • 27
    • 84886744293 scopus 로고    scopus 로고
    • Safety of direct cardiac administration of AdVEGF-All6A+, a replication-deficient adenovirus vector cDNA/genomic hybrid expressing all three major isoforms of human vascular endothelial growth factor, to the ischemic myocardium of rats
    • 27 Kaminsky, S.M., Quach, L., Chen, S., Pierre-Destine, L., Van de Graaf, B., Monette, S., Rosenberg, J.B., De, B.P., Sondhi, D., Hackett, N.R., et al. Safety of direct cardiac administration of AdVEGF-All6A+, a replication-deficient adenovirus vector cDNA/genomic hybrid expressing all three major isoforms of human vascular endothelial growth factor, to the ischemic myocardium of rats. Hum. Gene Ther. Clin. Dev. 24 (2013), 38–46.
    • (2013) Hum. Gene Ther. Clin. Dev. , vol.24 , pp. 38-46
    • Kaminsky, S.M.1    Quach, L.2    Chen, S.3    Pierre-Destine, L.4    Van de Graaf, B.5    Monette, S.6    Rosenberg, J.B.7    De, B.P.8    Sondhi, D.9    Hackett, N.R.10
  • 29
    • 84886799949 scopus 로고    scopus 로고
    • Evaluation of ASPIRE trial: a Phase III pivotal registration trial, using intracoronary administration of Generx (Ad5FGF4) to treat patients with recurrent angina pectoris
    • 29 Kaski, J.C., Consuegra-Sanchez, L., Evaluation of ASPIRE trial: a Phase III pivotal registration trial, using intracoronary administration of Generx (Ad5FGF4) to treat patients with recurrent angina pectoris. Expert Opin. Biol. Ther. 13 (2013), 1749–1753.
    • (2013) Expert Opin. Biol. Ther. , vol.13 , pp. 1749-1753
    • Kaski, J.C.1    Consuegra-Sanchez, L.2
  • 30
  • 32
    • 70349239135 scopus 로고    scopus 로고
    • Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy
    • 32 Turunen, M.P., Lehtola, T., Heinonen, S.E., Assefa, G.S., Korpisalo, P., Girnary, R., Glass, C.K., Väisänen, S., Ylä-Herttuala, S., Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ. Res. 105 (2009), 604–609.
    • (2009) Circ. Res. , vol.105 , pp. 604-609
    • Turunen, M.P.1    Lehtola, T.2    Heinonen, S.E.3    Assefa, G.S.4    Korpisalo, P.5    Girnary, R.6    Glass, C.K.7    Väisänen, S.8    Ylä-Herttuala, S.9
  • 34
    • 84867391757 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection
    • 34 Hinkel, R., Trenkwalder, T., Kupatt, C., Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection. Ann. N Y Acad. Sci. 1269 (2012), 102–109.
    • (2012) Ann. N Y Acad. Sci. , vol.1269 , pp. 102-109
    • Hinkel, R.1    Trenkwalder, T.2    Kupatt, C.3
  • 36
    • 84960158338 scopus 로고    scopus 로고
    • Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction
    • discussion 1497
    • 36 Henri, O., Pouehe, C., Houssari, M., Galas, L., Nicol, L., Edwards-Lévy, F., Henry, J.P., Dumesnil, A., Boukhalfa, I., Banquet, S., et al. Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction. Circulation 133 (2016), 1484–1497 discussion 1497.
    • (2016) Circulation , vol.133 , pp. 1484-1497
    • Henri, O.1    Pouehe, C.2    Houssari, M.3    Galas, L.4    Nicol, L.5    Edwards-Lévy, F.6    Henry, J.P.7    Dumesnil, A.8    Boukhalfa, I.9    Banquet, S.10
  • 38
    • 85016270589 scopus 로고    scopus 로고
    • Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury
    • 38 Wang, C., Zhang, C., Liu, L., A, X., Chen, B., Li, Y., Du, J., Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury. Mol. Ther. 25 (2017), 192–204.
    • (2017) Mol. Ther. , vol.25 , pp. 192-204
    • Wang, C.1    Zhang, C.2    Liu, L.3    A, X.4    Chen, B.5    Li, Y.6    Du, J.7
  • 39
    • 84883319296 scopus 로고    scopus 로고
    • Gene therapy for therapeutic angiogenesis in peripheral arterial disease - a systematic review and meta-analysis of randomized, controlled trials
    • 39 Hammer, A., Steiner, S., Gene therapy for therapeutic angiogenesis in peripheral arterial disease - a systematic review and meta-analysis of randomized, controlled trials. Vasa 42 (2013), 331–339.
    • (2013) Vasa , vol.42 , pp. 331-339
    • Hammer, A.1    Steiner, S.2
  • 40
    • 0036665610 scopus 로고    scopus 로고
    • Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study
    • 40 Mäkinen, K., Manninen, H., Hedman, M., Matsi, P., Mussalo, H., Alhava, E., Ylä-Herttuala, S., Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol. Ther. 6 (2002), 127–133.
    • (2002) Mol. Ther. , vol.6 , pp. 127-133
    • Mäkinen, K.1    Manninen, H.2    Hedman, M.3    Matsi, P.4    Mussalo, H.5    Alhava, E.6    Ylä-Herttuala, S.7
  • 41
    • 33745643590 scopus 로고    scopus 로고
    • Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial
    • 41 Kusumanto, Y.H., van Weel, V., Mulder, N.H., Smit, A.J., van den Dungen, J.J.A.M., Hooymans, J.M., Sluiter, W.J., Tio, R.A., Quax, P.H., Gans, R.O., et al. Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. Hum. Gene Ther. 17 (2006), 683–691.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 683-691
    • Kusumanto, Y.H.1    van Weel, V.2    Mulder, N.H.3    Smit, A.J.4    van den Dungen, J.J.A.M.5    Hooymans, J.M.6    Sluiter, W.J.7    Tio, R.A.8    Quax, P.H.9    Gans, R.O.10
  • 42
    • 0142023866 scopus 로고    scopus 로고
    • Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication
    • 42 Rajagopalan, S., Mohler, E.R. 3rd, Lederman, R.J., Mendelsohn, F.O., Saucedo, J.F., Goldman, C.K., Blebea, J., Macko, J., Kessler, P.D., Rasmussen, H.S., Annex, B.H., Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 108 (2003), 1933–1938.
    • (2003) Circulation , vol.108 , pp. 1933-1938
    • Rajagopalan, S.1    Mohler, E.R.2    Lederman, R.J.3    Mendelsohn, F.O.4    Saucedo, J.F.5    Goldman, C.K.6    Blebea, J.7    Macko, J.8    Kessler, P.D.9    Rasmussen, H.S.10    Annex, B.H.11
  • 45
    • 79958118819 scopus 로고    scopus 로고
    • Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    • 45 Belch, J., Hiatt, W.R., Baumgartner, I., Driver, I.V., Nikol, S., Norgren, L., Van Belle, E., TAMARIS Committees and Investigators. Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet 377 (2011), 1929–1937.
    • (2011) Lancet , vol.377 , pp. 1929-1937
    • Belch, J.1    Hiatt, W.R.2    Baumgartner, I.3    Driver, I.V.4    Nikol, S.5    Norgren, L.6    Van Belle, E.7
  • 46
    • 84930734502 scopus 로고    scopus 로고
    • Gene Therapy for peripheral arterial disease using Sendai Virus vector: from preclinical studies to the Phase I/IIa clinical trial
    • Y. Nagai First Edition Springer Japan
    • 46 Yonemitsu, Y., Matsumoto, T., Maehara, Y., Gene Therapy for peripheral arterial disease using Sendai Virus vector: from preclinical studies to the Phase I/IIa clinical trial. Nagai, Y., (eds.) Sendai Virus Vector, First Edition, 2013, Springer, Japan, 183–201.
    • (2013) Sendai Virus Vector , pp. 183-201
    • Yonemitsu, Y.1    Matsumoto, T.2    Maehara, Y.3
  • 47
    • 34247353352 scopus 로고    scopus 로고
    • Results from a phase II multicenter, double-blind placebo-controlled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease
    • 47 Grossman, P.M., Mendelsohn, F., Henry, T.D., Hermiller, J.B., Litt, M., Saucedo, J.F., Weiss, R.J., Kandzari, D.E., Kleiman, N., Anderson, R.D., et al. Results from a phase II multicenter, double-blind placebo-controlled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease. Am. Heart J. 153 (2007), 874–880.
    • (2007) Am. Heart J. , vol.153 , pp. 874-880
    • Grossman, P.M.1    Mendelsohn, F.2    Henry, T.D.3    Hermiller, J.B.4    Litt, M.5    Saucedo, J.F.6    Weiss, R.J.7    Kandzari, D.E.8    Kleiman, N.9    Anderson, R.D.10
  • 48
    • 80054960235 scopus 로고    scopus 로고
    • Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication
    • 48 Creager, M.A., Olin, J.W., Belch, J.J.F., Moneta, G.L., Henry, T.D., Rajagopalan, S., Annex, B.H., Hiatt, W.R., Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication. Circulation 124 (2011), 1765–1773.
    • (2011) Circulation , vol.124 , pp. 1765-1773
    • Creager, M.A.1    Olin, J.W.2    Belch, J.J.F.3    Moneta, G.L.4    Henry, T.D.5    Rajagopalan, S.6    Annex, B.H.7    Hiatt, W.R.8
  • 49
    • 33847421319 scopus 로고    scopus 로고
    • Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine
    • 49 Ylä-Herttuala, S., Rissanen, T.T., Vajanto, I., Hartikainen, J., Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J. Am. Coll. Cardiol. 49 (2007), 1015–1026.
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 1015-1026
    • Ylä-Herttuala, S.1    Rissanen, T.T.2    Vajanto, I.3    Hartikainen, J.4
  • 50
    • 84875126728 scopus 로고    scopus 로고
    • Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
    • 50 Dragneva, G., Korpisalo, P., Ylä-Herttuala, S., Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success. Dis. Model. Mech. 6 (2013), 312–322.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 312-322
    • Dragneva, G.1    Korpisalo, P.2    Ylä-Herttuala, S.3
  • 52
    • 70449461353 scopus 로고    scopus 로고
    • Antegrade flow and peripheral resistance determine the level of endogenous arteriogenesis in patients with superficial femoral artery occlusion
    • 52 Vajanto, I., Korpisalo, P., Karjalainen, J., Hakala, T., Mäkinen, K., Ylä-Herttuala, S., Antegrade flow and peripheral resistance determine the level of endogenous arteriogenesis in patients with superficial femoral artery occlusion. Eur. J. Clin. Invest. 39 (2009), 1048–1054.
    • (2009) Eur. J. Clin. Invest. , vol.39 , pp. 1048-1054
    • Vajanto, I.1    Korpisalo, P.2    Karjalainen, J.3    Hakala, T.4    Mäkinen, K.5    Ylä-Herttuala, S.6
  • 53
    • 50949129278 scopus 로고    scopus 로고
    • Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia
    • 53 Powell, R.J., Simons, M., Mendelsohn, F.O., Daniel, G., Henry, T.D., Koga, M., Morishita, R., Annex, B.H., Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 118 (2008), 58–65.
    • (2008) Circulation , vol.118 , pp. 58-65
    • Powell, R.J.1    Simons, M.2    Mendelsohn, F.O.3    Daniel, G.4    Henry, T.D.5    Koga, M.6    Morishita, R.7    Annex, B.H.8
  • 54
    • 77956611658 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia
    • 54 Shigematsu, H., Yasuda, K., Iwai, T., Sasajima, T., Ishimaru, S., Ohashi, Y., Yamaguchi, T., Ogihara, T., Morishita, R., Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Ther. 17 (2010), 1152–1161.
    • (2010) Gene Ther. , vol.17 , pp. 1152-1161
    • Shigematsu, H.1    Yasuda, K.2    Iwai, T.3    Sasajima, T.4    Ishimaru, S.5    Ohashi, Y.6    Yamaguchi, T.7    Ogihara, T.8    Morishita, R.9
  • 56
    • 84961207124 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial
    • 56 Greenberg, B., Butler, J., Felker, G.M., Ponikowski, P., Voors, A.A., Desai, A.S., Barnard, D., Bouchard, A., Jaski, B., Lyon, A.R., et al. Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial. Lancet 387 (2016), 1178–1186.
    • (2016) Lancet , vol.387 , pp. 1178-1186
    • Greenberg, B.1    Butler, J.2    Felker, G.M.3    Ponikowski, P.4    Voors, A.A.5    Desai, A.S.6    Barnard, D.7    Bouchard, A.8    Jaski, B.9    Lyon, A.R.10
  • 57
    • 84943549038 scopus 로고    scopus 로고
    • Gene Therapy for Heart Failure: Back to the Bench
    • 57 Ylä-Herttuala, S., Gene Therapy for Heart Failure: Back to the Bench. Mol. Ther. 23 (2015), 1551–1552.
    • (2015) Mol. Ther. , vol.23 , pp. 1551-1552
    • Ylä-Herttuala, S.1
  • 58
    • 84941313402 scopus 로고    scopus 로고
    • Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial
    • 58 Chung, E.S., Miller, L., Patel, A.N., Anderson, R.D., Mendelsohn, F.O., Traverse, J., Silver, K.H., Shin, J., Ewald, G., Farr, M.J., et al. Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial. Eur. Heart J. 36 (2015), 2228–2238.
    • (2015) Eur. Heart J. , vol.36 , pp. 2228-2238
    • Chung, E.S.1    Miller, L.2    Patel, A.N.3    Anderson, R.D.4    Mendelsohn, F.O.5    Traverse, J.6    Silver, K.H.7    Shin, J.8    Ewald, G.9    Farr, M.J.10
  • 60
    • 61949383594 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms
    • 60 Lähteenvuo, J.E., Lähteenvuo, M.T., Kivelä, A., Rosenlew, C., Falkevall, A., Klar, J., Heikura, T., Rissanen, T.T., Vähäkangas, E., Korpisalo, P., et al. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms. Circulation 119 (2009), 845–856.
    • (2009) Circulation , vol.119 , pp. 845-856
    • Lähteenvuo, J.E.1    Lähteenvuo, M.T.2    Kivelä, A.3    Rosenlew, C.4    Falkevall, A.5    Klar, J.6    Heikura, T.7    Rissanen, T.T.8    Vähäkangas, E.9    Korpisalo, P.10
  • 67
    • 84994607113 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials
    • 67 Viney, N.J., van Capelleveen, J.C., Geary, R.S., Xia, S., Tami, J.A., Yu, R.Z., Marcovina, S.M., Hughes, S.G., Graham, M.J., Crooke, R.M., et al. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet 388 (2016), 2239–2253.
    • (2016) Lancet , vol.388 , pp. 2239-2253
    • Viney, N.J.1    van Capelleveen, J.C.2    Geary, R.S.3    Xia, S.4    Tami, J.A.5    Yu, R.Z.6    Marcovina, S.M.7    Hughes, S.G.8    Graham, M.J.9    Crooke, R.M.10
  • 70
    • 84888090979 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial
    • 70 Thomas, G.S., Cromwell, W.C., Ali, S., Chin, W., Flaim, J.D., Davidson, M., Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial. J. Am. Coll. Cardiol. 62 (2013), 2178–2184.
    • (2013) J. Am. Coll. Cardiol. , vol.62 , pp. 2178-2184
    • Thomas, G.S.1    Cromwell, W.C.2    Ali, S.3    Chin, W.4    Flaim, J.D.5    Davidson, M.6
  • 71
    • 85004011287 scopus 로고    scopus 로고
    • Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis
    • 71 Wacker, B.K., Dronadula, N., Zhang, J., Dichek, D.A., Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 37 (2017), 316–327.
    • (2017) Arterioscler. Thromb. Vasc. Biol. , vol.37 , pp. 316-327
    • Wacker, B.K.1    Dronadula, N.2    Zhang, J.3    Dichek, D.A.4
  • 75
    • 0032559625 scopus 로고    scopus 로고
    • Gene therapy for restenosis: are we ready?
    • 75 DeYoung, M.B., Dichek, D.A., Gene therapy for restenosis: are we ready?. Circ. Res. 82 (1998), 306–313.
    • (1998) Circ. Res. , vol.82 , pp. 306-313
    • DeYoung, M.B.1    Dichek, D.A.2
  • 76
    • 0037116555 scopus 로고    scopus 로고
    • Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenting (ITALICS) trial
    • 76 Kutryk, M.J., Foley, D.P., van den Brand, M., Hamburger, J.N., van der Giessen, W.J., deFeyter, P.J., Bruining, N., Sabate, M., Serruys, P.W., ITALICS Trial. Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenting (ITALICS) trial. J. Am. Coll. Cardiol. 39 (2002), 281–287.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 281-287
    • Kutryk, M.J.1    Foley, D.P.2    van den Brand, M.3    Hamburger, J.N.4    van der Giessen, W.J.5    deFeyter, P.J.6    Bruining, N.7    Sabate, M.8    Serruys, P.W.9
  • 77
    • 33645914432 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase with vaccinia virus anti-inflammatory protein 35K or tissue inhibitor of metalloproteinase-1: Combination gene therapy in the treatment of vein graft stenosis in rabbits
    • 77 Turunen, P., Puhakka, H.L., Heikura, T., Romppanen, E., Inkala, M., Leppänen, O., Ylä-Herttuala, S., Extracellular superoxide dismutase with vaccinia virus anti-inflammatory protein 35K or tissue inhibitor of metalloproteinase-1: Combination gene therapy in the treatment of vein graft stenosis in rabbits. Hum. Gene Ther. 17 (2006), 405–414.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 405-414
    • Turunen, P.1    Puhakka, H.L.2    Heikura, T.3    Romppanen, E.4    Inkala, M.5    Leppänen, O.6    Ylä-Herttuala, S.7
  • 78
    • 80052735881 scopus 로고    scopus 로고
    • Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy
    • 78 George, S.J., Wan, S., Hu, J., MacDonald, R., Johnson, J.L., Baker, A.H., Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy. Circulation 124:11, Suppl (2011), S135–S142.
    • (2011) Circulation , vol.124 , Issue.11 , pp. S135-S142
    • George, S.J.1    Wan, S.2    Hu, J.3    MacDonald, R.4    Johnson, J.L.5    Baker, A.H.6
  • 79
    • 33645734355 scopus 로고    scopus 로고
    • Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery
    • discussion 751
    • 79 Conte, M.S., Bandyk, D.F., Clowes, A.W., Moneta, G.L., Seely, L., Lorenz, T.J., Namini, H., Hamdan, A.D., Roddy, S.P., Belkin, M., et al., PREVENT III Investigators. Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery. J. Vasc. Surg. 43 (2006), 742–751 discussion 751.
    • (2006) J. Vasc. Surg. , vol.43 , pp. 742-751
    • Conte, M.S.1    Bandyk, D.F.2    Clowes, A.W.3    Moneta, G.L.4    Seely, L.5    Lorenz, T.J.6    Namini, H.7    Hamdan, A.D.8    Roddy, S.P.9    Belkin, M.10
  • 80
    • 27744431927 scopus 로고    scopus 로고
    • Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial
    • 80 Alexander, J.H., Hafley, G., Harrington, R.A., Peterson, E.D., Ferguson, T.B. Jr., Lorenz, T.J., Goyal, A., Gibson, M., Mack, M.J., Gennevois, D., et al., PREVENT IV Investigators. Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. JAMA 294 (2005), 2446–2454.
    • (2005) JAMA , vol.294 , pp. 2446-2454
    • Alexander, J.H.1    Hafley, G.2    Harrington, R.A.3    Peterson, E.D.4    Ferguson, T.B.5    Lorenz, T.J.6    Goyal, A.7    Gibson, M.8    Mack, M.J.9    Gennevois, D.10
  • 81
    • 85018239111 scopus 로고    scopus 로고
    • Ark Therapeutics. (2009) Ark Therapeutics completes potency test qualification enabling Trinam Phase III trial to begin. Quick Facts RTTNews. 8.1.2009.
    • 81 Ark Therapeutics. (2009) Ark Therapeutics completes potency test qualification enabling Trinam Phase III trial to begin. Quick Facts RTTNews. 8.1.2009.
  • 82
    • 34250772826 scopus 로고    scopus 로고
    • Current status of cardiovascular gene therapy
    • 82 Rissanen, T.T., Ylä-Herttuala, S., Current status of cardiovascular gene therapy. Mol. Ther. 15 (2007), 1233–1247.
    • (2007) Mol. Ther. , vol.15 , pp. 1233-1247
    • Rissanen, T.T.1    Ylä-Herttuala, S.2


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